Pathogenesis and treatment of stroke-like episodes in MELAS

Clinical Neurology

Volumn 48, Issue 11, 2008, Pages 1006-1009

  Iizuka, Takahiro ^a  

^a KITASATO UNIVERSITY   (Japan)

Author keywords

Hyperperfusion; MELAS; Neuronal hyperexcitability; Stroke

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; RNA; TAURINE; URIDINE;

ASTROCYTE; BRAIN CORTEX; BRAIN EDEMA; BRAIN PERFUSION; BRAIN REGION; CAPILLARY ENDOTHELIUM; CAPILLARY PERMEABILITY; CELL LOSS; CELL MEMBRANE DEPOLARIZATION; CODON; CONFERENCE PAPER; ENDOTHELIUM CELL; ENERGY EXPENDITURE; EPILEPSY; EPILEPTIC DISCHARGE; GENE MUTATION; HUMAN; MELAS SYNDROME; NERVE CELL; NERVE CELL EXCITABILITY; PATHOGENESIS; PROTEIN MODIFICATION; PROTEIN SYNTHESIS INHIBITION; RNA TRANSLATION; DIAGNOSTIC IMAGING; FEMALE; GENETICS; MALE; MUTATION; PATHOPHYSIOLOGY; REVIEW; TRANSCRANIAL MAGNETIC STIMULATION;

DIAGNOSTIC IMAGING; DNA, MITOCHONDRIAL; FEMALE; HUMANS; MALE; MELAS SYNDROME; MUTATION; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 63849147157     PISSN: 0009918X     EISSN: None     Source Type: Journal    
DOI: 10.5692/clinicalneurol.48.1006     Document Type: Conference Paper

References (9)

1. Pavlakis SG, Phillips PC, DiMauro S, et al: Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 1984; 16: 481-488 (Pubitemid 14021826)
2. Iizuka T, Sakai F: Pathogenesis of stroke-like episodes in MELAS: analysis of neurovascular cellular mechanisms. Curr Neurovasc Res 2005; 2: 29-45 (Pubitemid 41419944)
3. Kirino Y, Suzuki T: Human mitochondrial diseases associated with tRNA wobble modification deficiency. RNA Biol 2005; 2: 41-44 (Pubitemid 41359797)
4. Iizuka T, Sakai F, Ide T, et al: Regional cerebral blood flow and cerebrovascular reactivity during chronic stage of stroke-like episodes in MELAS-implication of neurovascular cellular mechanism. J Neurol Sci 2007; 257: 126-138 (Pubitemid 46856497)
5. Iizuka T, Sakai F, Endo M, et al: Response to sumatriptan in headache of MELAS syndrome. Neurology 2003; 61: 577-578 (Pubitemid 37025390)
6. Iizuka T,Sakai F, Suzuki N, et al: Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome. Neurology 2002; 59: 816-824
7. Iizuka T, Sakai F, Kan S, et al: Slowly progressive spread of the stroke-like lesions in MELAS. Neurology 2003; 61: 1238-1244 (Pubitemid 37377544)
8. Iizuka T, Miyakawa S, Sato M, et al: Neuronal Hyperexcitability and Trigeminovascular Activation during Acute Stage of Stroke-like Episodes in MELAS. Neurology 2008; 70 (Suppl1): A49
9. Difrancesco JC, Cooper JM, Lam A, et al. MELAS mitochondrial DNA mutation A3243G reduces glutamate transport in cybrids cell lines. Exp Neurol 2008; [Epub ahead of print].