-
1
-
-
0030921893
-
Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation
-
Steinberg HO, Tarshoby M, Monestel R et al: Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest,1997; 100: 1230-1239 (Pubitemid 27386309)
-
(1997)
Journal of Clinical Investigation
, vol.100
, Issue.5
, pp. 1230-1239
-
-
Steinberg, H.O.1
Tarshoby, M.2
Monestel, R.3
Hook, G.4
Cronin, J.5
Johnson, A.6
Bayazeed, B.7
Baron, A.D.8
-
2
-
-
33749329784
-
Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase
-
DOI 10.2337/db05-1574
-
Wang XL, Zhang L, Youker K et al: Free Fatty Acids Inhibit Insulin Signaling-Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase. Diabetes, 2006; 55: 2301-2310 (Pubitemid 44743628)
-
(2006)
Diabetes
, vol.55
, Issue.8
, pp. 2301-2310
-
-
Xing, L.W.1
Zhang, L.2
Youker, K.3
Zhang, M.-X.4
Wang, J.5
Lemaire, S.A.6
Coselli, J.S.7
Shen, Y.H.8
-
3
-
-
21544462572
-
Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: A summary of theevidence
-
Ford ES: Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of theevidence. Diabetes Care, 2005; 28: 1769-1778
-
(2005)
Diabetes Care
, vol.28
, pp. 1769-1778
-
-
Ford, E.S.1
-
4
-
-
0033927667
-
Cellular mechanisms of insulin resistance
-
Shulman GI: Cellular mechanisms of insulin resistance. Clin Invest,2000; 106: 171-176
-
(2000)
Clin Invest
, vol.106
, pp. 171-176
-
-
Shulman, G.I.1
-
5
-
-
50249160167
-
High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome
-
Rosolova H, Petrlova B, Simon J et al: High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome. Med Sci Monit, 2008; 14(8): CR411-15
-
(2008)
Med Sci Monit
, vol.14
, Issue.8
-
-
Rosolova, H.1
Petrlova, B.2
Simon, J.3
-
6
-
-
0032954778
-
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
-
Dresner A, Laurent D, Marcucci M et al: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest, 1999; 103: 253-259 (Pubitemid 29053143)
-
(1999)
Journal of Clinical Investigation
, vol.103
, Issue.2
, pp. 253-259
-
-
Dresner, A.1
Laurent, D.2
Marcucci, M.3
Griffin, M.E.4
Dufour, S.5
Cline, G.W.6
Slezak, L.A.7
Andersen, D.K.8
Hundal, R.S.9
Rothman, D.L.10
Petersen, K.F.11
Shulman, G.I.12
-
7
-
-
0037219256
-
Intramyocellular lipid and insulin resistance: A longitudinal in vivo 1H-spectroscopic study in Zuckerdiabetic fatty rats
-
Kuhlmann J, Neumann-Haefelin C, Belz U et al: Intramyocellular lipid and insulin resistance: a longitudinal in vivo 1H-spectroscopic study in Zuckerdiabetic fatty rats. Diabetes, 2003; 52: 138-144
-
(2003)
Diabetes
, vol.52
, pp. 138-144
-
-
Kuhlmann, J.1
Neumann-Haefelin, C.2
Belz, U.3
-
8
-
-
0025123408
-
1,2-Diacylglycerol and ceramide. levels in insulin-resistant tissues of the rat in vivo
-
Turinsky J, O'Sullivan DM, Bayly BP: 1,2-Diacylglycerol and ceramide. levels in insulin-resistant tissues of the rat in vivo. J Biol Chem, 1990; 265: 16880-16885
-
(1990)
J Biol Chem
, vol.265
, pp. 16880-16885
-
-
Turinsky, J.1
O'Sullivan, D.M.2
Bayly, B.P.3
-
9
-
-
0031841949
-
Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
-
Summers SA, Garza LA, Zhou H, Birnbaum MJ: Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Molecular AND Cellular Biolog,1998; 18: 5457-5464 (Pubitemid 28388128)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.9
, pp. 5457-5464
-
-
Summers, S.A.1
Garza, L.A.2
Zhou, H.3
Birnbaum, M.J.4
-
10
-
-
0035133331
-
Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells
-
DOI 10.1007/s001250051596
-
Hajduch E, Balendran A, Batty IH et al: Ceramide impairs the insulindependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia, 2001; 44: 173-183 (Pubitemid 32156201)
-
(2001)
Diabetologia
, vol.44
, Issue.2
, pp. 173-183
-
-
Hajduch, E.1
Balendran, A.2
Batty, I.H.3
Litherland, G.J.4
Blair, A.S.5
Downes, C.P.6
Hundal, H.S.7
-
11
-
-
0035513703
-
Ceramide Mediates Insulin Resistance by Tumor Necrosis Factor-{alpha} in Brown Adipocytes by Maintaining Akt in an Inactive Dephosphorylated State
-
Teruel T, Hernandez R, Lorenzo M: Ceramide Mediates Insulin Resistance by Tumor Necrosis Factor-{alpha} in Brown Adipocytes by Maintaining Akt in an Inactive Dephosphorylated State.Diabetes, 2001; 50: 2563-2571
-
(2001)
Diabetes
, vol.50
, pp. 2563-2571
-
-
Teruel, T.1
Hernandez, R.2
Lorenzo, M.3
-
12
-
-
0031964986
-
Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes
-
Wang CN, O'Brien L, Brindley DN: Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes. Diabetes, 1998; 47: 24-31 (Pubitemid 28030803)
-
(1998)
Diabetes
, vol.47
, Issue.1
, pp. 24-31
-
-
Wang, C.-N.1
O'Brien, L.2
Brindley, D.N.3
-
13
-
-
0027437753
-
Diacylglycerol/protein kinase C signalling: A mechanism for insulin resistance?
-
Shmueli E, Alberti KG, Record CO: Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance? Journal of International Medicine, 1993; 234: 397-400
-
(1993)
Journal of International Medicine
, vol.234
, pp. 397-400
-
-
Shmueli, E.1
Alberti, K.G.2
Record, C.O.3
-
14
-
-
0026362778
-
Diacylglycerol-protein kinase C signalling in skeletal muscle: A possible link to insulin resistance
-
Chen KS, Heydrick S, Kurowski T, Ruderman NB: Diacylglycerol-protein kinase C signalling in skeletal muscle: a possible link to insulin resistance. Trans Assoc Am Physicians, 1991; 104: 206-212
-
(1991)
Trans Assoc Am Physicians
, vol.104
, pp. 206-212
-
-
Chen, K.S.1
Heydrick, S.2
Kurowski, T.3
Ruderman, N.B.4
-
15
-
-
0038532298
-
A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids
-
Chavez JA, Knotts TA, Wang L-P et al: A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids. Journal of Biological Chemistry, 2003; 278: 10297-10303
-
(2003)
Journal of Biological Chemistry
, vol.278
, pp. 10297-10303
-
-
Chavez, J.A.1
Knotts, T.A.2
Wang, L.-P.3
-
16
-
-
0141671792
-
Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium
-
Vincent MA, Montagnani M, Michael J: Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium. Current Diabetes Reports, 2003; 3: 279-288 (Pubitemid 38906783)
-
(2003)
Current Diabetes Reports
, vol.3
, Issue.4
, pp. 279-288
-
-
Vincent, M.A.1
Montagnani, M.2
Quon, M.J.3
-
17
-
-
0034603858
-
Roles for insulin receptor, PI3-kinase, and Akt in insulinsignaling pathways related to production of nitric oxide in human vascular endothelial cells
-
Zeng G, Nystrom FH, Ravichandran LV et al: Roles for insulin receptor, PI3-kinase, and Akt in insulinsignaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation, 2000; 101: 1539-1545
-
(2000)
Circulation
, vol.101
, pp. 1539-1545
-
-
Zeng, G.1
Nystrom, F.H.2
Ravichandran, L.V.3
-
18
-
-
85037412903
-
Migration by an Inhibitory Effect on the Akt/Endothelial Nitric Oxide Synthase
-
Dimmeler Z, Dimmeler S, Chavakis E et al: Migration by an Inhibitory Effect on the Akt/Endothelial Nitric Oxide Synthase.Circulation, 2001; 103: 2102-2107
-
(2001)
Circulation
, vol.103
, pp. 2102-2107
-
-
Dimmeler, Z.1
Dimmeler, S.2
Chavakis, E.3
-
19
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt- Dependent phosphorylation
-
DOI 10.1038/21224
-
Dimmeler S, Fleming I, Fisslthaler B et al: Activation of nitric oxide synthase in endothelial cells by Akt-dependentphosphorylation. Nature, 1999; 399: 601-605 (Pubitemid 29279182)
-
(1999)
Nature
, vol.399
, Issue.6736
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
20
-
-
0025296906
-
Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes
-
Svedberg J, Bjorntorp P, Smith U, Lonnroth P: Free fatty acid inhibition of insulin binding, aggregation, and action in isolated rat adipocytes. Diabetes, 1990; 39: 570-574 (Pubitemid 20223782)
-
(1990)
Diabetes
, vol.39
, Issue.5
, pp. 570-574
-
-
Svedberg, J.1
Bjorntorp, P.2
Smith, U.3
Lonnroth, P.4
-
21
-
-
0029840829
-
Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds
-
Nims RW, Cook JC, Krishna MC et al: Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds. Methods Enzymol, 1996; 268: 93-105
-
(1996)
Methods Enzymol
, vol.268
, pp. 93-105
-
-
Nims, R.W.1
Cook, J.C.2
Krishna, M.C.3
-
22
-
-
0037111117
-
Quantitation of yeast ceramides using high-performance liquid chromatography-evaporative light-scattering detection
-
DOI 10.1016/S1570-0232(02)00466-X, PII S157002320200466X
-
Zhou Q, Zhang L, Fu X-Q, Chen G-Q. Quantitation of yeast ceramides using high-performance liquid chromatography-evaporative light-scattering detection. Journal of Chromatography, 2002; 780: 161-169 (Pubitemid 35279755)
-
(2002)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.780
, Issue.1
, pp. 161-169
-
-
Zhou, Q.1
Zhang, L.2
Fu, X.-Q.3
Chen, G.-Q.4
-
23
-
-
0037135536
-
De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway
-
Merrill AH Jr: De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway. J Biol Chem, 2002; 277: 25843-25846
-
(2002)
J Biol Chem
, vol.277
, pp. 25843-25846
-
-
Merrill Jr., A.H.1
-
24
-
-
0037312230
-
Endothelial dysfunction and the metabolicsyndrome
-
McVeigh GE, Cohn JN: Endothelial dysfunction and the metabolicsyndrome. Current Diabetes Reports, 2003; 3: 87-92
-
(2003)
Current Diabetes Reports
, vol.3
, pp. 87-92
-
-
McVeigh, G.E.1
Cohn, J.N.2
-
25
-
-
0035839532
-
1179
-
DOI 10.1074/jbc.M103702200
-
Montagnani M, Chen H, Barr VA, Quon MJ: Insulin-stimulated activation of eNOS is independent of Ca2- but requires phosphorylation by Akt at Ser(1179). Journal of Biological Chemistry, 2001; 276: 30392-30398 (Pubitemid 37385124)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.32
, pp. 30392-30398
-
-
Montagnani, M.1
Chen, H.2
Barr, V.A.3
Quon, M.J.4
-
26
-
-
0029789432
-
Insulin-stimulated production of nitric oxide is inhibited by Wortmannin: Direct measurement in vascular endothelial cells
-
Zeng G, Quon MJ: Insulin-stimulated production of nitric oxide is inhibited by wortmannin: direct measurement in vascular endothelial cells. J Clin Invest, 1996; 98: 894-898 (Pubitemid 26293305)
-
(1996)
Journal of Clinical Investigation
, vol.98
, Issue.4
, pp. 894-898
-
-
Zeng, G.1
Quon, M.J.2
-
27
-
-
0034603858
-
Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide inhuman vascular endothelial cells
-
Zeng G, Nystrom FH, Ravichandran LV et al: Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide inhuman vascular endothelial cells.Circulation, 2002; 101: 1539-1545
-
(2002)
Circulation
, vol.101
, pp. 1539-1545
-
-
Zeng, G.1
Nystrom, F.H.2
Ravichandran, L.V.3
-
28
-
-
0036020513
-
Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells
-
DOI 10.1210/me.2002-0074
-
Montagnani M, Ravichandran LV, Chen H et al: Insulin receptor substrate- 1 and phosphoinositide-dependent kinase-1 are required for insulin- stimulated production of nitric oxide in endothelial cells. Molecular Endocrinology, 2002; 16: 1931-1942 (Pubitemid 34828099)
-
(2002)
Molecular Endocrinology
, vol.16
, Issue.8
, pp. 1931-1942
-
-
Montagnani, M.1
Ravichandran, L.V.2
Chen, H.3
Esposito, D.L.4
Quon, M.J.5
-
29
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt- Dependent phosphorylation
-
DOI 10.1038/21224
-
Dimmeler S, Fleming I, Fisslthaler B et al: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature, 1999; 399: 601-605 (Pubitemid 29279182)
-
(1999)
Nature
, vol.399
, Issue.6736
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
30
-
-
0033588253
-
Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
-
Schmitz-Peiffer C, Craig DL, Biden TJ: Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate. J Biol Chem, 1999; 274: 24202-24210 (Pubitemid 129528468)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.34
, pp. 24202-24210
-
-
Schmitz-Peiffer, C.1
Craig, D.L.2
Biden, T.J.3
-
32
-
-
2342621476
-
Relationship between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle
-
DOI 10.2337/diabetes.53.5.1215
-
Straczkowski M, Kowalska I, Nikolajuk A et al: Relationship Between Insulin Sensitivity and Sphingomyelin Signaling Pathway in Human Skeletal Muscle. Diabetes, 2004; 53: 1215-1221 (Pubitemid 38569006)
-
(2004)
Diabetes
, vol.53
, Issue.5
, pp. 1215-1221
-
-
Straczkowski, M.1
Kowalska, I.2
Nikolajuk, A.3
Dzienis-Straczkowska, S.4
Kinalska, I.5
Baranowski, M.6
Zendzian-Piotrowska, M.7
Brzezinska, Z.8
Gorski, J.9
-
33
-
-
14644417747
-
Ceramide down-regulates System a amino acid transport and protein synthesis in rat skeletal muscle cell-sThe
-
Hyde R, Hajduch E, Powell DJ et al: Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cell-sThe FASEB Journal, 2005; 19: 461-463
-
(2005)
FASEB Journal
, vol.19
, pp. 461-463
-
-
Hyde, R.1
Hajduch, E.2
Powell, D.J.3
|