메뉴 건너뛰기




Volumn 86, Issue 5, 2009, Pages 1247-1258

Role of STAT1, NF-κB, and C/EBPβ in the macrophage transcriptional regulation of hepcidin by mycobacterial infection and IFN-γ

Author keywords

Interferon ; Iron; Mycobacterium tuberculosis

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; GAMMA INTERFERON; HEPCIDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; SMALL INTERFERING RNA; STAT1 PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA;

EID: 70350738509     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1208719     Document Type: Article
Times cited : (74)

References (51)
  • 1
    • 0033581124 scopus 로고    scopus 로고
    • Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project
    • Dye, C., Scheele, S., Dolin, P., Pathania, V., Raviglione, M. C. (1999) Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 282, 677-686.
    • (1999) JAMA , vol.282 , pp. 677-686
    • Dye, C.1    Scheele, S.2    Dolin, P.3    Pathania, V.4    Raviglione, M.C.5
  • 2
    • 25844435292 scopus 로고    scopus 로고
    • Receptor-mediated recognition of Mycbacterium tuberculosis by host cells
    • S. T. Cole, K. D. Eisenach, D. H. McMurray, W. R. Jacobs Jr., eds., ASM, New York, NY, USA
    • Fenton, M. J., Riley, L. W., Schlesinger, L. S. (2005) Receptor-mediated recognition of Mycbacterium tuberculosis by host cells. In Tuberculosis and the Tubercle Bacillus (S. T. Cole, K. D. Eisenach, D. H. McMurray, W. R. Jacobs Jr., eds.), ASM, New York, NY, USA, 405-426.
    • (2005) Tuberculosis and the Tubercle Bacillus , pp. 405-426
    • Fenton, M.J.1    Riley, L.W.2    Schlesinger, L.S.3
  • 3
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E., Jr., Kerr, I. M., Stark, G. R. (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 4
    • 0030046753 scopus 로고    scopus 로고
    • STATs: Signal transducers and activators of transcription
    • Ihle, J. N. (1996) STATs: Signal transducers and activators of transcription. Cell 84, 331-334.
    • (1996) Cell , vol.84 , pp. 331-334
    • Ihle, J.N.1
  • 6
    • 0026549480 scopus 로고
    • Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated macrophages
    • Chan, J., Xing, Y., Magliozzo, R. S., Bloom, B. R. M. (1992) Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated macrophages. J. Exp. Med. 175, 1111-1122.
    • (1992) J. Exp. Med. , vol.175 , pp. 1111-1122
    • Chan, J.1    Xing, Y.2    Magliozzo, R.S.3    Bloom, B.R.M.4
  • 7
    • 0035064072 scopus 로고    scopus 로고
    • Immunology of tuberculosis
    • Flynn, J. L., Chan, J. (2001) Immunology of tuberculosis. Annu. Rev. Immunol. 19, 93-119.
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 93-119
    • Flynn, J.L.1    Chan, J.2
  • 9
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • DOI 10.1016/S0014-5793(00)01920-7, PII S0014579300019207
    • Krause, A., Neitz, S., Magert, H. G., Schulz, A., Forssmann, W. G., Schulz- Knappe, P., Adermann, K. (2000) LEAP-1, a novel highly disulfidebonded human peptide, exhibits antimicrobial activity. FEBS Lett. 480, 147-150. (Pubitemid 30682492)
    • (2000) FEBS Letters , vol.480 , Issue.2-3 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.-J.3    Schulz, A.4    Forssmann, W.-G.5    Schulz-Knappe, P.6    Adermann, K.7
  • 10
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver
    • DOI 10.1074/jbc.M008922200
    • Park, C. H., Valore, E. V., Waring, A. J., Ganz, T. (2001) Hepcidin: a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276, 7806-7810. (Pubitemid 37385573)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.11 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 12
    • 4644320292 scopus 로고    scopus 로고
    • Inhibition of iron transport across human intestinal epithelial cells by hepcidin
    • DOI 10.1182/blood-2004-03-0829
    • Yamaji, S., Sharp, P., Ramesh, B., Srai, S. K. S. (2004) Inhibition of iron transport across human intestinal epithelial cells by hepcidin. Blood 104, 2178-2180. (Pubitemid 39297875)
    • (2004) Blood , vol.104 , Issue.7 , pp. 2178-2180
    • Yamaji, S.1    Sharp, P.2    Ramesh, B.3    Srai, S.K.4
  • 13
    • 13444252281 scopus 로고    scopus 로고
    • Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin
    • Knutson, M. D., Oukka, M., Koss, L. M., Aydemir, R., Wessling-Resnick, M. (2005) Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc. Natl. Acad. Sci. USA 102, 1324-1328.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1324-1328
    • Knutson, M.D.1    Oukka, M.2    Koss, L.M.3    Aydemir, R.4    Wessling-Resnick, M.5
  • 16
    • 0035896581 scopus 로고    scopus 로고
    • A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload
    • DOI 10.1074/jbc.M008923200
    • Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., Loreal, O. (2001) A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide, hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276, 7811-7819. (Pubitemid 37385574)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.11 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 17
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • DOI 10.1182/blood-2002-10-3235
    • Nemeth, E., Valore, E. V., Territo, M., Schiller, G., Lichtenstein, A., Ganz, T. (2003) Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101, 2461-2463. (Pubitemid 36857598)
    • (2003) Blood , vol.101 , Issue.7 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 20
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • DOI 10.1172/JCI200420945
    • Nemeth, E., Rivera, S., Gabayan, V., Keller, C., Taudorf, S., Pedersen, B. K., Ganz, T. (2004) IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113, 1271-1276. (Pubitemid 39069926)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.9 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 21
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidin transcription by interleukin-1 and interleukin-6
    • Lee, P., Peng, H., Gelbart, T., Wang, L., Beutler, E. (2005) Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc. Natl. Acad. Sci. USA 102, 1906-1910.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Wang, L.4    Beutler, E.5
  • 22
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting, D. M., Andrews, N. C. (2006) Interleukin-6 induces hepcidin expression through STAT3. Blood 108, 3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 24
    • 21544449756 scopus 로고    scopus 로고
    • Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
    • DOI 10.1016/j.bcmd.2005.04.006, PII S1079979605000586, Including Workshop on Exosomes: Part II
    • Liu, X. B., Ngugen, N. H., Marquess, K. D., Yang, F., Haile, D. J. (2005) Regulation of hepcidin and ferroportin expression by lipopolysacharide in splenic macrophages. Blood Cells Mol. Dis. 35, 47-56. (Pubitemid 40922774)
    • (2005) Blood Cells, Molecules, and Diseases , vol.35 , Issue.1 , pp. 47-56
    • Liu, X.-B.1    Nguyen, N.-B.H.2    Marquess, K.D.3    Yang, F.4    Haile, D.J.5
  • 25
    • 33646427702 scopus 로고    scopus 로고
    • TLR-4 dependent hepcidin expression by myeloid cells in response to bacterial pathogens
    • Peyssonnaux, C., Zinkernagel, A. S., Datta, V., Lauth, X., Johnson, R. S., Nizet, V. (2006) TLR-4 dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 107, 3727-3732.
    • (2006) Blood , vol.107 , pp. 3727-3732
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Datta, V.3    Lauth, X.4    Johnson, R.S.5    Nizet, V.6
  • 26
  • 28
    • 10644225350 scopus 로고    scopus 로고
    • Toll-like receptor 2 stimulation decreases IFN-γ receptor expression in mouse RAW264.7 macrophages
    • DOI 10.1089/1079990042722873
    • Curry, H., Alvarez, G. R., Zwilling, B. S., Lafuse, W. P. (2004) Toll-like receptor 2 stimulation decreases IFN-γ receptor expression in mouse RAW264.7 macrophages. J. Interferon Cytokine Res. 24, 699-710. (Pubitemid 39658233)
    • (2004) Journal of Interferon and Cytokine Research , vol.24 , Issue.12 , pp. 699-710
    • Curry, H.1    Alvarez, G.R.2    Zwilling, B.S.3    Lafuse, W.P.4
  • 29
    • 33747885059 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis and Mycobacterium avium inhibit IFN-γ-induced gene expression by TLR2-dependent and independent pathways
    • Lafuse, W. P., Alvarez, G. R., Curry, H. M., Zwilling, B. S. (2006) Mycobacterium tuberculosis and Mycobacterium avium inhibit IFN-γ-induced gene expression by TLR2-dependent and independent pathways. J. Interferon Cytokine Res. 26, 548-561.
    • (2006) J. Interferon Cytokine Res. , vol.26 , pp. 548-561
    • Lafuse, W.P.1    Alvarez, G.R.2    Curry, H.M.3    Zwilling, B.S.4
  • 30
    • 0035710746 scopus 로고    scopus 로고
    • -Δ ΔCT method
    • DOI 10.1006/meth.2001.1262
    • Livak, K. J., Schmittgen, D. T. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCt method. Methods 25, 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 31
    • 0036467562 scopus 로고    scopus 로고
    • Surfactant protein D inhibition of human macrophage uptake of Mycobacterium tuberculosis is independent of bacterial agglutination
    • Ferguson, J. S., Voelker, D. R., Ufnar, J. A., Dawson, A. J., Schlesinger, L. S. (2002) Surfactant protein D inhibition of human macrophage uptake of Mycobacterium tuberculosis is independent of bacterial agglutination. J. Immunol. 168, 1309-1314.
    • (2002) J. Immunol. , vol.168 , pp. 1309-1314
    • Ferguson, J.S.1    Voelker, D.R.2    Ufnar, J.A.3    Dawson, A.J.4    Schlesinger, L.S.5
  • 32
    • 0033567089 scopus 로고    scopus 로고
    • Mycobacterium avium infection of mouse macrophages inhibits IFN-γ Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-γ receptor
    • Hussain, S., Zwilling, B. S., Lafuse, W. P. (1999) Mycobacterium avium infection of mouse macrophages inhibits IFN-γ Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-γ receptor. J. Immunol. 163, 2041-2048.
    • (1999) J. Immunol. , vol.163 , pp. 2041-2048
    • Hussain, S.1    Zwilling, B.S.2    Lafuse, W.P.3
  • 34
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signaling
    • Akira, S., Takeda, K. (2004) Toll-like receptor signaling. Nat. Rev. Immunol. 4, 499-510.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 499-510
    • Akira, S.1    Takeda, K.2
  • 36
    • 0025936177 scopus 로고
    • A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA
    • Descombes, P., Schibler, U. (1991) A liver-enriched transcriptional activator protein, LAP, and transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67, 569-579. (Pubitemid 121001471)
    • (1991) Cell , vol.67 , Issue.3 , pp. 569-579
    • Descombes, P.1    Schibler, U.2
  • 37
    • 0032491401 scopus 로고    scopus 로고
    • The role of C/EBP isoforms in the control of inflammatory and native immunity functions
    • Poli, V. (1998) The role of C/EBP isoforms in the control of inflammatory and native immunity functions. J. Biol. Chem. 273, 29279-29282.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29279-29282
    • Poli, V.1
  • 38
    • 33748569185 scopus 로고    scopus 로고
    • Distribution of the iron-regulating protein hepcidin in the murine central nervous system
    • DOI 10.1002/jnr.20991
    • Zechel, S., Huber-Wittmer, K., von Bohlen und Halbach, O. (2006) Distrubution of the iron-regulating protein hepcidin in the murine central nervous system. J. Neurosicence Res. 84, 790-800. (Pubitemid 44366680)
    • (2006) Journal of Neuroscience Research , vol.84 , Issue.4 , pp. 790-800
    • Zechel, S.1    Huber-Wittmer, K.2    Von Halbach, O.B.3
  • 39
    • 41649120714 scopus 로고    scopus 로고
    • Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe
    • Gnana-Prakasam, J. P., Martin, P. M., Mysona, B. A., Roon, P., Smith, S. B. (2008) Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. Biochem. J. 411, 79-88.
    • (2008) Biochem. J. , vol.411 , pp. 79-88
    • Gnana-Prakasam, J.P.1    Martin, P.M.2    Mysona, B.A.3    Roon, P.4    Smith, S.B.5
  • 40
    • 34047262879 scopus 로고    scopus 로고
    • Intracellular signaling cascades regulating innate immune responses to Mycobacteria: Branching out from Toll-like receptors
    • Jo, E.-K., Yang, C. S., Hee, C., Harding, C. V. (2007) Intracellular signaling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors. Cell. Microbiol. 9, 1087-1098.
    • (2007) Cell. Microbiol. , vol.9 , pp. 1087-1098
    • Jo, E.-K.1    Yang, C.S.2    Hee, C.3    Harding, C.V.4
  • 43
    • 0038111991 scopus 로고    scopus 로고
    • C/EBPβ regulation in lipopolysacharide-stimulated macrophages
    • Bradley, M. N., Zhou, L., Smale, S. T. (2003) C/EBPβ regulation in lipopolysacharide-stimulated macrophages. Mol. Cell. Biol. 23, 4841-4858.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 4841-4858
    • Bradley, M.N.1    Zhou, L.2    Smale, S.T.3
  • 44
    • 30344442102 scopus 로고    scopus 로고
    • CCAAT/Enhancer binding proteins and interferon signaling pathways
    • Kalvakolanu, D. V., Roy, S. K. (2005) CCAAT/Enhancer binding proteins and interferon signaling pathways. J. Interferon Cytokine Res. 25, 757-769.
    • (2005) J. Interferon Cytokine Res. , vol.25 , pp. 757-769
    • Kalvakolanu, D.V.1    Roy, S.K.2
  • 45
    • 0037168677 scopus 로고    scopus 로고
    • The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor and CCAAT/enhancer binding protein β
    • Hurgin, V., Novick, D., Rubinstein, M. (2002) The promoter of IL-18 binding protein: Activation by an IFN-γ-induced complex of IFN regulatory factor and CCAAT/enhancer binding protein β. Proc. Natl. Acad. Sci. USA 99, 16957-16962.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16957-16962
    • Hurgin, V.1    Novick, D.2    Rubinstein, M.3
  • 46
    • 0026730105 scopus 로고
    • The p50 subunit of NF-κB associates with the NF-IL6 transcription factor
    • LeClair, K. P., Blanar, M. A., Sharp, P. A. (1992) The p50 subunit of NF-κB associates with the NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89, 8145-8149.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 8145-8149
    • LeClair, K.P.1    Blanar, M.A.2    Sharp, P.A.3
  • 47
    • 0028792116 scopus 로고
    • Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6β (C/EBPδ, CRP3)
    • Nagulapalli, S., Pongubala, J. M. R., Atchison, M. L. (1995) Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6β (C/EBPδ, CRP3). J. Immunol. 155, 4330-4338.
    • (1995) J. Immunol. , vol.155 , pp. 4330-4338
    • Nagulapalli, S.1    Pongubala, J.M.R.2    Atchison, M.L.3
  • 48
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2) and IL-6
    • Truksa, J., Peng, H., Lee, P., Beutler, E. (2006) Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2) and IL-6. Proc. Natl. Acad. Sci. USA 103, 10289-10293.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 50
    • 34548559118 scopus 로고    scopus 로고
    • Different regulatory elements are required for responses of hepcidin to interleukin-6 and bone morphogenetic proteins
    • Truksa, J., Peng, H., Lee, P., Beutler, E. (2007) Different regulatory elements are required for responses of hepcidin to interleukin-6 and bone morphogenetic proteins. Br. J. Haematol. 139, 138-147.
    • (2007) Br. J. Haematol. , vol.139 , pp. 138-147
    • Truksa, J.1    Peng, H.2    Lee, P.3    Beutler, E.4
  • 51
    • 36148955432 scopus 로고    scopus 로고
    • The distal location of the iron responsive region of the hepcidin promoter
    • Truksa, J., Lee, P., Peng, H., Flanagan, J., Beutler, E. (2007) The distal location of the iron responsive region of the hepcidin promoter. Blood 110, 3436-3437.
    • (2007) Blood , vol.110 , pp. 3436-3437
    • Truksa, J.1    Lee, P.2    Peng, H.3    Flanagan, J.4    Beutler, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.