The potential of P1 site alterations in peptidomimetic protease inhibitors as suggested by virtual screening and explored by the use of C-C-coupling reagents.

ChemMedChem

Volumn 1, Issue 4, 2006, Pages 445-457

  Weik, Steffen ^a   Luksch, Torsten ^a   Evers, Andreas ^a   Böttcher, Jark ^a   Sotriffer, Christoph A ^a   Hasilik, Andrej ^a   Löffler, Hans Gerhard ^a   Klebe, Gerhard ^a   Rademann, Jörg ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 HYDROXY 5 METHYLHEXANOIC ACID; 3-AMINO-2-HYDROXY-5-METHYLHEXANOIC ACID; AMINOCAPROIC ACID DERIVATIVE; ASPARTIC PROTEINASE; CATHEPSIN D; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; PLASMEPSIN II; PROTEINASE; PROTEINASE INHIBITOR;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; MOLECULAR MIMICRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STEREOISOMERISM;

AMINOCAPROIC ACIDS; ASPARTIC ENDOPEPTIDASES; CATHEPSIN D; HIV PROTEASE; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR MIMICRY; PROTEASE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM;

EID: 33750613785     PISSN: 18607179     EISSN: None     Source Type: Journal    
DOI: 10.1002/cmdc.200500027     Document Type: Article

References (0)