Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 34, 2007, Pages 13827-13832

  Perry, Matthew ^a,b   Sachse, Frank B ^a,c   Sanguinetti, Michael C ^a,b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH   (United States)

^c Department of Electrical and Computer Engineering   (United States)

Author keywords

Long QT syndrome; Voltage clamp; Xenopus

Indexed keywords

4 [3 (6 METHOXYQUINOLIN 4 YL) 3 OXOPROPYL] 1 [3 (2,3,5 TRIFLUOROPHENYL) PROP 2 YNYL]PIPERIDINE 3 CARBOXYLIC ACID; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL STIMULATING AGENT; RPR 260243; UNCLASSIFIED DRUG; KCNH1 PROTEIN, HUMAN; PIPERIDINE DERIVATIVE; QUINOLINE DERIVATIVE; RPR260243;

ANIMAL CELL; ARTICLE; COMPARTMENT MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; NONHUMAN; OOCYTE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROBABILITY; QT PROLONGATION; STATISTICAL MODEL; VOLTAGE CLAMP; XENOPUS LAEVIS; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ELECTROPHYSIOLOGY; GENETICS; HUMAN; METABOLISM; MUTATION; PATCH CLAMP; PROTEIN TERTIARY STRUCTURE; TIME;

XENOPUS LAEVIS;

ANIMALS; BINDING SITES; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; ION CHANNEL GATING; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PIPERIDINES; PROTEIN STRUCTURE, TERTIARY; QUINOLINES; TIME FACTORS; XENOPUS LAEVIS;

EID: 35348824829     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0703934104     Document Type: Article

References (38)

1. Jones EM, Roti Roti EC, Wang J, Delfosse SA, Robertson GA (2004) J Biol Chem 279:44690-44694.
2. Sanguinetti MC, Jiang C, Curran ME, Keating MT (1995) Cell 81:299-307.
3. Trudeau M, Warmke JW, Ganetzky B, Robertson GA (1995) Science 269:92-95.
4. Sanguinetti MC, Jurkiewicz NK (1990) J Gen Physiol 96:195-215.
5. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT (1995) Cell 80:795-803.
6. Sanguinetti MC, Mitcheson JS (2005) Trends Pharmacol Sci 26:119-124.
7. Keating MT, Sanguinetti MC (2001) Cell 104:569-580.
8. Schwartz PJ (2006) J Intern Med 259:39-47.
9. Moss AJ, Zareba W, Hall WJ, Schwartz PJ, Crampton RS, Benhorin J, Vincent GM, Locati EH, Priori SG, Napolitano C, et al. (2000) Circulation 101:616-623.
10. Hua F, Gilmour RF, Jr (2004) Circ Res 94:810-819.
11. Hua F, Johns DC, Gilmour RF, Jr (2004) Am J Physiol 286:H2342-H2351.
12. Casis O, Olesen SP, Sanguinetti MC (2006) Mol Pharmacol 69:658-665.
13. Hansen RS, Diness TG, Christ T, Demnitz J, Ravens U, Olesen S-P, Grunnet M (2005) Mol Pharmacol 69:266-277.
14. Zhou J, Augelli-Szafran CE, Bradley JA, Chen X, Koci BJ, Volberg WA, Sun Z, Cordes JS (2005) Mol Pharmacol 68:876-884.
15. Kang J, Chen XL, Wang H, Ji J, Cheng H, Incardona J, Reynolds W, Viviani F, Tabart M, Rampe D (2005) Mol Pharmacol 67:827-836.
16. De Biasi M, Hartmann HA, Drewe JA, Taglialatela M, Brown AM, Kirsch G (1993) Pflügers Arch 422:354-363.
17. Schenzer A, Friedrich T, Pusch M, Saftig P, Jentsch TJ, Grotzinger J, Schwake M (2005) J Neurosci 25:5051-5060.
18. Wuttke TV, Seebohm G, Bail S, Maljevic S, Lerche H (2005) Mol Pharmacol 67:1009-1017.
19. Seebohm G, Pusch M, Chen J, Sanguinetti MC (2003) Circ Res 93:941-947.
20. Xiong Q, Sun H, Li M (2007) Nat Chem Biol 3:287-296.
21. Long SB, Campbell EB, Mackinnon R (2005) Science 309:897-903.
22. Zou A, Xu QP, Sanguinetti MC (1998) J Physiol (London) 509:129-138.
23. Webster SM, Del Camino D, Dekker JP, Yellen G (2004) Nature 428:864-868.
24. Loots E, Isacoff EY (1998) J Gen Physiol 112:377-389.
25. Liu J, Zhang M, Jiang M, Tseng GN (2002) J Gen Physiol 120:723-737.
26. Ferrer T, Rupp J, Piper DR, Tristani-Firouzi M (2006) J Biol Chem 281:12858-12864.
27. Sanguinetti MC, Xu QP (1999) J Physiol (London) 514:667-675.
28. Tristani-Firouzi M, Chen J, Sanguinetti MC (2002) J Biol Chem 277:18994-19000.
29. Mitcheson JS, Chen J, Lin M, Culberson C, Sanguinetti MC (2000) Proc Natl Acad Sci USA 97:12329-12333.
30. Fernandez D, Ghanta A, Kauffman GW, Sanguinetti MC (2004) J Biol Chem 279:10120-10127.
31. Shih TM, Smith RD, Toro L, Goldin AL (1998) Methods Enzymol 293:529-556.
32. Stühmer W (1992) Methods Enzymol 207:319-339.
33. Iyer V, Mazhari R, Winslow RL (2004) Biophys J 87:1507-1525.
34. Lu Y, Mahaut-Smith MP, Varghese A, Huang CL, Kemp PR, Vandenberg JI (2001) J Physiol (London) 537:843-851.
35. Press WH, Teukolsky SA, Vetterling WT, Flannery BP (1992) Numerical Recipes in C (Cambridge Univ Press, Cambridge, UK).
36. Ficker E, Jarolimek W, Kiehn J, Baumann A, Brown AM (1998) Circ Res 82:386-395.
37. Brugada R, Hong K, Dumaine R, Cordeiro J, Gaita F, Borggrefe M, Menendez TM, Brugada J, Pollevick GD, Wolpert C, et al. (2004) Circulation 109:30-35.
38. Smith PL, Baukrowitz T, Yellen G (1996) Nature 379:833-836.