6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol, a specific glutathione S-transferase inhibitor, overcomes the multidrug resistance (MDR)-associated protein 1-mediated MDR in small cell lung cancer

Molecular Cancer Therapeutics

Volumn 7, Issue 2, 2008, Pages 371-379

  Filomeni, Giuseppe ^a   Turella, Paola ^a   Dupuis, Maria Luisa ^b   Forini, Olindo ^a   Ciriolo, Maria Rosa ^a,c   Cianfriglia, Maurizio ^b   Pezzola, Silvia ^a   Federici, Giorgio ^d   Caccuri, Anna Maria ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c IRCCS SAN RAFFAELE PISANA   (Italy)

^d Children's Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 (7 NITRO 2,1,3 BENZOXADIAZOL 4 YLTHIO)HEXANOL; ABC TRANSPORTER; CASPASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN BCL 2; PROTEIN C JUN; STRESS ACTIVATED PROTEIN KINASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG SPECIFICITY; DRUG TRANSPORT; ENZYME ACTIVATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; LC 50; LUNG SMALL CELL CANCER; MULTIDRUG RESISTANCE; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SMALL CELL; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; ENZYME ACTIVATION; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEXANOLS; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LUNG NEOPLASMS; NECROSIS; OXADIAZOLES; OXIDATION-REDUCTION; P-GLYCOPROTEIN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-JUN; SUBSTRATE SPECIFICITY;

EID: 39749154709     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0487     Document Type: Article

References (41)