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Volumn 59, Issue 6, 2002, Pages 816-824

Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE ETHYL ESTER TC 99M; HEXAMETHYLPROPYLENE AMINE OXIME TECHNETIUM TC 99M; MITOCHONDRIAL DNA;

EID: 0037167550     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.59.6.816     Document Type: Article
Times cited : (172)

References (48)
  • 1
    • 0021143782 scopus 로고
    • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: A distinctive clinical syndrome
    • Pavlakis SG, Phillips PC, Dimauro S, De Vivo DC, Rowland LP. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: a distinctive clinical syndrome. Ann Neurol 1984;16:481-488.
    • (1984) Ann Neurol , vol.16 , pp. 481-488
    • Pavlakis, S.G.1    Phillips, P.C.2    Dimauro, S.3    De Vivo, D.C.4    Rowland, L.P.5
  • 2
    • 0023270881 scopus 로고
    • Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy
    • Ohama E, Ohara S, Ikuta F, Tanaka K, Nishizawa M, Miyatake T. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol 1987;74:226-233.
    • (1987) Acta Neuropathol , vol.74 , pp. 226-233
    • Ohama, E.1    Ohara, S.2    Ikuta, F.3    Tanaka, K.4    Nishizawa, M.5    Miyatake, T.6
  • 3
    • 0025867042 scopus 로고
    • Purpuric cutaneous manifestations in mitochondrial encephalomyopathy
    • Horiguchi Y, Fujii T, Imamura S. Purpuric cutaneous manifestations in mitochondrial encephalomyopathy. J Dermatol 1991;18:295-301.
    • (1991) J Dermatol , vol.18 , pp. 295-301
    • Horiguchi, Y.1    Fujii, T.2    Imamura, S.3
  • 4
    • 0026566806 scopus 로고
    • Central nervous system changes in mitochondrial encephalomyopathy: Light and electron microscopic study
    • Mizukami K, Sasaki M, Suzuki T, et al. Central nervous system changes in mitochondrial encephalomyopathy: light and electron microscopic study. Acta Neuropathol 1992;83:449-452.
    • (1992) Acta Neuropathol , vol.83 , pp. 449-452
    • Mizukami, K.1    Sasaki, M.2    Suzuki, T.3
  • 5
    • 0024343409 scopus 로고
    • Vascular involvement in mitochondrial myopathy
    • Sakuta R, Nonaka I. Vascular involvement in mitochondrial myopathy. Ann Neurol 1989;25:594-601.
    • (1989) Ann Neurol , vol.25 , pp. 594-601
    • Sakuta, R.1    Nonaka, I.2
  • 6
    • 0029938221 scopus 로고    scopus 로고
    • MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy
    • Clark LM, Marks MP, Adalsteinsson E, et al. MELAS: clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy. Neurology 1996;46:223-227.
    • (1996) Neurology , vol.46 , pp. 223-227
    • Clark, L.M.1    Marks, M.P.2    Adalsteinsson, E.3
  • 7
    • 0029840031 scopus 로고    scopus 로고
    • Adult-onset MELAS. Evidence for involvement of neurons as well as cerebral vasculature in stroke like episodes
    • Gilchrist JM, Sikirica M, Stopa E, Shanske S. Adult-onset MELAS. Evidence for involvement of neurons as well as cerebral vasculature in stroke like episodes. Stroke 1996;27:1420-1423.
    • (1996) Stroke , vol.27 , pp. 1420-1423
    • Gilchrist, J.M.1    Sikirica, M.2    Stopa, E.3    Shanske, S.4
  • 8
    • 0027454928 scopus 로고
    • Neuropathology of mitochondrial encephalopathies due to mitochondrial DNA defects
    • Sparaco M, Bonilla E, Dimauro S, Powers JM. Neuropathology of mitochondrial encephalopathies due to mitochondrial DNA defects J Neuropathol Exp Neurol 1993;52:1-10.
    • (1993) J Neuropathol Exp Neurol , vol.52 , pp. 1-10
    • Sparaco, M.1    Bonilla, E.2    Dimauro, S.3    Powers, J.M.4
  • 9
    • 0033837143 scopus 로고    scopus 로고
    • Cerebral blood flow and glucose metabolism in mitochondrial disorders
    • Molnár MJ, Valikovics A, Molnár S, et al. Cerebral blood flow and glucose metabolism in mitochondrial disorders. Neurology 2000;55:544-548.
    • (2000) Neurology , vol.55 , pp. 544-548
    • Molnár, M.J.1    Valikovics, A.2    Molnár, S.3
  • 10
    • 0025666322 scopus 로고
    • Leu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies
    • Leu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature 1990;348:651-653.
    • (1990) Nature , vol.348 , pp. 651-653
    • Goto, Y.1    Nonaka, I.2    Horai, S.3
  • 11
    • 0026004614 scopus 로고
    • A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)
    • Goto Y, Nonaka I, Horai S. A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Biochim Biophys Acta 1991;1097:238-240.
    • (1991) Biochim Biophys Acta , vol.1097 , pp. 238-240
    • Goto, Y.1    Nonaka, I.2    Horai, S.3
  • 13
    • 0010340917 scopus 로고
    • A MERRF/MELAS overlap syndrome associated with a new point mutation in the mitochondrial DNA tRNA(Lys) gene
    • Zeviani M, Muntoni F, Savarese N, et al. A MERRF/MELAS overlap syndrome associated with a new point mutation in the mitochondrial DNA tRNA(Lys) gene. Eur J Hum Biochem Biophys Res Commun 1994;202:1624-1630.
    • (1994) Eur J Hum Biochem Biophys Res Commun , vol.202 , pp. 1624-1630
    • Zeviani, M.1    Muntoni, F.2    Savarese, N.3
  • 14
    • 0027935355 scopus 로고
    • L-eu(UUR) gene in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)
    • L-eu(UUR) gene in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Biochem Biophys Res Commun 1994;202:1624-1630.
    • (1994) Biochem Biophys Res Commun , vol.202 , pp. 1624-1630
    • Goto, Y.1    Tsugane, K.2    Tanabe, Y.3    Nonaka, I.4    Horai, S.5
  • 15
    • 0028030728 scopus 로고
    • L-eu(UUR) mutation at 3256 associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like symptoms
    • L-eu(UUR) mutation at 3256 associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like symptoms. Biochem Mol Biol Intern 1994;33:1055-1061.
    • (1994) Biochem Mol Biol Intern , vol.33 , pp. 1055-1061
    • Sato, W.1    Hayasaka, K.2    Shoji, Y.3
  • 16
    • 0029145589 scopus 로고
    • A novel point mutation in the mitochondrial tRNA(Ser(UCN)) gene detected in a family with MERRF/MELAS overlap syndrome
    • Nakamura M, Nakano S, Goto Y, et al. A novel point mutation in the mitochondrial tRNA(Ser(UCN)) gene detected in a family with MERRF/MELAS overlap syndrome. Biochem Biophys Res Commun 1995;214:86-93.
    • (1995) Biochem Biophys Res Commun , vol.214 , pp. 86-93
    • Nakamura, M.1    Nakano, S.2    Goto, Y.3
  • 17
    • 0029046428 scopus 로고
    • A new mutation associated with MELAS is located in a mitochondrial DNA polypeptide-coding gene
    • Manfredi G, Manfredi G, Schon EA, et al. A new mutation associated with MELAS is located in a mitochondrial DNA polypeptide-coding gene. Neuromuscul Disord 1995;5:391-398.
    • (1995) Neuromuscul Disord , vol.5 , pp. 391-398
    • Manfredi, G.1    Manfredi, G.2    Schon, E.A.3
  • 18
    • 0029787365 scopus 로고    scopus 로고
    • MELAS associated with a mutation in the valine transfer RNA gene of mitochondrial DNA
    • Taylor RW, Chinnery PF, Haldane F, et al. MELAS associated with a mutation in the valine transfer RNA gene of mitochondrial DNA. Ann Neurol 1996;40:459-462.
    • (1996) Ann Neurol , vol.40 , pp. 459-462
    • Taylor, R.W.1    Chinnery, P.F.2    Haldane, F.3
  • 19
    • 0029822865 scopus 로고    scopus 로고
    • The 3260 mutation in mitochondrial DNA can cause mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS)
    • Nishino I, Komatsu M, Kodama S, Horai S, Nonaka I, Goto Y. The 3260 mutation in mitochondrial DNA can cause mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke like episodes (MELAS). Muscle Nerve 1996;19:1603-1604.
    • (1996) Muscle Nerve , vol.19 , pp. 1603-1604
    • Nishino, I.1    Komatsu, M.2    Kodama, S.3    Horai, S.4    Nonaka, I.5    Goto, Y.6
  • 20
    • 0031577531 scopus 로고    scopus 로고
    • Bilateral striatal necrosis and MELAS associated with a new T3308C mutation in the mitochondrial ND1 gene
    • Campos Y, Martin MA, Rubio JC, et al. Bilateral striatal necrosis and MELAS associated with a new T3308C mutation in the mitochondrial ND1 gene. Biophys Res Commun 1997; 238:323-235.
    • (1997) Biophys Res Commun , vol.238 , pp. 323-235
    • Campos, Y.1    Martin, M.A.2    Rubio, J.C.3
  • 22
    • 0031727452 scopus 로고    scopus 로고
    • MELAS a new disease associated mitochondrial DNA mutation and evidence for further genetic heterogeneity
    • Hanna MG, Nelson IP, Morgan-Hughes JA, Wood NW. MELAS: a new disease associated mitochondrial DNA mutation and evidence for further genetic heterogeneity. J Neurol Neurosurg Psychiatry 1998;65:512-517.
    • (1998) J Neurol Neurosurg Psychiatry , vol.65 , pp. 512-517
    • Hanna, M.G.1    Nelson, I.P.2    Morgan-Hughes, J.A.3    Wood, N.W.4
  • 23
    • 0031906139 scopus 로고    scopus 로고
    • A mitochondrial tRNA(Val) gene mutation (G1642A) in a patient with mitochondrial myopathy, lactic acidosis, and stroke-like episodes
    • de Coo IF, Sistermans EA, de Wijs IJ, et al. A mitochondrial tRNA(Val) gene mutation (G1642A) in a patient with mitochondrial myopathy, lactic acidosis, and stroke-like episodes. Neurology 1998;50:293-295.
    • (1998) Neurology , vol.50 , pp. 293-295
    • De Coo, I.F.1    Sistermans, E.A.2    De Wijs, I.J.3
  • 25
    • 0025825012 scopus 로고
    • Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes
    • Hasegawa H, Matsuoka T, Goto Y, Nonaka I. Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Ann Neurol 1991;29:601-605.
    • (1991) Ann Neurol , vol.29 , pp. 601-605
    • Hasegawa, H.1    Matsuoka, T.2    Goto, Y.3    Nonaka, I.4
  • 26
    • 0026774161 scopus 로고
    • Non-heme mechanisms for T1 shortening: Pathologic, CT, and MR elucidation
    • Boyko OB, Burger PC, Shelburne JD, Ingram P. Non-heme mechanisms for T1 shortening: pathologic, CT, and MR elucidation. AJNR Am J Neuroradiol 1992;13:1439-1445.
    • (1992) AJNR Am J Neuroradiol , vol.13 , pp. 1439-1445
    • Boyko, O.B.1    Burger, P.C.2    Shelburne, J.D.3    Ingram, P.4
  • 27
    • 0030095889 scopus 로고    scopus 로고
    • Postmortem MR imaging of lobar cerebral infarction with pathologic and in vivo correlation
    • Castillo M, Scatliff JH, Kwock L, et al. Postmortem MR imaging of lobar cerebral infarction with pathologic and in vivo correlation. Radiographics 1996;16:241-250.
    • (1996) Radiographics , vol.16 , pp. 241-250
    • Castillo, M.1    Scatliff, J.H.2    Kwock, L.3
  • 28
    • 0021183491 scopus 로고
    • The neurobiology of vascular head pain
    • Moskowitz MA. The neurobiology of vascular head pain. Ann Neurol 1984;16:157-168.
    • (1984) Ann Neurol , vol.16 , pp. 157-168
    • Moskowitz, M.A.1
  • 29
    • 0025187465 scopus 로고
    • The concept of migraine as a state of central neuronal hyperexcitabiliy
    • Welch KMA, D'Andrea, Tepley N, Barkley G, Ramadan NM. The concept of migraine as a state of central neuronal hyperexcitabiliy. Neurol Clin 1990;8:817-828.
    • (1990) Neurol Clin , vol.8 , pp. 817-828
    • Welch, K.M.A.1    D'Andrea2    Tepley, N.3    Barkley, G.4    Ramadan, N.M.5
  • 30
    • 0031921361 scopus 로고    scopus 로고
    • Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine
    • Aurora SK, Ahmad BK, Welch KMA, Bhardhjwaj P, Ramadan NM. Transcranial magnetic stimulation confirms hyperexcitability of occipital cortex in migraine. Neurology 1998;50: 1111-1114.
    • (1998) Neurology , vol.50 , pp. 1111-1114
    • Aurora, S.K.1    Ahmad, B.K.2    Welch, K.M.A.3    Bhardhjwaj, P.4    Ramadan, N.M.5
  • 31
    • 0010341279 scopus 로고    scopus 로고
    • Clinical significance of PLEDs in acute stage of cardioembolic stroke
    • Iigaya M, Iizuka T, Yoshimoto K, Sakai F. Clinical significance of PLEDs in acute stage of cardioembolic stroke (in Japanese). Clinical Encephalography 1999;41:23-30.
    • (1999) Clinical Encephalography , vol.41 , pp. 23-30
    • Iigaya, M.1    Iizuka, T.2    Yoshimoto, K.3    Sakai, F.4
  • 32
    • 0032507974 scopus 로고    scopus 로고
    • Cerebral blood flow and oxygen metabolism before and after a stroke-like episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)
    • Takahashi S, Tohgi H, Yonezawa H, Obara S, Nagane Y. Cerebral blood flow and oxygen metabolism before and after a stroke-like episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). J Neurol Sci 1998;158:58-64.
    • (1998) J Neurol Sci , vol.158 , pp. 58-64
    • Takahashi, S.1    Tohgi, H.2    Yonezawa, H.3    Obara, S.4    Nagane, Y.5
  • 34
    • 0035035212 scopus 로고    scopus 로고
    • Reversible brain dysfunction in MELAS: MEG and (1)H MRS analysis
    • Kamada K, Takeuchi F, Houkin K, et al. Reversible brain dysfunction in MELAS: MEG and (1)H MRS analysis. J Neurol Neurosurg Psychiatry 2001;70:675-678.
    • (2001) J Neurol Neurosurg Psychiatry , vol.70 , pp. 675-678
    • Kamada, K.1    Takeuchi, F.2    Houkin, K.3
  • 35
    • 0034032519 scopus 로고    scopus 로고
    • Cerebral blood flow, vascular response and metabolism in patients with MELAS syndrome-xenon CT and PET study
    • Nariai T, Ohno K, Akimoto H, et al. Cerebral blood flow, vascular response and metabolism in patients with MELAS syndrome-xenon CT and PET study. Keio J Med 2000;49: A68-70.
    • (2000) Keio J Med , vol.49
    • Nariai, T.1    Ohno, K.2    Akimoto, H.3
  • 36
    • 18144433134 scopus 로고    scopus 로고
    • SPECT findings in mitochondrial encephalomyopathy
    • Watanabe Y, Hashikawa K, Moriwaki H, et al. SPECT findings in mitochondrial encephalomyopathy. J Nucl Med 1998; 39:961-964.
    • (1998) J Nucl Med , vol.39 , pp. 961-964
    • Watanabe, Y.1    Hashikawa, K.2    Moriwaki, H.3
  • 37
    • 0027328501 scopus 로고
    • Leu[3243]) in tissues of symptomatic relatives with MELAS: The role of mitotic segregation
    • Leu[3243]) in tissues of symptomatic relatives with MELAS: the role of mitotic segregation. Neurology 1993;43:1586-1590.
    • (1993) Neurology , vol.43 , pp. 1586-1590
    • Macmillan, C.1    Lach, B.2    Shoubridge, E.A.3
  • 38
    • 0027256708 scopus 로고
    • Sequencing and quantitative assessment of mutant and wild-type mitochondrial DNA in paraffin sections from cases of MELAS
    • Love S, Nicoll JA, Kinrade E. Sequencing and quantitative assessment of mutant and wild-type mitochondrial DNA in paraffin sections from cases of MELAS. J Pathol 1993;170:9-14.
    • (1993) J Pathol , vol.170 , pp. 9-14
    • Love, S.1    Nicoll, J.A.2    Kinrade, E.3
  • 40
    • 0032763818 scopus 로고    scopus 로고
    • Vasogenic edema on MELAS: A serial study with diffusion-weighted MR imaging
    • Yoneda M, Maeda M, Kimura H. Fujii A, Katayama K, Kuriyama M. Vasogenic edema on MELAS: a serial study with diffusion-weighted MR imaging. Neurology 1999;53:2182-2184.
    • (1999) Neurology , vol.53 , pp. 2182-2184
    • Yoneda, M.1    Maeda, M.2    Kimura, H.3    Fujii, A.4    Katayama, K.5    Kuriyama, M.6
  • 41
    • 0033941639 scopus 로고    scopus 로고
    • Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like events in MELAS?
    • Oppenheim C, Galanaud D, Samson Y, et al. Can diffusion weighted magnetic resonance imaging help differentiate stroke from stroke-like events in MELAS? J Neurol Neurosurg Psychiatry 2000;69:248-250.
    • (2000) J Neurol Neurosurg Psychiatry , vol.69 , pp. 248-250
    • Oppenheim, C.1    Galanaud, D.2    Samson, Y.3
  • 42
    • 0033809548 scopus 로고    scopus 로고
    • Serial diffusion-weighted imaging in MELAS
    • Ohshita T, Oka M, Imon Y, et al. Serial diffusion-weighted imaging in MELAS. Neuroradiology 2000;42:651-656.
    • (2000) Neuroradiology , vol.42 , pp. 651-656
    • Ohshita, T.1    Oka, M.2    Imon, Y.3
  • 43
    • 0017487289 scopus 로고
    • The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat
    • Oldendolf WH, Cornford ME, Brown WJ. The large apparent work capability of the blood-brain barrier: a study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat. Ann Neurol 1977;1:409-417.
    • (1977) Ann Neurol , vol.1 , pp. 409-417
    • Oldendolf, W.H.1    Cornford, M.E.2    Brown, W.J.3
  • 45
    • 0014864849 scopus 로고
    • Activation of experimental epileptogenic foci
    • Zuckermann EC, Glaser GH. Activation of experimental epileptogenic foci. Arch Neurol 1970;23:358-364.
    • (1970) Arch Neurol , vol.23 , pp. 358-364
    • Zuckermann, E.C.1    Glaser, G.H.2
  • 46
    • 0030037874 scopus 로고    scopus 로고
    • Laminar cortical necrosis in MELAS syndrome: MR and neuropathological observations
    • Valanne L, Paetau A, Suomalainen A, Ketonen L, Pihko H. Laminar cortical necrosis in MELAS syndrome: MR and neuropathological observations. Neuropediatrics 1996;27:154-160.
    • (1996) Neuropediatrics , vol.27 , pp. 154-160
    • Valanne, L.1    Paetau, A.2    Suomalainen, A.3    Ketonen, L.4    Pihko, H.5
  • 47
    • 0025180872 scopus 로고
    • CT, MRI, and autopsy findings in brain of a patient with MELAS
    • Fujii T, Okuno T, Ito M, et al. CT, MRI, and autopsy findings in brain of a patient with MELAS. Pediatr Neurol 1990;6:253-256.
    • (1990) Pediatr Neurol , vol.6 , pp. 253-256
    • Fujii, T.1    Okuno, T.2    Ito, M.3
  • 48
    • 0024454860 scopus 로고
    • Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Report of an autopsy
    • Hamazaki S, Okada S, Kusaka H, et al. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Report of an autopsy. Acta Pathol Jpn 1989;39:599-606.
    • (1989) Acta Pathol Jpn , vol.39 , pp. 599-606
    • Hamazaki, S.1    Okada, S.2    Kusaka, H.3


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