Environmental contributions to disparities in pregnancy outcomes

Epidemiologic Reviews

Volumn 31, Issue 1, 2009, Pages 67-83

  Miranda, Marie Lynn ^a   Maxson, Pamela ^a   Edwards, Sharon ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Environment; Environmental pollution; Health status disparities; Infant, low birth weight; Pregnancy outcome; Premature birth; Public health

Indexed keywords

HEAVY METAL; TOBACCO SMOKE;

AIR QUALITY; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; GEOGRAPHIC DISTRIBUTION; HEALTH DISPARITY; HUMAN; LOW BIRTH WEIGHT; MATERNAL CARE; MATERNAL WELFARE; PESTICIDE SPRAYING; PREGNANCY OUTCOME; PREMATURITY; PRIORITY JOURNAL; REVIEW; TREND STUDY; UNITED STATES; WATER QUALITY;

ENVIRONMENTAL EXPOSURE; FEMALE; HEALTH STATUS DISPARITIES; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; PREGNANCY; PREGNANCY OUTCOME; PUBLIC HEALTH; UNITED STATES;

EID: 70350677649     PISSN: 0193936X     EISSN: 14786729     Source Type: Journal    
DOI: 10.1093/epirev/mxp011     Document Type: Review

References (211)

1. Singh GK, Yu SM. Infant mortality in the United States: trends, differentials, and projections, 1950 through 2010. Am J Public Health. 1995;85(7):957-964.
2. Johnston RB Jr, Williams MA, Hogue CJ, et al. Overview: new perspectives on the stubborn challenge of preterm birth. Paediatr Perinat Epidemiol. 2001;15(suppl 2):3-6.
3. Wise PH, Kotelchuck M, Wilson ML, et al. Racial and so-cioeconomic disparities in childhood mortality in Boston. N Engl J Med. 1985;313(6):360-366.
4. National Center for Health Statistics. Natality Public Use Files 1990-2006. Hyattsville, MD: Centers for Disease Control and Prevention, US Department of Health and Human Services. (http://www.cdc.gov/nchs/data-access/ Vitalstatsonline.htm). (Accessed January 6, 2009).
5. Mathews TJ, MacDorman MF. Infant mortality statistics from the 2005 period linked birth/infant death data set. Natl Vital Stat Rep. 2008;57(2):1-32.
6. Behrman RE, Butler AS. Preterm Birth-Causes, Consequences and Prevention. Washington, DC: National Academies Press; 2007.
7. Hack M, Klein NK, Taylor HG. Long-term developmental outcomes of low birth weight infants. Future Child. 1995; 5(1):176-196.
8. Lemons JA, Bauer CR, Oh W, et al. Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1995 through December 1996. NICHD Neonatal Research Network [electronic article]. Pediatrics. 2001;107(1):E1.
9. Doussard-Roosevelt JA, Porges SW, Scanlon JW, et al. Vagal regulation of heart rate in the prediction of developmental outcome for very low birth weight preterm infants. Child Dev. 1997;68(2):173-186.
10. Ment LR, Vohr B, Allan W, et al. The etiology and outcome of cerebral ventriculomegaly at term in very low birth weight preterm infants. Pediatrics. 1999;104(2 pt 1):243-248. (Pubitemid 29362131)
11. Kuban KC, Leviton A. Cerebral palsy. N Engl J Med. 1994; 330(3):188-195.
12. Lorenz JM, Wooliever DE, Jetton JR, et al. A quantitative review of mortality and developmental disability in extremely premature newborns. Arch Pediatr Adolesc Med. 1998;152(5):425-435.
13. Crofts BJ, King R, Johnson A. The contribution of low birth weight to severe vision loss in a geographically defined population. Br J Ophthalmol. 1998;82(1):9-13.
14. Saigal S, Hoult LA, Streiner DL, et al. School difficulties at adolescence in a regional cohort of children who were extremely low birth weight. Pediatrics. 2000;105(2):325-331.
15. Resnick MB, Gueorguieva RV, Carter RL, et al. The impact of low birth weight, perinatal conditions, and sociodemo-graphic factors on educational outcome in kindergarten [electronic article]. Pediatrics. 1999;104(6):e74.
16. Ross G, Lipper EG, Auld PA. Social competence and behavior problems in premature children at school age. Pediatrics. 1990;86(3):391-397. (Pubitemid 20334972)
17. Avchen RN, Scott KG, Mason CA. Birth weight and school-age disabilities: a population-based study. Am J Epidemiol. 2001;154(10):895-901.
18. Osmond C, Barker DJ, Winter PD, et al. Early growth and death from cardiovascular disease in women. BMJ. 1993; 307(6918):1519-1524.
19. Barker DJ, Martyn CN, Osmond C, et al. Growth in utero and serum cholesterol concentrations in adult life [comment]. BMJ. 1993;307(6918):1524- 1527.
20. Weiss JL, Malone FD, Emig D, et al. Obesity, obstetric complications and cesarean delivery rate-a population-based screening study. Am J Obstet Gynecol. 2004;190(4): 1091-1097.
21. Weck RL, Paulose T, Flaws JA. Impact of environmental factors and poverty on pregnancy outcomes. Clin Obstet Gynecol. 2008;51(2):349-359.
22. Stillerman KP, Mattison DR, Giudice LC, et al. Environmental exposures and adverse pregnancy outcomes: a review of the science. Reprod Sci. 2008;15(7):631-650.
23. Geronimus AT. The weathering hypothesis and the health of African-American women and infants: evidence and speculations. Ethn Dis. 1992;2(3):207-221.
24. Geronimus AT. Black/white differences in the relationship of maternal age to birthweight: a population-based test of the weathering hypothesis. Soc Sci Med. 1996;42(4):589-597.
25. Geronimus AT. Understanding and eliminating racial inequalities in women?s health in the United States: the role of the weathering conceptual framework. J Am Med Womens Assoc. 2001;56(4):133-136, 149-150.
26. Geronimus AT, Bound J, Waidmann TA, et al. Inequality in life expectancy, functional status, and active life expectancy across selected black and white populations in the United States. Demography. 2001;38(2):227-251.
27. Geronimus AT, Bound J, Waidmann TA, et al. Excess mortality among blacks and whites in the United States. N Engl J Med. 1996;335(21):1552-1558.
28. Rich-Edwards JW, Buka SL, Brennan RT, et al. Diverging associations of maternal age with low birthweight for black and white mothers. Int J Epidemiol. 2003;32(1):83-90.
29. Rauh VA, Andrews HF, Garfinkel RS. The contribution of maternal age to racial disparities in birthweight: a multilevel perspective. Am J Public Health. 2001;91(11): 1815-1824.
30. US Department of Health and Human Services. Healthy People 2010: Understanding and Improving Health. 2nd ed. Washington, DC: US Government Printing Office; 2000.
31. Centers for Disease Control and Prevention, National Center for Health Statistics. VitalStats. (http://www.cdc.gov/nchs/ vitalstats.htm). (Accessed April 6, 2009)
32. North Carolina State Center for Health Statistics. Detailed Birth Record. Confidential Patient Record Database, 1990-2007. Raleigh, NC: State Center for Health Statistics.
33. Gray S, Edwards S, Miranda M. Assessing exposure metrics for air pollution and birthweight models in North Carolina. J Expo Sci Environ Epidemiol. In press.
34. Tassone E, Miranda ML, Gelfand AE. Disaggregated spatial modeling for areal unit categorical data. J R Stat Soc Ser (C). In press.
35. Berrocal VJ, Gelfand AE, Holland DM. A spatio-temporal downscaler for output from numerical models. J Agric Biol Environ Stat. In press.
36. Branum AM, Schoendorf KC. Changing patterns of low birthweight and preterm birth in the United States, 1981-1998. Paediatr Perinat Epidemiol. 2002;16(1):8-15.
37. Lynch JW, Everson SA, Kaplan GA, et al. Does low so-cioeconomic status potentiate the effects of heightened cardiovascular responses to stress on the progression of carotid atherosclerosis? Am J Public Health. 1998;88(3): 389-394.
38. Lynch J, Smith GD, Hillemeier M, et al. Income inequality, the psychosocial environment, and health: comparisons of wealthy nations. Lancet. 2001;358(9277):194-200.
39. Lynch J, Smith GD, Harper S, et al. Is income inequality a determinant of population health? Part 1. A systematic review. Milbank Q. 2004;82(1):5-99.
40. Finch BK. Early origins of the gradient: the relationship between socioeconomic status and infant mortality in the United States. Demography. 2003;40(4):675-699.
41. Cogswell ME, Yip R. The influence of fetal and maternal factors on the distribution of birthweight. Semin Perinatol. 1995;19(3):222-240.
42. Roberts EM. Neighborhood social environments and the distribution of low birthweight in Chicago. Am J Public Health. 1997;87(4):597-603.
43. Luo ZC, Wilkins R, Kramer MS. Effect of neighbourhood income and maternal education on birth outcomes: a population-based study. CMAJ. 2006;174(10):1415-1421.
44. McGrady GA, Sung JF, Rowley DL, et al. Preterm delivery and low birth weight among first-born infants of black and white college graduates. Am J Epidemiol. 1992;136(3): 266-276.
45. Schoendorf KC, Hogue CJ, Kleinman JC, et al. Mortality among infants of black as compared with white college-educated parents. N Engl J Med. 1992;326(23):1522-1526.
46. Simons RL, Lorenz FO, Wu CI, et al. Social network and marital support as mediators and moderators of the impact of stress and depression on parental behavior. Dev Psychol. 1993;29(2):368-381.
47. Williams L, Morrow B, Shulman H, et al. 2002 PRAMS Surveillance Report: Unintended Pregnancy and Contraceptive Use. Atlanta, GA: Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention; 2006.
48. Hamilton BE, Martin JA, Ventura SJ. Births: preliminary data for 2007. Natl Vital Stat Rep. 2006;55(11):1-18.
49. Leddy MA, Power ML, Schulkin J. The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol. 2008;1(4):170-178.
50. Watkins ML, Rasmussen SA, Honein MA, et al. Maternal obesity and risk for birth defects. Pediatrics. 2003;111(5 pt 2): 1152-1158.
51. Xiong X, Saunders LD, Wang FL, et al. Gestational diabetes mellitus: prevalence, risk factors, maternal and infant outcomes. Int J Gynaecol Obstet. 2001;75(3):221-228.
52. Porter TF, Fraser AM, Hunter CY, et al. The risk of preterm birth across generations. Obstet Gynecol. 1997;90(1):63-67.
53. Treloar SA, Macones GA, Mitchell LE, et al. Genetic influences on premature parturition in an Australian twin sample. Twin Res. 2000;3(2):80-82.
54. Engel SA, Erichsen HC, Savitz DA, et al. Risk of spontaneous preterm birth is associated with common proinflamma-tory cytokine polymorphisms. Epidemiology. 2005;16(4): 469-477.
55. Engel SA, Olshan AF, Savitz DA, et al. Risk of small-for-gestational age is associated with common anti-inflammatory cytokine polymorphisms. Epidemiology. 2005;16(4): 478-486.
56. Annells MF, Hart PH, Mullighan CG, et al. Interleukins-1,-4,-6,-10, tumor necrosis factor, transforming growth factor-beta, FAS, and mannose-binding protein C gene polymorphisms in Australian women: risk of preterm birth. Am J Obstet Gynecol. 2004;191(6):2056-2067.
57. Amory JH, Adams KM, Lin MT, et al. Adverse outcomes after preterm labor are associated with tumor necrosis factor-alpha polymorphism-863, but not-308, in mother-infant pairs. Am J Obstet Gynecol. 2004;191(4):1362-1367.
58. Roberts AK, Monzon-Bordonaba F, Van Deerlin PG, et al. Association of polymorphism within the promoter of the tumor necrosis factor alpha gene with increased risk of preterm premature rupture of the fetal membranes. Am J Obstet Gynecol. 1999;180(5):1297-1302.
59. Zhang XQ, Varner M, Dizon-Townson D, et al. A molecular variant of angiotensinogen is associated with idiopathic in-trauterine growth restriction. Obstet Gynecol. 2003;101(2): 237-242.
60. Kajantie E, Rautanen A, Kere J, et al. The effects of the ACE gene insertion/deletion polymorphism on glucose tolerance and insulin secretion in elderly people are modified by birth weight. J Clin Endocrinol Metab. 2004;89(11):5738-5741.
61. Doh K, Sziller I, Vardhana S, et al. Beta2-adrenergic receptor gene polymorphisms and pregnancy outcome. J Perinat Med. 2004;32(5):413-417.
62. Bray MS, Krushkal J, Li L, et al. Positional genomic analysis identifies the b2-adrenergic receptor gene as a susceptibility locus for human hypertension. Circulation. 2000;101(25): 2877-2882.
63. Ward K, Hata A, Jeunemaitre X, et al. A molecular variant of angiotensinogen associated with preeclampsia. Nat Genet. 1993;4(1):59-61.
64. Arngŕimsson R, Purandare S, Connor M, et al. Angiotensin-ogen: a candidate gene involved in preeclampsia? Nat Genet. 1993;4(2):114-115.
65. Wang X, Zuckerman B, Pearson C, et al. Maternal cigarette smoking, metabolic gene polymorphism, and infant birth weight. JAMA. 2002;287(2):195-202.
66. Infante-Rivard C. Drinking water contaminants, gene polymorphisms, and fetal growth. Environ Health Perspect. 2004; 112(11):1213-1216.
67. Lee DK, Fu K, Liang L, et al. Transgenic mouse blastocysts that overexpress metallothionein-I resist cadmium toxicity in vitro. Mol Reprod Dev. 1996;43(2):158-166.
68. Yang K, Julan L, Rubio F, et al. Cadmium reduces 11 beta-hydroxysteroid dehydrogenase type 2 activity and expression in human placental trophoblast cells [electronic article]. Am J Physiol Endocrinol Metab. 2005;290(1): E135-E142.
69. Wang X, Chen D, Niu T, et al. Genetic susceptibility to benzene and shortened gestation: evidence of gene-environment interaction. Am J Epidemiol. 2000;152(8):693-700.
70. Brown P. Race, class, and environmental health: a review and systematization of the literature. Environ Res. 1995;69(1): 15-30.
71. Lopez R. Segregation and black/white differences in exposure to air toxics in 1990. Environ Health Perspect. 2002; 110(suppl 2):289-295.
72. Stretesky PB. The distribution of air lead levels across U.S. counties: implications for the production of racial inequality. Sociol Spectr. 2003;23(1):91-118.
73. Stretesky P, Lynch M. Environmental justice and the predictions of distance to accidental chemical releases in Hills-borough County, Florida. Soc Sci Q. 1999;80(4):830-846.
74. Wolff MS, Britton JA, Wilson VP. Environmental risk factors for breast cancer among African-American women. Cancer. 2003;97(1 suppl):289-310.
75. Adler NE, Marmot M, McEwen BS, et al. Socioeconomic Status and Health in Industrial Nations: Social, Psychological, and Biological Pathways. Vol 896. New York, NY: The New York Academy of Sciences; 1999.
76. Do DP, Finch K, Basurto-Davila R, et al. Does place explain racial health disparities? Quantifying the contribution of residential context to the black/white health gap in the United States. Soc Sci Med. 2008;67(8):1258-1268.
77. Matthews TJ, Menacker F, MacDorman MF. Infant mortality statistics from the 2002 period: linked birth/infant death data set. Natl Vital Stat Rep. 2004;53(10):1-30.
78. Auten RL Jr, Mason SN, Tanaka DT, et al. Anti-neutrophil chemokine preserves alveolar development in hyperoxia-exposed newborn rats. Am J Physiol Lung Cell Mol Physiol. 2001;281(2):L336-L344.
79. Bobak M. Outdoor air pollution, low birth weight, and prematurity. Environ Health Perspect. 2000;108(2):173-176.
80. Bobak M, Leon DA. Air pollution and infant mortality in the Czech Republic, 1986-1988. Lancet. 1992;340(8826): 1010-1014.
81. Gouveia N, Bremner SA, Novaes HM. Association between ambient air pollution and birth weight in São Paulo, Brazil. J Epidemiol Community Health. 2004;58(1):11-17.
82. Maisonet M, Bush TJ, Correa A, et al. Relation between ambient air pollution and low birth weight in the Northeastern United States. Environ Health Perspect. 2001;109(suppl 3): 351-356.
83. Loomis D, Castillejos M, Gold DR, et al. Air pollution and infant mortality in Mexico City. Epidemiology. 1999;10(2): 118-123.
84. Maroziene L, Grazuleviciene R. Maternal exposure to low-level air pollution and pregnancy outcomes: a population-based study. Environ Health. 2002;1(1):6.
85. Pereira LA, Loomis D, Conceixcão GM, et al. Association between air pollution and intrauterine mortality in São Paulo, Brazil. Environ Health Perspect. 1998;106(6):325-329.
86. Ritz B, Yu F, Chapa G, et al. Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiology. 2000;11(5):502-511.
87. Liu S, Krewski D, Shi Y, et al. Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada. Environ Health Perspect. 2003;111(14): 1773-1778.
88. Lee BE, Ha EH, Park HS, et al. Exposure to air pollution during different gestational phases contributes to risks of low birth weight. Hum Reprod. 2003;18(3):638-643.
89. Lin CM, Li CY, Yang GY, et al. Association between maternal exposure to elevated ambient sulfur dioxide during pregnancy and term low birth weight. Environ Res. 2004; 96(1):41-50.
90. Wang X, Ding H, Ryan L, et al. Association between air pollution and low birth weight: a community-based study. Environ Health Perspect. 1997;105(5):514-520.
91. Ritz B, Yu F. The effect of ambient carbon monoxide on low birth weight among children born in Southern California between 1989 and 1993. Environ Health Perspect. 1999; 107(1):17-25.
92. Yang CY, Tseng YT, Chang CC. Effects of air pollution on birth weight among children born between 1995 and 1997 in Kaohsiung, Taiwan. J Toxicol Environ Health A. 2003;66(9): 807-816.
93. Perera F, Hemminki K, Jedrychowski W, et al. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns. Cancer Epidemiol Bio-markers Prev. 2002;11(10 pt 1):1134-1137.
94. Jedrychowski W, Bendkowska I, Flak E, et al. Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environ Health Perspect. 2004;112(14): 1398-1402.
95. Perlin SA, Wong D, Sexton K. Residential proximity to industrial sources of air pollution: interrelationships among race, poverty, and age. J Air Waste Manag Assoc. 2001; 51(3):406-421.
96. Ritz B, Wilhelm M. Ambient air pollution and adverse birth outcomes: methodologic issues in an emerging field. Basic Clin Pharmacol Toxicol. 2008;102(2):182-190.
97. Ritz B, Wilhelm M, Hoggatt KJ, et al. Ambient air pollution and preterm birth in the environment and pregnancy outcomes study at the University of California, Los Angeles. Am J Epidemiol. 2007;166(9):1045-1052.
98. Huynh M, Woodruff TJ, Parker JD, et al. Relationships between air pollution and preterm birth in California. Paediatr Perinat Epidemiol. 2006;20(6):454-461.
99. Sagiv SK, Mendola P, Loomis D, et al. A time-series analysis of air pollution and preterm birth in Pennsylvania, 1997-2001. Environ Health Perspect. 2005;113(5): 602-606.
100. Yang CY, Chang CC, Chuang HY, et al. Evidence for increased risks of preterm delivery in a population residing near a freeway in Taiwan. Arch Environ Health. 2003;58(10): 649-654.
101. Wilhelm M, Ritz B. Residential proximity to traffic and adverse birth outcomes in Los Angeles county, California, 1994-1996. Environ Health Perspect. 2003;111(2):207-216.
102. Metzer R, Delgado JL, Herrell R. Environmental health and Hispanic children. Environ Health Perspect. 1995;103(suppl 6): 25-32.
103. Sharara FI, Seifer DB, Flaws JA. Environmental toxicants and female reproduction. Fertil Steril. 1998;70(4):613-622.
104. Savitz DA, Whelan EA, Kleckner RC. Effect of parents? occupational exposures on risk of stillbirth, preterm delivery, and small-for-gestational-age infants. Am J Epidemiol. 1989; 129(6):1201-1218.
105. Gerhard I, Monga B, Waldbrenner A, et al. Heavy metals and fertility. J Toxicol Environ Health A. 1998;54(8):593-611.
106. Ronco AM, Arguello G, Muñoz L, et al. Metals content in placentas from moderate cigarette consumers: correlation with newborn birth weight. Biometals. 2005; 18(3):233-241.
107. Hopenhayn C, Ferreccio C, Browning SR, et al. Arsenic exposure from drinking water and birth weight. Epidemiology. 2003;14(5):593-602.
108. Ahmad SA, Sayed MH, Barua S, et al. Arsenic in drinking water and pregnancy outcomes. Environ Health Perspect. 2001;109(6):629-631.
109. Ostrea EM, Morales V, Ngoumgna E, et al. Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology. 2002;23(3):329-339.
110. Gonzáles-Cosśio T, Peterson KE, Sanin LH, et al. Decrease in birth weight in relation to maternal bone-lead burden. Pediatrics. 1997;100(5):856-862.
111. von Ehrenstein OS, Guha Mazumder DN, Hira-Smith M, et al. Pregnancy outcomes, infant mortality, and arsenic in drinking water in West Bengal, India. Am J Epidemiol. 2006; 163(7):662-669.
112. Brody DJ, Pirkle JL, Kramer RA, et al. Blood lead levels in the US population. Phase 1 of the Third National Health and Nutrition Examination Survey (NHANES III, 1988 to 1991). JAMA. 1994;272(4):277-283.
113. Geronimus AT, Hillemeier MM. Patterns of blood lead levels in US black and white women of childbearing age. Ethn Dis. 1992;2(3):222-231.
114. Pirkle JL, Kaufmann RB, Brody DJ, et al. Exposure of the U.S. population to lead, 1991-1994. Environ Health Perspect. 1998;106(11):745-750.
115. Lanphear BP, Weitzman M, Eberly S. Racial differences in urban children?s environmental exposures to lead. Am J Public Health. 1996;86(10):1460-1463.
116. Hertz-Picciotto I, Schramm M, Watt-Morse M, et al. Patterns and determinants of blood lead during pregnancy. Am J Epidemiol. 2000;152(9):829-837.
117. Vupputuri S, He J, Muntner P, et al. Blood lead level is associated with elevated blood pressure in blacks. Hypertension. 2003;41(3):463-468.
118. Sorel JE, Heiss G, Tyroler HA, et al. Black-white differences in blood pressure among participants in NHANES II: the contribution of blood lead. Epidemiology. 1991;2(5):348-352.
119. Téllez-Rojo MM, Hernández-Avila M, González- Cossío T, et al. Impact of breastfeeding on the mobilization of lead from bone. Am J Epidemiol. 2002;155(5):420-428.
120. Nieuwenhuijsen MJ, Toledano MB, Eaton NE, et al. Chlo-rination disinfection byproducts in water and their association with adverse reproductive outcomes: a review. Occup Environ Med. 2000;57(2):73-85.
121. King WD, Dodds L, Allen AC. Relation between stillbirth and specific chlorination by-products in public water supplies. Environ Health Perspect. 2000;108(9):883-886.
122. Rodenbeck SE, Sanderson LM, Rene A. Maternal exposure to trichloroethylene in drinking water and birth-weight outcomes. Arch Environ Health. 2000;55(3):188-194.
123. Elliott P, Briggs D, Morris S, et al. Risk of adverse birth outcomes in populations living near landfill sites. BMJ. 2001;323(7309):363-368.
124. Munger R, Isacson P, Hu S, et al. Intrauterine growth retardation in Iowa communities with herbicide-contaminated drinking water supplies. Environ Health Perspect. 1997; 105(3):308-314.
125. Wilson SM, Howell F, Wing S, et al. Environmental injustice and the Mississippi hog industry. Environ Health Perspect. 2002;110(suppl 2):195-201.
126. Faber DR, Krieg EJ. Unequal exposure to ecological hazards: environmental injustices in the Commonwealth of Massachusetts. Environ Health Perspect. 2002;110(suppl 2): 277-288.
127. Calderon RL, Johnson CC Jr, Craun GF, et al. Health risks from contaminated water: do class and race matter? Toxicol Ind Health. 1993;9(5):879-900.
128. Whyatt RM, Garfinkel R, Hoepner LA, et al. Within-and between-home variability in indoor-air insecticide levels during pregnancy among an inner-city cohort from New York City. Environ Health Perspect. 2007;115(3):383-389.
129. Wolff MS, Engel S, Berkowitz G, et al. Prenatal pesticide and PCB exposures and birth outcomes. Pediatr Res. 2007;61(2): 243-250.
130. Whyatt RM, Camann D, Perera FP, et al. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth. Toxicol Appl Pharmacol. 2005; 206(2):246-254.
131. Vassilev ZP, Robson MG, Klotz JB. Outdoor exposure to airborne polycyclic organic matter and adverse reproductive outcomes: a pilot study. Am J Ind Med. 2001;40(3):255-262.
132. Rull RP, Ritz B, Shaw GM. Neural tube defects and maternal residential proximity to agricultural pesticide applications. Am J Epidemiol. 2006;163(8):743-753.
133. Schreinemachers DM. Birth malformations and other adverse perinatal outcomes in four U.S. wheat-producing states. Environ Health Perspect. 2003;111(9):1259-1264.
134. Etzel RA, Balk SJ. Pediatric Environmental Health. 2nd ed. Elk Grove Village, IL: American Academy of Pediatrics; 2003.
135. US Environmental Protection Agency. America?s Children and the Environment: Measures of Contaminants, Body Burdens, and Illnesses. EPA 240-R-03-001. Washington, DC: United States Environmental Protection Agency, Office of Children?s Health Protection; 2003. (http://www.epa.gov/ envirohealth/children). (Accessed April 6, 2009).
136. Wilson SE, Kahn RS, Khoury J, et al. Racial differences in exposure to environmental tobacco smoke among children. Environ Health Perspect. 2005;113(3):362-367.
137. Weaver VM, Davoli CT, Murphy SE, et al. Environmental tobacco smoke exposure in inner-city children. Cancer Epidemiol Biomarkers Prev. 1996;5(2):135-137.
138. McFarlane J, Parker B, Soeken K. Physical abuse, smoking, and substance use during pregnancy: prevalence, interrelationships, and effects on birth weight. J Obstet Gynecol Neonatal Nurs. 1996;25(4):313-320.
139. Goel P, Radotra A, Singh I, et al. Effects of passive smoking on outcome in pregnancy. JPostgrad Med. 2004;50(1):12-16.
140. Buescher PA. Smoking in pregnancy in North Carolina. Maternal characteristics and trends, 1988-1994. N C Med J. 1997;58(5):356-360.
141. Schoendorf KC, Kiely JL. Relationship of sudden infant death syndrome to maternal smoking during and after pregnancy. Pediatrics. 1992;90(6):905-908.
142. Mitchell EA, Ford RP, Stewart AW, et al. Smoking and the sudden infant death syndrome. Pediatrics. 1993;91(5): 893-896.
143. Klonoff-Cohen HS, Edelstein SL, Lefkowitz ES, et al. The effect of passive smoking and tobacco exposure through breast milk on sudden infant death syndrome. JAMA. 1995; 273(10):795-798.
144. Perera FP, Rauh V, Whyatt RM, et al. Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic population. Environ Health Perspect. 2004;112(5):626-630.
145. Choi H, Rauh V, Garfinkel R, et al. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and risk of in-trauterine growth restriction. Environ Health Perspect. 2008; 116(5):658-665.
146. Centers for Disease Control and Prevention. Behavioral Risk Factor Surveillance System Survey Data 1996 and 2006. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention. (http:// apps.nccd.cdc.gov/brfss/). (Accessed April 6, 2009).
147. Malek SH, Hopkins DP, Molloy M, et al. The public health challenge of youth smoking in North Carolina. Putting what we know into practice. N C Med J. 2002;63(3):153-161.
148. Adler NE, Boyce T, Chesney MA, et al. Socioeconomic status and health. The challenge of the gradient. Am Psychol. 1994;49(1):15-24.
149. Weich S, Burton E, Blanchard M, et al. Measuring the built environment: validity of a site survey instrument for use in urban settings. Health Place. 2001;7(4):283-292.
150. Barry K, Britt DW. Outreach: targeting high-risk women through community partnerships. Womens Health Issues. 2002;12(2):66-78.
151. Schulz AJ, Zenk SN, Israel BA, et al. Do neighborhood economic characteristics, racial composition, and residential stability predict perceptions of stress associated with the physical and social environment? Findings from a multilevel analysis in Detroit. J Urban Health. 2008;85(5):642-661.
152. Wilkinson D. Poor Housing and Ill Health: A Summary of Research Evidence. Edinburgh, United Kingdom: The Scottish Office Central Research Unit, Housing Research Branch; 1999:1-15.
153. Evans GW, Wells NM, Chan HY, et al. Housing quality and mental health. J Consult Clin Psychol. 2000;68(3):526-530.
154. Steptoe A, Feldman PJ. Neighborhood problems as sources of chronic stress: development of a measure of neighborhood problems, and associations with socioeconomic status and health. Ann Behav Med. 2001;23(3):177-185.
155. Saelens BE, Sallis JF, Black JB, et al. Neighborhood-based differences in physical activity: an environment scale evaluation. Am J Public Health. 2003;93(9):1552-1558.
156. Saelens BE, Sallis JF, Frank LD. Environmental correlates of walking and cycling: findings from the transportation, urban design, and planning literatures. Ann Behav Med. 2003;25(2): 80-91.
157. Acevedo-Garcia D, Lochner KA. Residential segregation and health. In: Kawachi I, Berkman L, eds. Neighborhoods and Health. New York, NY: Oxford University Press; 2003: 265-287.
158. Bullard RD. Dumping in Dixie: Race, Class, and Environmental Quality. 3rd ed. Boulder, CO: Westview Press; 2000.
159. Williams DR, Collins C. Racial residential segregation: a fundamental cause of racial disparities in health. Public Health Rep. 2001;116(5):404-416.
160. Corburn J. Confronting the challenges in reconnecting urban planning and public health. Am J Public Health. 2004;94(4): 541-546.
161. Diez Roux AV. Residential environments and cardiovascular risk. J Urban Health. 2003;80(4):569-589.
162. Reagan PB, Salsberry PJ. Race and ethnic differences in determinants of preterm birth in the USA: broadening the social context. Soc Sci Med. 2004;60(10):2217-2228.
163. Zeka A, Melly SJ, Schwartz J. The effects of socioeconomic status and indices of physical environment on reduced birth weight and preterm births in Eastern Massachusetts. Environ Health. 2008;7:60.
164. Messer LC, Vinikoor LC, Laraia BA, et al. Socioeconomic domains and associations with preterm birth. Soc Sci Med. 2008;67(8):1247-1257.
165. Krieger N, Chen J, Waterman P, et al. Choosing area based socioeconomic measures to monitor social inequalities in low birth weight and childhood lead poisoning: the Public Health Disparities Geocoding Project (US). J Epidemiol Community Health. 2003;57(3):186-199.
166. Masi CM, Hawkley LC, Piotrowski ZH, et al. Neighborhood economic disadvantage, violent crime, group density, and pregnancy outcomes in a diverse, urban population. Soc Sci Med. 2007;65(12):2440-2457.
167. Schempf A, Strobino D, O?Campo P. Neighborhood effects on birthweight: an exploration of psychosocial and behavioral pathways in Baltimore, 1995-1996. Soc Sci Med. 2009; 68(1):100-110.
168. Shiono PH, Rauh VA, Park M, et al. Ethnic differences in birthweight: the role of lifestyle and other factors. Am J Public Health. 1997;87(5):787-793.
169. Grady SC. Racial disparities in low birthweight and the contribution of residential segregation: a multilevel analysis. Soc Sci Med. 2006;63(12):3013-3029.
170. Bell JF, Zimmerman FJ, Almgren GR, et al. Birth outcomes among urban African-American women: a multilevel analysis of the role of racial residential segregation. Soc Sci Med. 2006;63(12):3030-3045.
171. Auger N, Daniel M, Platt RW, et al. Association between perceived security of the neighbourhood and small-for-gestational-age birth. Paediatr Perinat Epidemiol. 2008; 22(5):467-477.
172. Hogue CJ, Hoffman S, Hatch MC. Stress and preterm delivery: a conceptual framework. Paediatr Perinat Epidemiol. 2001;15(suppl 2):30-40.
173. Dix T. The affective organization of parenting: adaptive and maladaptive processes. Psychol Bull. 1991;110(1): 3-25.
174. Downey G, Coyne JC. Children of depressed parents: an in-tegrative review. Psychol Bull. 1990;108(1):50-76.
175. Tjaden P, Thoennes N. Prevalence, Incidences, and Consequences of Violence Against Women: Findings From the National Violence Against Women Survey. Washington, DC: National Institute of Justice and Centers for Disease and Prevention; 1998.
176. White L, Rogers SJ. Economic circumstances and family outcomes: a review of the 1990s. J Marriage Fam. 2000;62: 1035-1051.
177. Sims M, Rainge Y. Urban poverty and infant-health disparities among African Americans and whites in Milwaukee. J Natl Med Assoc. 2002;94(6):472-479.
178. Collins JW Jr, David RJ. Urban violence and African-American pregnancy outcome: an ecologic study. Ethn Dis. 1997;7(3):184-190.
179. DeNavas-Walt C, Proctor BD, Smith JC. Income, Poverty, and Health Insurance Coverage in the United States: 2007. Washington, DC: US Census Bureau; 2008. (Current Population Reports, P60-235).
180. Guilarte TR, Toscano CD, McGlothan JL, et al. Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure. Ann Neurol. 2003;53(1):50-56.
181. Staessen JA, Nawrot T, Hond ED, et al. Renal function, cytogenetic measurements, and sexual development in adolescents in relation to environmental pollutants: a feasibility study of biomarkers. Lancet. 2001;357(9269): 1660-1669.
182. Thatcher RW, Lester ML, McAlaster R, et al. Effects of low levels of cadmium and lead on cognitive functioning in children. Arch Environ Health. 1982;37(3):159-166.
183. Agency for Toxic Substances and Disease Registry. ToxFAQs for Cadmium. Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2008. (CAS#: 7440-43-9).
184. Culhane JF, Rauh V, McCollum KF, et al. Maternal stress is associated with bacterial vaginosis in human pregnancy. Matern Child Health J. 2001;5(2):127-134.
185. Nansel TR, Riggs MA, Yu KF, et al. The association of psychosocial stress and bacterial vaginosis in a longitudinal cohort. Am J Obstet Gynecol. 2006;194(2):381-386.
186. Ness RB, Hillier S, Richter HE, et al. Can known risk factors explain racial differences in the occurrence of bacterial vaginosis? J Natl Med Assoc. 2003;95(3):201-212.
187. Petraglia F, Sutton S, Vale W. Neurotransmitters and peptides modulate the release of immunoreactive corticotropin-releasing factor from cultured human placental cells. Am J Obstet Gynecol. 1989;160(1):247-251. (Pubitemid 19055300)
188. Falkenberg ER, Davis RO, DuBard M, et al. Effects of maternal infections on fetal adrenal steroid production. Endocr Res. 1999;25(3-4):239-249.
189. Gomez R, Romero R, Edwin SS, et al. Pathogenesis of pre-term labor and preterm premature rupture of membranes associated with intraamniotic infection. Infect Dis Clin North Am. 1997;11(1):135-176.
190. Romero R, Gomez R, Ghezzi F, et al. A fetal systemic inflammatory response is followed by the spontaneous onset of pre-term parturition. Am J Obstet Gynecol. 1998;179(1):186-193.
191. Glynn LM, Wadhwa PD, Dunkel-Schetter C, et al. When stress happens matters: effects of earthquake timing on stress responsivity in pregnancy. Am J Obstet Gynecol. 2001; 184(4):637-642.
192. Wadhwa PD, Glynn L, Hobel CJ, et al. Behavioral perina-tology: biobehavioral processes in human fetal development. Regul Pept. 2002;108(2-3):149-157.
193. Krocova Z, Macela A, Kroca M, et al. The immunomodula-tory effect(s) of lead and cadmium on the cells of immune system in vitro. Toxicol In Vitro. 2000;14(1):33-40.
194. Kayama F, Yoshida T, Elwell MR, et al. Cadmium-induced renal damage and proinflammatory cytokines: possible role of IL-6 in tubular epithelial cell regeneration. Toxicol Appl Pharmacol. 1995;134(1):26-34.
195. Chen CJ, Liao SL. Oxidative stress involved in astrocytic alterations induced by manganese. Exp Neurol. 2002;175(1): 216-225.
196. Steerenberg PA, Zonnenberg JA, Dormans JA, et al. Diesel exhaust particles induced release of interleukin 6 and 8 by (primed) human bronchial epithelial cells (BEAS 2B) in vitro. Exp Lung Res. 1998;24(1):85-100.
197. O?Neill M, Veves A, Zanobetti A, et al. Air pollution and cardiovascular health among subjects with diabetes in Greater Boston: a preliminary analysis: ISEE-590. Epidemiology. 2003;14(5):S116-S117.
198. Takizawa H, Abe S, Ohtoshi T, et al. Diesel exhaust particles up-regulate expression of intercellular adhesion molecule-1 (ICAM-1) in human bronchial epithelial cells. Clin Exp Immunol. 2000;120(2):356-362. (Pubitemid 30304234)
199. Gentile D, Howe-Adams J, Trecki J, et al. Association between environmental tobacco smoke and diminished dendritic cell interleukin 10 production during infancy. Ann Allergy Asthma Immunol. 2004;92(4):433-437.
200. Cozen W, Diaz-Sanchez D, James Gauderman W, et al. Th1 and Th2 cytokines and IgE levels in identical twins with varying levels of cigarette consumption. J Clin Immunol. 2004;24(6):617-622.
201. Noakes PS, Holt PG, Prescott SL. Maternal smoking in pregnancy alters neonatal cytokine responses. Allergy. 2003; 58(10):1053-1058.
202. Race/ethnicity, gender, socioeconomic status-research exploring their effects on child health: a subject review. Pediatrics. 2000;105(6):1349-1351.
203. Collins JW Jr, David RJ, Symons R, et al. Low-income African-American mothers? perception of exposure to racial discrimination and infant birth weight. Epidemiology. 2000; 11(3):337-339.
204. Mustillo S, Krieger N, Gunderson EP, et al. Self-reported experiences of racial discrimination and Black-White differences in preterm and low-birthweight deliveries: the CARDIA Study. Am J Public Health. 2004;94(12): 2125-2131.
205. Berkman L, Breslow L, Wingard D. Health practices and mortality risk. In: Berkman L, Breslow L, eds. Health and Ways of Living: The Alameda County Study. New York, NY: Oxford University Press; 1983:61-112.
206. Repetti RL, Taylor SE, Seeman TE. Risky families: family social environments and the mental and physical health of offspring. Psychol Bull. 2002;128(2):330-366.
207. American Lung Association. State of the Air 2009. Washington, DC: American Lung Association; 2009.
208. Bureau of the Census, US Department of Commerce. Census 2000 Summary File 3. Washington, DC: Bureau of the Census; 2003. (http://www2.census.gov/census- 2000/datasets/ Summary-File-3/). (Accessed February 24, 2007).
209. Bureau of the Census, US Department of Commerce. Housing and Household Economic Statistics Division. American Housing Survey 2007, National Data. 2008. (http://www. census.gov/hhes/www/housing/ahs/nationaldata.html). (Accessed May 29, 2009).
210. Bureau of the Census and Bureau of Labor Statistics, US Department of Commerce. Current Population Survey, Annual Social and Economic Supplement. Females, Aged 20-44. 2007. (http://www.census.gov/cps/). (Accessed May 29, 2009)
211. National Center for Health Statistics. Health, United States, 2008 With Chartbook. Hyattsville, MD: Centers for Disease Control and Prevention, US Department of Health and Human Services; 2009.