Sphingomyelin synthase 2 deficiency attenuates NFκB activation

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 28, Issue 8, 2008, Pages 1519-1526

  Hailemariam, Tiruneh K ^a   Huan, Chongmin ^a   Liu, Jing ^a   Li, Zhiqiang ^a   Roman, Christopher ^a   Kalbfeisch, Michael ^b   Bui, Hai H ^b   Peake, David A ^b   Kuo, Ming Shang ^b   Cao, Guoqing ^b   Wadgaonkar, Raj ^a   Jiang, Xian Cheng ^a  

^a SUNY DOWNSTATE MEDICAL CENTER   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Atherosclerosis; Lipid rafts; NF B; Sphingomyelin; Sphingomyelin synthase 2

Indexed keywords

CERAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; PROTEIN SMS2; SMALL INTERFERING RNA; SPHINGOMYELIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CERAMIDE CHOLINEPHOSPHOTRANSFERASE; NERVE PROTEIN; PHOSPHOTRANSFERASE; SGMS1 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; ATHEROSCLEROSIS; CELL MEMBRANE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME REGULATION; GENE EXPRESSION; GENE REPRESSION; HUMAN; INFLAMMATION; LIPID RAFT; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CELL LINE; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

ANIMALS; CELL LINE; HUMANS; MACROPHAGES; MEMBRANE MICRODOMAINS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NF-KAPPA B; SPHINGOMYELINS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 52449124284     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.108.168682     Document Type: Article

References (34)

1. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-874.
2. Mayo MW, Baldwin AS. The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochim Biophys Acta. 2000; 1470:M55-62.
3. Branen L, Hovgaard L, Nitulescu M, Bengtsson E, Nilsson J, Jovinge S. Inhibition of tumor necrosis factor-{alpha} reduces atherosclerosis in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol. 2004; 24:2137-2142.
4. -/- mice. J Interferon Cytokine Res. 2002;22:661-670.
5. Simons K, Ikonen E. Functional rafts in cell membranes. Nature. 1997; 387:569-572.
6. Simons K, Ikonen E. How cells handle cholesterol. Science. 2000;290: 1721-1726.
7. Legier DF, Micheau O, Doucey MA, Tschopp J, Bron C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity. 2003;18:655-664.
8. Hunter I, Nixon GF. Spatial compartmentalization of tumor necrosis factor (TNF) receptor 1-dependent signaling pathways in human airway smooth muscle cells. Lipid rafts are essential for TNF-alpha-mediated activation of RhoA but dispensable for the activation of the NF-kappaB and MAPK pathways. J Biol Chem. 2006;281:34705-34715.
9. Triantafilou M, Miyake K, Golenbock T, Triantafilou K. Mediators of innate immune recognition of bacteria concentrate in lipid rafts and facilitate lipopolysaccharide-induced cell activation. J Cell Sci. 2002;115: 2603-2611.
10. Higuchi M, Singh S, Jaffrezou JP, Aggarwal BB. Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation. J Immunol. 1996;157:297-304.
11. Schütze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K, Kränke M. TNF activates NF-kappa B by phosphatidylcholine-speciflc phospholipase C-induced "acidic" sphingomyelin breakdown. Cell. 1992;71: 765-776.
12. Gamard CJ, Dbaibo GS, Liu B, Obeid LM, Hannun YA. Selective involvement of ceramide in cytokine-induced apoptosis. Ceramide inhibits phorbol ester activation of nuclear factor kappaB. J Biol Chem. 1997;272:16474-16481.
13. Merrill AH, Jones DD. An update of the enzymology and regulation sphingomyelin metabolism. Biochim Biophysi Acta. 1990;1044:1-12.
14. Luberto C, Yoo DS, Suidan HS, Bartoli GM, Hannun YA. Differential effects of sphingomyelin hydrolysis and resynthesis on the activation of NF-kappa B in normal and SV40-transformed human fibroblasts. J Biol Chem. 2000;275:14760-14766.
15. Schutze S, Potthoff K, Machleidt T, Berkovic D, Wiegmann K, Kronke M. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell. 1992;71: 765-766.
16. Huitema K, van den Dikkenberg J, Brouwers JF, Holthuis JC. Identification of a family of animal sphingomyelin synthases. EMBO J. 2004; 23:33-44.
17. Yamaoka S, Miyaji M, Kitano T, Umehara H, Okazaki T. Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells. J Biol Chem. 2004;279:18688-18693.
18. Miyaji M, Jin ZX, Yamaoka S, Amakawa R, Fukuhara S, Sato SB, Kobayashi T, Domae N, Mimori T, Bloom ET, Okazaki T, Umehara H. Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis. J Exp Med. 2005;202:249-259.
19. Van der Luit AH, Budde M, Zerp S, Caan W, Klarenbeek JB, Verheij M, Van Blitterswijk WJ. Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts. Kochern J. 2007;401:541-549.
20. Li Z, Hailemariam TK, Zhou H, Li Y, Duckworth DC, Peake DA, Zhang Y, Kuo MS, Cao G, Jiang XC. Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organization. Biochim Biophysi Acta. 2007;1771: 1186-1194.
21. Dignam JD, Lebovitz RM, Roeder RG. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 1983;11:1475-1489.
22. Yamaji A, Sekizawa Y, Emoto K, Sakuraba H, Inoue K, Kobayashi H, Umeda M. Lysenin, a novel sphingomyelin-specific binding protein, J Biol Chem. 1998;273:5300-5306.
23. Ishitsuka R, Yamaji-Hasegawa A, Makino A, Hirabayashi Y, Kobayashi TR. A lipid-specific toxin reveals heterogeneity of sphingomyelin-containing membranes. Biophys J. 2004;86:296-307.
24. Xie QW, Kashiwabara Y, Nathan C. Role of transcription factor NFκB/Rel in induction of nitric oxide synthase. J Biol Chem. 1994;269: 4705-4708.
25. Xie QW, Whisnant R, Nathan C. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide. J Exp Med. 1993;177: 1779-1784.
26. Schneider-Brachen W, Tchikov V, Merkel O, Jakob M, Hailas C, Kruse ML, Groitl P, Lehn A, Hildt E, Held-Feindt J, Dobner T, Kabelitz D, Krönke M, Schütze S. Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism. J Clin Invest. 2006;116:2901-2913.
27. Ogawa S, Lozach J, Benner C, Pascual G, Tangirala RK, Weson S, Hoffmann A, Subramaniam S, David M, Rosenfeld MG, Glass CK. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell. 2005;122:707-721.
28. Tafesse FG, Ternes P, Holthuis JC. The multigenic sphingomyelin synthase family. J Biol Chem. 2006;281:29421-29425.
29. Tafesse FG, Huitema K, Hermansson M, van der Poel S, van den Dikkenberg J, Uphoff A, Somerharju P, Holthuis JC. Both sphingomyelin synthase SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells. J Biol Chem. 2007;282:17537-17547.
30. Lee NP, Mruk DD, Xia W, Cbeng CY. Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes. J Endocrinol. 2007;192:17-32.
31. Wakelam MJ. Diacylglycerol-when is it an intracellular messenger? Biochim Biophys Acta. 1998;1436:117-126.
32. Griner EM, Kazanietz MG. Protein kinase C and other diacylglycerol effectors in cancer. Nat Rev Cancer. 2007;7:281-294.
33. Vancurova I, Miskolci V, Davidsou D. NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase C delta. Correlation to nuclear Ikappa Balpha. J Biol Chem. 2001;276: 19746-19752.
34. Satoh A, Gukovskaya AS, Nieto JM, Cheng JH, Gukovsky I, Reeve JR Jr, Shimosegawa T, Pandol SJ. PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells. Am J Physiol Gasstroin Liver Physiol. 2004; 287:G582-G591.