Radiosensitization of human glioma cells in vitro and in vivo with acyclovir and mutant HSV-TK75 expressed from adenovirus

International Journal of Radiation Oncology Biology Physics

Volumn 52, Issue 3, 2002, Pages 831-836

  Rosenberg, Elizabeth ^a   Hawkins, William ^a   Holmes, Matthew ^a   Amir, Cyrus ^a   Schmidt Ullrich, Rupert K ^a   Lin, Peck Sun ^a   Valerie, Kristoffer ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Adenovirus; Gene therapy; Glioma; Thymidine kinase

Indexed keywords

ASSAYS; CONCENTRATION (PROCESS); GRAFTS; MONITORING; VIRUSES;

RADIOSENSITIZATION;

MUTAGENS;

ACICLOVIR; THYMIDINE KINASE; VIRUS ENZYME;

ADENOVIRUS; ARTICLE; BRAIN TUMOR; CELL SURVIVAL; COLONY FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG SENSITIVITY; GENE MUTATION; GENETIC TRANSDUCTION; GLIOMA CELL; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIOSENSITIZATION; TUMOR GROWTH; VIRUS EXPRESSION; XENOGRAFT;

ACYCLOVIR; ADENOVIRIDAE; ANIMALS; ANTIVIRAL AGENTS; COMBINED MODALITY THERAPY; GLIOMA; HERPESVIRIDAE; HUMANS; MICE; MICE, NUDE; MUTATION; RADIATION TOLERANCE; RADIOBIOLOGY; THYMIDINE KINASE; TRANSDUCTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; TUMOR STEM CELL ASSAY;

EID: 0036499064     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(01)02754-7     Document Type: Article

References (25)

1. Enhanced cytotoxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rat glioma cells
2. Adenovirus-mediated gene therapy of experimental gliomas
3. Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo
4. Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity
5. Preferential radiosensitization of 9L glioma cells transduced with HSV- tk gene by acyclovir
6. Double suicide gene therapy augments the antitumor activity of a replication-competent lytic adenovirus through enhanced cytotoxicity and radiosensitization
7. Selective enhancement by an antiviral agent of the radiation-induced cell killing of human glioma cells transduced with HSV-tk gene
8. Ganciclovir for the treatment and suppression of serious infections caused by cytomegalovirus
9. Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy
10. Enhanced delivery of ganciclovir to the brain through the use of redox targeting
11. Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy
12. Substantially improved in vivo radiosensitization of rat glioma with mutant HSV-TK and acyclovir
13. Improved radiosensitization of rat glioma cells with adenovirus-expressed mutant HSV-TK in combination with acyclovir
14. Long term culture of normal and neoplastic human glia
15. A truncated form of the human XPA protein expressed from an adenovirus sensitizes human tumor cells to ultraviolet light and cisplatin
16. Radiosensitization of rat glioma with bromodeoxycytidine and adenovirus expressing HSV-TK delivered by slow positive pressure infusion
17. A double-blind randomized placebo trial on very high doses of acyclovir in weakly symptomatic HIV-patients
18. Differential mechanism of cytostatic effect of (E)-5-(2-bromovinyl)-2′- deoxyuridine, 9-(1,3-dihydroxy-2-propoxymethyl)guanine, and other antiherpetic drugs on tumor cells transfected by the thymidine kinase gene of herpes simplex virus type 1 or type 2
19. 9-([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine: A selective inhibitor of herpes group virus replication
20. Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice
21. Systematic evaluation of primary brain tumors
22. Permeability characteristics of brain adjacent to tumors in rats
23. Effects of steroids and nonsteroid anti-inflammatory agents on vascular permeability in a rat glioma model
24. Intravenous RMP-7 increases delivery of ganciclovir into rat brain tumors and enhances the effects of herpes simplex virus thymidine kinase gene therapy