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Volumn , Issue , 2008, Pages 291-302

Mining metabolic networks for optimal drug targets

Author keywords

[No Author keywords available]

Indexed keywords

BRANCH-AND-BOUND ALGORITHMS; DAMAGE MODEL; DRUG TARGETS; EXHAUSTIVE SEARCH; FILTERING STRATEGIES; GRAPH-BASED; IDENTIFICATION PROBLEM; LOWER BOUNDS; METABOLIC NETWORK; OPTIMAL SOLUTIONS; OPTIMIZATION PROBLEMS; ORDERS OF MAGNITUDE; SEARCH SPACES; SEARCH TIME; SIDE EFFECT; TARGET COMPOUND; UPPER BOUND;

EID: 40549083075     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper
Times cited : (48)

References (31)
  • 2
    • 1242319556 scopus 로고    scopus 로고
    • The metabolic world of Escherichia coli is not small
    • Feb
    • Masanori AritA. The metabolic world of Escherichia coli is not small. PNAS, 101(6):1543-1547, Feb 2004.
    • (2004) PNAS , vol.101 , Issue.6 , pp. 1543-1547
    • Masanori Arit, A.1
  • 3
    • 0028896231 scopus 로고
    • Release of glutamate from striatum of freely moving rats by pros-methylimidazoleacetic acid
    • P. Blandina and G. Cherici et al. Release of glutamate from striatum of freely moving rats by pros-methylimidazoleacetic acid. Journal of Neurochemistry, 64(2):788-793, 1995.
    • (1995) Journal of Neurochemistry , vol.64 , Issue.2 , pp. 788-793
    • Blandina, P.1    Cherici, G.2
  • 4
    • 0034077507 scopus 로고    scopus 로고
    • Sequencing the entire genomes of free-living organisms: The foundation of pharmacology in the new millennium
    • Apr
    • Samuel Broder and J. Craig Venter. Sequencing the Entire Genomes of Free-Living Organ-isms: The Foundation of Pharmacology in the New Millennium. Annual Review of Pharma-cology and Toxicology, 40:97-132, Apr 2000.
    • (2000) Annual Review of Pharma-cology and Toxicology , vol.40 , pp. 97-132
    • Broder, S.1    Craig Venter, J.2
  • 5
    • 0037441560 scopus 로고    scopus 로고
    • Fulfilling the promise: Drug discovery in the post-genomic erA
    • Feb
    • Sumit K. Chanda and Jeremy S. Caldwell. Fulfilling the promise: drug discovery in the post-genomic erA. Drug Discovery Today, 8(4):168-174, Feb 2003.
    • (2003) Drug Discovery Today , vol.8 , Issue.4 , pp. 168-174
    • Chanda, S.K.1    Caldwell, J.S.2
  • 6
    • 0022470755 scopus 로고
    • Why is uncompetitive inhibition so rare?: A possible explanation with implications for the design of drugs and pesticides
    • 3-6 Jul
    • A. Cornish-Bowden. Why is uncompetitive inhibition so rare?: A possible explanation, with implications for the design of drugs and pesticides. FEBS Letters, 203(1):3-6, Jul 1986.
    • (1986) FEBS Letters , vol.203 , Issue.1
    • Cornish-Bowden, A.1
  • 7
    • 0036304317 scopus 로고    scopus 로고
    • The role of stoichiometric analysis in studies of metabolism: An example
    • May
    • A. Cornish-Bowden and J. S. Hofmeyr. The Role of Stoichiometric Analysis in Studies of Metabolism: An Example. Journal of Theoretical Biology, 216: 179-191, May 2002.
    • (2002) Journal of Theoretical Biology , vol.216 , pp. 179-191
    • Cornish-Bowden, A.1    Hofmeyr, J.S.2
  • 8
    • 0037441522 scopus 로고    scopus 로고
    • Advancing drug discovery through systems biology
    • Feb
    • Eugene J. Davidov, Joanne M. Holland, Edward W. Marple, and Stephen Naylor. Advancing drug discovery through systems biology. Drug Discovery Today, 8(4):175-1 83, Feb 2003.
    • (2003) Drug Discovery Today , vol.8 , Issue.4 , pp. 175-183
    • Eugene, J.D.1    Joanne, M.H.2    Marple, E.W.3    Naylor, S.4
  • 9
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • Mar
    • J Drews. Drug Discovery: A Historical Perspective. Science, 287(5460): 1960-1964. Mar 2000.
    • (2000) Science , vol.287 , Issue.5460 , pp. 1960-1964
    • Drews, J.1
  • 11
    • 18744380689 scopus 로고    scopus 로고
    • Investigating metabolite essentiality through genome scale analysis of E. coli production capabilities
    • Jan
    • 1I. Marcin Imielinski, Calin Belta, Adam Halasz, and Harvey Rubin. Investigating metabolite essentiality through genome scale analysis of E. coli production capabilities. Bioinformatics, Jan 2005.
    • (2005) Bioinformatics
    • Marcin Imielinski, I.1    Belta, C.2    Halasz, A.3    Rubin, H.4
  • 12
    • 33746616957 scopus 로고    scopus 로고
    • Computational strategy for discovering druggable gene networks from genome-wide rna expression profiles
    • S. Imoto and Y. Tamada et. al. Computational Strategy for Discovering Druggable Gene Networks from Genome-Wide RNA Expression Profiles. In PSE, 2006.
    • (2006) PSE
    • Imoto, S.1    Tamada, Y.2
  • 14
    • 0012624911 scopus 로고    scopus 로고
    • Prediction of protein essen-tiality based on genomic data
    • Hawoong Jeong, Zoltan N. Oltvai, and Albert-Laszlo Barabasi. Prediction of Protein Essen-tiality Based on Genomic DatA. ComPlexUs, 1:19-28, 2003.
    • (2003) Com PlexUs , vol.1 , pp. 19-28
    • Jeong, H.1    Oltvai, Z.N.2    Albert-Laszlo, B.3
  • 15
    • 0033982936 scopus 로고    scopus 로고
    • KEGG: Kyoto encyclopedia of genes and genomes
    • Jan
    • M Kanehisa and S Goto. KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res., 28(1):27-30, Jan 2000.
    • (2000) Nucleic Acids Res , vol.28 , Issue.1 , pp. 27-30
    • Kanehisa, M.1    Goto, S.2
  • 18
    • 4444234772 scopus 로고    scopus 로고
    • Decomposition of metabolic network into functional modules based on the global connectivity structure of reaction graph
    • Hong-Wu Ma, Xue-Ming Zhao, Ying-Jin Yuan, and An-Ping Zeng. Decomposition of metabolic network into functional modules based on the global connectivity structure of reaction graph. Eioinformatics, 20( 12): 1870-1 876, 2004.
    • (2004) Eioinformatics , vol.20 , Issue.12 , pp. 1870-1876
    • Hong-Wu, M.A.1    Zhao, X.2    Yuan, Y.3    Zeng, A.4
  • 19
    • 84872961987 scopus 로고    scopus 로고
    • Bioinformatics analysis of mycoplasma metabolism: Important enzymes, metabolic similarities, and redundancy
    • J. C. Mombach and N. Lemke et al. Bioinformatics analysis of mycoplasma metabolism: Important enzymes, metabolic similarities, and redundancy. Computers in Biology and Medicine, 2005.
    • (2005) Computers in Biology and Medicine
    • Mombach, J.C.1    Lemke, N.2
  • 20
    • 0036333553 scopus 로고    scopus 로고
    • Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity
    • Sep
    • M. T. A. Ocampo and W. Chaung et. al. Targeted deletion of mNth1 reveals a novel DNA repair enzyme activity. Mol Cell Bid, 22(17):6111-21, Sep 2002.
    • (2002) Mol Cell Bid , vol.22 , Issue.17 , pp. 6111-6121
    • Ocampo, M.T.A.1    Chaung Et. Al., W.2
  • 21
    • 0025773131 scopus 로고
    • Levels of pros-methylimidazoleacetic acid: Correlation with seventy of Parkinson's disease in CSF of patients and with the depletion of striatal dopamine and its metabolites in MPTP-treated mice
    • G. D. Prell, J. K. Khandelwal, R. S. Burns, P. Blandina, A. M. Momshow, and J. P. Green. Levels of pros-methylimidazoleacetic acid: Correlation with seventy of Parkinson's disease in CSF of patients and with the depletion of striatal dopamine and its metabolites in MPTP-treated mice. Journal of Neural Transmission, 3(2): 1435-1463, 1991.
    • (1991) Journal of Neural Transmission , vol.3 , Issue.2 , pp. 1435-1463
    • Prell, G.D.1    Khandelwal, J.K.2    Burns, R.S.3    Blandina, P.4    Momshow, A.M.5    Green, J.P.6
  • 22
    • 34248570465 scopus 로고    scopus 로고
    • Dunford. Anti-inflammatory activity of a potent, selec-tive leukotriene A4 hydrolase inhibitor in comparison with the 5-lipoxygenase inhibitor zileuton
    • Navin L. Rao and Paul J. et al. Dunford. Anti-Inflammatory Activity of a Potent, Selec-tive Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton. J Pharmacol Exp Ther, 321(3):1154-1160, 2007.
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.3 , pp. 1154-1160
    • Rao, N.L.1    Paul, J.2
  • 23
    • 0037457250 scopus 로고    scopus 로고
    • Hitting the target
    • Mar
    • C Smith. Hitting the target. Nature, 422:341-347, Mar 2003.
    • (2003) Nature , vol.422 , pp. 341-347
    • Smith, C.1
  • 24
    • 0002054202 scopus 로고    scopus 로고
    • Modeling the complexity of genetic networks: Understand-ing multi-gene and pleiotropic regulation
    • R. Somogyi and C. A. Sniegoski. Modeling the complexity of genetic networks: Understand-ing multi-gene and pleiotropic regulation. Complexig, 1:45-63, 1996.
    • (1996) Complexig , vol.1 , pp. 45-63
    • Somogyi, R.1    Sniegoski, C.A.2
  • 25
    • 38449123881 scopus 로고    scopus 로고
    • An iterative algorithm for metabolic network-based drug target identification
    • Padmavati Sridhar, Tamer Kahveci, and Sanjay RankA. An iterative algorithm for metabolic network-based drug target identification. In PSE, volume 12, pages 88-99. 2007.
    • (2007) PSE , vol.12 , pp. 88-99
    • Sridhar, P.1    Kahveci, T.2    Sanjay, R.A.3
  • 27
    • 0034792736 scopus 로고    scopus 로고
    • Classical vs reverse pharmacology in drug discovery
    • Sep
    • T. Takenak. Classical vs reverse pharmacology in drug discovery. BJU International, 88(2):7-10, Sep 2001.
    • (2001) BJU International , vol.88 , Issue.2 , pp. 7-10
    • Takenak, T.1
  • 28
    • 0035943351 scopus 로고    scopus 로고
    • The evolution and structural anatomy of the small molecule metabolic pathways in escherichia coli
    • S. A. Teichmann and S. C. G. Rison et al. The Evolution and Structural Anatomy of the Small Molecule Metabolic Pathways in Escherichia coli. JME, 31 1:693-708, 2001.
    • (2001) JME , vol.31 , Issue.1 , pp. 693-708
    • Teichmann, S.A.1    Rison, S.C.G.2
  • 29
    • 0035658329 scopus 로고    scopus 로고
    • LTC4-synthase A-444C polymorphism: Lack of association with NSAID-induced isolated periorbital angioedema in a Spanish population
    • M. J. Torres-Galvan and N. Ortega et al. LTC4-synthase A-444C polymorphism: lack of association with NSAID-induced isolated periorbital angioedema in a Spanish population. Ann Allergy Asthma Immunol., 87(6):506-10, 2001.
    • (2001) Ann Allergy Asthma Immunol , vol.87 , Issue.6 , pp. 506-510
    • Torres-Galvan, M.J.1    Ortega Et Al., N.2
  • 30
    • 0037092610 scopus 로고    scopus 로고
    • How to escape the bottleneck of medicinal chemistry
    • May
    • Gunther Wess. How to escape the bottleneck of medicinal chemistry. Drug Discovery Today, 7(10):533-535, May 2002.
    • (2002) Drug Discovery Today , vol.7 , Issue.10 , pp. 533-535
    • Gunther, W.1
  • 31
    • 2442636351 scopus 로고    scopus 로고
    • Computational Analysis of Plasmodium falciparum Metabolism: Organizing Genomic Information to Facilitate Drug Discovery
    • I. Yeh and T. Hanekamp et al. Computational Analysis of Plasmodium falciparum Metabolism: Organizing Genomic Information to Facilitate Drug Discovery. Genome Re-search. 14:917-924. 2004.
    • (2004) Genome Re-search , vol.14 , pp. 917-924
    • Yeh, I.1    Hanekamp, T.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.