메뉴 건너뛰기




Volumn 20, Issue 10, 2009, Pages 2127-2137

TβRI independently activates Smad- and CD2AP-dependent pathways in podocytes

Author keywords

[No Author keywords available]

Indexed keywords

CD2 ASSOCIATED PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; CD2-ASSOCIATED PROTEIN; CDKN1A PROTEIN, MOUSE; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOSKELETON PROTEIN; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SMAD2 PROTEIN, MOUSE; SMAD3 PROTEIN, MOUSE; TGF BETA TYPE I RECEPTOR; TGF-BETA TYPE I RECEPTOR;

EID: 70349914263     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2008070806     Document Type: Article
Times cited : (39)

References (41)
  • 1
    • 0030271736 scopus 로고    scopus 로고
    • Regulation of differentiation by TGF-beta
    • Moses HL, Serra R: Regulation of differentiation by TGF-beta. Curr Opin Genet Dev 6: 581-586, 1996
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 581-586
    • Moses, H.L.1    Serra, R.2
  • 4
    • 33644877366 scopus 로고    scopus 로고
    • TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes
    • DOI 10.1681/ASN.2004121055
    • Wu DT, Bitzer M, Ju W, Mundel P, Bottinger EP: TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes. J Am Soc Nephrol 16: 3211-3221, 2005 (Pubitemid 46179327)
    • (2005) Journal of the American Society of Nephrology , vol.16 , Issue.11 , pp. 3211-3221
    • Wu, D.T.1    Bitzer, M.2    Ju, W.3    Mundel, P.4    Bottinger, E.P.5
  • 5
    • 0035071341 scopus 로고    scopus 로고
    • Gene expression profile in streptozotocin-induced diabetic mice kidneys undergoing glomerulosclerosis
    • DOI 10.1046/j.1523-1755.2001.0590041363.x
    • Wada J, Zhang H, Tsuchiyama Y, Hiragushi K, Hida K, Shikata K, Kanwar YS, Makino H: Gene expression profile in streptozotocin-induced diabetic mice kidneys undergoing glomerulosclerosis. Kidney Int 59: 1363-1373, 2001 (Pubitemid 32281224)
    • (2001) Kidney International , vol.59 , Issue.4 , pp. 1363-1373
    • Wada, J.1    Zhang, H.2    Tsuchiyama, Y.3    Hiragushi, K.4    Hida, K.5    Shikata, K.6    Kanwar, Y.S.7    Makino, H.8
  • 6
    • 34250006557 scopus 로고    scopus 로고
    • The spectrum of podocytopathies: A unifying view of glomerular diseases
    • Wiggins RC: The spectrum of podocytopathies: A unifying view of glomerular diseases. Kidney Int 71: 1205-1214, 2007
    • (2007) Kidney Int , vol.71 , pp. 1205-1214
    • Wiggins, R.C.1
  • 7
    • 33745058119 scopus 로고    scopus 로고
    • The podocyte's response to injury: Role in proteinuria and glomerulosclerosis
    • DOI 10.1038/sj.ki.5000410, PII 5000410
    • Shankland SJ: The podocyte's response to injury: Role in proteinuria and glomerulosclerosis. Kidney Int 69: 2131-2147, 2006 (Pubitemid 43882099)
    • (2006) Kidney International , vol.69 , Issue.12 , pp. 2131-2147
    • Shankland, S.J.1
  • 8
    • 34249052234 scopus 로고    scopus 로고
    • TGF-beta in renal injury and disease
    • Bottinger EP: TGF-beta in renal injury and disease. Semin Nephrol 27: 309-320, 2007
    • (2007) Semin Nephrol , vol.27 , pp. 309-320
    • Bottinger, E.P.1
  • 9
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • DOI 10.1038/nature02006
    • Derynck R, Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425: 577-584, 2003 (Pubitemid 37280136)
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 10
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-beta signaling from cell membrane to the nucleus
    • DOI 10.1016/S0092-8674(03)00432-X
    • Shi Y, Massague J: Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 113: 685-700, 2003 (Pubitemid 36724933)
    • (2003) Cell , vol.113 , Issue.6 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 11
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signalling
    • ten Dijke P, Hill CS: New insights into TGF-beta-Smad signalling. Trends Biochem Sci 29: 265-273, 2004
    • (2004) Trends Biochem Sci , vol.29 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 13
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas A, Heldin CH: Non-Smad TGF-beta signals. J Cell Sci 118: 3573-3584, 2005
    • (2005) J Cell Sci , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 16
    • 0034023127 scopus 로고    scopus 로고
    • Role of Ras and MAPKs in TGFbeta signaling
    • Mulder KM: Role of Ras and MAPKs in TGFbeta signaling. Cytokine Growth Factor Rev 11: 23-35, 2000
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 23-35
    • Mulder, K.M.1
  • 17
    • 34548386720 scopus 로고    scopus 로고
    • TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
    • DOI 10.1038/sj.emboj.7601818, PII 7601818
    • Lee MK, Pardoux C, Hall MC, Lee PS, Warburton D, Qing J, Smith SM, Derynck R: TGF-beta activates ERK MAP kinase signalling through direct phosphorylation of ShcA. EMBO J 26: 3957-3967, 2007 (Pubitemid 47367487)
    • (2007) EMBO Journal , vol.26 , Issue.17 , pp. 3957-3967
    • Lee, M.K.1    Pardoux, C.2    Hall, M.C.3    Lee, P.S.4    Warburton, D.5    Qing, J.6    Smith, S.M.7    Derynck, R.8
  • 18
    • 28544450380 scopus 로고    scopus 로고
    • Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2
    • DOI 10.1158/0008-5472.CAN-05-1522
    • Wilkes MC, Mitchell H, Penheiter SG, Dore JJ, Suzuki K, Edens M, Sharma DK, Pagano RE, Leof EB: Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res 65: 10431-10440, 2005 (Pubitemid 41743737)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10431-10440
    • Wilkes, M.C.1    Mitchell, H.2    Penheiter, S.G.3    Dore, J.J.4    Suzuki, K.5    Edens, M.6    Sharma, D.K.7    Pagano, R.E.8    Leof, E.B.9
  • 19
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol-3 kinase function is required for TGFbeta-mediated epithelial to mesenchymal transition and cell migration
    • Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL: Phosphatidylinositol-3 kinase function is required for TGFbeta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-36810, 2000
    • (2000) J Biol Chem , vol.275 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 20
    • 4344685529 scopus 로고    scopus 로고
    • A novel role for the adaptor molecule CD2-associated protein in TGF-beta-induced apoptosis
    • Schiffer M, Mundel P, Shaw AS, Bottinger EP: A novel role for the adaptor molecule CD2-associated protein in TGF-beta-induced apoptosis. J Biol Chem 279: 37004-37012, 2004
    • (2004) J Biol Chem , vol.279 , pp. 37004-37012
    • Schiffer, M.1    Mundel, P.2    Shaw, A.S.3    Bottinger, E.P.4
  • 22
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • Massague J, Chen YG: Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 23
    • 0031563832 scopus 로고    scopus 로고
    • Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
    • DOI 10.1006/excr.1997.3739
    • Mundel P, Reiser J, Zuniga Mejia BA, Pavenstadt H, Davidson GR, Kriz W, Zeller R: Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines. Exp Cell Res 236: 248-258, 1997 (Pubitemid 27452369)
    • (1997) Experimental Cell Research , vol.236 , Issue.1 , pp. 248-258
    • Mundel, P.1    Reiser, J.2    Borja, A.Z.M.3    Pavenstadt, H.4    Davidson, G.R.5    Kriz, W.6    Zeller, R.7
  • 24
    • 0035816691 scopus 로고    scopus 로고
    • Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target Gene
    • DOI 10.1074/jbc.M102678200
    • Gineitis D, Treisman R: Differential usage of signal transduction pathways defines two types of serum response factor target gene. J Biol Chem 276: 24531-24539, 2001 (Pubitemid 37412916)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.27 , pp. 24531-24539
    • Gineitis, D.1    Treisman, R.2
  • 26
    • 0034665274 scopus 로고    scopus 로고
    • SRF-dependent gene expression is required for P13-kinase-regulated cell proliferation
    • Poser S, Impey S, Trinh K, Xia Z, Storm DR: SRF-dependent gene expression is required for PI3-kinase-regulated cell proliferation. EMBO J 19: 4955-4966, 2000 (Pubitemid 30727352)
    • (2000) EMBO Journal , vol.19 , Issue.18 , pp. 4955-4966
    • Poser, S.1    Impey, S.2    Trinh, K.3    Xia, Z.4    Storm, D.R.5
  • 28
    • 4544262684 scopus 로고    scopus 로고
    • Mammalian target of rapamycin and 3-phosphatidylinositol 3-kinase pathway inhibition enhances growth inhibition of transforming growth factor-beta1 in prostate cancer cells
    • van der Poel HG: Mammalian target of rapamycin and 3-phosphatidylinositol 3-kinase pathway inhibition enhances growth inhibition of transforming growth factor-beta1 in prostate cancer cells. J Urol 172: 1333-1337, 2004
    • (2004) J Urol , vol.172 , pp. 1333-1337
    • Van Der Poel, H.G.1
  • 31
    • 33745220527 scopus 로고    scopus 로고
    • Differential interactions between transforming growth factor-beta3/ TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and sertoli-germ cell adhesion
    • DOI 10.1074/jbc.M601618200
    • Xia W, Mruk DD, Lee WM, Cheng CY: Differential interactions between transforming growth factor-beta3/TbetaR1, TAB1, and CD2AP disrupt blood-testis barrier and Sertoli-germ cell adhesion. J Biol Chem 281: 16799-16813, 2006 (Pubitemid 43909636)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.24 , pp. 16799-16813
    • Xia, W.1    Mruk, D.D.2    Lee, W.M.3    Cheng, C.Y.4
  • 32
    • 0023676353 scopus 로고
    • Transforming growth factor beta: Potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells
    • Arteaga CL, Tandon AK, Von Hoff DD, Osborne CK: Transforming growth factor beta: Potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells. Cancer Res 48: 3898-3904, 1988
    • (1988) Cancer Res , vol.48 , pp. 3898-3904
    • Arteaga, C.L.1    Tandon, A.K.2    Von Hoff, D.D.3    Osborne, C.K.4
  • 33
    • 15444372825 scopus 로고    scopus 로고
    • Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase
    • DOI 10.1074/jbc.M413223200
    • Yi JY, Shin I, Arteaga CL: Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 280: 10870-10876, 2005 (Pubitemid 40395952)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 10870-10876
    • Jae, Y.Y.1    Shin, I.2    Arteaga, C.L.3
  • 34
    • 33748709227 scopus 로고    scopus 로고
    • Expression profile of nephrin, podocin, and CD2AP in Chinese children with MCNS and IgA nephropathy
    • DOI 10.1007/s00467-006-0218-z
    • Mao J, Zhang Y, Du L, Dai Y, Yang C, Liang L: Expression profile of nephrin, podocin, and CD2AP in Chinese children with MCNS and IgA nephropathy. Pediatr Nephrol 21: 1666-1675, 2006 (Pubitemid 44390831)
    • (2006) Pediatric Nephrology , vol.21 , Issue.11 , pp. 1666-1675
    • Mao, J.1    Zhang, Y.2    Du, L.3    Dai, Y.4    Yang, C.5    Liang, L.6
  • 35
    • 0038136885 scopus 로고    scopus 로고
    • CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility
    • DOI 10.1126/science.1081068
    • Kim JM, Wu H, Green G, Winkler CA, Kopp JB, Miner JH, Unanue ER, Shaw AS: CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. Science 300: 1298-1300, 2003 (Pubitemid 36618242)
    • (2003) Science , vol.300 , Issue.5623 , pp. 1298-1300
    • Kim, J.H.1    Wu, H.2    Green, G.3    Winkler, C.A.4    Kopp, J.B.5    Miner, J.H.6    Unanue, E.R.7    Shawl, A.S.8
  • 37
    • 0033104503 scopus 로고    scopus 로고
    • Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    • Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, Roberts AB, Deng C: Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J 18: 1280-1291, 1999 (Pubitemid 29110312)
    • (1999) EMBO Journal , vol.18 , Issue.5 , pp. 1280-1291
    • Yang, X.1    Letterio, J.J.2    Lechleider, R.J.3    Chen, L.4    Hayman, R.5    Gu, H.6    Roberts, A.B.7    Deng, C.8
  • 38
    • 0035191415 scopus 로고    scopus 로고
    • CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain
    • Shih NY, Li J, Cotran R, Mundel P, Miner JH, Shaw AS: CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain. Am J Pathol 159: 2303-2308, 2001 (Pubitemid 33104283)
    • (2001) American Journal of Pathology , vol.159 , Issue.6 , pp. 2303-2308
    • Shi, N.-Y.1    Li, J.2    Cotran, R.3    Mundel, P.4    Miner, J.H.5    Shaw, A.S.6
  • 39
    • 0029022221 scopus 로고
    • GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex
    • Wieser R, Wrana JL, Massague J: GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J 14: 2199-2208, 1995
    • (1995) EMBO J , vol.14 , pp. 2199-2208
    • Wieser, R.1    Wrana, J.L.2    Massague, J.3
  • 40
    • 23844523455 scopus 로고    scopus 로고
    • CD2AP expression in a renal ischemia/reperfusion injury model and analysis of its related genes using overexpression and RNA interference technique
    • DOI 10.1159/000087209
    • Nishimura S, Yoshida T, Sugiura H, Shirota S, Tsuchiya K, Nihei H: CD2AP expression in a renal ischemia/reperfusion injury model and analysis of its related genes using overexpression and RNA interference technique. Am J Nephrol 25: 373-381, 2005 (Pubitemid 41160996)
    • (2005) American Journal of Nephrology , vol.25 , Issue.4 , pp. 373-381
    • Nishimura, S.1    Yoshida, T.2    Sugiura, H.3    Shirota, S.4    Tsuchiya, K.5    Nihei, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.