Selective identification of cooperatively binding fragments in a high-throughput ligation assay enables development of a picomolar caspase-3 inhibitor

Angewandte Chemie - International Edition

Volumn 48, Issue 34, 2009, Pages 6346-6349

  Schmidt, Marco F ^a,b   El Dahshan, Adeeb ^a,b   Keller, Sandro ^a   Rademann, Jörg ^a,b  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Caspase 3; Drug discovery; Fluorescence polarization; High throughput screening; Protease inhibitors

Indexed keywords

CASPASE-3; DRUG DISCOVERY; FLUORESCENCE POLARIZATION; HIGH-THROUGHPUT SCREENING; PROTEASE INHIBITORS;

POLARIZATION;

FLUORESCENCE;

ALDEHYDE; CASPASE 3; CYSTEINE PROTEINASE INHIBITOR;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG SCREENING; FLUORESCENCE POLARIZATION; METABOLISM; PROTEIN BINDING;

ALDEHYDES; CASPASE 3; CYSTEINE PROTEINASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; FLUORESCENCE POLARIZATION; PROTEIN BINDING;

EID: 70349907092     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200901647     Document Type: Article

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