Cerebral blood flow and oxygen metabolism before and after a stroke- like episode in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

Journal of the Neurological Sciences

Volumn 158, Issue 1, 1998, Pages 58-64

  Takahashi, Satoshi ^a   Tohgi, Hideo ^a   Yonezawa, Hisashi ^a   Obara, Satoko ^a   Nagane, Yuriko ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

Author keywords

Cerebral blood flow; Encephalopathy, lactic acidosis and stroke like episodes (MELAS); Hyperemia; Magnetic resonance imaging (MRI); Mitochondrial myopathy; Oxygen metabolism; Positron emission tomography (PET)

Indexed keywords

OXYGEN;

ADULT; ARTICLE; BRAIN CIRCULATION; CASE REPORT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; LACTIC ACIDOSIS; MALE; MITOCHONDRIAL MYOPATHY; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN CONSUMPTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STEADY STATE; STROKE;

ADULT; APHASIA; BRAIN; CEREBELLUM; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; EPILEPSY, TONIC-CLONIC; FEMALE; HEARING LOSS, SENSORINEURAL; HUMANS; HYPEREMIA; MAGNETIC RESONANCE IMAGING; MALE; MELAS SYNDROME; MIDDLE AGED; MUSCLE WEAKNESS; OXYGEN; OXYGEN CONSUMPTION; STATUS EPILEPTICUS; THALAMUS; TOMOGRAPHY, EMISSION-COMPUTED; VASODILATION; VISION DISORDERS;

EID: 0032507974     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00105-1     Document Type: Article

References (22)

1. Clark J.M., Marks M.P., Adalsteinsson E., Spielman D.M., Shuster D., Horoupian D., Albers G.W. MELAS: clinical and pathologic correlations with MRI, xenon/CT, and MR spectroscopy. Neurology. 46:1996;223-227.
2. Gilchrist J.M., Sikirica M., Stipa E., Shanske S. Adult-onset MELAS. Evidence for involvement of neurons as well as cerebral vasculature in stroke-like episodes. Stroke. 27:1996;420-1423.
3. Leu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature. 348:1990;651-653.
4. Goto Y., Nonaka I., Horai S. A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Biochem Biophys Acta. 1097:1991;238-240.
5. Gropen T.I., Prohovnik I., Tatemichi T.K., Hirano M. Cerebral hyperemia in MELAS. Stroke. 25:1994;1873-1876.
6. Hasuo K., Tamura S., Yasumori K., Uchino A., Goda S., Ishimoto S., Kamikaseda K., Wakuta Y., Kishi M., Masuda K. Computed tomography and angiography in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes); report of 3 cases. Neuroradiology. 29:1987;393-397.
7. Leu(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes). Biochem Biophys Res Commun. 173:1990;816-822.
8. 3. Ann Neurol. 8:1980;348-360.
9. Kuriyama M., Umezaki H., Fukuda Y., Osame M., Koike K., Tateishi J., Igata A. Mitochondrial encephalomyopathy with lactate-pyruvate elevation and brain infarctions. Neurology. 34:1984;72-77.
10. Lammertsma A.A., Jones T. Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metab. 3:1983;416-424.
11. Morita K., Ono S., Fukunaga M., Yasuda T., Higashi Y., Terao A., Morita R. Increased accumulation of N-isopropyl-p-(123I)-iodoamphetamine in two cases with mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS). Neuroradiology. 31:1989;358-361.
12. Ohama E., Ohara S., Ikuta F., Tanaka K., Nishizawa M., Miyatake T. Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol (Berl). 74:1987;226-233.
13. Ooiwa Y., Uernatsu Y., Terada T., Nakai K., Itakura T., Komai N., Moriwaki H. Cerebral blood flow in mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. Stroke. 24:1993;304-309.
14. Pavlakis S.G., Phillips P.C., DiMauro S., De Vivo D.C., Rowland L.P. Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes: A distinctive clinical syndrome. Ann Neurol. 16:1984;481-488.
15. Phelps M.E., Huang S.C., Hoffman E.J., Kuhl D.E. Vasodilation of tomographic measurement of cerebral blood volume with C-11-labelled carboxyhemoglobin. J Nucl Med. 20:1979;328-334.
16. Rodriguez G., Nobili F., Regesta G., Ottonello G. Cerebral hyperperfusion antedates by years stroke-like episodes in the MELAS syndrome. Stroke. 27:1996;340-342.
17. Sakuta R., Nonaka I. Vascular involvement in mitochondrial myopathy. Ann Neurol. 25:1989;594-601.
18. Sano M., Ishii K., Momose Y., Uchigata M., Senda M. Cerebral metabolism of oxygen and glucose in a patient with MELAS syndrome. Acta Neurol Scand. 92:1995;497-502.
19. Satoh M., Ishikawa N., Yoshizawa T., Yakeda T. Akisada, M. (N-Isopropyl-p-[123I) iodoamphetamine SPECT in MELAS syndrome; comparison with CT and MR imaging. J Comput Assist Tomogr. 15:1991;77-82.
20. Suzuki T., Koizumi J., Shiraishi H., Ishikawa N., Ofuku K., Sasaki M., Hori T., Ohkoshi N., Anno I. Mitochondrial encephalomyopathy (MELAS) with mental disorder. CT, MRI and SPECT findings. Neuroradiology. 32:1990;74-76.
21. Tokunaga M., Mita S., Sakuta R., Nonaka I., Araki S. Increased mitochondrial DNA in blood vessels and ragged-red fibers in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS). Ann Neurol. 33:1993;275-280.
22. Watahiki Y., Tomiyama M., Nagata K., Shishido F., Kobayashi Y., Komatsu K., Goto A., Takada G. Positron emission tomographic study in patients with MELAS. No to Hattatsu. 20:1988;404-411.