Simvastatin induces heme oxygenase-1: A novel mechanism of vessel protection

Circulation

Volumn 110, Issue 10, 2004, Pages 1296-1302

  Lee, Tzong Shyuan ^a   Chang, Chih Chieh ^a   Zhu, Yi ^a   Shyy, John Y J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Muscle, smooth; Statins; Vasculature

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; HEME OXYGENASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTOPORPHYRIN ZINC; SIMVASTATIN; SMALL INTERFERING RNA; SYNAPTOPHYSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CLINICAL PATHWAY; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; TUNICA MEDIA; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTHRACENES; AORTA; CELL DIVISION; CELLS, CULTURED; CHROMONES; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INDUCTION; FLAVONOIDS; HEME OXYGENASE (DECYCLIZING); HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MACROPHAGES; MICE; MICE, INBRED C57BL; MORPHOLINES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NF-KAPPA B; NITRIC OXIDE; ORGAN SPECIFICITY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTOPORPHYRINS; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIMVASTATIN;

EID: 4444369432     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000140694.67251.9C     Document Type: Article

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