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Volumn 15, Issue 9, 2009, Pages

Ceramide mediates inhibition of the AKT/eNOS signaling pathway by palmitate in human vascular endothelial cells

Author keywords

Ceramide; HUVEC; Insulin; Nitric oxide synthase (NOS); Palmitate; Signal transduction pathway

Indexed keywords

CERAMIDE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FATTY ACID; INSULIN; NITRIC OXIDE; PALMITIC ACID; PROTEIN KINASE B;

EID: 70349932831     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (31)

References (33)
  • 2
    • 33749329784 scopus 로고    scopus 로고
    • Free fatty acids inhibit insulin signaling-stimulated endothelial nitric oxide synthase activation through upregulating PTEN or inhibiting Akt kinase
    • DOI 10.2337/db05-1574
    • Wang XL, Zhang L, Youker K et al: Free Fatty Acids Inhibit Insulin Signaling-Stimulated Endothelial Nitric Oxide Synthase Activation Through Upregulating PTEN or Inhibiting Akt Kinase. Diabetes, 2006; 55: 2301-2310 (Pubitemid 44743628)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2301-2310
    • Xing, L.W.1    Zhang, L.2    Youker, K.3    Zhang, M.-X.4    Wang, J.5    Lemaire, S.A.6    Coselli, J.S.7    Shen, Y.H.8
  • 3
    • 21544462572 scopus 로고    scopus 로고
    • Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: A summary of theevidence
    • Ford ES: Risks for all-cause mortality, cardiovascular disease, and diabetes associated with the metabolic syndrome: a summary of theevidence. Diabetes Care, 2005; 28: 1769-1778
    • (2005) Diabetes Care , vol.28 , pp. 1769-1778
    • Ford, E.S.1
  • 4
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI: Cellular mechanisms of insulin resistance. Clin Invest,2000; 106: 171-176
    • (2000) Clin Invest , vol.106 , pp. 171-176
    • Shulman, G.I.1
  • 5
    • 50249160167 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome
    • Rosolova H, Petrlova B, Simon J et al: High-sensitivity C-reactive protein and the hypertriglyceridemic waist in patients with type 2 diabetes and metabolic syndrome. Med Sci Monit, 2008; 14(8): CR411-15
    • (2008) Med Sci Monit , vol.14 , Issue.8
    • Rosolova, H.1    Petrlova, B.2    Simon, J.3
  • 7
    • 0037219256 scopus 로고    scopus 로고
    • Intramyocellular lipid and insulin resistance: A longitudinal in vivo 1H-spectroscopic study in Zuckerdiabetic fatty rats
    • Kuhlmann J, Neumann-Haefelin C, Belz U et al: Intramyocellular lipid and insulin resistance: a longitudinal in vivo 1H-spectroscopic study in Zuckerdiabetic fatty rats. Diabetes, 2003; 52: 138-144
    • (2003) Diabetes , vol.52 , pp. 138-144
    • Kuhlmann, J.1    Neumann-Haefelin, C.2    Belz, U.3
  • 8
    • 0025123408 scopus 로고
    • 1,2-Diacylglycerol and ceramide. levels in insulin-resistant tissues of the rat in vivo
    • Turinsky J, O'Sullivan DM, Bayly BP: 1,2-Diacylglycerol and ceramide. levels in insulin-resistant tissues of the rat in vivo. J Biol Chem, 1990; 265: 16880-16885
    • (1990) J Biol Chem , vol.265 , pp. 16880-16885
    • Turinsky, J.1    O'Sullivan, D.M.2    Bayly, B.P.3
  • 9
    • 0031841949 scopus 로고    scopus 로고
    • Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide
    • Summers SA, Garza LA, Zhou H, Birnbaum MJ: Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide. Molecular AND Cellular Biolog,1998; 18: 5457-5464 (Pubitemid 28388128)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.9 , pp. 5457-5464
    • Summers, S.A.1    Garza, L.A.2    Zhou, H.3    Birnbaum, M.J.4
  • 10
    • 0035133331 scopus 로고    scopus 로고
    • Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells
    • DOI 10.1007/s001250051596
    • Hajduch E, Balendran A, Batty IH et al: Ceramide impairs the insulindependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells. Diabetologia, 2001; 44: 173-183 (Pubitemid 32156201)
    • (2001) Diabetologia , vol.44 , Issue.2 , pp. 173-183
    • Hajduch, E.1    Balendran, A.2    Batty, I.H.3    Litherland, G.J.4    Blair, A.S.5    Downes, C.P.6    Hundal, H.S.7
  • 11
    • 0035513703 scopus 로고    scopus 로고
    • Ceramide Mediates Insulin Resistance by Tumor Necrosis Factor-{alpha} in Brown Adipocytes by Maintaining Akt in an Inactive Dephosphorylated State
    • Teruel T, Hernandez R, Lorenzo M: Ceramide Mediates Insulin Resistance by Tumor Necrosis Factor-{alpha} in Brown Adipocytes by Maintaining Akt in an Inactive Dephosphorylated State.Diabetes, 2001; 50: 2563-2571
    • (2001) Diabetes , vol.50 , pp. 2563-2571
    • Teruel, T.1    Hernandez, R.2    Lorenzo, M.3
  • 12
    • 0031964986 scopus 로고    scopus 로고
    • Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes
    • Wang CN, O'Brien L, Brindley DN: Effects of cell-permeable ceramides and tumor necrosis factor-alpha on insulin signaling and glucose uptake in 3T3-L1 adipocytes. Diabetes, 1998; 47: 24-31 (Pubitemid 28030803)
    • (1998) Diabetes , vol.47 , Issue.1 , pp. 24-31
    • Wang, C.-N.1    O'Brien, L.2    Brindley, D.N.3
  • 13
    • 0027437753 scopus 로고
    • Diacylglycerol/protein kinase C signalling: A mechanism for insulin resistance?
    • Shmueli E, Alberti KG, Record CO: Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance? Journal of International Medicine, 1993; 234: 397-400
    • (1993) Journal of International Medicine , vol.234 , pp. 397-400
    • Shmueli, E.1    Alberti, K.G.2    Record, C.O.3
  • 14
    • 0026362778 scopus 로고
    • Diacylglycerol-protein kinase C signalling in skeletal muscle: A possible link to insulin resistance
    • Chen KS, Heydrick S, Kurowski T, Ruderman NB: Diacylglycerol-protein kinase C signalling in skeletal muscle: a possible link to insulin resistance. Trans Assoc Am Physicians, 1991; 104: 206-212
    • (1991) Trans Assoc Am Physicians , vol.104 , pp. 206-212
    • Chen, K.S.1    Heydrick, S.2    Kurowski, T.3    Ruderman, N.B.4
  • 15
    • 0038532298 scopus 로고    scopus 로고
    • A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids
    • Chavez JA, Knotts TA, Wang L-P et al: A Role for Ceramide, but Not Diacylglycerol, in the Antagonism of Insulin Signal Transduction by Saturated Fatty Acids. Journal of Biological Chemistry, 2003; 278: 10297-10303
    • (2003) Journal of Biological Chemistry , vol.278 , pp. 10297-10303
    • Chavez, J.A.1    Knotts, T.A.2    Wang, L.-P.3
  • 16
    • 0141671792 scopus 로고    scopus 로고
    • Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium
    • Vincent MA, Montagnani M, Michael J: Molecular and physiologic actions of insulin related to production of nitric oxide in vascular endothelium. Current Diabetes Reports, 2003; 3: 279-288 (Pubitemid 38906783)
    • (2003) Current Diabetes Reports , vol.3 , Issue.4 , pp. 279-288
    • Vincent, M.A.1    Montagnani, M.2    Quon, M.J.3
  • 17
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulinsignaling pathways related to production of nitric oxide in human vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran LV et al: Roles for insulin receptor, PI3-kinase, and Akt in insulinsignaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation, 2000; 101: 1539-1545
    • (2000) Circulation , vol.101 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3
  • 18
    • 85037412903 scopus 로고    scopus 로고
    • Migration by an Inhibitory Effect on the Akt/Endothelial Nitric Oxide Synthase
    • Dimmeler Z, Dimmeler S, Chavakis E et al: Migration by an Inhibitory Effect on the Akt/Endothelial Nitric Oxide Synthase.Circulation, 2001; 103: 2102-2107
    • (2001) Circulation , vol.103 , pp. 2102-2107
    • Dimmeler, Z.1    Dimmeler, S.2    Chavakis, E.3
  • 19
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt- Dependent phosphorylation
    • DOI 10.1038/21224
    • Dimmeler S, Fleming I, Fisslthaler B et al: Activation of nitric oxide synthase in endothelial cells by Akt-dependentphosphorylation. Nature, 1999; 399: 601-605 (Pubitemid 29279182)
    • (1999) Nature , vol.399 , Issue.6736 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 20
    • 0025296906 scopus 로고
    • Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes
    • Svedberg J, Bjorntorp P, Smith U, Lonnroth P: Free fatty acid inhibition of insulin binding, aggregation, and action in isolated rat adipocytes. Diabetes, 1990; 39: 570-574 (Pubitemid 20223782)
    • (1990) Diabetes , vol.39 , Issue.5 , pp. 570-574
    • Svedberg, J.1    Bjorntorp, P.2    Smith, U.3    Lonnroth, P.4
  • 21
    • 0029840829 scopus 로고    scopus 로고
    • Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds
    • Nims RW, Cook JC, Krishna MC et al: Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds. Methods Enzymol, 1996; 268: 93-105
    • (1996) Methods Enzymol , vol.268 , pp. 93-105
    • Nims, R.W.1    Cook, J.C.2    Krishna, M.C.3
  • 23
    • 0037135536 scopus 로고    scopus 로고
    • De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway
    • Merrill AH Jr: De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway. J Biol Chem, 2002; 277: 25843-25846
    • (2002) J Biol Chem , vol.277 , pp. 25843-25846
    • Merrill Jr., A.H.1
  • 24
    • 0037312230 scopus 로고    scopus 로고
    • Endothelial dysfunction and the metabolicsyndrome
    • McVeigh GE, Cohn JN: Endothelial dysfunction and the metabolicsyndrome. Current Diabetes Reports, 2003; 3: 87-92
    • (2003) Current Diabetes Reports , vol.3 , pp. 87-92
    • McVeigh, G.E.1    Cohn, J.N.2
  • 25
    • 0035839532 scopus 로고    scopus 로고
    • 1179
    • DOI 10.1074/jbc.M103702200
    • Montagnani M, Chen H, Barr VA, Quon MJ: Insulin-stimulated activation of eNOS is independent of Ca2- but requires phosphorylation by Akt at Ser(1179). Journal of Biological Chemistry, 2001; 276: 30392-30398 (Pubitemid 37385124)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.32 , pp. 30392-30398
    • Montagnani, M.1    Chen, H.2    Barr, V.A.3    Quon, M.J.4
  • 26
    • 0029789432 scopus 로고    scopus 로고
    • Insulin-stimulated production of nitric oxide is inhibited by Wortmannin: Direct measurement in vascular endothelial cells
    • Zeng G, Quon MJ: Insulin-stimulated production of nitric oxide is inhibited by wortmannin: direct measurement in vascular endothelial cells. J Clin Invest, 1996; 98: 894-898 (Pubitemid 26293305)
    • (1996) Journal of Clinical Investigation , vol.98 , Issue.4 , pp. 894-898
    • Zeng, G.1    Quon, M.J.2
  • 27
    • 0034603858 scopus 로고    scopus 로고
    • Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide inhuman vascular endothelial cells
    • Zeng G, Nystrom FH, Ravichandran LV et al: Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide inhuman vascular endothelial cells.Circulation, 2002; 101: 1539-1545
    • (2002) Circulation , vol.101 , pp. 1539-1545
    • Zeng, G.1    Nystrom, F.H.2    Ravichandran, L.V.3
  • 28
    • 0036020513 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 and phosphoinositide-dependent kinase-1 are required for insulin-stimulated production of nitric oxide in endothelial cells
    • DOI 10.1210/me.2002-0074
    • Montagnani M, Ravichandran LV, Chen H et al: Insulin receptor substrate- 1 and phosphoinositide-dependent kinase-1 are required for insulin- stimulated production of nitric oxide in endothelial cells. Molecular Endocrinology, 2002; 16: 1931-1942 (Pubitemid 34828099)
    • (2002) Molecular Endocrinology , vol.16 , Issue.8 , pp. 1931-1942
    • Montagnani, M.1    Ravichandran, L.V.2    Chen, H.3    Esposito, D.L.4    Quon, M.J.5
  • 29
    • 0033542476 scopus 로고    scopus 로고
    • Activation of nitric oxide synthase in endothelial cells by Akt- Dependent phosphorylation
    • DOI 10.1038/21224
    • Dimmeler S, Fleming I, Fisslthaler B et al: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature, 1999; 399: 601-605 (Pubitemid 29279182)
    • (1999) Nature , vol.399 , Issue.6736 , pp. 601-605
    • Dimmeler, S.1    Fleming, I.2    Fisslthaler, B.3    Hermann, C.4    Busse, R.5    Zeiher, A.M.6
  • 30
    • 0033588253 scopus 로고    scopus 로고
    • Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate
    • Schmitz-Peiffer C, Craig DL, Biden TJ: Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate. J Biol Chem, 1999; 274: 24202-24210 (Pubitemid 129528468)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.34 , pp. 24202-24210
    • Schmitz-Peiffer, C.1    Craig, D.L.2    Biden, T.J.3
  • 33
    • 14644417747 scopus 로고    scopus 로고
    • Ceramide down-regulates System a amino acid transport and protein synthesis in rat skeletal muscle cell-sThe
    • Hyde R, Hajduch E, Powell DJ et al: Ceramide down-regulates System A amino acid transport and protein synthesis in rat skeletal muscle cell-sThe FASEB Journal, 2005; 19: 461-463
    • (2005) FASEB Journal , vol.19 , pp. 461-463
    • Hyde, R.1    Hajduch, E.2    Powell, D.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.