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Volumn 90, Issue 11, 2005, Pages 6237-6243

Expression of the human glucocorticoid receptor splice variants α, β, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; GLUCOCORTICOID RECEPTOR P; HYDROCORTISONE; ISOPROTEIN; MESSENGER RNA; METYRAPONE; UNCLASSIFIED DRUG;

EID: 27744432217     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1042     Document Type: Article
Times cited : (47)

References (40)
  • 2
    • 0033485289 scopus 로고    scopus 로고
    • Mechanisms of glucocorticoid-receptor-mediated repression of gene expression
    • Webster JC, Cidlowski JA 1999 Mechanisms of glucocorticoid-receptor- mediated repression of gene expression. Trends Endocrinol Metab 10:396-402
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 396-402
    • Webster, J.C.1    Cidlowski, J.A.2
  • 4
    • 0029056558 scopus 로고
    • Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans
    • Bamberger CM, Bamberger AM, de Castro M, Chrousos GP 1995 Glucocorticoid receptor β, a potential endogenous inhibitor of glucocorticoid action in humans. J Clin Invest 95:2435-2441
    • (1995) J Clin Invest , vol.95 , pp. 2435-2441
    • Bamberger, C.M.1    Bamberger, A.M.2    De Castro, M.3    Chrousos, G.P.4
  • 5
    • 0029993518 scopus 로고    scopus 로고
    • The human glucocorticoid receptor β isoform. Expression, biochemical properties, and putative function
    • Oakley RH, Sar M, Cidlowski JA 1996 The human glucocorticoid receptor β isoform. Expression, biochemical properties, and putative function. J Biol Chem 271:9550-9559
    • (1996) J Biol Chem , vol.271 , pp. 9550-9559
    • Oakley, R.H.1    Sar, M.2    Cidlowski, J.A.3
  • 6
    • 0033600936 scopus 로고    scopus 로고
    • The dominant negative activity of the human glucocorticoid receptor β isoform. Specificity and mechanisms of action
    • Oakley RH, Jewell CM, Yudt MR, Bofetiado DM, Cidlowski JA 1999 The dominant negative activity of the human glucocorticoid receptor β isoform. Specificity and mechanisms of action. J Biol Chem 274:27857-27866
    • (1999) J Biol Chem , vol.274 , pp. 27857-27866
    • Oakley, R.H.1    Jewell, C.M.2    Yudt, M.R.3    Bofetiado, D.M.4    Cidlowski, J.A.5
  • 8
    • 0034058875 scopus 로고    scopus 로고
    • Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis
    • Honda M, Orii F, Ayabe T, Imai S, Ashida T, Obara T, Kohgo Y 2000 Expression of glucocorticoid receptor β in lymphocytes of patients with glucocorticoid-resistant ulcerative colitis. Gastroenterology 118:859-866
    • (2000) Gastroenterology , vol.118 , pp. 859-866
    • Honda, M.1    Orii, F.2    Ayabe, T.3    Imai, S.4    Ashida, T.5    Obara, T.6    Kohgo, Y.7
  • 9
    • 0004815929 scopus 로고    scopus 로고
    • Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform
    • Sousa AR, Lane SJ, Cidlowski JA, Staynov DZ, Lee TH 2000 Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor β-isoform. J Allergy Clin Immunol 105:943-950
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 943-950
    • Sousa, A.R.1    Lane, S.J.2    Cidlowski, J.A.3    Staynov, D.Z.4    Lee, T.H.5
  • 10
    • 0035809314 scopus 로고    scopus 로고
    • High constitutive glucocorticoid receptor β in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids
    • Strickland I, Kisich K, Hauk PJ, Vottero A, Chrousos GP, Klemm DJ, Leung DY 2001 High constitutive glucocorticoid receptor β in human neutrophils enables them to reduce their spontaneous rate of cell death in response to corticosteroids. J Exp Med 193:585-594
    • (2001) J Exp Med , vol.193 , pp. 585-594
    • Strickland, I.1    Kisich, K.2    Hauk, P.J.3    Vottero, A.4    Chrousos, G.P.5    Klemm, D.J.6    Leung, D.Y.7
  • 12
    • 0001065189 scopus 로고    scopus 로고
    • Glucocorticoid receptor β: View II
    • Carlstedt-Duke J 1999 Glucocorticoid receptor β: view II. Trends Endocrinol Metab 10:339-342
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 339-342
    • Carlstedt-Duke, J.1
  • 13
    • 0027169076 scopus 로고
    • Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells
    • Moalli PA, Pillay S, Krett NL, Rosen ST 1993 Alternatively spliced glucocorticoid receptor messenger RNAs in glucocorticoid-resistant human multiple myeloma cells. Cancer Res 53:3877-3879
    • (1993) Cancer Res , vol.53 , pp. 3877-3879
    • Moalli, P.A.1    Pillay, S.2    Krett, N.L.3    Rosen, S.T.4
  • 14
    • 0032566133 scopus 로고    scopus 로고
    • An ACTH producing small cell lung cancer expresses aberrant glucocorticoid receptor transcripts from a normal gene
    • Parks LL, Turney MK, Detera-Wadleigh S, Kovacs WJ 1998 An ACTH producing small cell lung cancer expresses aberrant glucocorticoid receptor transcripts from a normal gene. Mol Cell Endocrinol 142:175-181
    • (1998) Mol Cell Endocrinol , vol.142 , pp. 175-181
    • Parks, L.L.1    Turney, M.K.2    Detera-Wadleigh, S.3    Kovacs, W.J.4
  • 16
    • 0028607388 scopus 로고
    • Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormoneinducible receptor messenger RNA down-regulation through multiple mechanisms
    • Burnstein KL, Jewell CM, Sar M, Cidlowski JA 1994 Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormoneinducible receptor messenger RNA down-regulation through multiple mechanisms. Mol Endocrinol 8:1764-1773
    • (1994) Mol Endocrinol , vol.8 , pp. 1764-1773
    • Burnstein, K.L.1    Jewell, C.M.2    Sar, M.3    Cidlowski, J.A.4
  • 17
    • 0028277949 scopus 로고
    • Regulation of the human glucocorticoid receptor by long-term and chronic treatment with glucocorticoid
    • Silva CM, Powell-Oliver FE, Jewell CM, Sar M, Allgood VE, Cidlowski JA 1994 Regulation of the human glucocorticoid receptor by long-term and chronic treatment with glucocorticoid. Steroids 59:436-442
    • (1994) Steroids , vol.59 , pp. 436-442
    • Silva, C.M.1    Powell-Oliver, F.E.2    Jewell, C.M.3    Sar, M.4    Allgood, V.E.5    Cidlowski, J.A.6
  • 18
    • 0022516758 scopus 로고
    • Regulation of the glucocorticoid receptor by glucocorticoids in human mononuclear leukocytes
    • Brentani MM, Wajchenberg BL, Cesar FP, Martins VR 1986 Regulation of the glucocorticoid receptor by glucocorticoids in human mononuclear leukocytes. Horm Res 24:9-17
    • (1986) Horm Res , vol.24 , pp. 9-17
    • Brentani, M.M.1    Wajchenberg, B.L.2    Cesar, F.P.3    Martins, V.R.4
  • 19
    • 0032882855 scopus 로고    scopus 로고
    • Glucocorticoid receptors in anorexia nervosa and Cushing's disease
    • Invitti C, Redaelli G, Baldi G, Cavagnini F 1999 Glucocorticoid receptors in anorexia nervosa and Cushing's disease. Biol Psychiatry 45:1467-1471
    • (1999) Biol Psychiatry , vol.45 , pp. 1467-1471
    • Invitti, C.1    Redaelli, G.2    Baldi, G.3    Cavagnini, F.4
  • 20
    • 0024510808 scopus 로고
    • A correlative study between glucocorticoid receptor levels in human mononuclear leukocytes and biochemical data in Cushing's disease
    • Copenh
    • Pardes EM, de Yampey JW, Soto RJ, Moses DF, De Nicola AF 1989 A correlative study between glucocorticoid receptor levels in human mononuclear leukocytes and biochemical data in Cushing's disease. Acta Endocrinol (Copenh) 120:55-61
    • (1989) Acta Endocrinol , vol.120 , pp. 55-61
    • Pardes, E.M.1    De Yampey, J.W.2    Soto, R.J.3    Moses, D.F.4    De Nicola, A.F.5
  • 21
    • 0025766322 scopus 로고
    • Regulation of glucocorticoid receptors in human mononuclear cells: Effects of glucocorticoid treatment, Cushing's disease and ketoconazole
    • Pardes E, De Yampey JE, Moses DF, De Nicola AF 1991 Regulation of glucocorticoid receptors in human mononuclear cells: effects of glucocorticoid treatment, Cushing's disease and ketoconazole. J Steroid Biochem Mol Biol 39:233-238
    • (1991) J Steroid Biochem Mol Biol , vol.39 , pp. 233-238
    • Pardes, E.1    De Yampey, J.E.2    Moses, D.F.3    De Nicola, A.F.4
  • 24
    • 85003076917 scopus 로고
    • Decreased glucocorticoid receptor binding in adrenal insufficiency
    • Schlechte JA, Sherman BM 1982 Decreased glucocorticoid receptor binding in adrenal insufficiency. J Clin Endocrinol Metab 54:145-149
    • (1982) J Clin Endocrinol Metab , vol.54 , pp. 145-149
    • Schlechte, J.A.1    Sherman, B.M.2
  • 26
    • 0029166231 scopus 로고
    • Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock
    • Oxf
    • Molijn GJ, Koper JW, van Uffelen CJ, de Jong FH, Brinkmann AO, Bruining HA, Lamberts SW 1995 Temperature-induced down-regulation of the glucocorticoid receptor in peripheral blood mononuclear leucocyte in patients with sepsis or septic shock. Clin Endocrinol (Oxf) 43:197-203
    • (1995) Clin Endocrinol , vol.43 , pp. 197-203
    • Molijn, G.J.1    Koper, J.W.2    Van Uffelen, C.J.3    De Jong, F.H.4    Brinkmann, A.O.5    Bruining, H.A.6    Lamberts, S.W.7
  • 27
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD 2001 Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25:402-408
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 28
    • 0025895395 scopus 로고
    • The genomic structure of the human glucocorticoid receptor
    • Encio IJ, Detera-Wadleigh SD 1991 The genomic structure of the human glucocorticoid receptor. J Biol Chem 266:7182-7188
    • (1991) J Biol Chem , vol.266 , pp. 7182-7188
    • Encio, I.J.1    Detera-Wadleigh, S.D.2
  • 30
    • 0027942433 scopus 로고
    • Coordinate regulation of glucocorticoid receptor and c-junmRNAlevels: Evidence for cross-talk between two signaling pathways' at the transcriptional level
    • Vig E, Barrett TJ, Vedeckis WV 1994 Coordinate regulation of glucocorticoid receptor and c-junmRNAlevels: evidence for cross-talk between two signaling pathways' at the transcriptional level. Mol Endocrinol 8:1336-1346
    • (1994) Mol Endocrinol , vol.8 , pp. 1336-1346
    • Vig, E.1    Barrett, T.J.2    Vedeckis, W.V.3
  • 31
    • 0021946175 scopus 로고
    • Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form
    • McIntyre WR, Samuels HH 1985 Triamcinolone acetonide regulates glucocorticoid-receptor levels by decreasing the half-life of the activated nuclear-receptor form. J Biol Chem 260:418-427
    • (1985) J Biol Chem , vol.260 , pp. 418-427
    • McIntyre, W.R.1    Samuels, H.H.2
  • 33
    • 0035810930 scopus 로고    scopus 로고
    • Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance
    • USA
    • Webster JC, Oakley RH, Jewell CM, Cidlowski JA 2001 Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci USA 98:6865-6870
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 6865-6870
    • Webster, J.C.1    Oakley, R.H.2    Jewell, C.M.3    Cidlowski, J.A.4
  • 34
    • 0029807036 scopus 로고    scopus 로고
    • The non-ligand binding β-isoform of the human glucocorticoid receptor (hGRβ): Tissue levels, mechanism of action, and potential physiologic role
    • de Castro M, Elliot S, Kino T, Bamberger C, Karl M, Webster E, Chrousos GP 1996 The non-ligand binding β-isoform of the human glucocorticoid receptor (hGRβ): tissue levels, mechanism of action, and potential physiologic role. Mol Med 2:597-607
    • (1996) Mol Med , vol.2 , pp. 597-607
    • De Castro, M.1    Elliot, S.2    Kino, T.3    Bamberger, C.4    Karl, M.5    Webster, E.6    Chrousos, G.P.7
  • 35
    • 0034048372 scopus 로고    scopus 로고
    • Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens
    • Hauk PJ, Hamid QA, Chrousos GP, Leung DY 2000 Induction of corticosteroid insensitivity in human PBMCs by microbial superantigens. J Allergy Clin Immunol 105:782-787
    • (2000) J Allergy Clin Immunol , vol.105 , pp. 782-787
    • Hauk, P.J.1    Hamid, Q.A.2    Chrousos, G.P.3    Leung, D.Y.4
  • 36
    • 0035000828 scopus 로고    scopus 로고
    • Regulation of glucocorticoid receptor and β isoforms and type I 11β-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: A key role in the pathogenesis of insulin resistance?
    • Whorwood CB, Donovan SJ, Wood PJ, Phillips DI 2001 Regulation of glucocorticoid receptor and β isoforms and type I 11β-hydroxysteroid dehydrogenase expression in human skeletal muscle cells: a key role in the pathogenesis of insulin resistance? J Clin Endocrinol Metab 86:2296-2308
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 2296-2308
    • Whorwood, C.B.1    Donovan, S.J.2    Wood, P.J.3    Phillips, D.I.4
  • 37
    • 3042831099 scopus 로고    scopus 로고
    • The origin and functions of multiple human glucocorticoid receptor isoforms
    • Lu NZ, Cidlowski JA 2004 The origin and functions of multiple human glucocorticoid receptor isoforms. Ann NY Acad Sci 1024:102-123
    • (2004) Ann NY Acad Sci , vol.1024 , pp. 102-123
    • Lu, N.Z.1    Cidlowski, J.A.2
  • 38
    • 0036206548 scopus 로고    scopus 로고
    • Raised serum levels of interleukin-8 and interleukin-18 in relation to bone metabolism in endogenous Cushing's syndrome
    • Kristo C, Godang K, Ueland T, Lien E, Aukrust P, Froland SS, Bollerslev J 2002 Raised serum levels of interleukin-8 and interleukin-18 in relation to bone metabolism in endogenous Cushing's syndrome. Eur J Endocrinol 146:389-395
    • (2002) Eur J Endocrinol , vol.146 , pp. 389-395
    • Kristo, C.1    Godang, K.2    Ueland, T.3    Lien, E.4    Aukrust, P.5    Froland, S.S.6    Bollerslev, J.7
  • 39
    • 0037372002 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid receptor mobility in living cells: The importance of ligand affinity
    • Schaaf MJ, Cidlowski JA 2003 Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity. Mol Cell Biol 23:1922-1934
    • (2003) Mol Cell Biol , vol.23 , pp. 1922-1934
    • Schaaf, M.J.1    Cidlowski, J.A.2
  • 40
    • 0030026713 scopus 로고    scopus 로고
    • Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
    • Bamberger CM, Schulte HM, Chrousos GP 1996 Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17:245-261
    • (1996) Endocr Rev , vol.17 , pp. 245-261
    • Bamberger, C.M.1    Schulte, H.M.2    Chrousos, G.P.3


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