Heavy metals and fertility

Journal of Toxicology and Environmental Health - Part A

Volumn 54, Issue 8, 1998, Pages 593-611

  Gerhard, Ingrid ^a   Monga, Bondo ^a   Waldbrenner, Andreas ^a   Runnebaum, Benno ^a  

^a UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HEAVY METAL; TRACE ELEMENT; UNITHIOL; VITAMIN;

ADULT; ARTICLE; BODY MASS; ENDOCRINE DISEASE; FEMALE; FEMALE INFERTILITY; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SPONTANEOUS ABORTION; URINARY EXCRETION; UTERUS MYOMA;

ADULT; AGE FACTORS; BODY BURDEN; CADMIUM; CHELATING AGENTS; DENTAL AMALGAM; ENDOCRINE SYSTEM DISEASES; FEMALE; GERMANY; HORMONES; HUMANS; INFERTILITY, FEMALE; MERCURY; METALS, HEAVY; UNITHIOL;

EID: 0031710420     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841098158638     Document Type: Article

References (78)

1. Adachi, T., Yasutake, A., and Hirayama, K. 1992. Influence of dietary protein levels on the fate of methylmercury and glutathione metabolism in mice. Toxicology 72:17-26.
2. Al-Hakkak, Z. S., Hamamy, H. A., Murad, A. M., and Hussain, A. F. 1986. Chromosome aberrations in workers at a storage battery plant in Iraq. Mutat. Res. 171:53-60.
3. Aposhian, H. V., Bruce, D. C., Alter, W., Dart, R. C., Hurlbut, K. M., and Aposhian, M. M. 1992. Urinary mercury after administration of 2,3-dimercaptopropane-1-sulfonic acid: Correlation with dental amalgam score. FASEB J. 6:2472-2476.
4. Baghurst, P. A., Robertson, E. F., Oldfield, R. K., King, B. M., McMichael, A. J., and Wigg, N. R. 1991. Lead in the placenta, membranes, and umbilical cord in relation to pregnancy outcome in a lead-smelter community. Environ. Health Perspect. 90:315-320.
5. Bellinger, D., Sloman, J., Leviton, A., Rabinowitz, M., Needleman, H. L., and Waternaux, C. 1991. Low-level lead exposure and children's cognitive function in the preschool years. Pediatrics 87:219-227.
6. Bellinger, D., Stiles, K. M., and Needleman, H. L. 1992. Low-level lead exposure, intelligence and academic achievement: A long-term follow-up study. Pediatrics 90:855-861.
7. Cagiano, R., De Salvia, M. A., Renna, G., Tortella, E., Braghiroli, D., Parenti, C., Zanoli, P., Baraldi, M., Annau, Z., and Cuomo, V. 1990. Evidence that exposure to methyl mercury during gestation induces behavioral and neurochemical changes in offspring of rats. Neurotoxicol. Teratol. 12:23-28.
8. Chambers, B. J., and Klein, N. W. 1993. Role of laminin autoantibodies on the embryo toxicity of sera from mercuric chloride treated brown Norway rats. Reprod. Toxicol. 7:333-341.
9. Cherian, M. G., Miles, E. F., Clarkson, T. W., and Cox, C. 1988. Estimation of mercury burdens in rats by chelation with dimercaptopropane sulfonate. J. Pharmacol. Exp. Ther. 245:479-484.
10. Colborn, T., Dumanoski, D., and Myers, J. P. 1996. Our stolen future. New York: Dutton Press, Penguin Group.
11. Conaway, M. R., Waternaux, C., Allred, E., Bellinger, D., and Leviton, A. 1992. Pre-natal blood lead levels and learning difficulties in children: An analysis of non-randomly missing categorical data. Stat. Med. 11:799-811.
12. Danscher, G. P., Horstedt-Bindslev, P., and Rungby, J. 1990. Traces of mercury in organs from primates with amalgam fillings. Exp. Mol. Pathol. 52:291-299.
13. Daunderer, M. 1990. Handbuch der Umweltgifte. Landsberg/Lech: Ecomed-Verlag.
14. De, S. K., Paria, B. C., Dey, S. K., and Andrews, G. K. 1993. Stage-specific effects of cadmium on preimplantation embryo development and implantation in the mouse. Toxicology 80:13-25.
15. Dietrich, K. N., Berger, O. G., Succop, P. A., Hammond, P. B., and Bornschein, R. L. 1993. The developmental consequences of low to moderate prenatal and postnatal lead exposure: Intellectual attainment in the Cincinnati Lead Study Cohort following school entry. Neurotoxicol. Teratol. 15:37-44.
16. Dondero, F., Lenzi, A., Lombardo, F., and Gandini, L. 1991. Therapy of immunologic infertility. Acta Eur. Fertil. 22:139-145.
17. Drasch, G., Schupp, I., Riedel, G., and Günter, G. 1992. EinfluU von Amalgamfüllungen auf die Quecksilberkonzentration i n menschlichen Organen. Dtsch. Zahnärztliche. Z. 47:490-496.
18. Drasch, G., Scharl, K., Roider, G., Schiwara, H.-W., and Zilker, T. 1997. Aussagekraft des DMPS-Test auf Quecksilber. Umweltmed. Forsch. Prax. 2(1):2-10.
19. Duhr, E., Pendergrass, C., Kasarskis, E., Slevin, J., and Haley, B. 1991. Hg + induces GTP-tubulin interactions i n rat brain similar to those observed i n Alzheimer's disease. FASEBJ. 5:456.
20. Ellingsen, D. G., Holland, R. I., Thomassen, Y., Landro-Olstad, M., Frech, W., and Kjuus, H. 1993. Mercury and selenium in workers previously exposed to mercury vapour at a chloralkali plant. Br. J. Ind. Med. 50:745-752.
21. Ernhart, C. B., and Greene, T. 1990. Low-level lead exposure in the prenatal and preschool periods: Language development. Arch. Environ. Health 45:342-354.
22. Factor-Litvak, P., Graziano, J. H., Kline, J. K., Popovac, D., Mehmeti, A., Ahmedi, G., Shrout, P., Murphy, M. J., Gashi, E., and Haxhiu, R. 1991. A prospective study of birthweight and length of gestation in a population surrounding a lead smelter in Kosovo, Yugoslavia. Int. J. Epidemiol. 20:722-728.
23. Fagher, U., Laudanski, T., Schutz, A., Sipowicz, M., and Akerlund, M. 1993. The relationship between cadmium and lead burdens and preterm l abor. Int. J. Gynaecol. Obstet. 40:109-114.
24. Farris, F. F., Dedrick, R. L., Allen, P. V., and Smith, J. C. 1993. Physiological model for the pharmacokinetics of methyl mercury on the growing rat. Toxicol. Appl. Pharmacol. 119:74-90.
25. Foster, W. G., McMahon, A., Young Lai, E. V., Hughes, E. G., and Rice, D. C. 1993. Reproductive endocrine effects of chronic lead exposure in the male cynomolgus monkey. Reprod. Toxicol. 7:203-209.
26. Gerhard, I., and Runnebaum, B. 1992a. Schadstoffe und Fertilitätsstörungen—Schwermetalle und Mineralstoffe. Geburtshilfe Frauenheilkd. 52:383-396.
27. Gerhard, I., and Runnebaum, B. 1992b. Schadstoffe und Fertilitätsstörungen—Genußgifte. Geburtshilfe Frauenheilkd. 52:509-515.
28. Gerhard, I., and Runnebaum, B. 1992c. Grenzen der Hormonsubstitution bei Schadstoffbelastung und Fertilitätsstörungen. Zentralbl. Gynäkol. 114:593-602.
29. Gerhard, I., and Runnebaum, B. 1997. Environmental contamination and infertility. In Gynecological endocrinology and reproductive medicine, eds. B. Runnebaum and T. Rabe, vol. 2, pp. 187-224. New York: Springer-Verlag.
30. Gerhard, I., Reischmann, T., Eggert-Kruse, W., and Runnebaum, B. 1990. Untersuchungen der Faktoren, die den Schwangerschaftseintritt und -ausgang durch medikamentöse Therapie bei sterilen Frauen beeinflussen. I. Anamnestische und klinische Parameter. Fertilität 6:123-125.
31. Gerhard, I., Becker, T., Eggert-Kruse, W., Klinga, K., and Runnebaum, B. 1991. Thyroid and ovarian function i n infertile women. Human. Reprod. 6:338-345.
32. Gerhard, I., Waldbrenner, A., Thuro, H., and Runnebaum, B. 1992. Diagnostik von Schwermetallbelastungen mit dem peroralen DMPS-Test und dem Kaugummitest. Klin. Lab. 38:404-411.
33. Gerhard, I., Frick, A., and Monga, B. 1997. Diagnosis of mercury body burden. Clin. Lab. 43:637-647.
34. Gleichmann, E., Vohr, H. W., Mirtschewa, J., Stiller-Winkler, R., and Vogeler, S. 1987. Zur Induktion von Autoimmunkrankheiten und anderen stimulativen Immunopathien durch Quecksilber und andere Chemikalien. In Umwelthygiene, Jahresbericht 1986/1987, vol. 19, ed. K. Beyen, pp. 270-319. Düsseldorf: Gesellschaft zur Förderung der Lufthygiene und Silikoseforschung e.V.
35. Gleichmann, E., Kimber, I., and Purchase, F. H. 1989. Immunotoxicology: Suppressive and stimulatory effects of drugs and environmental chemicals on the immune system. Arch. Toxicol. 63:257-273.
36. Gonzalez-Ramirez, D., Maiorino, R. M., and Zuniga-Charles, M. 1995. Sodium 2,3-dimercapto-propane-1-sulfonate challenge test for mercury in humans: II. Urinary mercury, porphyrins and neurobehavioral changes of dental workers in Monterrey, Mexico. J. Pharmacol. Exp. Ther. 272: 264-274.
37. Graziano, J. H., Popovac, D., Factor-Litvak, P., Shrout, P., Kline, J. K., Murphy, M. J., Zhao, Y. H., Mehmeti, A., Ahmedi, X., and Rajovic, B. 1990. Determinants of elevated blood lead during pregnancy in a population surrounding a lead smelter in Kosovo, Yugoslavia. Environ. Health Perspect. 89:95-100.
38. Hahn, L. J., Kloiber, R., Leininger, R. W., Vimy, M. J., and Lorscheider, F. L. 1990. Whole-body i mag-ing of the distribution of mercury released from dental fillings into monkey tissues. FASEB J. 4: 3256-3260.
39. Huel, G., Tubert, P., Frery, N., Moreau, T., and Dreyfus, J. 1992. Joint effect of gestational age and maternal lead exposure on psychomotor development of the child at six years. Neurotoxicology 13:249-254.
40. Hultman, P., Johansson, U., Turley, S. J., Lindh, U., Eneström, S., and Pollard, K. M. 1994. Adverse immunological effects and autoimmunity induced by dental amalgam and alloy in mice. FASEB J. 8:1183-1190.
41. Hursh, J. B., Greenwood, M. R., Clarkson, T. W., Allen, J., and Demuth, S. 1980. The effect of ethanol on the fate of mercury vapor inhaled by man. J. Pharmacol. Exp. Ther. 214:520-527.
42. Johansson, L., and Pelliciari, C. E. 1988. Lead-induced changes in the stabilization of the mouse sperm chromatin. Toxicology 51:11-24.
43. Klages, K., Sourgens, H., Bertram, H. P., Müller, C., and Kemper, F. H. 1987. Lead exposure and endocrine functions: Impact on the hypophyseal-gonadal axis and the pituitary-thyroid system. Acta Endocrinol. Suppl. 283:17-18.
44. Koren, G., Chang, N., Gonen, R., Klein, J., Weiner, L., Demshar, H., Pizzolato, S., Radde, I., and Shime, J. 1990. Lead exposure among mothers and their newborns in Toronto. Can. Med. Assoc. J. 142:1241-1244.
45. Lakshmana, M. K., Desiraju, T., and Raju, T. R. 1993. Mercuric chloride-induced alterations of levels of noradrenaline, dopamine, serotonin and acetylcholine esterase activity in different regions of rat brain during postnatal development. Arch. Toxicol. 67:422-427.
46. Laudanski, T., Sipowicz, M., Modzelewski, P., Bolinski, J., Szamatowicz, J., Razniewska, G., and Akerlund, M. 1991. Influence of high lead and cadmium soil content on human reproductive outcome. Int. J. Gynaecol. Obstet. 36:309-315.
47. Lewis, M., Worobey, J., Ramsey, D. S., and McCormack, M. K. 1992. Prenatal exposure to heavy metals: Effect on childhood cognitive skills and health status. Pediatrics 9:1010-1015.
48. Lindbohm, M. L., Hemminki, K., Bonhomme, M. G., Anttila, A., Rantala, K., Heikkila, P., and Rosenberg, M. J. 1991. Effects of paternal occupational lead exposure on spontaneous abortions. Am. J. Public Health 81:1029-1033.
49. Lindstrom, H., Luthman, J., Oskarsson, A., Sundberg, J., and Olson, L. 1991. Effects of long-term treatment with methyl mercury on the developing rat brain. Environ. Res. 56:158-169.
50. Lorscheider, F. L., Vimy, M. J., and Summers, A. O. 1995. Mercury exposure from "silver" tooth fillings: Emerging evidence questions a traditional dental paradigm. FASEB J. 9:504-508.
51. McGivern, R. F., Sokol, R. Z., and Berman, N. G. 1991. Prenatal lead exposure in the rat during the third week of gestation: Long-term behavioral, physiological, and anatomical effects associated with reproduction. Toxicol. Appl. Pharmacol. 110:206-215.
52. McMichael, A. J., Vimpani, G. V., Robertson, E. F., Baghurst, P. A., and Clark, P. D. 1986. The Port Pirie cohort study: Maternal blood lead and pregnancy outcome. J. Epidemiol. Commun. Health 40:18-25.
53. 2 during unstimulated steroid synthesis. Cell. Biol. Toxicol. 10:23-33.
54. Murphy, M. J., Graziano, J. H., Popovac, D., Kline, J. K., Mehmeti, A., Factor-Litvak, P., Ahmedi, G., Shrout, P., Rajovic, B., and Nenezic, D. U. 1991. Past pregnancy outcomes among women living in the vicinity of a lead smelter in Kosovo, Yugoslavia. Am. J. Public Health 80:33-35.
55. Nogawa, K., and Kido, T. 1993. Biological monitoring of cadmium exposure in itai-itai disease epidemiology. Int. Arch. Occup. Environ. Health 65:43-46.
56. Nunez, C. M., Klitzman, S., and Goodman A. 1993. Lead exposure among automobile radiator repair workers and their children i n New York City. Am. J. Ind. Med. 23:763-777.
57. Nylander, M., Friberg, L., Eggleston, D., and Björkman, L. 1989. Mercury accumulation in tissues from dental staff and controls in relation to exposure. Swed. Dent. J. 13:235-243.
58. Padmanabhan, R., and Hameed, M. S. 1990. Characteristics of the limb malformations induced by maternal exposure to cadmium in the mouse. Reprod. Toxicol. 4:291-304.
59. Pasky, K., Varga, B., Naray, M., Olajos, F., and Folly, G. 1992a. Altered ovarian progesterone secretion Induced by cadmium fails to interfere with embryo transport in the oviduct of the rat. Reprod. Toxicol. 6:77-83.
60. Pasky, K., Varga, B., and Lazar, P. 1992b. Cadmium interferes with steroid biosynthesis in rat granulosa and luteal cells in vitro. Biometals 5:245-250.
61. Piasek, M., and Laskey, J. W. 1994. Acute cadmium exposure and ovarian steroidogenesis in cycling and pregnant rats. Reprod. Toxicol. 8:495-507.
62. Pinon-Lataillade, G., Thoreux-Manlay, A., Coffigny, H., Monchaux, G., Masse, R., and Soufir, J. C. 1993. Effects of ingestion and inhalation of lead on the reproductive system and fertility of adult male rats and their progeny. Human. Exp. Toxicol. 12:165-172.
63. Pisa, J., Cibulka, J., and Ptacek, M. 1990. Effect of subcutaneous application of a single cadmium dose on oocyte maturation in vitro. Physiol. Bohemoslov. 39:185-190.
64. Preston, A. M. 1991. Cigarette smoking—Nutritional implications. Prog. Food Nutr. Sci. 15:183-217.
65. Qu, J.-B., Xin, X.-F., Li, S.-X., and Ikeda, M. 1993. Blood lead and cadmium in a general population in Jinan City, China. Int. Arch. Occup. Environ. Health 65:201-204.
66. Rowlands, A. S., Baird, D. D., Weinberg, C. P., Shore, D. L., Shy, C. M., and Wilcox, A. J. 1994. The effect of occupational exposure to mercury vapour on the fertility of female dental assistants. Occup. Environ. Med. 51:28-34.
67. Runnebaum, B., Rabe, T., Sillem, M., and Eggert-Kruse, W. 1997. Infertility. In Gynecological endocrinology and reproductive medicine, eds. B. Runnebaum and T. Rabe, vol. 2, pp. 107-164. New York: Springer-Verlag.
68. Schionning, J. D. 1993. Retrograde axonal transport of mercury in rat sciatic nerve. Toxicol. Appl. Pharmacol. 121:43-49.
69. Siblerud, R. L., Kienholz, E., and Motl, J. 1993. Evidence that mercury from silver dental fillings may be an etiological factor in smoking. Toxicol. Lett. 68:307-310.
70. Snapp, K. R., Boyer, D. B., Peterson, L. C., and Svare, C. W. 1989. The contribution of amalgam to mercury i n blood. J. Dent. Res. 68:780-785.
71. Soukupova, D., and Dostal, M. 1991. Developmental toxicity of cadmium in mice I. Embryotoxic effects. Funct. Dev. Morphol. 1:3-9.
72. Störtebecker, P. 1989. Mercury poisoning from dental amalgam. Lancet 3:9.
73. Templeton, A., Fraser, C., and Thompson, B. 1990. The epidemiology of infertility in Aberdeen. Br. Med. J. 301:148-152.
74. Vallon, V., Roller, E., and Cledon, P. 1995. Schwermetallionen beeinflussen die Progesteronsynthese von humanen Granulosazellen bei i.v.F.-Patientinnen: Anwendung eines alternativen i n-vitro-Zytotoxizitätstests. J. Fertil. Reprod. 3:31.
75. Vimy, M. J., and Lorscheider, F. L. 1985. Serial measurement of intraoral air mercury: Estimation of daily dose from dental amalgam. J. Dent. Res. 64:1972-1975.
76. Watanabe, T., Shimada, T., and Endo, A. 1982. Effects of mercury compounds on ovulation and mei-otic and mitotic chromosomes in female golden hamster. Teratology 25:381-384.
77. Wiebe, J. P., Barr, K. J., and Buckingham, K. D. 1988 Effects of prenatal and neonatal exposure to lead on gonadotropin receptors and steroidogenesis in rat ovaries. J. Toxicol. Environ. Health 24:461-476.
78. World Health Organization. 1991. Environmental Health Criteria 118, Inorganic Mercury. Geneva: WHO.