Tamoxifen induces apoptosis in Fas+ tumor cells by upregulating the expression of Fas ligand

Cancer Chemotherapy and Pharmacology

Volumn 51, Issue 4, 2003, Pages 284-290

  Nagarkatti, Nisha ^a,b   Davis, Barbara A ^a,c  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b HARVARD UNIVERSITY   (United States)

^c PFIZER INC   (United States)

Author keywords

Apoptosis; Metalloproteinase Inhibitor; Tamoxifen

Indexed keywords

ESTROGEN RECEPTOR; FAS ANTIGEN; FAS LIGAND; ILOMASTAT; METALLOPROTEINASE INHIBITOR; TAMOXIFEN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL LINE; UPREGULATION;

EID: 0037902190     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-003-0581-4     Document Type: Article

References (19)

1. Takahashi T, Tanaka M, Brannan CI, Jenkins NA, Copeland NG, Suda T, Nagata S (1994) Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969
2. Suda T, Takahashi T, Golstein P, Nagata S (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169
3. Walker PR, Saas P, Dietrich PY (1997) Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back. J Immunol 158:4521
4. Nagarkatti N (2000) Tumor-derived FasL induces toxicity in lymphoid organs and plays an important role in successful chemotherapy. Cancer Immunol Immunother 49:46
5. Jordan VC (1997) TAM treatment for breast cancer: concept to gold standard. Oncology 11:7
6. Suh-Burgmann EJ, Goodman A (1999) Surveillance for endometrial cancer in women receiving TAM. Ann Intern Med 131:127
7. Price A, Shi Q, Morris D, Wilcox ME, Brasher PM, Rewcastle NB, Shalinsky D, Zou H, Appelt K, Johnston RN, Yong VW, Edwards D, Forsyth P (1999) Marked inhibition of tumor growth in a malignant glioma tumor model by a novel synthetic matrix metalloproteinase inhibitor AG3340. Clin Cancer Res 5:845
8. Schneider P, Holler N, Bodmer JL, Hahne M, Frei K, Fontana A, Tschopp J (1998) Conversion of membrane-bound Fas (CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity. J Exp Med 187:1205
9. Angus WG, Larsen MC, Jefcoate CR (1999) Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status. Carcinogenesis 6:947
10. Hwang PL, Shoon MY, Low YL, Lin L, Ng HL (1995) Inhibitors of protein and RNA synthesis block the cytotoxic effects of non-steroidal antiestrogens. Biochim Biophys Acta 1266:215
11. Rouvier E, Luciani MF, Golstein P (1993) Fas involvement in Ca(2+)-independent T cell-mediated cytotoxicity. J Exp Med 177:195
12. Matsui K, Jodo S, Xiao S, Ju ST (1999) Hypothesis: a recurrent, moderate activation fosters systemic autoimmunity - the apoptotic roles of TCR, IL-2 and Fas ligand. J Biomed Sci 6:306
13. Pan G, Vickers SM, Pickens A, Phillips JO, Ying W, Thompson JA, Siegal GP, McDonald JM (1999) Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin. Am J Pathol 155:193
14. Mor G, Kohen F, Garcia-Velasco J, Nilsen J, Brown W, Song J, Naftolin F (2000) Regulation of fas ligand expression in breast cancer cells by estrogen: functional differences between estradiol and tamoxifen. J Steroid Biochem Mol Biol 73:185
15. Hoffmann TK, Bojar H, Eckel J, van Lierop A, Balz V, Friebe-Hoffmann U, Hauser U, Bier H (2002) Effects of tamoxifen on human squamous cell carcinoma lines of the head and neck. Anticancer Drugs 13:521
16. Dietze EC, Caldwell LE, Grupin SL, Mancini M, Seewaldt VL (2001) Tamoxifen but not 4-hydroxytamoxifen initiates apoptosis in p53(-) normal human mammary epithelial cells by inducing mitochondrial depolarization. J Biol Chem 276:5384
17. Seewaldt VL, Mrozek K, Dietze EC, Parker M, Caldwell LE (2001) Human papillomavirus type 16 E6 inactivation of p53 in normal human mammary epithelial cells promotes tamoxifen-mediated apoptosis. Cancer Res 61:616
18. Mandlekar S, Kong AN (2001) Mechanisms of tamoxifen-induced apoptosis. Apoptosis 6:469
19. Mariani SM, Matiba B, Baumler C, Krammer PH (1995) Regulation of cell surface APO-1/Fas (CD95) ligand expression by metalloproteases. Eur J Immunol 25:2303