MELAS: Clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy

Neurology

Volumn 46, Issue 1, 1996, Pages 223-227

  Clark, J M ^a   Marks, M P ^a   Adalsteinsson, E ^a   Spielman, D M ^a   Shuster, D ^a   Horoupian, D ^a   Albers, G W ^a  

^a Stanford California and Cofounder   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AEROBIC METABOLISM; ARTICLE; AUTOREGULATION; BRAIN DISEASE; CASE REPORT; DIAGNOSTIC IMAGING; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ELECTRON MICROSCOPY; FEMALE; HUMAN; LACTIC ACIDEMIA; LACTIC ACIDOSIS; MELAS SYNDROME; MITOCHONDRIAL MYOPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; STROKE;

EID: 0029938221     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.46.1.223     Document Type: Article

References (19)

1. Pavlakis S, Phillips P, DiMauro S, DeVivo D, Rowland L. Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 1984;16:481-488.
2. Nonaka I. Mitochondrial diseases. Curr Opin Neurol 1992; 5:622-632.
3. Kishi M, Yamamura Y, Kurihara T, et al. An autopsy case of mitochondrial encephalomyopathy: biochemical and electron microscopic studies of the brain. J Neurol Sci 1988;86:31-40.
4. Sakuta R, Nonaka I. Vascuar involvement in mitochondrial myopathy. Ann Neurol 1989;25:594-601.
5. Hasegawa H, Matsuoka T, Goto Y, Nonaka I. Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Ann Neurol 1991;29:601-605.
6. Adalsteinsson E, Spielman D, Wright G, Pauly J, Meyer C, Macovski A. Incorporating lactate/lipid discrimination into a spectroscopic imaging sequence. Magn Reson Med 1993;30: 124-130.
7. Ohama E, Ohara S, Ikuta F, Tanaka K, Nishizawa M, Miyatake T. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol (Berl) 1987;74:226-233.
8. Mizukami K, Sasaki M, Suzuki T, et al. Central nervous system changes in mitochondrial encephalomyopathy: light and electron microscopic study. Acta Neuropathol (Berl) 1992;83: 449-452.
9. Morita K, Ono S, Fukunaga M, et al. Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and strokelike episodes (MELAS). Neuroradiology 1989;31:358-361.
10. Ooiwa Y, Uematsu Y, Terada T, et al. Cerebral blood flow in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Stroke 1993;24:304-309.
11. Gropen T, Prohovnik I, Tatemichi T, Hirano M. Cerebral hyperemia in MELAS. Stroke 1994;25:1873-1876.
12. Barkovich A, Good W, Koch T, Berg B. Mitochondrial disorders: analysis of their clinical and imaging characteristics. AJNR Am J Neuroradiol 1993;14:1119-1137.
13. Matthews P, Andermann F, Silver K, Karpati G, Arnold D. Proton MR spectroscopic characterization of differences in regional brain metabolic abnormalities in mitochondrial encephalomyopathies. Neurology 1993;43:2484-2490.
14. Sparaco M, Bonilla E, DiMauro S, Powers J. Neuropathology of mitochondrial encephalopathies due to mitochondrial DNA defects. J Neuropathol Exp Neurol 1993;52:1-10.
15. LEU mtDNA mutation in MELAS brain [abstract]. Neurology 1992;42(suppl 3):282.
16. Ohama E, Ikuta F. Involvement of choroid plexus in mitochondrial encephalomyopathy (MELAS). Acta Neuropathol (Berl) 1987;75:1-7.
17. Koo B, Becker L, Chuang S, et al. Mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes (MELAS): clinical, radiological, pathological, and genetic observations. Ann Neurol 1993;34:25-32.
18. Matthews P, Tampieri D, Berkovic S, et al. Magnetic resonance imaging shows specific abnormalities in the MELAS syndrome. Neurology 1991;41:1043-1046.
19. Rosen L, Phillips S, Enzmann D. Magnetic resonance imaging in MELAS syndrome. Neuroradiology 1990;32:168-171.