Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione S-transferases

Cancer Research

Volumn 69, Issue 20, 2009, Pages 8025-8034

  Federici, Luca ^a   Lo Sterzo, Carlo ^b   Pezzola, Silvia ^c   Di Matteo, Adele ^b   Scaloni, Flavio ^b   Federici, Giorgio ^c   Caccuri, Anna Maria ^c  

^a UNIVERSITY OF CHIETI   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 ( 7 NITRO 2,1,3 BENZOXADIAZOL 4 YLTHIO)HEXANOL; ALANINE; ANTINEOPLASTIC AGENT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M2; GLUTATHIONE TRANSFERASE P1; HISTIDINE; ISOENZYME; ISOLEUCINE; STRESS ACTIVATED PROTEIN KINASE; SULFUR; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; COMPLEX FORMATION; CONJUGATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG BINDING; DRUG BINDING SITE; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR CELL; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXADIAZOLES; PROTEIN CONFORMATION;

EID: 70350236453     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-1314     Document Type: Article

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