Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis

Apoptosis

Volumn 12, Issue 7, 2007, Pages 1269-1280

  Asakura, Tadashi ^a   Sasagawa, Atsuko ^a,b   Takeuchi, Hitoshi ^a,b   Shibata, Shun Ichi ^a   Marushima, Hideki ^a   Mamori, Satoshi ^a   Ohkawa, Kiyoshi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Apoptosis; c Jun N terminal kinase; Doxorubicin; Glutathione S transferase P1 1; Glutathione Doxorubicin conjugate; Rat hepatoma cell

Indexed keywords

DOXORUBICIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1; STRESS ACTIVATED PROTEIN KINASE;

ALLOSTERISM; ANIMAL CELL; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ANIMALS; APOPTOSIS; CELL LINE; DOXORUBICIN; ENZYME ACTIVATION; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MUTATION; RATS; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

RATTUS;

EID: 34250003256     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-007-0053-0     Document Type: Article

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