The glutathione S-transferase inhibitor 6-(7-nitro-2,1,3-benzoxadiazol-4- ylthio)hexanol overcomes the MDR1-P-glycoprotein and MRP1-mediated multidrug resistance in acute myeloid leukemia cells

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 2, 2009, Pages 419-424

  Ascione, Alessandro ^a   Cianfriglia, Maurizio ^a   Dupuis, Maria Luisa ^a   Mallano, Alessandra ^a   Sau, Andrea ^b   Pellizzari Tregno, Francesca ^b   Pezzola, Silvia ^b   Caccuri, Anna Maria ^b  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Acute myeloid leukemia; Anti tumor drugs; Multidrug resistance; NBDHEX

Indexed keywords

6 (7 NITRO 2,1,3 BENZOXADIAZOL 4 YLTHIO)HEXANOL; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BCL 2; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CELL DEATH; CELL PROLIFERATION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG SENSITIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLOW CYTOMETRY; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HUMANS; LEUKEMIA, MYELOID, ACUTE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NECROSIS; OXADIAZOLES; P-GLYCOPROTEIN; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED;

EID: 67349262033     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-009-0960-6     Document Type: Article

References (16)

1. DM van der Kolk EG de Vries M Müller E Vellenga 2002 The role of drug efflux pumps in acute myeloid leukemia Leuk Lymphoma 43 685 701 (Pubitemid 34428655)
2. MM Gottesman T Fojo SE Bates 2002 Multidrug resistance in cancer: role of ATP-dependent transporters Nat Rev Cancer 2 48 58 (Pubitemid 37328807)
3. O Legrand G Simonin R Zittoun JP Marie 1998 Both P-gp and MRP contribute to drug resistance in AML Leukemia 12 1327 1328 (Pubitemid 28396001)
4. Z Benderra AM Faussat L Sayada JY Perrot R Tang D Chaoui H Morjani C Marzac JP Marie O Legrand 2005 MRP3, BCRP, and P-glycoprotein activities are prognostic factors in adult acute myeloid leukemia Clin Cancer Res 11 7764 7772 (Pubitemid 41611620)
5. DD Ross 2000 Novel mechanisms of drug resistance in leukemia Leukemia 14 467 473 (Pubitemid 30142873)
6. G Ricci F De Maria G Antonini P Turella A Bullo L Stella G Filomeni G Federici AM Caccuri 2005 7-Nitro-2,1,3-benzoxadiazole derivatives, a new class of suicide inhibitors for glutathione S-transferases. Mechanism of action of potential anticancer drugs J Biol Chem 280 26397 26405 (Pubitemid 41022236)
7. E Bakos L Homolya 2007 Portrait of multifaceted transporter, the multidrug resistance-associated protein 1 (MRP1/ABCC1) Eur J Physiol 453 621 641 (Pubitemid 46192535)
8. P Turella C Cerella G Filomeni A Bullo F De Maria L Ghibelli MR Ciriolo M Cianfriglia M Mattei G Federici G Ricci AM Caccuri 2005 Proapoptotic activity of new glutathione S-transferase inhibitors Cancer Res 65 3751 3761 (Pubitemid 40616353)
9. P Turella G Filomeni ML Dupuis MR Ciriolo A Molinari F De Maria M Tombesi M Cianfriglia G Federici G Ricci AM Caccuri 2006 A strong glutathione S-transferase inhibitor overcomes the P-glycoprotein-mediated resistance in tumor cells. 6-(7-Nitro-2, 1, 3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) triggers a caspase-dependent apoptosis in MDR1-expressing leukemia cells J Biol Chem 281 23725 23732 (Pubitemid 44274147)
10. G Filomeni P Turella ML Dupuis O Forini MR Ciriolo M Cianfriglia S Pezzola G Federici AM Caccuri 2008 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer Mol Cancer Ther 7 371 379
11. M Pasello F Michelacci I Scionti CM Hattinger M Zuntini AM Caccuri K Scotlandi P Picci M Serra 2008 Overcoming glutathione S-transferase P1-related cisplatin resistance in osteosarcoma Cancer Res 68 6661 6668
12. R Tang AM Faussat P Majdak JY Perrot D Chaoui O Legrand JP Marie 2004 Valproic acid inhibits proliferation and induces apoptosis in acute myeloid leukemia cells expressing P-gp and MRP1 Leukemia 18 1246 1251 (Pubitemid 39023135)
13. M Cianfriglia MC Willingham M Tombesi GV Scagliotti G Frasca A Chersi 1994 P-glycoprotein epitope mapping. I. Identification of a linear human-specific epitope in the fourth loop of the P-glycoprotein extracellular domain by MM4.17 murine monoclonal antibody to human multidrugresistantcells Int J Cancer 56 153 160
14. DR Hipfner M Gao G Scheffer RJ Scheper RG Deeley SP Cole 1998 Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP) Br J Cancer 78 1134 1140 (Pubitemid 28479139)
15. M Schultz S Dutta KD Tew 1997 Inhibitors of glutathione S-transferases as therapeutic agents Adv Drug Deliv Rev 26 91 104 (Pubitemid 27289527)
16. KD Tew A Monks L Barone D Rosser G Akerman JA Montali JB Wheatley DE Schmidt 1996 Glutathione-associated enzymes in the human cell lines of the National Cancer Institute Drug Screening Program Mol Pharmacol 50 149 159 (Pubitemid 26250086)