Increase of blood NAD+ and attenuation of lactacidemia during nicotinamide treatment of a patient with the MELAS syndrome

Life Sciences

Volumn 58, Issue 8, 1996, Pages 691-699

  Majamaa, Kari ^a   Rusanen, Harri ^a   Remes, Anne M ^a   Pyhtinen, Juhani ^a   Hassinen, Ilmo E ^a  

^a UNIVERSITY OF OULU   (Finland)

Author keywords

Complex I activity; Lactate; Mitochondrial encephalomyopathy; Point mutaiton; Skin fibroblast culture; Vitamin E therapy

Indexed keywords

CARBAMAZEPINE; LACTIC ACID; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ADULT; ARTICLE; BLOOD LEVEL; CASE REPORT; CELL CULTURE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; FIBROBLAST; HUMAN; HUMAN CELL; LACTIC ACIDEMIA; MALE; MELAS SYNDROME; MITOCHONDRIAL RESPIRATION; NUCLEAR MAGNETIC RESONANCE IMAGING; ORAL DRUG ADMINISTRATION; POINT MUTATION; SKELETAL MUSCLE; STROKE; URINE LEVEL;

EID: 0030020607     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(96)80008-7     Document Type: Article

References (28)

1. S. DiMAURO and C.T. MORAES, Arch. Neurol. 50 1197-1208 (1993).
2. S.R. HAMMANS and J.A. MORGAN-HUGHES, Mitochondrial disorders in neurology, A.H.V. Schapira, and S. DiMauro (Eds), 49-74, Butterworth-Heinemann, Oxford (1994).
3. D.C. WALLACE, Annu. Rev. Biochem. 61 1175-1212 (1992).
4. C.T. MORAES, F. CIACCI, E. BONILLA, C. JANSEN, M. HIRANO, M. RAO, R.E. LOVELACE, L.P. ROWLAND, E.A. SCHON and S. DiMAURO J. Clin. Invest. 92 2906-2915 (1993).
5. M.P. KING, Y. KOGA, M. DAVIDSON and E.A. SCHON, Mol. Cell Biol. 12 480-490 (1992)
6. B. OBERMAIER-KUSSER, I. PAETZKE-BRUNNER, C. ENTER, J. MULLER-HÖCKER, S. ZIERZ, W. RUITENBEEK and K.-D. GERBITZ, FEBS Lett. 286 67-70 (1991).
7. J.E. WALKER, J.M. ARIZMENDI, A. DUPUIS, I.M. FEARNLEY, M. FINEL, S.M. MEDD, S.J. PILKINGTON, M.J. RUNSWICK and J.M. SKEHEL, J. Mol. Biol. 226 1051-1072 (1992).
8. R.H. YLIKAHRI, I. HASSINEN and M.T. KÄHÖNEN, Biochem. Biophys. Res. Commun. 44 150-156 (1971).
9. Y. IHARA, R. NAMBA, S. KURODA, T. SATO and T. SHIRABE, J. Neurol. Sci. 90 263-271 (1989).
10. A.M.W. PENN, J.W.K. LEE, P. THUILLIER, M. WAGNER, K.M. MACLURE, M.R. MENARD, L.D. HALL and N.G. KENNAWAY, Neurology. 42 2147-2152 (1992).
11. C.P.J. ERIKSSON, FEBS Lett. 40 317-320 (1974).
12. N.O. KAPLAN, A. GOLDIN, S.R. HUMPHREYS, M.M. CIOTTI and F.E. STOLZENBACH, J. Biol. Chem. 219 287-292 (1956).
13. Y. KOBAYASHI, M.Y. MOMOI, K. TOMINAGA, T. MOMOI, K. NIHEI, M. YANASIGAWA, Y. KAGAWA and S. OHTA, Biochem. Biophys. Res. Commun. 173 816-822 (1990).
14. J.M. SHOFFNER, M.T. LOTT, A.M.S. LEZZA, P. SEIBEL, S.W. BALLINGER and D.C. WALLACE, Cell. 61 931-933 (1990).
15. M.W. MAKINEN and C.P. LEE, Arch. Biophys. Biochem. 126 75-82 (1968).
16. X. ZHENG, J.M. SHOFFNER, A.S. VOLJAVEC and D.C. WALLACE, Biochim. Biophys. Acta. 1019 1-10 (1990).
17. S.-L. YUN and C.H. SUELTER, Biochim. Biophys. Acta. 480 1-13 (1977).
18. K. MAJAMAA, E.R. SAVOLAINEN and V.V. MYLLYLÄ, Biochim. Biophys. Acta. 1138 191-196 (1992).
19. M. KLINGENBERG, Methods of Enzymatic Analysis, H.U. Bergmeyer (Ed), 582-630, Academic Press, New York (1963).
20. M. KLINGENBERG, Methods of Enzymatic Analysis, H.U. Bergmeyer (Ed), 531-534, Academic Press, New York (1963).
21. O.H. LOWRY and J.V. PASSONNEAU, A flexible system of enzymatic analysis, 136-139, Academic Press, New York (1972)
22. D.H. WILLIAMSON, P. LUND and H.A. KREBS, Biochem. J. 103 514-527 (1967).
23. J.E. WALKER, Q. Rev. Biophys. 25 253-324 (1992).
24. M.F. BEAL, D.R. HENSHAW, B.G. JENKINS, B.R. ROSEN and J.B. SCHULZ, Ann. Neurol. 36 882-888 (1994).
25. M.R. HORSMAN, M. HOYER, D.J. HONESS, I.F. DENNIS and J. OVERGAARD, Radiother. Oncol. 27 131-139 (1993).
26. M.R.L. STRATFORD, A. ROJAS, D.W. HALL, M.F. DENNIS, S. DISCHE, M.C. JOINER and R.J. HODGKISS, Radiother. Oncol. 25 37-42 (1992).
27. D.J. HONESS and N.M. BLEEHEN, Radiother. Oncol. 27 140-148 (1993).
28. R.A. KAUPPINEN, J.K. HILTUNEN and I.E. HASSINEN, FEBS Lett. 112 273-276 (1980).