Stereoselective interactions of the enantiomers of chromanol 293B with human voltage-gated potassium channels

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 3, 2000, Pages 955-962

  Yang, I C H ^a   Scherz, M W ^a   Bahinski, A ^a   Bennett, P B ^a   Murray, K T ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIARRHYTHMIC AGENT; CHROMANOL 293B; POTASSIUM CHANNEL; POTASSIUM ION; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CHIRALITY; CONTROLLED STUDY; DRUG INDICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENANTIOMER; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RACEMIC MIXTURE; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHO CELLS; CHROMANS; CRICETINAE; HUMANS; ION CHANNEL GATING; KCNQ POTASSIUM CHANNELS; KCNQ1 POTASSIUM CHANNEL; KV1.5 POTASSIUM CHANNEL; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RECOMBINANT PROTEINS; SHAL POTASSIUM CHANNELS; STEREOISOMERISM; SULFONAMIDES;

EID: 0033842282     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Synthesis and antihypertensive activity of 4-(cyclic amido)-2H-1-benzopyrans
2. K(v)LQT1 and IsK (minK) proteins associate to form the I(Ks) cardiac potassium current
3. Catecholamines modulate the delayed rectifying potassium current (I(K)) in guinea pig ventricular myocytes
4. Selective I(Ks), but not I(Kr), blockade protects against ventricular fibrillation induced by myocardial ischemia (Abstract)
5. + current, on repolarization in human and guinea pig ventricular myocytes
6. Inhibition of I(Ks) in guinea pig cardiac myocytes and guinea pig I(sK) channels by the chromanol 293B
7. + channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias
8. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome
9. + channel in ventricular muscle: A molecular correlate for the transient outward current
10. Mutation of the gene for I(sK) associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long QT syndrome
11. Prolongation of guinea pig ventricular action potential duration by selective blockade of I(Ks) in enhanced by β-adrenergic stimulation (Abstract)
12. + current in cultured human atrial myocytes
13. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines
14. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
15. Class III antiarrhythmic agents have a lot of potential but a long way to go: Reduced effectiveness and dangers of reverse use dependence
16. + current by dofetilide
17. Azimilide dihydrochloride, a novel antiarrhythmic agent
18. Enantiomerically pure epoxychromans via asymetric catalysis
19. + conductance
20. KvLQT1 potassium channel but not I(sK) is the molecular target for trans-6-cyano-4-(N-ethylsulfonyl-N-methylamino)-3-hydroxy-2,2-dim ethyl-chromane
21. Dose response for azimilide treatment of paroxysmal supraventricular tarhycardia
22. Modulation of HERG potassium channels by extracellular magnesium and quinidine
23. Azimilide treatment of atrial fibrillation (Abstract)
24. Current status of class III antiarrhythmic drug therapy
25. Modulation of potassium channels by antiarrhythmic and antihypertensive drugs
26. +-channel dysfunction in an inherited cardiac arrhythmia
27. Coassembly of K(v)LQT1 and mink (IsK) proteins to form cardiac I(Ks) potassium channel
28. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the I(Kr) potassium channel
29. Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes: Mechanism of action
30. Differential effect of β-adrenergic stimulation on the frequency-dependent electrophysiologic actions of the new class III antiarrhythmics dofetilide, ambasilide, and chromanol 293B
31. The coming of age of the class III antiarrhythmic principle: Retrospective and future trends
32. Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel
33. A rapidly activating and slowly inactivating potassium channel cloned from human heart: Functional analysis after stable mammalian cell culture expression
34. Mutations in the hminK gene cause long QT syndrome and suppress I(Ks) function
35. Specific blockade of slowly activating I(sK) channels by chromanols: Impact on the role of I(sK) channels in epithelia
36. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias
37. + current similar to Kv1.5 cloned channel currents
38. HERG channel dysfunction in human long QT syndrome: Intracellular transport and functional defects