Oral administration of 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) yields PhlP-DNA adducts but not tumors in male Syrian hamsters congenic at the N-acetyltransferase 2 (NAT2) locus

Toxicological Sciences

Volumn 59, Issue 2, 2001, Pages 226-230

  Fretland, Adrian J ^a,b,c   Devanaboyina, Uday S ^a,d   Feng, Yi ^a,b   Leff, Matthew A ^a,b   Xiao, Gong H ^a   Webb, Stephanie J ^a   Hein, David W ^a,b  

^a University of Louisville School of Medicine   (United States)

^b UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

2 amino 1 methyl 6 phenylimidazo 4,5 b pyridine; Acetylator genotype; DNA adducts; N acetyltransferase 2 (NAT2); PhlP; Syrian hamster

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; ACYLTRANSFERASE; DNA; FAT;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; BLADDER; CARCINOGENESIS; CECUM; CONGENIC STRAIN; CONTROLLED STUDY; DESCENDING COLON; DNA ADDUCT; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; HEART; LIPID DIET; LIVER; MALE; NONHUMAN; PANCREAS; PROSTATE; RECTUM; SMALL INTESTINE; SYRIAN HAMSTER; TRANSVERSE COLON;

ACETYLATION; ANIMALS; ANIMALS, CONGENIC; ARYLAMINE N-ACETYLTRANSFERASE; CARCINOGENS; CRICETINAE; DISEASE MODELS, ANIMAL; DNA; DNA ADDUCTS; IMIDAZOLES; MALE; MESOCRICETUS; POLYMORPHISM, GENETIC;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0035127816     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/59.2.226     Document Type: Article

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