Glucocorticoid receptor gene and depression in patients with coronary heart disease: The Heart and Soul Study-2009 Curt Richter Award Winner

Psychoneuroendocrinology

Volumn 34, Issue 10, 2009, Pages 1574-1581

  Otte, Christian ^a   Wüst, Stefan ^b   Zhao, Shoujun ^c   Pawlikowska, Ludmila ^d   Kwok, Pui Yan ^d   Whooley, Mary A ^c,e  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cortisol; Depression; Genetics; Glucocorticoid receptor; Stress

Indexed keywords

ALANINE; ARGININE; ASPARAGINE; CYSTEINE; GLUCOCORTICOID RECEPTOR; GLUTAMIC ACID; GLYCINE; LYSINE; SERINE;

AGED; ARTICLE; CAUCASIAN; CHRONIC DISEASE; CONFOUNDING VARIABLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEPRESSION; DIAGNOSTIC INTERVIEW SCHEDULE; FEMALE; GENE DOSAGE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HAPLOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; OUTPATIENT; PREVALENCE; PRIORITY JOURNAL;

AGED; CORONARY DISEASE; CROSS-SECTIONAL STUDIES; DEPRESSION; FEMALE; HAPLOTYPES; HUMANS; HYDROCORTISONE; MALE; POLYMORPHISM, GENETIC; RECEPTORS, GLUCOCORTICOID;

EID: 70349952148     PISSN: 03064530     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2009.08.016     Document Type: Article

References (43)

1. Bet P.M., Penninx B.W.J.H., Bochdanovits Z., Uitterlinden A.G., Beekman A.T.F., Schoor N.M.v., Deeg D.J.H., and Hoogendijk W.J.G. Glucocorticoid receptor gene polymorphisms and childhood adversity are associated with depression: New evidence for a gene-environment interaction. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 150B (2009) 660-669
2. Binder E.B., Salyakina D., Lichtner P., Wochnik G.M., Ising M., Putz B., Papiol S., Seaman S., Lucae S., Kohli M.A., Nickel T., Kunzel H.E., Fuchs B., Majer M., Pfennig A., Kern N., Brunner J., Modell S., Baghai T., Deiml T., Zill P., Bondy B., Rupprecht R., Messer T., Kohnlein O., Dabitz H., Bruckl T., Muller N., Pfister H., Lieb R., Mueller J.C., Lohmussaar E., Strom T.M., Bettecken T., Meitinger T., Uhr M., Rein T., Holsboer F., and Muller-Myhsok B. Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat. Genet. 36 (2004) 1319
3. Boyle M.P., Brewer J.A., Funatsu M., Wozniak D.F., Tsien J.Z., Izumi Y., and Muglia L.J. Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior. Proc. Natl. Acad. Sci. 102 (2005) 473-478
4. de Kloet E.R., Joels M., and Holsboer F. Stress and the brain: from adaptation to disease. Nat. Rev. Neurosci. 6 (2005) 463-475
5. DeRijk R.H., and de Kloet E.R. Corticosteroid receptor polymorphisms: determinants of vulnerability and resilience. Eur. J. Pharmacol. 583 (2008) 303
6. DeRijk R.H., Schaaf M.J., Turner G., Datson N.A., Vreugdenhil E., Cidlowski J., de Kloet E.R., Emery P., Sternberg E.M., and Detera-Wadleigh S.D. A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta-isoform mRNA is associated with rheumatoid arthritis. J. Rheumatol. 28 (2001) 2383-2388
7. Gold P.W., and Chrousos G.P. Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. Mol. Psychiatry 7 (2002) 254-275
8. Hagendorf A., Koper J.W., de Jong F.H., Brinkmann A.O., Lamberts S.W.J., and Feelders R.A. Expression of the human glucocorticoid receptor splice variants {alpha}, {beta}, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism. J. Clin. Endocrinol. Metab. 90 (2005) 6237-6243
9. Hattersley A., and McCarthy M. What makes a good genetic association study?. Lancet 366 (2005) 1315-1323
10. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacol 23 (2000) 477-501
11. Hsu T., and Kwok P. Homogeneous primer extension assay with fluorescence polarization detection. Methods Mol. Biol. 212 (2003) 177-187
12. Huizenga N.A.T.M., Koper J.W., de Lange P., Pols H.A.P., Stolk R.P., Grobbee D.E., de Jong F.H., and Lamberts S.W.J. Interperson variability but intraperson stability of baseline plasma cortisol concentrations, and its relation to feedback sensitivity of the hypothalamo-pituitary-adrenal axis to a low dose of dexamethasone in elderly individuals. J. Clin. Endocrinol. Metab. 83 (1998) 47-54
13. Krishnamurthy P., Romagni P., Torvik S., Gold P.W., Charney D.S., Detera-Wadleigh S., Cizza G., and P.O.W.E.R.S.G. Glucocorticoid receptor gene polymorphisms in premenopausal women with major depression. Horm. Metab. Res. 40 (2008) 194-198
14. Kumsta D.M., Streit F., Koper J.W., Meyer J., and Wüst S. Characterization of a glucocorticoid receptor gene (GR, NR3C1) promoter polymorphism reveals functionality and extends a haplotype with putative clinical relevance. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 150B (2009) 476-482
15. Kumsta R., Entringer S., Koper J.W., van Rossum E.F.C., Hellhammer D.H., and Wüst S. Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. Biol. Psychiatry 62 (2007) 863
16. Lett H., Ali S., and Whooley M. Depression and cardiac function in patients with stable coronary heart disease: findings from the Heart and Soul Study. Psychosom. Med. (2008)
17. Matsubara T., Funato H., Kobayashi A., Nobumoto M., and Watanabe Y. Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives. Biol. Psychiatry 59 (2006) 689-695
18. McEwen B.S. Protective and damaging effects of stress mediators. N. Engl. J. Med. 338 (1998) 171-179
19. McGowan P.O., Sasaki A., D'Alessio A.C., Dymov S., Labonte B., Szyf M., Turecki G., and Meaney M.J. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat. Neurosci. 12 (2009) 342
20. Nelson J.C., and Davis J.M. DST studies in psychotic depression: a meta-analysis. Am. J. Psychiatry 154 (1997) 1497-1503
21. Nemeroff C.B. Neurobiological consequences of childhood trauma. J. Clin. Psychiatry 65 Suppl. 1 (2004) 18-28
22. Otte C., Marmar C.R., Pipkin S.S., Moos R., Browner W.S., and Whooley M.A. Depression and 24-hour urinary cortisol in medical outpatients with coronary heart disease: The Heart and Soul Study. Biol. Psychiatry 56 (2004) 241-247
23. Otte C., McCaffery J., Ali S., and Whooley M.A. Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: The Heart and Soul Study. Am. J. Psychiatry 164 (2007) 1379-1384
24. Otte C., Neylan T.C., Pipkin S.S., Browner W.S., and Whooley M.A. Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study. Am. J. Psychiatry 162 (2005) 2139-2145
25. Pariante C.M., and Miller A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49 (2001) 391-404
26. Ridder S., Chourbaji S., Hellweg R., Urani A., Zacher C., Schmid W., Zink M., Hortnagl H., Flor H., Henn F.A., Schutz G., and Gass P. Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J. Neurosci. 25 (2005) 6243-6250
27. Robins L.N., Helzer J.E., Croughan J., and Ratcliff K.S. National institute of mental health diagnostic interview schedule. its history, characteristics, and validity. Arch. Gen. Psychiatry 38 (1981) 381-389
28. Ruo B., Rumsfeld J.S., Hlatky M.A., Liu H., Browner W.S., and Whooley M.A. Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA 290 (2003) 215-221
29. Schulze T., and Mahon F.M. Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 114 (2002) 1-11
30. Spitzer R.L., Kroenke K., and Williams J.B. Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA 282 (1999) 1737-1744
31. van den Akker E.L.T., Koper J.W., van Rossum E.F.C., Dekker M.J.H., Russcher H., de Jong F.H., Uitterlinden A.G., Hofman A., Pols H.A., Witteman J.C.M., and Lamberts S.W.J. Glucocorticoid receptor gene and risk of cardiovascular disease. Arch. Intern. Med. 168 (2008) 33-39
32. van Rossum E.F.C., and Lamberts S.W.J. Polymorphisms in the glucocorticoid receptor gene and their associations with metabolic parameters and body composition. Recent Prog. Horm. Res. 59 (2004) 333-357
33. van Rossum E.F.C., Russcher H., and Lamberts S.W.J. Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene. Trends Endocrinol. Metab. 16 (2005) 445
34. van Rossum E., Binder M., Majer J., Koper M., Ising S., Modell D., Salyakina S., Lamberts F., and Holsboer. Polymorphisms of the glucocorticoid receptor gene and major depression. Biol. Psychiatry 59 (2006) 681-688
35. van Schoor N.M., Dennison E., Lips P., Uitterlinden A., and Cooper C. Serum fasting cortisol in relation to bone, and the role of genetic variations in the glucocorticoid receptor. Clin. Endocrinol. 67 (2007) 871-878
36. van West D., Eede J.V.D., Del-Favero J., Souery D., Norrback K., Duijn C.V., Sluijs S., Adolfsson R., Mendlewicz J., Deboutte D., Broeckhoven C.V., and Claes S. Glucocorticoid receptor gene-based SNP analysis in patients with recurrent major depression. Neuropsychopharmacology 31 (2006) 620-627
37. Webster M.J., Knable M.B., O'Grady J., Orthmann J., and Weickert C.S. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol. Psychiatry 7 (2002) 985-994 924
38. Wells K.B., Hays R.D., Burnam M.A., Rogers W., Greenfield S., and Ware Jr. J.E. Detection of depressive disorder for patients receiving prepaid or fee-for-service care. Results from the Medical Outcomes Study. JAMA 262 (1989) 3298-3302
39. Whooley M.A., de Jonge P., Vittinghoff E., Otte C., Moos R., Carney R.M., Ali S., Dowray S., Na B., Feldman M.D., Schiller N.B., and Browner W.S. Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA 300 (2008) 2379-2388
40. Wüst S., Federenko I.S., Rossum E.F.C., Koper J.W., Kumsta R., Entringer S., and Hellhammer D.H. A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity. Ann. NY Acad. Sci. 1032 (2004) 52-62
41. Wüst S., van Rossum E.F.C., Federenko I.S., Koper J.W., Kumsta R., and Hellhammer D.H. Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress. J. Clin. Endocrinol. Metab. 89 (2004) 565-573
42. Yudt M.R., Jewell C.M., Bienstock R.J., and Cidlowski J.A. Molecular origins for the dominant negative function of human glucocorticoid receptor beta. Mol. Cell. Biol. 23 (2003) 4319-4330
43. Zobel A., Jessen F., vonWiddern O., Schuhmacher A., Höfels S., Metten M., Rietschel M., Scheef L., Block W., Becker T., Schild H., Maier W., and Schwab S. Unipolar depression and hippocampal volume: impact of DNA sequence variants of the glucocorticoid receptor gene. Am. J. Med. Genet. B: Neuropsychiatr. Genet. 147B (2008) 836-843