Developmental trajectories in early hematopoiesis

Genes and Development

Volumn 23, Issue 20, 2009, Pages 2366-2370

  Murre, Cornelis ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

B cell development; Fate decisions; Hematopoiesis; Lymphopoiesis; T cell development

Indexed keywords

TRANSCRIPTION FACTOR E2A;

CELL CYCLE ARREST; CELL LINEAGE; CELL MATURATION; GENE CONTROL; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; LYMPHOID PROGENITOR CELL; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROGENY; REVIEW;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEMATOPOIESIS; MICE; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 70350088522     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1861709     Document Type: Review

References (48)

1. Adolfsson J, Mansson R, Buza-Vidas N, Hultquist A, Liuba K, Jensen CT, Bryder D, Yang L, Borge OJ, Thoren LA, et al. 2005. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121: 295-306. (Pubitemid 40546396)
2. Agata Y, Tamaki N, Sakamoto S, Ikawa T, Masuda K, Kawamoto H, Murre C. 2007. Regulation of T cell receptor b gene rearrangements and allelic exclusion. Immunity 27: 871-884.
3. Akashi K, Traver D, Miyamoto T, Weissman IL. 2000. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404: 193-197. (Pubitemid 30154488)
4. Bain G, Engel I, Robanus Maandag EC, te Riele HPJ, Voland JR, Sharp LL, Chun J, Murre C. 1997a. E2A deficient mice show abnormalities in T cell development and rapidly develop malignant T cell lymphomas. Mol Cell Biol 17: 4782-4791.
5. Bain G, Robanus Maandag EC, te Riele HP, Feeney AJ, Sheehy A, Schlissel M, Shinton SA, Hardy RR, Murre C. 1997b. Both E12 and E47 allow commitment to the B cell lineage. Immunity 6: 145-154.
6. Barndt RJ, Dai M, Zhuang Y. 2000. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol Cell Biol 20: 6677-6685. (Pubitemid 30700786)
7. Borghesi L, Aites J, Nelson S, Lefterov P, James P, Gerstein R. 2005. E47 is required for V(D)J recombinase activity in common lymphoid progenitors. J Exp Med 202: 1669-1677. (Pubitemid 41815873)
8. Chen MJ, Yokomizo T, Brandon MZ, Dzierzak E, Speck NA. 2009. Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 457: 887-891.
9. Dias S, Mansson R, Gurbuxani S, Sigvardsson M, Kee BL. 2008. E2A proteins promote development of lymphoid-primed multipotent progenitors. Immunity 29: 217-227.
10. Engel I, Murre C. 2004. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J 23: 202-211. (Pubitemid 38165760)
11. Fuxa M, Skok J, Souabni A, Salvagiotto G, Roldan E, Busslinger M. 2004. Pax5 induces V-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. Genes & Dev 18: 411-422. (Pubitemid 38316348)
12. Georgescu C, Longabaugh WJ, Scripture-Adams DD, David-Fung ES, Yui MA, Zarnegar MA, Bolouri H, Rothenberg EV. 2008. A gene regulatory network armature for T lymphocyte specification. Proc Natl Acad Sci 105: 20100-20105.
13. Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. 2004. Gfi-1 restricts proliferation and preserves functional integrity of haematopietic stem cells. Nature 431: 1002-1007. (Pubitemid 39434423)
14. Ikawa T, Kawamoto H, Wright LY, Murre C. 2004. Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent. Immunity 20: 349-360. (Pubitemid 38388236)
15. Ikawa T, Kawamoto H, Goldrath AW, Murre C. 2006. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J Exp Med 203: 1329-1342. (Pubitemid 43736601)
16. Inlay MA, Bhattacharya D, Sahoo D, Serwold T, Seita J, Karsunky H, Plevritis SK, Dill DL, Weissman IL. 2009. Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. Genes & Dev (this issue). doi: 10.1101/gad.1836009.
17. Kee BL, Murre C. 1998. Induction of early B cell factor (EBF) and multiple B lineage genes by the basic helix-loop-helix transcription factor E12. J Exp Med 188: 699-713. (Pubitemid 28387933)
18. Kondo M, Weissman IL, Akashi K. 1997. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91: 661-672. (Pubitemid 27513657)
19. Kwon K, Hutter C, Sun Q, Bilic I, Cobaleda C, Malin S, Busslinger MA. 2008. Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development. Immunity 28: 751-762.
20. Lai AY, Kondo M. 2008. Tand B lymphocyte differentiation from hematopoietic stem cells. Semin Immunol 20: 207-212.
21. Laslo P, Spooner CJ, Warmflash A, Lancki DW, Lee HJ, Sciammas R, Gantner BN, Dinner AR, Singh H. 2006. Multilineage transcriptional priming and determination of alternate hematopoietic cell fates. Cell 126: 755-766. (Pubitemid 44233633)
22. Laslo P, Pongubala JMR, Lancki DW, Singh H. 2008. Gene regulatory networks directing myeloid and lymphoid cell fates within the immune system. Semin Immunol 20: 228-235.
23. Lazorchak AS, Wojciechowski J, Dai M, Zhuang Y. 2006. E2A promotes the survival of precursor and mature B lymphocytes. J Immunol 177: 2495-2504. (Pubitemid 44201009)
24. Liu H, Schmidt-Supprian M, Shi M, Hobeika E, Barteneva N, Jumaa H, Pelanda R, Reth M, Skok J, Rajewsky K, et al. 2007. Yin Yang 1 is a critical regulator of B cell development. Genes & Dev 21: 1179-1189. (Pubitemid 46789876)
25. Maier H, Ostraat R, Gao H, Fields S, Shinto SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, et al. 2004. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol 5: 1069-1077. (Pubitemid 41057727)
26. Mansson R, Zandi S, Andersson IL, Jacobsen SE, Bryder D, Sigvardsson M. 2008. B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells. Blood 15: 1048-1055.
27. + lymphoid-restricted bone marrow cells with T precursor potential. Nat Immunol 4: 866-873.
28. Medina KL, Pongubala JM, Reddy KL, Lancki DW, Dekoter R, Kieslinger M, Grosschedl R, Singh H. 2004. Assembling a gene regulatory network for specification of the B cell fate. Dev Cell 7: 607-617. (Pubitemid 39341845)
29. Murre C. 2005. Helix-loop-helix proteins and lymphocyte development. Nat Immunol 6: 1079-1086.
30. Ng SY, Yoshida T, Zhang J, Georgopoulos K. 2009. Genomewide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. Immunity 30: 493-507.
31. Nutt SL, Heavey B, Rolink AG, Busslinger M. 1999. Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature 401: 556-562. (Pubitemid 129517063)
32. Pongubala JM, Northrup DL, Lancki DW, Medina KL, Treiber T, Bertolino E, Thomas M, Grosschedl R, Allman D, Singh H. 2008. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nat Immunol 9: 203-215.
33. Pronk CJ, Rossi DJ, Mansson R, Attema JL, Norddahl GL, Chan CK, Sigvardsson M, Weissman IL, Bryder D. 2007. Elucidation of the phenotypic, function and molecular topography of a myeloperythorid progenitor cell hierarchy. Cell Stem Cell 11: 428-442. (Pubitemid 47506534)
34. Rekhtman N, Radparvar F, Evans T, Skoultchi AI. 1999. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: Functional antagonism in erythroid cells. Genes & Dev 13: 1398-1411. (Pubitemid 29270245)
35. Reynaud D, Demarco IA, Reddy KL, Schjerven H, Bertolino E, Chen Z, Smale ST, Winandy S, Singh H. 2008. Regulation of B cell commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol 9: 927-936.
36. Roessler S, Gyory I, Imhof S, Spivakov M, Williams RR, Busslinger MA, Fisher AG, Grosschedl R. 2007. Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol 2: 579-594. (Pubitemid 46080126)
37. Schwartz R, Engel I, Fallahi-Sichani M, Petrie HT, Murre C. 2006. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Proc Natl Acad Sci 103: 9976-9981.
38. Scott EW, Simon MC, Anastasi J, Singh H. 1994. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Science 265: 1573-1577. (Pubitemid 24308970)
39. Seet CS, Brumbaugh RL, Kee BL. 2004. Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A. J Exp Med 199: 1689-1700.
40. Semerad CL, Mercer EM, Inlay MA, Weissman IL, Murre C. 2009. E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphid and myeloerythorid progenitors. Proc Natl Acad USA 106: 1930-1935.
41. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH. 1997. A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 16: 3965-3973. (Pubitemid 27281012)
42. Sigvardsson M, O'Riordan M, Grosschedl R. 1997. EBF and E47 collaborate to induce expression of the endogenous surrogate light chain genes. Immunity 7: 25-36. (Pubitemid 27357262)
43. Spangrude GJ, Heimfeld S, Weissman IL. 1988. Purification and characterization of mouse hematopoietic stem cells. Science 241: 58-62. (Pubitemid 18168116)
44. Wada H, Masuda K, Satoh R, Kakugawa K, Ikawa T, Katsura Y, Kawamoto H. 2008. Adult T-cell progenitors retain myeloid potential. Nature 452: 768-772.
45. Wang D, Claus CL, Vaccarelli G, Braunstein M, Schmitt TM, Zuniga-Pflucker JC, Rothenberg EV, Andersson MK. 2006. The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T-cell precursors. J Immunol 117: 109-119. (Pubitemid 43939122)
46. Yang Q, Kardava L, St Leger A, Martincic K, Varnum-Finney B, Bernstein ID, Milcarek C, Borghesi L. 2008. E47 controls the developmental integrity and cell cycle quiescence of multi-potential hematopoietic progenitors. J Immunol 181: 5885-5894.
47. Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Blacklow SC, Zhuang Y, et al. 2009. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes & Dev 23: 1665-1676.
48. Zandi S, Mansson R, Tsapogas P, Zetterblad J, Bryder D, Sigvardsson M. 2008. EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors. J Immunol 181: 3364-3372.