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Volumn 3, Issue 3, 2009, Pages 167-176

Statins in bacteremia, sepsis and pneumonia: Have we found the holy grail?

Author keywords

Pneumonia; Sepsis; Septic shock; Statins

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CHOLESTEROL; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; MEVALONIC ACID; MEVINOLIN; PLACEBO; SIMVASTATIN;

EID: 70350784300     PISSN: 1872213X     EISSN: None     Source Type: Journal    
DOI: 10.2174/187221309789257469     Document Type: Review
Times cited : (11)

References (95)
  • 1
    • 70350785360 scopus 로고    scopus 로고
    • Multiple effects of statins in non-lipid disease states
    • Sheffield MC. Multiple effects of statins in non-lipid disease states. US Pharm 2004; 6: 38-54.
    • (2004) US Pharm , vol.6 , pp. 38-54
    • Sheffield, M.C.1
  • 2
    • 0033596281 scopus 로고    scopus 로고
    • Effect of statins on risk of coronary disease: A meta-analysis of randomized controlled trials
    • La Rosa JC, He J, Vupputuri S. Effect of statins on risk of coronary disease: A meta-analysis of randomized controlled trials. JAMA 1999; 282: 2340-2346.
    • (1999) JAMA , vol.282 , pp. 2340-2346
    • La Rosa, J.C.1    He, J.2    Vupputuri, S.3
  • 3
    • 0027987849 scopus 로고
    • Randomised Trial of Cholesterol Lowering in 4444 Patients with Coronary Heart Disease: The Scandinavian Simvastatin Survival Study (4S)
    • Randomised Trial of Cholesterol Lowering in 4444 Patients with Coronary Heart Disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 1994; 344: 1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 4
    • 0032487931 scopus 로고    scopus 로고
    • Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels: The Long- Term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group
    • The Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) Study Group. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels: The Long- Term Intervention with Pravastatin in Ischemic Disease (LIPID) Study Group. N Engl J Med 1998; 339 (19): 1349-1357.
    • (1998) N Engl J Med , vol.339 , Issue.19 , pp. 1349-1357
  • 5
    • 70350766445 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of Cholesterol lowering with simvastatin in 20563 high-risk individuals. A randomized placebocontrolled trial. Lancet 2002; 360: 7-22.
    • MRC/BHF Heart Protection Study of Cholesterol lowering with simvastatin in 20563 high-risk individuals. A randomized placebocontrolled trial. Lancet 2002; 360: 7-22.
  • 6
    • 0342981862 scopus 로고    scopus 로고
    • The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels: Cholesterol and Recurrent Events Trial investigators
    • Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels: Cholesterol and Recurrent Events Trial investigators. N Engl J Med 1996; 335: 1001-1009.
    • (1996) N Engl J Med , vol.335 , pp. 1001-1009
    • Sacks, F.M.1    Pfeffer, M.A.2    Moye, L.A.3
  • 7
    • 0037178569 scopus 로고    scopus 로고
    • Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: A randomized controlled trial
    • Serruys PW, Pim de Feyter, Macaya C, et al. Fluvastatin for prevention of cardiac events following successful first percutaneous coronary intervention: A randomized controlled trial. JAMA 2002; 287: 3215-3522.
    • (2002) JAMA , vol.287 , pp. 3215-3522
    • Serruys, P.W.1    Pim de Feyter, M.C.2
  • 8
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study Group
    • Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study Group. N Engl J Med 1995; 333 (20): 1301-1307.
    • (1995) N Engl J Med , vol.333 , Issue.20 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3
  • 10
    • 33750958903 scopus 로고    scopus 로고
    • Statins and outcomes in patients admitted to hospital and community acquired pneumonia: Population based prospective cohort study
    • Majumdar SR, McAlister FA, Eurich DT, Padwal RS, Marrie TJ. Statins and outcomes in patients admitted to hospital and community acquired pneumonia: Population based prospective cohort study. BMJ 2006; 333: 999.
    • (2006) BMJ , vol.333 , pp. 999
    • Majumdar, S.R.1    McAlister, F.A.2    Eurich, D.T.3    Padwal, R.S.4    Marrie, T.J.5
  • 11
    • 70350782625 scopus 로고    scopus 로고
    • HMG-CoA reductase. Wikipedia the free encyclopedia
    • HMG-CoA reductase. Wikipedia the free encyclopedia.
  • 12
    • 0026720521 scopus 로고
    • Immunological evidence for 8 spans in the membrane domain of 3-Hydroxy-3-Methylglutaryl coenzyme A reductase: Implication for enzyme degradation in the endoplasmic reticulum
    • Roitelman J, Olender EH, Bar-Nun S, Dunn WA, Simoni RD. Immunological evidence for 8 spans in the membrane domain of 3-Hydroxy-3-Methylglutaryl coenzyme A reductase: Implication for enzyme degradation in the endoplasmic reticulum. J Cell Biol 1992; 117: 959-973.
    • (1992) J Cell Biol , vol.117 , pp. 959-973
    • Roitelman, J.1    Olender, E.H.2    Bar-Nun, S.3    Dunn, W.A.4    Simoni, R.D.5
  • 13
    • 33746097380 scopus 로고    scopus 로고
    • Statins in the intensive care unit
    • Merx MW, Weber C. Statins in the intensive care unit. Curr Opin Crit Care 2006; 12: 309-314.
    • (2006) Curr Opin Crit Care , vol.12 , pp. 309-314
    • Merx, M.W.1    Weber, C.2
  • 14
    • 0036322869 scopus 로고    scopus 로고
    • Isoprenoids as mediator of the biological effects of statins
    • Liao JK. Isoprenoids as mediator of the biological effects of statins. Clin Invest 2002; 110: 285-288.
    • (2002) Clin Invest , vol.110 , pp. 285-288
    • Liao, J.K.1
  • 15
    • 0027505992 scopus 로고
    • Serum cholesterol in young men and subsequent cardiovascular disease
    • Klag MJ, Ford DE, Mead LA, et al. Serum cholesterol in young men and subsequent cardiovascular disease. N Engl J Med 1993; 328(5): 313-318.
    • (1993) N Engl J Med , vol.328 , Issue.5 , pp. 313-318
    • Klag, M.J.1    Ford, D.E.2    Mead, L.A.3
  • 16
    • 0037233011 scopus 로고    scopus 로고
    • The statins as anticancer agents
    • Chan K, Oza A, Siu L. The statins as anticancer agents. Clin Cancer Res 2003; 9(1): 10-19.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 10-19
    • Chan, K.1    Oza, A.2    Siu, L.3
  • 17
    • 0036156342 scopus 로고    scopus 로고
    • The MRC/BHF Heart Protection Study: Preliminary results
    • Collins R, Peto R, Armitage J. The MRC/BHF Heart Protection Study: Preliminary results. Int J Clin Pract 2002; 56: 53-56.
    • (2002) Int J Clin Pract , vol.56 , pp. 53-56
    • Collins, R.1    Peto, R.2    Armitage, J.3
  • 18
    • 0027322448 scopus 로고
    • Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease
    • Brown BG, Zhao XQ, Sacco DE, Albers JJ. Lipid lowering and plaque regression. New insights into prevention of plaque disruption and clinical events in coronary disease. Circulation 1993; 87: 1781- 1791.
    • (1993) Circulation , vol.87 , pp. 1781-1791
    • Brown, B.G.1    Zhao, X.Q.2    Sacco, D.E.3    Albers, J.J.4
  • 19
    • 0035804846 scopus 로고    scopus 로고
    • Effects of atorvastatin on early reccurent ischemic events in acute coronary syndromes. The MIRACL study: A randomized controlled trial
    • Schwartz GG, Olsson AG, Ezekowitz MD, et al. Effects of atorvastatin on early reccurent ischemic events in acute coronary syndromes. The MIRACL study: A randomized controlled trial. JAMA 2001; 285: 1711-1718.
    • (2001) JAMA , vol.285 , pp. 1711-1718
    • Schwartz, G.G.1    Olsson, A.G.2    Ezekowitz, M.D.3
  • 20
    • 33645384019 scopus 로고    scopus 로고
    • Effects of statins beyond lipid lowering: Potential for clinical benefits
    • Almuti K, Rimawi R, Spevack D, Ostfeld RJ. Effects of statins beyond lipid lowering: Potential for clinical benefits. Int J Cardiol 2006; 109: 7-15.
    • (2006) Int J Cardiol , vol.109 , pp. 7-15
    • Almuti, K.1    Rimawi, R.2    Spevack, D.3    Ostfeld, R.J.4
  • 21
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis an inflammatory disease
    • Ross R. Atherosclerosis an inflammatory disease. N Engl J Med 1999; 340: 115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 22
    • 0033587667 scopus 로고    scopus 로고
    • Long term effects of pravastatin on plasma concentration of C-reactive protein
    • Ridker PM, Rifai N, Pfeffer MA, Sacks F, Braunwald E. Long term effects of pravastatin on plasma concentration of C-reactive protein. Circulation 1999; 100: 230-235.
    • (1999) Circulation , vol.100 , pp. 230-235
    • Ridker, P.M.1    Rifai, N.2    Pfeffer, M.A.3    Sacks, F.4    Braunwald, E.5
  • 23
    • 0035806626 scopus 로고    scopus 로고
    • PRINCE Investigators. Effect of statin therapy on C-reactive protein levels: The pravastatin inflammation/CRP evaluation (PRINCE): A randomized trial and cohort study
    • Albert MA, Danielson E, Rifai N, Ridker PM, PRINCE Investigators. Effect of statin therapy on C-reactive protein levels: the pravastatin inflammation/CRP evaluation (PRINCE): A randomized trial and cohort study. JAMA 2001; 286: 64-70.
    • (2001) JAMA , vol.286 , pp. 64-70
    • Albert, M.A.1    Danielson, E.2    Rifai, N.3    Ridker, P.M.4
  • 24
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U, La Fata J, Plutzky J, Liao JK. Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors. Circulation 1998; 97: 1129-1135.
    • (1998) Circulation , vol.97 , pp. 1129-1135
    • Laufs, U.1    La Fata, J.2    Plutzky, J.3    Liao, J.K.4
  • 25
    • 0028085059 scopus 로고
    • Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant morphology
    • Van der Wal AC, Becker AE, Van der Loos CM, Das PK. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant morphology. Circulation 1994; 89: 36-44.
    • (1994) Circulation , vol.89 , pp. 36-44
    • Van der Wal, A.C.1    Becker, A.E.2    Van der Loos, C.M.3    Das, P.K.4
  • 26
    • 0027253887 scopus 로고
    • Risk of thrombosis in human atherosclerotic plaques: The role of extracellular lipid, macrophages, and smooth muscle cell content
    • Davies M, Richardson P, Woolf N. Risk of thrombosis in human atherosclerotic plaques: The role of extracellular lipid, macrophages, and smooth muscle cell content. Br Heart J 1993; 69: 377-381.
    • (1993) Br Heart J , vol.69 , pp. 377-381
    • Davies, M.1    Richardson, P.2    Woolf, N.3
  • 27
    • 33745847843 scopus 로고    scopus 로고
    • Drug Insight: Immunomodulatory effects of statins-potential benefits for renal patients? Nat Clin Pract
    • Steffens S, Mach F. Drug Insight: Immunomodulatory effects of statins-potential benefits for renal patients? Nat Clin Pract Nephrol 2006; 2(7): 378-387.
    • (2006) Nephrol , vol.2 , Issue.7 , pp. 378-387
    • Steffens, S.1    Mach, F.2
  • 29
    • 16844387479 scopus 로고    scopus 로고
    • The Ras super family at a glance
    • Wennerberg K, Rossman KL, Der CJ. The Ras super family at a glance. J Cell Sci 2005; 118: 843-846.
    • (2005) J Cell Sci , vol.118 , pp. 843-846
    • Wennerberg, K.1    Rossman, K.L.2    CJ, D.3
  • 30
    • 0034994075 scopus 로고    scopus 로고
    • Statin induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-1
    • Marti G, Duez H, Blanquart C, et al. Statin induced inhibition of the Rho-signaling pathway activates PPARalpha and induces HDL apoA-1. J Clin Invest 2001; 107: 1423-1432.
    • (2001) J Clin Invest , vol.107 , pp. 1423-1432
    • Marti, G.1    Duez, H.2    Blanquart, C.3
  • 31
    • 0033527569 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-KappaB and AP-1
    • Delerive P, De Bosscher K, Besnard S, et al. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-KappaB and AP-1. J Biol Chem 1999; 274: 32048-32054.
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3
  • 32
    • 0032757209 scopus 로고    scopus 로고
    • Atorvastatin reduces NF-KappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells
    • Ortego M, Bustos C, Hernandez-Presa MA, et al. Atorvastatin reduces NF-KappaB activation and chemokine expression in vascular smooth muscle cells and mononuclear cells. Atherosclerosis 1999; 147: 253-261.
    • (1999) Atherosclerosis , vol.147 , pp. 253-261
    • Ortego, M.1    Bustos, C.2    Hernandez-Presa, M.A.3
  • 33
    • 0036445650 scopus 로고    scopus 로고
    • Modulation of inflammatory mediators and PPRgamma and NFKappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro
    • Zelvyte I, Dominaitiene R, Crisby M, Janciauskiene S. Modulation of inflammatory mediators and PPRgamma and NFKappaB expression by pravastatin in response to lipoproteins in human monocytes in vitro. Pharmacol Res 2002; 45: 147-54.
    • (2002) Pharmacol Res , vol.45 , pp. 147-154
    • Zelvyte, I.1    Dominaitiene, R.2    Crisby, M.3    Janciauskiene, S.4
  • 34
    • 0036694663 scopus 로고    scopus 로고
    • Regulation of cytokine signalling and inflammation
    • Hanada T, Yoshimura A. Regulation of cytokine signalling and inflammation. Cytokine Growth Factor Rev 2002; 13: 413-421.
    • (2002) Cytokine Growth Factor Rev , vol.13 , pp. 413-421
    • Hanada, T.1    Yoshimura, A.2
  • 36
    • 34548356919 scopus 로고    scopus 로고
    • Potential roles for Statins in Critically Ill patients
    • Weant KA, Cook AM. Potential roles for Statins in Critically Ill patients. Pharmacotherapy 2007; 27(9): 1279-1296.
    • (2007) Pharmacotherapy , vol.27 , Issue.9 , pp. 1279-1296
    • Weant, K.A.1    Cook, A.M.2
  • 37
    • 3242790926 scopus 로고    scopus 로고
    • Sepsis: Current status, future prospects
    • Marshall JC. Sepsis: Current status, future prospects. Curr Opin Crit Care 2004; 10: 250-264.
    • (2004) Curr Opin Crit Care , vol.10 , pp. 250-264
    • Marshall, J.C.1
  • 38
    • 0033590515 scopus 로고    scopus 로고
    • Treating patients with severe sepsis
    • Wheeler AP, Bernard GR. Treating patients with severe sepsis. N Engl J Med 1999; 340: 207-214.
    • (1999) N Engl J Med , vol.340 , pp. 207-214
    • Wheeler, A.P.1    Bernard, G.R.2
  • 39
    • 33846117867 scopus 로고    scopus 로고
    • Effectiveness of Statins in reducing the rate of Severe Sepsis: A Retrospective Evaluation
    • Martin CP, Talbert RL, Burgess DS, Peters JL. Effectiveness of Statins in reducing the rate of Severe Sepsis: A Retrospective Evaluation. Pharmacotherapy 2007; 27(1): 20-26.
    • (2007) Pharmacotherapy , vol.27 , Issue.1 , pp. 20-26
    • Martin, C.P.1    Talbert, R.L.2    Burgess, D.S.3    Peters, J.L.4
  • 40
    • 4143083577 scopus 로고    scopus 로고
    • Prior statin therapy is associated with a decreased rate of severe sepsis
    • Almog Y, Shefer A, Novack V, et al. Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation 2004; 110(7): 880-885.
    • (2004) Circulation , vol.110 , Issue.7 , pp. 880-885
    • Almog, Y.1    Shefer, A.2    Novack, V.3
  • 42
    • 13444304051 scopus 로고    scopus 로고
    • Fluvastatin inhibits the expression of tumor necrosis factor -alpha and activation of nuclear factor-kappab in human endothelial cells stimulated by C-reactive protein
    • Wang HR, Li JJ, Huang CX, Jiang H. Fluvastatin inhibits the expression of tumor necrosis factor -alpha and activation of nuclear factor-kappab in human endothelial cells stimulated by C-reactive protein. Clin Chim Acta 2005; 353: 53-60.
    • (2005) Clin Chim Acta , vol.353 , pp. 53-60
    • Wang, H.R.1    Li, J.J.2    Huang, C.X.3    Jiang, H.4
  • 43
    • 0036186165 scopus 로고    scopus 로고
    • Atorvastatin activates PPARgamma and attenuates the inflammatory response in human monocytes
    • Grip O, Janciauskiene S, Lindgren S. Atorvastatin activates PPARgamma and attenuates the inflammatory response in human monocytes. Inflamm Res 2002; 51: 58-62.
    • (2002) Inflamm Res , vol.51 , pp. 58-62
    • Grip, O.1    Janciauskiene, S.2    Lindgren, S.3
  • 44
    • 2942567910 scopus 로고    scopus 로고
    • Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors
    • Matsumoto M, Einhaus D, Gold ES, Aderem A. Simvastatin augments lipopolysaccharide-induced proinflammatory responses in macrophages by differential regulation of the c-Fos and c-Jun transcription factors. J Immunol 2004; 172: 7377-7384.
    • (2004) J Immunol , vol.172 , pp. 7377-7384
    • Matsumoto, M.1    Einhaus, D.2    Gold, E.S.3    Aderem, A.4
  • 45
    • 0033842917 scopus 로고    scopus 로고
    • Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis
    • Ando H, Takamura T, Ota T, Nagai Y, Kobayashi K. Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis. J Pharmacol Exp Ther 2000; 294: 1043-1046.
    • (2000) J Pharmacol Exp Ther , vol.294 , pp. 1043-1046
    • Ando, H.1    Takamura, T.2    Ota, T.3    Nagai, Y.4    Kobayashi, K.5
  • 46
    • 0033586472 scopus 로고    scopus 로고
    • Inhibition of proinflammatory cytokine production by pravastatin
    • Rosenson RS, Tangney CC, Casey LC. Inhibition of proinflammatory cytokine production by pravastatin. Lancet 1999; 353: 983-984.
    • (1999) Lancet , vol.353 , pp. 983-984
    • Rosenson, R.S.1    Tangney, C.C.2    Casey, L.C.3
  • 47
    • 9344256068 scopus 로고    scopus 로고
    • Simvastatin prevents vascular hyporeactivity during inflammation
    • Pleiner J, Schaller G, Mittermayer F, et al. Simvastatin prevents vascular hyporeactivity during inflammation. Circulation 2004; 110: 3349-3354.
    • (2004) Circulation , vol.110 , pp. 3349-3354
    • Pleiner, J.1    Schaller, G.2    Mittermayer, F.3
  • 48
    • 0035574650 scopus 로고    scopus 로고
    • in vivo Anti-inflammatory effects of statins are mediated by nonsterol mevalonate products
    • Diomede L, Albani D, Sottocorno M, et al. in vivo Anti-inflammatory effects of statins are mediated by nonsterol mevalonate products. Arterioscler Thromb Vasc Biol 2001; 21: 1327-1332.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1327-1332
    • Diomede, L.1    Albani, D.2    Sottocorno, M.3
  • 49
    • 0034681953 scopus 로고    scopus 로고
    • Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae
    • Kothe H, Dalhoff K, Rupp J, et al. Hydroxymethylglutaryl coenzyme A reductase inhibitors modify the inflammatory response of human macrophages and endothelial cells infected with Chlamydia pneumoniae. Circulation 2000; 101: 1760-1763.
    • (2000) Circulation , vol.101 , pp. 1760-1763
    • Kothe, H.1    Dalhoff, K.2    Rupp, J.3
  • 50
    • 20244378532 scopus 로고    scopus 로고
    • Simvastatin blunts endotoxin - induced tissue factor in vivo
    • Steiner S, Speidl WS, Pleiner J, et al. Simvastatin blunts endotoxin - induced tissue factor in vivo. Circulation 2005; 111: 1841-1846.
    • (2005) Circulation , vol.111 , pp. 1841-1846
    • Steiner, S.1    Speidl, W.S.2    Pleiner, J.3
  • 51
    • 0033913583 scopus 로고    scopus 로고
    • Inhibition of monocyte chemotactic protein -1 synthase by statins
    • Romano M, Diomede L, Sironi M, et al. Inhibition of monocyte chemotactic protein -1 synthase by statins. Lab Invest 2000; 80: 1095-1100.
    • (2000) Lab Invest , vol.80 , pp. 1095-1100
    • Romano, M.1    Diomede, L.2    Sironi, M.3
  • 52
    • 33746473678 scopus 로고    scopus 로고
    • Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages
    • Veillard NR, Braunersreuther V, Arnaud C, et al. Simvastatin modulates chemokine and chemokine receptor expression by geranylgeranyl isoprenoid pathway in human endothelial cells and macrophages. Atherosclerosis 2006; 188: 51-58.
    • (2006) Atherosclerosis , vol.188 , pp. 51-58
    • Veillard, N.R.1    Braunersreuther, V.2    Arnaud, C.3
  • 53
    • 0033398822 scopus 로고    scopus 로고
    • Simvastatin inhibits leukocyte - endothelial interactions and protects against inflammatory processes in normocholesterolemic rats
    • Pruefer D, Scalia R, Lefer AM. Simvastatin inhibits leukocyte - endothelial interactions and protects against inflammatory processes in normocholesterolemic rats. Arterioscler Thromb Vasc Biol 1999; 19: 2894-2900.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 2894-2900
    • Pruefer, D.1    Scalia, R.2    Lefer, A.M.3
  • 54
    • 0030838319 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia
    • Weber C, Erl W, Weber KS, Weber PC. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol 1997; 30: 1212-1217.
    • (1997) J Am Coll Cardiol , vol.30 , pp. 1212-1217
    • Weber, C.1    Erl, W.2    Weber, K.S.3    Weber, P.C.4
  • 55
    • 0035723275 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitor modulates monocyte endothelial cell interaction under physiological flow conditions in vitro: Involvement of Rho GTPase-dependent mechanism
    • Yoshida M, Sawada T, Ishii H, et al. HMG-CoA reductase inhibitor modulates monocyte endothelial cell interaction under physiological flow conditions in vitro: Involvement of Rho GTPase-dependent mechanism. Arterioscler Thromb Vasc Biol 2001; 21: 1165-1171.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1165-1171
    • Yoshida, M.1    Sawada, T.2    Ishii, H.3
  • 56
    • 0033543673 scopus 로고    scopus 로고
    • Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I -domain
    • Kallen J, Welzenbach K, Ramage P, et al. Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I -domain. J Mol Biol 1999; 292: 1-9.
    • (1999) J Mol Biol , vol.292 , pp. 1-9
    • Kallen, J.1    Welzenbach, K.2    Ramage, P.3
  • 57
    • 0034948339 scopus 로고    scopus 로고
    • Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site
    • Weitz- Schmidt G, Welzenbach K, Brinkmann V, et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001; 7: 687-692.
    • (2001) Nat Med , vol.7 , pp. 687-692
    • Weitz- Schmidt, G.1    Welzenbach, K.2    Brinkmann, V.3
  • 58
    • 0034533147 scopus 로고    scopus 로고
    • Statins as a newly recognized type of immunomodulator
    • Kwak B, Mullhaupt F, Myit S, Mach F. Statins as a newly recognized type of immunomodulator. Nat Med 2000; 6: 1399-1302.
    • (2000) Nat Med , vol.6 , pp. 1399-1302
    • Kwak, B.1    Mullhaupt, F.2    Myit, S.3    Mach, F.4
  • 60
    • 0141920370 scopus 로고    scopus 로고
    • Bench-to- bedside review; microvascular dysfunction in sepsis-hemodynamics oxygen transport, and nitric oxide
    • Bateman RM, Sharpe MD, Ellis CG. Bench-to- bedside review; microvascular dysfunction in sepsis-hemodynamics oxygen transport, and nitric oxide. Crit Care 2003; 7: 359-373.
    • (2003) Crit Care , vol.7 , pp. 359-373
    • Bateman, R.M.1    Sharpe, M.D.2    Ellis, C.G.3
  • 61
    • 70350785383 scopus 로고    scopus 로고
    • US20090047340
    • Guilford, F. T.: US20090047340 (2009).
    • (2009)
    • Guilford, F.T.1
  • 62
    • 0038646299 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages
    • Huang KC, Chen CW, Chen JC, Lin WW. HMG-CoA reductase inhibitors inhibit inducible nitric oxide synthase gene expression in macrophages. J Biomed Sci 2003; 10: 53-60.
    • (2003) J Biomed Sci , vol.10 , pp. 53-60
    • Huang, K.C.1    Chen, C.W.2    Chen, J.C.3    Lin, W.W.4
  • 63
    • 4744363569 scopus 로고    scopus 로고
    • Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats
    • Giusti-Paiva A, Martinez MR, Felix JV, et al. Simvastatin decreases nitric oxide overproduction and reverts the impaired vascular responsiveness induced by endotoxic shock in rats. Shock 2004; 21: 271-275.
    • (2004) Shock , vol.21 , pp. 271-275
    • Giusti-Paiva, A.1    Martinez, M.R.2    Felix, J.V.3
  • 64
    • 0037109098 scopus 로고    scopus 로고
    • Simvastatin inhibits inflammatory properties of Staphyloccocus aureus alpha-toxin
    • Pruefer D, Makowski J, Schnell M, et al. Simvastatin inhibits inflammatory properties of Staphyloccocus aureus alpha-toxin. Circulation 2002; 106: 2104-2110.
    • (2002) Circulation , vol.106 , pp. 2104-2110
    • Pruefer, D.1    Makowski, J.2    Schnell, M.3
  • 65
    • 0034596874 scopus 로고    scopus 로고
    • Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis
    • Brouard S, Otterbein LE, Anrather J, et al. Carbon monoxide generated by heme oxygenase 1 suppresses endothelial cell apoptosis. J Exp Med 2000; 192: 1015-1026.
    • (2000) J Exp Med , vol.192 , pp. 1015-1026
    • Brouard, S.1    Otterbein, L.E.2    Anrather, J.3
  • 66
    • 0031468072 scopus 로고    scopus 로고
    • Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells
    • Morita T, Mitsialis SA, Koike H, Liu Y, Kourembanas S. Carbon monoxide controls the proliferation of hypoxic vascular smooth muscle cells. J Biol Chem 1997; 272: 32804-32809.
    • (1997) J Biol Chem , vol.272 , pp. 32804-32809
    • Morita, T.1    Mitsialis, S.A.2    Koike, H.3    Liu, Y.4    Kourembanas, S.5
  • 67
    • 0034071424 scopus 로고    scopus 로고
    • Carbon monoxide has antiinflammatory effects involving the mitogen-activated protein Kinase pathway
    • Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has antiinflammatory effects involving the mitogen-activated protein Kinase pathway. Nat Med 2000; 6: 422-428.
    • (2000) Nat Med , vol.6 , pp. 422-428
    • Otterbein, L.E.1    Bach, F.H.2    Alam, J.3
  • 68
    • 0032901266 scopus 로고    scopus 로고
    • Carbon monoxide provides protection against hyperoxic lung injury
    • Otterbein LE, Mantell LL, Choi AM. Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol 1999; 276: L688-L694.
    • (1999) Am J Physiol , vol.276
    • Otterbein, L.E.1    Mantell, L.L.2    Choi, A.M.3
  • 69
    • 0036846145 scopus 로고    scopus 로고
    • Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen activated protein kinase pathway
    • Song R, Mahidhara RS, Liu F, Ning W, Otterbein LE, Choi AM. Carbon monoxide inhibits human airway smooth muscle cell proliferation via mitogen activated protein kinase pathway. Am J Resp Cell Moll Biol 2002; 27: 603-610.
    • (2002) Am J Resp Cell Moll Biol , vol.27 , pp. 603-610
    • Song, R.1    Mahidhara, R.S.2    Liu, F.3    Ning, W.4    Otterbein, L.E.5    Choi, A.M.6
  • 70
    • 4444369432 scopus 로고    scopus 로고
    • Simvastatin induces heme oxygenase -1: A novel mechanism of vessel protection
    • Lee TS, Chang CC, Zhu Y, Shyy JY. Simvastatin induces heme oxygenase -1: A novel mechanism of vessel protection. Circulation 2004; 110: 1296-1302.
    • (2004) Circulation , vol.110 , pp. 1296-1302
    • Lee, T.S.1    Chang, C.C.2    Zhu, Y.3    Shyy, J.Y.4
  • 71
    • 8544284074 scopus 로고    scopus 로고
    • The antioxidant defense protein heme oxygenase-1 is a novel target for statins in endothelial cells
    • Grosser N, Hemmerle A, Berndt G, et al. The antioxidant defense protein heme oxygenase-1 is a novel target for statins in endothelial cells. Free Radic Biol Med 2004; 37: 2064-2071.
    • (2004) Free Radic Biol Med , vol.37 , pp. 2064-2071
    • Grosser, N.1    Hemmerle, A.2    Berndt, G.3
  • 72
    • 28944451931 scopus 로고    scopus 로고
    • Platelets
    • Levi M. Platelets. Crit Care Med 2005; 33: (Suppl 12): S523-S525.
    • (2005) Crit Care Med , vol.33 , Issue.SUPPL. 12
    • Levi, M.1
  • 73
    • 10744233133 scopus 로고    scopus 로고
    • Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide -dependent mechanism and counteract tumor necrosis factor alpha induced thrombomodulin doenregulation
    • Shi J, Wang J, Zheng H, et al. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide -dependent mechanism and counteract tumor necrosis factor alpha induced thrombomodulin doenregulation. Blood Coagul Fibrinolysis 2003; 14: 575-585.
    • (2003) Blood Coagul Fibrinolysis , vol.14 , pp. 575-585
    • Shi, J.1    Wang, J.2    Zheng, H.3
  • 74
    • 0037233913 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells
    • Dichtl W, Dulak J, Frick M, et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 23: 58-63.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 58-63
    • Dichtl, W.1    Dulak, J.2    Frick, M.3
  • 75
    • 0033966049 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors reduces plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells
    • Bourcier T, Libby P. HMG-CoA reductase inhibitors reduces plasminogen activator inhibitor-1 expression by human vascular smooth muscle and endothelial cells. Arterioscler Thromb Vasc Biol 2000; 20: 556-562.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 556-562
    • Bourcier, T.1    Libby, P.2
  • 76
    • 0037709770 scopus 로고    scopus 로고
    • C-reactive protein levels correlate with mortality and organ failure in critically ill patients
    • Lobo SM, Lobo FR, Bota DP, et al. C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest 2003; 123: 2043-2049.
    • (2003) Chest , vol.123 , pp. 2043-2049
    • Lobo, S.M.1    Lobo, F.R.2    Bota, D.P.3
  • 77
    • 70350782730 scopus 로고    scopus 로고
    • US20080051417
    • Birnbaum, Y.: US20080051417 (2008).
    • (2008)
    • Birnbaum, Y.1
  • 78
    • 0345526805 scopus 로고    scopus 로고
    • Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Galpha(i2), a possible molecular marker for parasympathetic responsiveness
    • Welzig CM, Shin DG, Park HJ, et al. Lipid lowering by pravastatin increases parasympathetic modulation of heart rate: Galpha(i2), a possible molecular marker for parasympathetic responsiveness. Circulation 2003; 108: 2743 -2746
    • (2003) Circulation , vol.108 , pp. 2743-2746
    • Welzig, C.M.1    Shin, D.G.2    Park, H.J.3
  • 79
    • 33846817498 scopus 로고    scopus 로고
    • Physiology and immunology of the cholinergic antiinflammatory pathway
    • Tracey KH. Physiology and immunology of the cholinergic antiinflammatory pathway. J Clin Invest 2007; 117: 289-296.
    • (2007) J Clin Invest , vol.117 , pp. 289-296
    • Tracey, K.H.1
  • 80
    • 65249101633 scopus 로고    scopus 로고
    • Impaired regulation of cardiac function in sepsis, SIRS and MODS
    • Werdan K, Schmidt H, Ebelt H, et al. Impaired regulation of cardiac function in sepsis, SIRS and MODS. Can J Physiol Pharmacol 2009; 87: 266-274.
    • (2009) Can J Physiol Pharmacol , vol.87 , pp. 266-274
    • Werdan, K.1    Schmidt, H.2    Ebelt, H.3
  • 81
    • 65449182012 scopus 로고    scopus 로고
    • Statins for sepsis: A critical and updated review
    • Kopterides P, Falagas ME. Statins for sepsis: a critical and updated review. Clin Microbiol Infect 2009; 15(4): 325-334.
    • (2009) Clin Microbiol Infect , vol.15 , Issue.4 , pp. 325-334
    • Kopterides, P.1    Falagas, M.E.2
  • 82
    • 33645826944 scopus 로고    scopus 로고
    • Statin use and mortality within 180 days after bacteremia: A population- based cohort study
    • Thomsen RW, Hundborg HH, Johnsen SP, et al. Statin use and mortality within 180 days after bacteremia: A population- based cohort study. Crit Care Med 2006; 34: 1080-1086.
    • (2006) Crit Care Med , vol.34 , pp. 1080-1086
    • Thomsen, R.W.1    Hundborg, H.H.2    Johnsen, S.P.3
  • 83
    • 29844445926 scopus 로고    scopus 로고
    • Statin therapy is associated with fewer deaths in patients with bacteraemia
    • Kruger P, Fitzsimmons K, Cook D, Jones M, Nimmo G. Statin therapy is associated with fewer deaths in patients with bacteraemia. Intensive Care Med 2006; 32: 75-79.
    • (2006) Intensive Care Med , vol.32 , pp. 75-79
    • Kruger, P.1    Fitzsimmons, K.2    Cook, D.3    Jones, M.4    Nimmo, G.5
  • 84
    • 0035887840 scopus 로고    scopus 로고
    • The effect of statins on mortality in patients with bacteremia
    • Liappis AP, Kan VL, Rochester CG, Simon GL. The effect of statins on mortality in patients with bacteremia. Clin Infect Dis 2001; 33: 1352-1357.
    • (2001) Clin Infect Dis , vol.33 , pp. 1352-1357
    • Liappis, A.P.1    Kan, V.L.2    Rochester, C.G.3    Simon, G.L.4
  • 85
    • 31844434994 scopus 로고    scopus 로고
    • Statins and sepsis in patients with cardiovascular disease: A population- based cohort analysis
    • Hackman DG, Mamdani M, Li P, Redelmeier DA. Statins and sepsis in patients with cardiovascular disease: A population- based cohort analysis. Lancet 2006; 367: 413-418.
    • (2006) Lancet , vol.367 , pp. 413-418
    • Hackman, D.G.1    Mamdani, M.2    Li, P.3    Redelmeier, D.A.4
  • 86
    • 33747170119 scopus 로고    scopus 로고
    • Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome
    • Schmidt H, Hennen R, Keller A, et al. Association of statin therapy and increased survival in patients with multiple organ dysfunction syndrome. Intensive Care Med 2006; 32: 1248-1251.
    • (2006) Intensive Care Med , vol.32 , pp. 1248-1251
    • Schmidt, H.1    Hennen, R.2    Keller, A.3
  • 87
    • 26244441019 scopus 로고    scopus 로고
    • The effect of prior statin use on 30-day mortality for patients hospitalized with community acquired pneumonia (online exclusive article)
    • Mortensen EM, Restrepo MI, Anzueto A, Pugh J. The effect of prior statin use on 30-day mortality for patients hospitalized with community acquired pneumonia (online exclusive article). Respir Res 2005; 25: 82.
    • (2005) Respir Res , vol.25 , pp. 82
    • Mortensen, E.M.1    Restrepo, M.I.2    Anzueto, A.3    Pugh, J.4
  • 88
    • 33847321185 scopus 로고    scopus 로고
    • Statins and the Risk of Pneumonia: A population-based, nested case-control study
    • Schlienger RG, Fedson DS, Jick SS, Jick H, Meier CR. Statins and the Risk of Pneumonia: A population-based, nested case-control study. Pharmacotherapy 2007; (3): 325-332.
    • (2007) Pharmacotherapy , vol.3 , pp. 325-332
    • Schlienger, R.G.1    Fedson, D.S.2    Jick, S.S.3    Jick, H.4    Meier, C.R.5
  • 89
    • 34247209763 scopus 로고    scopus 로고
    • Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins
    • Frost FJ, Petersen H, Tollestrup K, Skipper B. Influenza and COPD mortality protection as pleiotropic, dose-dependent effects of statins. Chest 2007; 131: 1006-1012.
    • (2007) Chest , vol.131 , pp. 1006-1012
    • Frost, F.J.1    Petersen, H.2    Tollestrup, K.3    Skipper, B.4
  • 90
    • 65449144760 scopus 로고    scopus 로고
    • Incidence of Hajj-associated febrile cough episodes among French pilgrims: A prospective cohort study on the influence of statin use and risk factors
    • Gautret P, Yong W, Soula G, et al. Incidence of Hajj-associated febrile cough episodes among French pilgrims: A prospective cohort study on the influence of statin use and risk factors. Clin Microbiol Infect 2009; 15: 335-340.
    • (2009) Clin Microbiol Infect , vol.15 , pp. 335-340
    • Gautret, P.1    Yong, W.2    Soula, G.3
  • 91
    • 54349122201 scopus 로고    scopus 로고
    • Prior statin use is associated with improved outcomes in community-acquired pneumonia
    • Chalmers JD, Singanayagam A, Murray MP, Hill AT. Prior statin use is associated with improved outcomes in community-acquired pneumonia. Am J Med. 2008; 121(11): 1002-1007.
    • (2008) Am J Med , vol.121 , Issue.11 , pp. 1002-1007
    • Chalmers, J.D.1    Singanayagam, A.2    Murray, M.P.3    Hill, A.T.4
  • 92
    • 42949123466 scopus 로고    scopus 로고
    • Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumonia
    • Mortensen EM, Pugh MJ, Copeland LA, et al. Impact of statins and angiotensin-converting enzyme inhibitors on mortality of subjects hospitalised with pneumonia. Eur Respir J 2008; 31: 611-617.
    • (2008) Eur Respir J , vol.31 , pp. 611-617
    • Mortensen, E.M.1    Pugh, M.J.2    Copeland, L.A.3
  • 93
    • 34047222758 scopus 로고    scopus 로고
    • Statin use and hospitalization for sepsis in patients with chronic kidney disease
    • Gupta R, Plantinga LC, Fink NE, et al. Statin use and hospitalization for sepsis in patients with chronic kidney disease. JAMA 2007; 297: 1455-1464.
    • (2007) JAMA , vol.297 , pp. 1455-1464
    • Gupta, R.1    Plantinga, L.C.2    Fink, N.E.3
  • 94
    • 33846931592 scopus 로고    scopus 로고
    • Statin use is associated with reduced mortality in COPD
    • Soyseth V, Brekke PH, Smith P, Omland T. Statin use is associated with reduced mortality in COPD. Eur Respir J 2007; 29: 279-283.
    • (2007) Eur Respir J , vol.29 , pp. 279-283
    • Soyseth, V.1    Brekke, P.H.2    Smith, P.3    Omland, T.4


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