Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: Impact of smoking on risk

Gut

Volumn 47, Issue 5, 2000, Pages 703-709

  Yu, M W ^a   Pai, C I ^a   Yang, S Y ^a   Hsiao, T J ^b   Chang, H C ^a   Lin, S M ^c   Liaw, Y F ^c   Chen, P J ^d   Chen, C J ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b TAO YUAN GENERAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Genetic polymorphism; Hepatocellular carcinoma; N acetyltransferase; Smoking

Indexed keywords

ACYLTRANSFERASE; AROMATIC AMINE; HEPATITIS B SURFACE ANTIGEN; TOBACCO SMOKE;

ADULT; ALLELE; ARTICLE; CANCER RISK; CIGARETTE SMOKING; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME POLYMORPHISM; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HETEROZYGOTE; HOMOZYGOTE; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; VIRUS CARRIER;

EID: 84984578951     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.47.5.703     Document Type: Article

References (46)

1. Hepatitis B and C viruses in the development of hepatocellular carcinoma
2. Hepatitis B virus: The major etiology of hepatocellular carcinoma
3. Association between hepatitis C virus antibodies and hepatocellular carcinoma in Taiwan
4. Nonviral risk factors for hepatocellular carcinoma in a low-risk population, the Non-Asians of Los Angeles County, California
5. Cytochrome P450 2E 1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma
6. Plasma carotenoids, glutathione S-transferase M1 and T1 genetic polymorphisms, and risk of hepatocellular carcinoma: Independent and interactive effects
7. Cytochrome P450 1A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers
8. Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 polymorphisms who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma
9. Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan
10. Vegetable consumption, serum retinol level, and risk of hepatocellular carcinoma
11. Plasma selenium levels and risk of hepatocellular carcinoma among men with chronic hepatitis virus infection
12. A p53 genetic polymorphism as a modulator of hepatocellular carcinoma risk in relation to chronic liver disease, familial tendency, and cigarette smoking in hepatitis B carriers
13. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases
14. Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: Effects of 7 specific NAT2 nucleic acid substitutions
15. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon
16. Mutagens-carcinogens in food
17. Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: Identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct
18. Detection of 2-amino-3-methylimidazo[4,5-f]quinoline in cigarette smoke condensate
19. Molecular mechanism of slow acetylation of drugs and carcinogens in humans
20. Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: Association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue
21. The role of N-acetylation polymorphisms in smoking-associated bladder cancer: Evidence of a gene-gene-exposure three-way interaction
22. Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: The influence of smoking
23. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk
24. A prospective study of N-acetyltransferase genotype, red meat intake, and risk of colorectal cancer
25. Polyadenylation polymorphism in the acetyltransferase 1 gene (NAT1) increases risk of colorectal cancer
26. Cigarette smoking, N-acetyltransferase 2 genetic polymorphisms, and breast cancer risk
27. Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as a susceptibility factor for lung cancer
28. Human cytochrome P-450(PA) (P-4501A2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines
29. Metabolism of aromatic amines: Relationships of N-acetylation, O-acetylation, N,O-acetyltransfer and deacetylation in human liver and urinary bladder
30. Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract
31. Demonstration of carcinogenicity in F344 rats of 2-aminomethylimidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract
32. Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods
33. Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
34. Carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates: Induction of tumors in three macaques
35. DNA adduct formation and tumorigenesis in mice during the chronic administration of 4-aminobiphenyl at multiple dose levels
36. 4-aminobiphenyl-DNA damage in liver tissue of hepatocellular carcinoma patients and controls
37. Increased risk for hepatocellular carcinoma in NAT2-slow acetylators and CYP2D6-rapid metabolizers
38. Genotype/phenotype discordance for human NAT2 reveals a new slow-acetylator allele common in African-Americans
39. Cell proliferation and the etiology of hepatocellular carcinoma
40. Enhanced metabolic activation of chemical hepatocarcinogens in woodchucks infected with hepatitis B virus
41. Metabolic activation of hepatocarcinogens in chronic hepatitis B
42. Hepatitis B virus infection and hepatocellular carcinoma: Molecular genetics and clinical perspectives
43. Cell proliferation in carcinogenesis
44. Role of cytochrome P4501A2 in chemical carcinogenesis: Implications for human variability in expression and enzyme activity
45. Slow acetylator mutations in the human polymorphic N-acetyltransferase gene in 786 Asians, Blacks, Hispanics, and Whites: Application to metabolic epidemiology
46. Methods of adjustment for estimating the attributable risk in case-control studies: A review