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Volumn 16, Issue 11, 2009, Pages 1178-1184

Management of mitochondrial stroke-like-episodes

Author keywords

Cerebral imaging; Encephalomyopathy; Metabolic disease; Mitochondrial disorder; Mitochondrial DNA

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TOCOPHEROL NICOTINATE; ANTIOXIDANT; ARGININE; BIOTIN; CARNITINE; COCARBOXYLASE; CREATINE; CREATININE; CYTOCHROME C; DICHLOROACETIC ACID; FLAVINE MONONUCLEOTIDE; GLYCEROL; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; HUMANIN; IDEBENONE; LACTIC ACID; LIPID PEROXIDE; MERCAPTAMINE; MITOCHONDRIAL DNA; N ACETYLASPARTIC ACID; NICOTINAMIDE; NORPHENAZONE; PREDNISOLONE; PYRUVIC ACID; RIBOFLAVIN; STEROID; SUCCINIC ACID; UBIQUINONE; UNINDEXED DRUG;

EID: 70350135504     PISSN: 13515101     EISSN: 14681331     Source Type: Journal    
DOI: 10.1111/j.1468-1331.2009.02789.x     Document Type: Review
Times cited : (39)

References (61)
  • 1
    • 0033941639 scopus 로고    scopus 로고
    • Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like-events in MELAS?
    • Oppenheim C, Galanaud D, Samson Y, et al. Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like-events in MELAS? J Neurol Neurosurg Psychiatry 2000 69 : 248 250.
    • (2000) J Neurol Neurosurg Psychiatry , vol.69 , pp. 248-250
    • Oppenheim, C.1    Galanaud, D.2    Samson, Y.3
  • 2
    • 63649124202 scopus 로고    scopus 로고
    • MELAS-syndrome as a differential diagnosis of ischemic stroke
    • Finsterer J. MELAS-syndrome as a differential diagnosis of ischemic stroke. Fortschr Neurol Psychiatr 2009 77 : 25 31.
    • (2009) Fortschr Neurol Psychiatr , vol.77 , pp. 25-31
    • Finsterer, J.1
  • 3
    • 63849147157 scopus 로고    scopus 로고
    • Pathogenesis and treatment of stroke-like-episodes in MELAS
    • Iizuka T. Pathogenesis and treatment of stroke-like-episodes in MELAS. Rinsho Shinkeigaku 2008 48 : 1006 1009.
    • (2008) Rinsho Shinkeigaku , vol.48 , pp. 1006-1009
    • Iizuka, T.1
  • 4
    • 42649117196 scopus 로고    scopus 로고
    • Intestinal pseudo-obstruction in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like-episodes (MELAS) associated with phenytoin therapy
    • Chiyonobu T, Noda R, Yoshida M, et al. Intestinal pseudo-obstruction in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like-episodes (MELAS) associated with phenytoin therapy. Brain Dev 2008 30 : 430 433.
    • (2008) Brain Dev , vol.30 , pp. 430-433
    • Chiyonobu, T.1    Noda, R.2    Yoshida, M.3
  • 5
    • 33645243225 scopus 로고    scopus 로고
    • Stroke due to mitochondrial disorders in Saudi children
    • Salih MA, Abdel-Gader AG, Zahraa JN, et al. Stroke due to mitochondrial disorders in Saudi children. Saudi Med J 2006 27 (Suppl. 1 S81 S90.
    • (2006) Saudi Med J , vol.27 , Issue.SUPPL. 1
    • Salih, M.A.1    Abdel-Gader, A.G.2    Zahraa, J.N.3
  • 6
    • 0026795527 scopus 로고
    • MELAS: An original case and clinical criteria for diagnosis
    • Hirano M, Ricci E, Koenigsberger MR, et al. MELAS: an original case and clinical criteria for diagnosis. Neuromuscul Disord 1992 2 : 125 135.
    • (1992) Neuromuscul Disord , vol.2 , pp. 125-135
    • Hirano, M.1    Ricci, E.2    Koenigsberger, M.R.3
  • 7
    • 33644521249 scopus 로고    scopus 로고
    • An infant with a mitochondrial A3243G mutation demonstrating the MELAS phenotype
    • Kanaumi T, Hirose S, Goto Y, Naitou E, Mitsudome A. An infant with a mitochondrial A3243G mutation demonstrating the MELAS phenotype. Pediatr Neurol 2006 34 : 235 238.
    • (2006) Pediatr Neurol , vol.34 , pp. 235-238
    • Kanaumi, T.1    Hirose, S.2    Goto, Y.3    Naitou, E.4    Mitsudome, A.5
  • 8
    • 0031595424 scopus 로고    scopus 로고
    • Crossed cerebro-cellular diaschisis in a patients with MELAS with aphasia but without hemiparesis
    • Bohnen NI, Beran-Koehn M, Mullan B, Fulgham JR. Crossed cerebro-cellular diaschisis in a patients with MELAS with aphasia but without hemiparesis. Int J Neurosci 1998 93 : 181 184.
    • (1998) Int J Neurosci , vol.93 , pp. 181-184
    • Bohnen, N.I.1    Beran-Koehn, M.2    Mullan, B.3    Fulgham, J.R.4
  • 10
    • 0035404929 scopus 로고    scopus 로고
    • An autopsy case of mitochondrial encephalomyopathy with lactic acidosis and stroke-like-episodes syndrome with chronic renal failure
    • Yanagihara C, Oyama A, Tanaka M, Nakaji K, Nishimura Y. An autopsy case of mitochondrial encephalomyopathy with lactic acidosis and stroke-like-episodes syndrome with chronic renal failure. Intern Med 2001 40 : 662 665.
    • (2001) Intern Med , vol.40 , pp. 662-665
    • Yanagihara, C.1    Oyama, A.2    Tanaka, M.3    Nakaji, K.4    Nishimura, Y.5
  • 12
    • 34547578306 scopus 로고    scopus 로고
    • Siblings with infantile cerebral stroke and delayed multivessel involvement - A new hereditary vasculopathy?
    • Klein A, Fasnacht M, Huisman TA, Neuhaus TJ, Martin E, Boltshauser E. Siblings with infantile cerebral stroke and delayed multivessel involvement - a new hereditary vasculopathy? Eur J Paediatr Neurol 2007 11 : 292 296.
    • (2007) Eur J Paediatr Neurol , vol.11 , pp. 292-296
    • Klein, A.1    Fasnacht, M.2    Huisman, T.A.3    Neuhaus, T.J.4    Martin, E.5    Boltshauser, E.6
  • 13
    • 37849038344 scopus 로고    scopus 로고
    • MELAS-syndrome in a patient with a point mutation in MTTS1
    • Lindberg C, Moslemi AR, Oldfors A. MELAS-syndrome in a patient with a point mutation in MTTS1. Acta Neurol Scand 2008 117 : 128 132.
    • (2008) Acta Neurol Scand , vol.117 , pp. 128-132
    • Lindberg, C.1    Moslemi, A.R.2    Oldfors, A.3
  • 14
    • 33746427026 scopus 로고    scopus 로고
    • Evolution until death of two members of a family with A3243G mutation and MELAS phenotype versus diabetes mellitus
    • Pérez López-Fraile MI, Barrena R, Montoya J, Marta E. Evolution until death of two members of a family with A3243G mutation and MELAS phenotype versus diabetes mellitus. Neurologia 2006 21 : 327 332.
    • (2006) Neurologia , vol.21 , pp. 327-332
    • Pérez López-Fraile, M.I.1    Barrena, R.2    Montoya, J.3    Marta, E.4
  • 15
    • 0037167550 scopus 로고    scopus 로고
    • Neuronal hyperexcitability in stroke-like-episodes of MELAS-syndrome
    • Iizuka T, Sakai F, Suzuki N, et al. Neuronal hyperexcitability in stroke-like-episodes of MELAS-syndrome. Neurology 2002 59 : 816 824.
    • (2002) Neurology , vol.59 , pp. 816-824
    • Iizuka, T.1    Sakai, F.2    Suzuki, N.3
  • 16
    • 23444434131 scopus 로고    scopus 로고
    • A case of stroke-like-episode of MELAS of which progressive spread would be prevented by edaravone
    • Maeda K, Tatsumi M, Tahara M, Murata Y, Kawai H, Yasuda H. A case of stroke-like-episode of MELAS of which progressive spread would be prevented by edaravone. Rinsho Shinkeigaku 2005 45 : 416 421.
    • (2005) Rinsho Shinkeigaku , vol.45 , pp. 416-421
    • Maeda, K.1    Tatsumi, M.2    Tahara, M.3    Murata, Y.4    Kawai, H.5    Yasuda, H.6
  • 18
    • 0029011473 scopus 로고
    • MELAS-syndrome: Peripheral neuropathy and cytochrome-c-oxidase deficiency: A case report and review of the literature
    • Barak Y, Arnon S, Wolach B, et al. MELAS-syndrome: peripheral neuropathy and cytochrome-c-oxidase deficiency: a case report and review of the literature. Isr J Med Sci 1995 31 : 224 229.
    • (1995) Isr J Med Sci , vol.31 , pp. 224-229
    • Barak, Y.1    Arnon, S.2    Wolach, B.3
  • 19
    • 0028904714 scopus 로고
    • Severe mitochondrial cardiomyopathy and extra-neuromuscular abnormalities in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like-episode (MELAS)
    • Ishikawa Y, Asuwa N, Ishii T, et al. Severe mitochondrial cardiomyopathy and extra-neuromuscular abnormalities in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like-episode (MELAS). Pathol Res Pract 1995 191 : 64 69.
    • (1995) Pathol Res Pract , vol.191 , pp. 64-69
    • Ishikawa, Y.1    Asuwa, N.2    Ishii, T.3
  • 21
    • 67649409167 scopus 로고    scopus 로고
    • Recessive twinkle mutations cause severe epileptic encephalopathy
    • Lönnqvist T, Paetau A, Valanne L, Pihko H. Recessive twinkle mutations cause severe epileptic encephalopathy. Brain 2009 132 : 1553 1562.
    • (2009) Brain , vol.132 , pp. 1553-1562
    • Lönnqvist, T.1    Paetau, A.2    Valanne, L.3    Pihko, H.4
  • 22
    • 0035852868 scopus 로고    scopus 로고
    • Atypical MELAS-syndrome associated with a new mitochondrial tRNA glutamine point mutation
    • Bataillard M, Chatzoglou E, Rumbach L, et al. Atypical MELAS-syndrome associated with a new mitochondrial tRNA glutamine point mutation. Neurology 2001 56 : 405 407.
    • (2001) Neurology , vol.56 , pp. 405-407
    • Bataillard, M.1    Chatzoglou, E.2    Rumbach, L.3
  • 23
    • 0028024334 scopus 로고
    • Stroke, hemiparesis and deficient mitochondrial beta-oxidation
    • Vallée L, Fontaine M, Nuyts JP, et al. Stroke, hemiparesis and deficient mitochondrial beta-oxidation. Eur J Pediatr 1994 153 : 598 603.
    • (1994) Eur J Pediatr , vol.153 , pp. 598-603
    • Vallée, L.1    Fontaine, M.2    Nuyts, J.P.3
  • 24
    • 0033027623 scopus 로고    scopus 로고
    • Stroke-like-episodes in autosomal recessive cytochrome-oxidase deficiency
    • Morin C, Dubé J, Robinson BH, et al. Stroke-like-episodes in autosomal recessive cytochrome-oxidase deficiency. Ann Neurol 1999 45 : 389 392.
    • (1999) Ann Neurol , vol.45 , pp. 389-392
    • Morin, C.1    Dubé, J.2    Robinson, B.H.3
  • 25
    • 59149103919 scopus 로고    scopus 로고
    • Different neuroradiological findings during two stroke-like-episodes in a patient with a congenital disorder of glycosylation type Ia
    • Ishikawa N, Tajima G, Ono H, Kobayashi M. Different neuroradiological findings during two stroke-like-episodes in a patient with a congenital disorder of glycosylation type Ia. Brain Dev 2009 31 : 240 243.
    • (2009) Brain Dev , vol.31 , pp. 240-243
    • Ishikawa, N.1    Tajima, G.2    Ono, H.3    Kobayashi, M.4
  • 26
    • 58249143460 scopus 로고    scopus 로고
    • Increased brain lactate during stroke-like-episode in a patient with congenital disorder of glycosylation type Ia
    • van Baalen A, Stephani U, Rohr A. Increased brain lactate during stroke-like-episode in a patient with congenital disorder of glycosylation type Ia. Brain Dev 2009 31 : 183.
    • (2009) Brain Dev , vol.31 , pp. 183
    • Van Baalen, A.1    Stephani, U.2    Rohr, A.3
  • 27
    • 0031975917 scopus 로고    scopus 로고
    • Livedo reticularis, developmental delay and stroke-like-episode in a 7-year-old male
    • Wheeler PG, Medina S, Dusick A, et al. Livedo reticularis, developmental delay and stroke-like-episode in a 7-year-old male. Clin Dysmorphol 1998 7 : 69 74.
    • (1998) Clin Dysmorphol , vol.7 , pp. 69-74
    • Wheeler, P.G.1    Medina, S.2    Dusick, A.3
  • 29
    • 0033809548 scopus 로고    scopus 로고
    • Serial diffusion-weighted imaging in MELAS
    • Ohshita T, Oka M, Imon Y, et al. Serial diffusion-weighted imaging in MELAS. Neuroradiology 2000 42 : 651 656.
    • (2000) Neuroradiology , vol.42 , pp. 651-656
    • Ohshita, T.1    Oka, M.2    Imon, Y.3
  • 30
    • 0035035212 scopus 로고    scopus 로고
    • Reversible brain dysfunction in MELAS: MEG, and (1)H MRS analysis
    • Kamada K, Takeuchi F, Houkin K, et al. Reversible brain dysfunction in MELAS: MEG, and (1)H MRS analysis. J Neurol Neurosurg Psychiatry 2001 70 : 675 678.
    • (2001) J Neurol Neurosurg Psychiatry , vol.70 , pp. 675-678
    • Kamada, K.1    Takeuchi, F.2    Houkin, K.3
  • 31
    • 0029938221 scopus 로고    scopus 로고
    • MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy
    • Clark JM, Marks MP, Adalsteinsson E, et al. MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy. Neurology 1996 46 : 223 227.
    • (1996) Neurology , vol.46 , pp. 223-227
    • Clark, J.M.1    Marks, M.P.2    Adalsteinsson, E.3
  • 32
    • 58749101320 scopus 로고    scopus 로고
    • Progressive carotid artery stenosis with a novel tRNA phenylalanine mitochondrial DNA mutation
    • Iizuka T, Goto Y, Miyakawa S, et al. Progressive carotid artery stenosis with a novel tRNA phenylalanine mitochondrial DNA mutation. J Neurol Sci 2009 278 : 35 40.
    • (2009) J Neurol Sci , vol.278 , pp. 35-40
    • Iizuka, T.1    Goto, Y.2    Miyakawa, S.3
  • 33
    • 33745740660 scopus 로고    scopus 로고
    • Molecular neuropathology of MELAS: Level of heteroplasmy in individual neurones and evidence of extensive vascular involvement
    • Betts J, Jaros E, Perry RH, et al. Molecular neuropathology of MELAS: level of heteroplasmy in individual neurones and evidence of extensive vascular involvement. Neuropathol Appl Neurobiol 2006 32 : 359 373.
    • (2006) Neuropathol Appl Neurobiol , vol.32 , pp. 359-373
    • Betts, J.1    Jaros, E.2    Perry, R.H.3
  • 34
    • 18844415552 scopus 로고    scopus 로고
    • Vascular involvement in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like-episodes
    • Takahashi N, Shimada T, Murakami Y, et al. Vascular involvement in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like-episodes. Am J Med Sci 2005 329 : 265 266.
    • (2005) Am J Med Sci , vol.329 , pp. 265-266
    • Takahashi, N.1    Shimada, T.2    Murakami, Y.3
  • 35
    • 0032507974 scopus 로고    scopus 로고
    • Cerebral blood flow and oxygen metabolism before and after a stroke-like-episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like-episodes (MELAS)
    • Takahashi S, Tohgi H, Yonezawa H, Obara S, Nagane Y. Cerebral blood flow and oxygen metabolism before and after a stroke-like-episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like-episodes (MELAS). J Neurol Sci 1998 158 : 58 64.
    • (1998) J Neurol Sci , vol.158 , pp. 58-64
    • Takahashi, S.1    Tohgi, H.2    Yonezawa, H.3    Obara, S.4    Nagane, Y.5
  • 36
    • 45849142222 scopus 로고    scopus 로고
    • Serial brain imaging analysis of stroke-like-episodes in MELAS
    • Ito H, Mori K, Harada M, et al. Serial brain imaging analysis of stroke-like-episodes in MELAS. Brain Dev 2008 30 : 483 488.
    • (2008) Brain Dev , vol.30 , pp. 483-488
    • Ito, H.1    Mori, K.2    Harada, M.3
  • 37
    • 0030792614 scopus 로고    scopus 로고
    • Heat stroke-like-episode in a child caused by zonisamide
    • Shimizu T, Yamashita Y, Satoi M, et al. Heat stroke-like-episode in a child caused by zonisamide. Brain Dev 1997 19 : 366 368.
    • (1997) Brain Dev , vol.19 , pp. 366-368
    • Shimizu, T.1    Yamashita, Y.2    Satoi, M.3
  • 38
    • 27344441347 scopus 로고    scopus 로고
    • Precipitation of stroke-like-event by chickenpox in a child with MELAS-syndrome
    • Jian-Ren L. Precipitation of stroke-like-event by chickenpox in a child with MELAS-syndrome. Neurol India 2005 53 : 323 325.
    • (2005) Neurol India , vol.53 , pp. 323-325
    • Jian-Ren, L.1
  • 39
    • 0036347518 scopus 로고    scopus 로고
    • Effects of oral creatine supplementation in a patient with MELAS phenotype and associated nephropathy
    • Barisic N, Bernert G, Ipsiroglu O, et al. Effects of oral creatine supplementation in a patient with MELAS phenotype and associated nephropathy. Neuropediatrics 2002 33 : 157 161.
    • (2002) Neuropediatrics , vol.33 , pp. 157-161
    • Barisic, N.1    Bernert, G.2    Ipsiroglu, O.3
  • 40
    • 0028145185 scopus 로고
    • Free radical, lipid peroxide and antioxidant in mitochondrial encephalomyopathy
    • Ihara Y, Hayabara T, Namba R, Nobukuni K, Mori A. Free radical, lipid peroxide and antioxidant in mitochondrial encephalomyopathy. Rinsho Shinkeigaku 1994 34 : 593 595.
    • (1994) Rinsho Shinkeigaku , vol.34 , pp. 593-595
    • Ihara, Y.1    Hayabara, T.2    Namba, R.3    Nobukuni, K.4    Mori, A.5
  • 41
    • 29544436107 scopus 로고    scopus 로고
    • Platelet mitochondrial evaluation during cytochrome-c and dichloroacetate treatments of MELAS
    • Nakano K, Tarashima M, Tachikawa E, et al. Platelet mitochondrial evaluation during cytochrome-c and dichloroacetate treatments of MELAS. Mitochondrion 2005 5 : 426 433.
    • (2005) Mitochondrion , vol.5 , pp. 426-433
    • Nakano, K.1    Tarashima, M.2    Tachikawa, E.3
  • 42
    • 27744548056 scopus 로고    scopus 로고
    • Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like-episodes
    • Fujii K, Tanabe Y, Kobayashi K, Uchikawa H, Kohno Y. Detection of 14-3-3 protein in the cerebrospinal fluid in mitochondrial encephalopathy with lactic acidosis and stroke-like-episodes. J Neurol Sci 2005 239 : 115 118.
    • (2005) J Neurol Sci , vol.239 , pp. 115-118
    • Fujii, K.1    Tanabe, Y.2    Kobayashi, K.3    Uchikawa, H.4    Kohno, Y.5
  • 43
    • 60549093363 scopus 로고    scopus 로고
    • Serial diffusion imaging in a case of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like-episodes
    • Tzoulis C, Bindoff LA. Serial diffusion imaging in a case of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like-episodes. Stroke 2009 40 : e15 e17.
    • (2009) Stroke , vol.40
    • Tzoulis, C.1    Bindoff, L.A.2
  • 44
    • 0025249215 scopus 로고
    • Fluctuating MR images with mitochondrial encephalopathy, lactic acidosis, stroke-like-syndrome (MELAS)
    • Abe K, Inui T, Hirono N, Mezaki T, Kobayashi Y, Kameyama M. Fluctuating MR images with mitochondrial encephalopathy, lactic acidosis, stroke-like-syndrome (MELAS). Neuroradiology 1990 32 : 77.
    • (1990) Neuroradiology , vol.32 , pp. 77
    • Abe, K.1    Inui, T.2    Hirono, N.3    Mezaki, T.4    Kobayashi, Y.5    Kameyama, M.6
  • 45
    • 0034000525 scopus 로고    scopus 로고
    • Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT
    • Peng NJ, Liu RS, Li JY, et al. Increased cerebral blood flow in MELAS shown by Tc-99m HMPAO brain SPECT. Neuroradiology 2000 42 : 26 29.
    • (2000) Neuroradiology , vol.42 , pp. 26-29
    • Peng, N.J.1    Liu, R.S.2    Li, J.Y.3
  • 46
    • 70350107651 scopus 로고    scopus 로고
    • Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images
    • In press).
    • Tsujikawa T, Yoneda M, Shimizu Y, et al. Pathophysiologic evaluation of MELAS strokes by serially quantified MRS and CASL perfusion images. Brain Dev 2009 In press).
    • (2009) Brain Dev
    • Tsujikawa, T.1    Yoneda, M.2    Shimizu, Y.3
  • 48
    • 0032724863 scopus 로고    scopus 로고
    • Quantitative proton magnetic resonance spectroscopy of cerebral metabolic disturbances in patients with MELAS
    • Wilichowski E, Pouwels PJ, Frahm J, Hanefeld F. Quantitative proton magnetic resonance spectroscopy of cerebral metabolic disturbances in patients with MELAS. Neuropediatrics 1999 30 : 256 263.
    • (1999) Neuropediatrics , vol.30 , pp. 256-263
    • Wilichowski, E.1    Pouwels, P.J.2    Frahm, J.3    Hanefeld, F.4
  • 49
    • 0028882549 scopus 로고
    • Cerebral metabolism of oxygen and glucose in a patient with MELAS-syndrome
    • Sano M, Ishii K, Momose Y, Uchigata M, Senda M. Cerebral metabolism of oxygen and glucose in a patient with MELAS-syndrome. Acta Neurol Scand 1995 92 : 497 502.
    • (1995) Acta Neurol Scand , vol.92 , pp. 497-502
    • Sano, M.1    Ishii, K.2    Momose, Y.3    Uchigata, M.4    Senda, M.5
  • 51
    • 3042613363 scopus 로고    scopus 로고
    • Successful treatment with succinate in a patient with MELAS
    • Oguro H, Iijima K, Takahashi K, et al. Successful treatment with succinate in a patient with MELAS. Intern Med 2004 43 : 427 431.
    • (2004) Intern Med , vol.43 , pp. 427-431
    • Oguro, H.1    Iijima, K.2    Takahashi, K.3
  • 52
    • 0030974794 scopus 로고    scopus 로고
    • Treatment of mitochondrial encephalomyopathy with a combination of cytochrome-C and vitamins B1 and B2
    • Tanaka J, Nagai T, Arai H, et al. Treatment of mitochondrial encephalomyopathy with a combination of cytochrome-C and vitamins B1 and B2. Brain Dev 1997 19 : 262 267.
    • (1997) Brain Dev , vol.19 , pp. 262-267
    • Tanaka, J.1    Nagai, T.2    Arai, H.3
  • 54
    • 63849303050 scopus 로고    scopus 로고
    • L-arginine therapy on MELAS
    • Koga Y. L-arginine therapy on MELAS. Rinsho Shinkeigaku 2008 48 : 1010 1012.
    • (2008) Rinsho Shinkeigaku , vol.48 , pp. 1010-1012
    • Koga, Y.1
  • 56
    • 33846498389 scopus 로고    scopus 로고
    • Usefulness of L-arginine infusion for status epilepticus in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like-episodes
    • Toribe Y, Tominaga K, Ogawa K, Suzuki Y. Usefulness of L-arginine infusion for status epilepticus in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like-episodes. No To Hattatsu 2007 39 : 38 43.
    • (2007) No to Hattatsu , vol.39 , pp. 38-43
    • Toribe, Y.1    Tominaga, K.2    Ogawa, K.3    Suzuki, Y.4
  • 57
  • 58
    • 0030020607 scopus 로고    scopus 로고
    • Increase of blood NAD+ and attenuation of lactacidemia during nicotinamide treatment of a patient with the MELAS-syndrome
    • Majamaa K, Rusanen H, Remes AM, Pyhtinen J, Hassinen IE. Increase of blood NAD+ and attenuation of lactacidemia during nicotinamide treatment of a patient with the MELAS-syndrome. Life Sci 1996 58 : 691 699.
    • (1996) Life Sci , vol.58 , pp. 691-699
    • Majamaa, K.1    Rusanen, H.2    Remes, A.M.3    Pyhtinen, J.4    Hassinen, I.E.5
  • 59
    • 0029834971 scopus 로고    scopus 로고
    • Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS
    • Ikejiri Y, Mori E, Ishii K, Nishimoto K, Yasuda M, Sasaki M. Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS. Neurology 1996 47 : 583 585.
    • (1996) Neurology , vol.47 , pp. 583-585
    • Ikejiri, Y.1    Mori, E.2    Ishii, K.3    Nishimoto, K.4    Yasuda, M.5    Sasaki, M.6
  • 60
    • 33646202306 scopus 로고    scopus 로고
    • Dichloroacetate causes toxic neuropathy in MELAS: A randomized, controlled clinical trial
    • Kaufmann P, Engelstad K, Wei Y, et al. Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology 2006 66 : 324 330.
    • (2006) Neurology , vol.66 , pp. 324-330
    • Kaufmann, P.1    Engelstad, K.2    Wei, Y.3
  • 61
    • 18344390443 scopus 로고    scopus 로고
    • Humanin detected in skeletal muscles of MELAS patients: A possible new therapeutic agent
    • Kariya S, Hirano M, Furiya Y, Sugie K, Ueno S. Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent. Acta Neuropathol 2005 109 : 367 372.
    • (2005) Acta Neuropathol , vol.109 , pp. 367-372
    • Kariya, S.1    Hirano, M.2    Furiya, Y.3    Sugie, K.4    Ueno, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.