Effect of N-acetyltransferase 2 polymorphism on tumor target tissue DNA adduct levels in rapid and slow acetylator congenic rats administered 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine or 2-amino-3,8-dimethylimidazo- [4,5-f]quinoxaline

Drug Metabolism and Disposition

Volumn 37, Issue 11, 2009, Pages 2123-2126

  Metry, Kristin J ^a,b   Neale, Jason R ^a,c   Bendaly, Jean ^a,d   Smith, Ned B ^a   Pierce Jr , William M ^a   Hein, David W ^a  

^a University of Louisville School of Medicine   (United States)

^b WIL RESEARCH LABORATORIES   (United States)

^c ARRAY BIOPHARMA INC   (United States)

^d ALCON RESEARCH LTD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; ARYLAMINE ACETYLTRANSFERASE; DEOXYGUANOSINE; DEOXYRIBONUCLEOSIDE; DEUTERIUM;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST TUMOR; COLON TUMOR; CONTROLLED STUDY; DNA DAMAGE; DNA ISOLATION; DNA POLYMORPHISM; FEEDING; FEMALE; ISOTOPE DILUTION ASSAY; LIVER TUMOR; NONHUMAN; PANCREAS TUMOR; PRIORITY JOURNAL; RAT;

ACETYLATION; ANIMALS; ANIMALS, CONGENIC; ARYLAMINE N-ACETYLTRANSFERASE; CARCINOGENS; COLONIC NEOPLASMS; DEOXYGUANOSINE; DNA ADDUCTS; FEMALE; GENE TARGETING; GENETIC PREDISPOSITION TO DISEASE; IMIDAZOLES; LIVER NEOPLASMS; MUTAGENS; POLYMORPHISM, GENETIC; QUINOXALINES; RATS; RATS, INBRED F344; RATS, INBRED WKY; TIME FACTORS;

RATTUS;

EID: 70350316498     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.029512     Document Type: Article

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