Lipid Lowering by Pravastatin Increases Parasympathetic Modulation of Heart Rate: Gαi2, a Possible Molecular Marker for Parasympathetic Responsiveness

Circulation

Volumn 108, Issue 22, 2003, Pages 2743-2746

  Welzig, C Michael ^a   Shin, Dong Gu ^b   Park, Ho Jin ^c   Kim, Young Jo ^b   Saul, J Philip ^a   Galper, Jonas B ^c,d  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b Young Nam University Hospital   (South Korea)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d TUFTS MEDICAL CENTER   (United States)

Author keywords

Heart rate; Lipids; Statins

Indexed keywords

CARBACHOL; CHOLESTEROL; G ALPHA I2 PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; MOLECULAR MARKER; PRAVASTATIN; SIMVASTATIN; STATINE DERIVATIVE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CHOLINERGIC ACTIVITY; CHRONOTROPISM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ACTIVITY; FEMALE; HEART RATE; HEART RATE VARIABILITY; HOLTER MONITORING; HUMAN; LIPID LOWERING ACTIVITY; LYMPHOCYTE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; RR INTERVAL; SIGNAL TRANSDUCTION; SINGLE BLIND PROCEDURE; SLEEP; WESTERN BLOTTING;

ADULT; AGED; ANTILIPEMIC AGENTS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CROSS-OVER STUDIES; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HEART RATE; HUMANS; HYPERLIPIDEMIAS; LIPIDS; LYMPHOCYTES; MALE; MIDDLE AGED; PARASYMPATHETIC NERVOUS SYSTEM; PRAVASTATIN; PREDICTIVE VALUE OF TESTS; PROTO-ONCOGENE PROTEINS; SIMVASTATIN; SINGLE-BLIND METHOD;

EID: 0345526805     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000103680.61390.16     Document Type: Article

References (14)

1. Haigh LS, Leatherman GF, O'Hara DS, et al. Effects of low density lipoproteins and mevinolin on cholesterol content and muscarinic cholinergic responsiveness in cultured chick atrial cells: regulation of levels of muscarinic receptors and guanine nucleotide regulatory proteins. J Biol Chem. 1988;263:15608-15618.
2. Donahue JK, Heldman AW, Fraser H, et al. Focal modification of electrical conduction in the heart by viral gene transfer. Nat Med. 2000;6:1395-1398.
3. Grundy SM. Statin trials and goals of cholesterol-lowering therapy. Circulation. 1998;97:1436-1439.
4. Freeman R, Saul JP, Roberts MS, et al. Spectral analysis of heart rate in diabetic autonomic neuropathy: a comparison with standard tests of autonomic function. Arch Neurol. 1991;48:185-190.
5. Grimm M, Gsell S, Mittmann C, et al. Inactivation of (Gialpha) proteins increases arrhythmogenic effects of beta-adrenergic stimulation in the heart. J Mol Cell Cardiol. 1998;30:1917-1928.
6. Gadbut AP, Wu L, Tang D, et al. Induction of the cholesterol metabolic pathway regulates the farnesylation of RAS in embryonic chick heart cells: a new role for ras in regulating the expression of muscarinic receptors and G proteins. EMBO J. 1997;16:7250-7260.
7. Lerman BB, Dong B, Stein KM, et al. DF. Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2. J Clin Invest. 1998;101:2862-2868.
8. Offermanns S. In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice. Oncogene. 2001;20:1635-1642.
9. Hamelin BA. Turgeon J. Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol Sci. 1998;19:26-37.
10. Bocan TM, Ferguson E, McNally W, et al. Hepatic and nonhepatic sterol synthesis and tissue distribution following administration of a liver selective HMG-CoA reductase inhibitor, CI-981: comparison with selected HMG-CoA reductase inhibitors. Biochim Biophys Acta. 1992;1123:133-144.
11. Schwartz PJ, La Rovere MT, Vanoli E. Autonomic nervous system and sudden cardiac death: experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation. 1992;85:177-191.
12. Dotani MI, Elnicki DM, Jain AC, et al. Effect of preoperative statin therapy and cardiac outcomes after coronary artery bypass grafting. Am J Cardiol. 2000;86:1128-1130.
13. De Sutter J, Firsovaite V, Tavernier R. Prevention of sudden death in patients with coronary artery disease: do lipid-lowering drugs play a role? Prev Cardiol. 2002;5:177-182.
14. Bigger JT Jr, Dresdale FJ, Heissenbuttel RH, et al. Ventricular arrhythmias in ischemic heart disease: mechanism, prevalence, significance, and management. Prog Cardiovasc Dis. 1977;19:255-300.