Probing the mechanisms underlying modulation of quinidine sensitivity to cardiac IKs block by protein kinase A-mediated IKs phosphorylation

British Journal of Pharmacology

Volumn 157, Issue 6, 2009, Pages 952-961

  Yang, Tao ^a   Kanki, Hideaki ^a   Zhang, Wei ^a   Roden, Dan M ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

IKs; KCNQ1; Negative charged residue; PKA stimulation; Protein kinase A (PKA) sites; Quinidine block; Whole cell voltage clamp

Indexed keywords

ASPARTIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; POTASSIUM CHANNEL KCNQ1; PROTEIN SUBUNIT; QUINIDINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SENSITIVITY; DRUG TARGETING; ENZYME PHOSPHORYLATION; HEART REPOLARIZATION; HYPERPOLARIZATION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SLOWLY ACTIVATING DELAYED RECTIFIER POTASSIUM CURRENT; VOLTAGE CLAMP;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; KCNQ1 POTASSIUM CHANNEL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; QUINIDINE;

EID: 70350303577     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00293.x     Document Type: Article

References (45)

1. Abitbol I, Peretz A, Lerche C, Busch AE, Attali B (1999). Stilbenes and fenamates rescue the loss of I(KS) Channel function induced by an LQT5 mutation and other IsK mutants. EMBO J 18: 4137-4148.
2. Alexander SP, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd Edition. Br J Pharmacol 153 (Suppl. 2): S1-209.
3. Armstrong CM (1971). Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J Gen Physiol 58: 413-437.
4. Balser JR, Bennett PB, Roden DM (1990). Time-dependent outward current in guinea pig ventricular myocytes. gating kinetics of the delayed rectifier. J Gen Physiol 96: 835-863.
5. Balser JR, Bennett PB, Hondeghem LM, Roden DM (1991). Suppression of time-dependent outward current in guinea pig ventricular myocytes. actions of quinidine and amiodarone. Circ Res 69: 519-529.
6. Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G (1996). K(V)LQT1 and LsK (MinK) proteins associate to form the I(Ks) cardiac potassium current. Nature 384: 78-80.
7. Bosch RF, Gaspo R, Busch AE, Lang HJ, Li GR, Nattel S (1998). Effects of the chromanol 293B, a selective blocker of the slow, component of the delayed rectifier K+ current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 38: 441-450.
8. Boucherot A, Schreiber R, Kunzelmann K (2001). Regulation and properties of KCNQ1 (K(V)LQT1) and impact of the cystic fibrosis trans-membrane conductance regulator. J Membr Biol 182: 39-47.
9. Busch AE, Herzer T, Takumi T, Krippeit-Drews P, Waldegger S, Lang F (1994). Blockade of human IsK channels expressed in xenopus oocytes by the novel class III antiarrhythmic NE-10064. Eur J Pharmacol 264: 33-37.
10. Caballero R, Delpon E, Valenzuela C, Longobardo M, Gonzalez T, Tamargo J (2001). Direct effects of candesartan and eprosartan on human cloned potassium channels involved in cardiac repolariza-tion. Mol Pharmacol 59: 825-836.
11. Carmeliet E (1992). Voltage-and Time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. J Pharmacol Exp Ther 262: 809-817.
12. Carmeliet E (1993). Use-dependent block and use-dependent unblock of the delayed rectifier K+ current by almokalant in rabbit ventricular myocytes. Circ Res 73: 857-868.
13. Giles WR, Shibata EF (1985). Voltage clamp of bull-frog cardiac pacemaker cells: a quantitative analysis of potassium currents. J Physiol 368: 265-292.
14. Han W, Wang Z, Nattel S (2001). Slow delayed rectifier current and repolarization in canine cardiac purkinje cells. Am J Physiol Heart Circ Physiol 280: H1075-H1080.
15. Harvey RD, Hume JR (1989). Autonomic regulation of delayed rectifier K+ current in mammalian heart involves G proteins. Am J Physiol 257: H818-H823.
16. Jost N, Virag L, Bitay M, Takacs J, Lengyel C, Biliczki P et al. (2005). Restricting excessive cardiac action potential and QT prolongation: a vital role for IKs in human ventricular muscle. Circulation 112: 1392-1399.
17. Jost N, Papp JG, Varro A (2007). Slow delayed rectifier potassium current (IKs) and the repolarization reserve. Ann Noninvasive Elec-trocardiol 12: 64-78.
18. Kanki H, Kupershmidt S, Yang T, Wells S, Roden DM (2004). A structural requirement for processing the cardiac K+ channel KCNQ1. J Biol Chem 279: 33976-33983.
19. Lo CF, Numann R (1998). Independent and exclusive modulation of cardiac delayed rectifying K+ current by protein kinase C and protein kinase A. Circ Res 83: 995-1002.
20. Loussouarn G, Park KH, Bellocq C, Baro I, Charpentier F, Escande D (2003). Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels. EMBO J 22: 5412-5421.
21. Lundquist AL, Manderfield LJ, Vanoye CG, Rogers CS, Donahue BS, Chang PA et al. (2005). Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks). J Mol Cell Cardiol 38: 277-287.
22. Marx SO, Kurokawa J, Reiken S, Motoike H, D'Armiento J, Marks AR et al. (2002). Requirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channel. Science 295: 496-499.
23. Mitcheson J, Perry M, Stansfeld P, Sanguinetti MC, Witchel H, Hancox J (2005). Structural determinants for high-affinity block of HERG potassium channels. Novartis Found Symp 266: 136-150.
24. Mitcheson JS, Chen J, Sanguinetti MC (2000). Trapping of a methane-sulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol 115: 229-240.
25. Perry M, de Groot MJ, Helliwell R, Leishman D, Tristani-Firouzi M, Sanguinetti MC et al. (2004). Structural determinants of HERG channel block by clofilium and ibutilide. Mol Pharmacol 66: 240-249.
26. Perry M, Sachse FB, Sanguinetti MC (2007). Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator. Proc Natl Acad Sci USA 104: 13827-13832.
27. Ramos E, O'leary ME (2004). State-dependent trapping of flecainide in the cardiac sodium channel. J Physiol 560: 37-49.
28. Roden DM (1998). Taking the 'idio' out of 'idiosyncratic': predicting torsades de pointes. Pacing Clin Electrophysiol 21: 1029-1034.
29. Roden DM (2006). Long QT syndrome: reduced repolarization reserve and the genetic link. J Intern Med 259: 59-69.
30. Roden DM (2008). Repolarization reserve: a moving target. Circulation 118: 981-982.
31. Roden DM, Yang T (2005). Protecting the heart against arrhythmias: potassium current physiology and repolarization reserve. Circulation 112: 1376-1378.
32. Salata JJ, Jurkiewicz NK, Wang J, Evans BE, Orme HT, Sanguinetti MC (1998). A novel benzodiazepine that activates cardiac slow delayed rectifier K+ currents. Mol Pharmacol 54: 220-230.
33. Sanguinetti MC, Jurkiewicz NK (1990). Two components of cardiac delayed rectifier K+ current. differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 96: 195-215.
34. Sanguinetti MC, Jurkiewicz NK, Scott A, Siegl PK (1991). Isoproterenol antagonizes prolongation of refractory period by the class III anti-arrhythmic agent E-4031 in guinea pig myocytes. mechanism of action. Circ Res 68: 77-84.
35. Sanguinetti MC, Curran ME, Zou A, Shen J, Spector PS, Atkinson DL et al. (1996). Coassembly of K(V)LQT1 and MinK (IsK) proteins to form cardiac I(Ks) potassium channel. Nature 384: 80-83.
36. Seebohm G, Chen J, Strutz N, Culberson C, Lerche C, Sanguinetti MC (2003). Molecular determinants of KCNQ1 channel block by a ben-zodiazepine. Mol Pharmacol 64: 70-77.
37. Shin KS, Rothberg BS, Yellen G (2001). Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate. J Gen Physiol 117: 91-101.
38. Silva J, Rudy Y (2005). Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve. Circulation 112: 1384-1391.
39. Thomas GP, Gerlach U, Antzelevitch C (2003). HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol 41: 140-147.
40. Varro A, Balati B, Iost N, Takacs J, Virag L, Lathrop DA et al. (2000). The role of the delayed rectifier component IKs in dog ventricular muscle and purkinje fibre repolarization. J Physiol 523 (Pt 1): 67-81.
41. Volders PG, Stengl M, van Opstal JM, Gerlach U, Spatjens RL, Beekman JD et al. (2003). Probing the contribution of IKs to canine ventricular repolarization: key role for beta-adrenergic receptor stimulation. Circulation 107: 2753-2760.
42. Yang IC, Scherz MW, Bahinski A, Bennett PB, Murray KT (2000). Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels. J Pharmacol Exp Ther 294: 955-962.
43. Yang T, Kanki H, Roden DM (2003). Phosphorylation of the IKs channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions. Circulation 108: 132-134.
44. Yang WP, Levesque PC, Little WA, Conder ML, Shalaby FY, Blanar MA (1997). KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proc Natl Acad Sci USA 94: 4017-4021.
45. Yellen G (2002). The voltage-gated potassium channels and their relatives. Nature 419: 35-42.