-
1
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker, B. J., Talpaz, M., Resta, D. J., Peng, B., Buchdunger, E., Ford, J. M., Lydon, N. B., Kantarjian, H., Capdeville, R., Ohno-Jones, S., and Sawyers, C. L. (2001) Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344, 1031-1037
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
2
-
-
10744233716
-
-
O'Brien, S. G., Guilhot, F., Larson, R. A., Gathmann, I., Baccarani, M., Cervantes, F., Cornelissen, J. J., Fischer, T., Hochhaus, A., Hughes, T., Lechner, K., Nielsen, J. L., Rousselot, P., Reiffers, J., Saglio, G., Shepherd, J., Simonsson, B., Gratwohl, A., Goldman, J. M., Kantarjian, H., Taylor, K., Verhoef, G., Bolton, A. E., Capdeville, R., Druker, B. J., and the IRIS Investigators (2003) Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994-1004
-
O'Brien, S. G., Guilhot, F., Larson, R. A., Gathmann, I., Baccarani, M., Cervantes, F., Cornelissen, J. J., Fischer, T., Hochhaus, A., Hughes, T., Lechner, K., Nielsen, J. L., Rousselot, P., Reiffers, J., Saglio, G., Shepherd, J., Simonsson, B., Gratwohl, A., Goldman, J. M., Kantarjian, H., Taylor, K., Verhoef, G., Bolton, A. E., Capdeville, R., Druker, B. J., and the IRIS Investigators (2003) Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N. Engl. J. Med. 348, 994-1004
-
-
-
-
3
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
Demetri, G. D., von Mehren, M., Blanke, C. D., Van den Abbeele, A. D., Eisenberg, B., Roberts, P. J., Heinrich, M. C., Tuveson, D. A., Singer, S., Janicek, M., Fletcher, J. A., Silverman, S. G., Silberman, S. L., Capdeville, R., Kiese, B., Peng, B., Dimitrijevic, S., Druker, B. J., Corless, C., Fletcher, C. D., and Joensuu, H. (2002) Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. 347, 472-480
-
(2002)
N. Engl. J. Med
, vol.347
, pp. 472-480
-
-
Demetri, G.D.1
von Mehren, M.2
Blanke, C.D.3
Van den Abbeele, A.D.4
Eisenberg, B.5
Roberts, P.J.6
Heinrich, M.C.7
Tuveson, D.A.8
Singer, S.9
Janicek, M.10
Fletcher, J.A.11
Silverman, S.G.12
Silberman, S.L.13
Capdeville, R.14
Kiese, B.15
Peng, B.16
Dimitrijevic, S.17
Druker, B.J.18
Corless, C.19
Fletcher, C.D.20
Joensuu, H.21
more..
-
4
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon, D. J., Leyland-Jones, B., Shak, S., Fuchs, H., Paton, V., Bajamonde, A., Fleming, T., Eiermann, W., Wolter, J., Pegram, M., Baselga, J., and Norton, L. (2001) Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792
-
(2001)
N. Engl. J. Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
5
-
-
26844536978
-
-
Romond, E. H., Perez, E. A., Bryant, J., Suman, V. J., Geyer, C. E., Jr., Davidson, N. E., Tan-Chiu, E., Martino, S., Paik, S., Kaufman, P. A., Swain, S. M., Pisansky, T. M., Fehrenbacher, L., Kutteh, L. A., Vogel, V. G., Visscher, D. W., Yothers, G., Jenkins, R. B., Brown, A. M., Dakhil, S. R., Mamounas, E. P., Lingle, W. L., Klein, P. M., Ingle, J. N., and Wolmark, N. (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer N. Engl. J. Med. 353, 1673-1684
-
Romond, E. H., Perez, E. A., Bryant, J., Suman, V. J., Geyer, C. E., Jr., Davidson, N. E., Tan-Chiu, E., Martino, S., Paik, S., Kaufman, P. A., Swain, S. M., Pisansky, T. M., Fehrenbacher, L., Kutteh, L. A., Vogel, V. G., Visscher, D. W., Yothers, G., Jenkins, R. B., Brown, A. M., Dakhil, S. R., Mamounas, E. P., Lingle, W. L., Klein, P. M., Ingle, J. N., and Wolmark, N. (2005) Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer N. Engl. J. Med. 353, 1673-1684
-
-
-
-
6
-
-
26844503270
-
-
Piccart-Gebhart, M. J., Procter, M., Leyland-Jones, B., Goldhirsch, A., Untch, M., Smith, I., Gianni, L., Baselga, J., Bell, R., Jackisch, C., Cameron, D., Dowsett, M., Barrios, C. H., Steger, G., Huang, C.-S., Andersson, M., Inbar, M., Lichinitser, M., Lang, I., Nitz, U., Iwata, H., Thomssen, C., Lohrisch, C., Suter, T. M., Ruschoff, J., Suto, T., Greatorex, V., Ward, C., Straehle, C., McFadden, E., Dolci, M. S., Gelber, R. D., and the Herceptin Adjuvant (HERA) Trial Study Team (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. 353, 1659-1672
-
Piccart-Gebhart, M. J., Procter, M., Leyland-Jones, B., Goldhirsch, A., Untch, M., Smith, I., Gianni, L., Baselga, J., Bell, R., Jackisch, C., Cameron, D., Dowsett, M., Barrios, C. H., Steger, G., Huang, C.-S., Andersson, M., Inbar, M., Lichinitser, M., Lang, I., Nitz, U., Iwata, H., Thomssen, C., Lohrisch, C., Suter, T. M., Ruschoff, J., Suto, T., Greatorex, V., Ward, C., Straehle, C., McFadden, E., Dolci, M. S., Gelber, R. D., and the Herceptin Adjuvant (HERA) Trial Study Team (2005) Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. 353, 1659-1672
-
-
-
-
7
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer, R. J., Michaelson, M. D., Redman, B. G., Hudes, G. R., Wilding, G., Figlin, R. A., Ginsberg, M. S., Kim, S. T., Baum, C. M., DePrimo, S. E., Li, J. Z., Bello, C. L., Theuer, C. P., George, D. J., and Rini, B. I. (2006) Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 16-24
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
DePrimo, S.E.10
Li, J.Z.11
Bello, C.L.12
Theuer, C.P.13
George, D.J.14
Rini, B.I.15
-
8
-
-
33744984843
-
Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma
-
Ratain, M. J., Eisen, T., Stadler, W. M., Flaherty, K. T., Kaye, S. B., Rosner, G. L., Gore, M., Desai, A. A., Patnaik, A., Xiong, H. Q., Rowinsky, E., Abbruzzese, J. L., Xia, C., Simantov, R., Schwartz, B., and O'Dwyer, P. J. (2006) Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 24, 2505-2512
-
(2006)
J. Clin. Oncol
, vol.24
, pp. 2505-2512
-
-
Ratain, M.J.1
Eisen, T.2
Stadler, W.M.3
Flaherty, K.T.4
Kaye, S.B.5
Rosner, G.L.6
Gore, M.7
Desai, A.A.8
Patnaik, A.9
Xiong, H.Q.10
Rowinsky, E.11
Abbruzzese, J.L.12
Xia, C.13
Simantov, R.14
Schwartz, B.15
O'Dwyer, P.J.16
-
9
-
-
33750284658
-
In melanoma, RAS mutations are accompanied by switching signaling from BRaf to CRaf and disrupted cyclic AMP signaling
-
Dumaz, N., Hayward, R., Martin, J., Ogilvie, L., Hedley, D., Curtin, J. A., Bastian, B. C., Springer, C., and Marais, R. (2006) In melanoma, RAS mutations are accompanied by switching signaling from BRaf to CRaf and disrupted cyclic AMP signaling. Cancer Res. 66, 9483-9491
-
(2006)
Cancer Res
, vol.66
, pp. 9483-9491
-
-
Dumaz, N.1
Hayward, R.2
Martin, J.3
Ogilvie, L.4
Hedley, D.5
Curtin, J.A.6
Bastian, B.C.7
Springer, C.8
Marais, R.9
-
10
-
-
18444374405
-
-
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C. J., Wooster, R., Stratton, M. R., and Futreal, P. A. (2002) Mutations of the BRaf gene in human cancer. Nature 417, 949-954
-
Davies, H., Bignell, G. R., Cox, C., Stephens, P., Edkins, S., Clegg, S., Teague, J., Woffendin, H., Garnett, M. J., Bottomley, W., Davis, N., Dicks, E., Ewing, R., Floyd, Y., Gray, K., Hall, S., Hawes, R., Hughes, J., Kosmidou, V., Menzies, A., Mould, C., Parker, A., Stevens, C., Watt, S., Hooper, S., Wilson, R., Jayatilake, H., Gusterson, B. A., Cooper, C., Shipley, J., Hargrave, D., Pritchard-Jones, K., Maitland, N., Chenevix-Trench, G., Riggins, G. J., Bigner, D. D., Palmieri, G., Cossu, A., Flanagan, A., Nicholson, A., Ho, J. W., Leung, S. Y., Yuen, S. T., Weber, B. L., Seigler, H. F., Darrow, T. L., Paterson, H., Marais, R., Marshall, C. J., Wooster, R., Stratton, M. R., and Futreal, P. A. (2002) Mutations of the BRaf gene in human cancer. Nature 417, 949-954
-
-
-
-
11
-
-
14544268965
-
Detection of B-RAF and N-RAS mutations in human melanoma
-
Goydos, J. S., Mann, B., Kim, H. J., Gabriel, E. M., Alsina, J., Germino, F. J., Shih, W., and Gorski, D. H. (2005) Detection of B-RAF and N-RAS mutations in human melanoma. J. Am. Coll. Surg. 200, 362-370
-
(2005)
J. Am. Coll. Surg
, vol.200
, pp. 362-370
-
-
Goydos, J.S.1
Mann, B.2
Kim, H.J.3
Gabriel, E.M.4
Alsina, J.5
Germino, F.J.6
Shih, W.7
Gorski, D.H.8
-
12
-
-
33644774541
-
Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma
-
Goel, V. K., Lazar, A. J., Warneke, C. L., Redston, M. S., and Haluska, F. G. (2006) Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J. Invest. Dermatol. 126, 154-160
-
(2006)
J. Invest. Dermatol
, vol.126
, pp. 154-160
-
-
Goel, V.K.1
Lazar, A.J.2
Warneke, C.L.3
Redston, M.S.4
Haluska, F.G.5
-
13
-
-
1442274619
-
Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma
-
Tsao, H., Goel, V., Wu, H., Yang, G., and Haluska, F. G. (2004) Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J. Invest. Dermatol. 122, 337-341
-
(2004)
J. Invest. Dermatol
, vol.122
, pp. 337-341
-
-
Tsao, H.1
Goel, V.2
Wu, H.3
Yang, G.4
Haluska, F.G.5
-
14
-
-
0034085811
-
Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines
-
Tsao, H., Zhang, X., Fowlkes, K., and Haluska, F. G. (2000) Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines. Cancer Res. 60, 1800-1804
-
(2000)
Cancer Res
, vol.60
, pp. 1800-1804
-
-
Tsao, H.1
Zhang, X.2
Fowlkes, K.3
Haluska, F.G.4
-
15
-
-
33644684217
-
Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
-
Strumberg, D. (2005) Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc.) 41, 773-784
-
(2005)
Drugs Today (Barc.)
, vol.41
, pp. 773-784
-
-
Strumberg, D.1
-
16
-
-
13144281830
-
BAY 43-9006 in patients with advanced melanoma: The Royal Marsden experience
-
Ahmad, T., Marais, R., Pyle, L., James, B., Schwartz, B., Gore, M., and Eisen, T. (2004) BAY 43-9006 in patients with advanced melanoma: the Royal Marsden experience. J. Clin. Oncol. 22(14S), 7506
-
(2004)
J. Clin. Oncol
, vol.22
, Issue.14 S
, pp. 7506
-
-
Ahmad, T.1
Marais, R.2
Pyle, L.3
James, B.4
Schwartz, B.5
Gore, M.6
Eisen, T.7
-
17
-
-
23944439944
-
Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies
-
Lorusso, P. M., Adjei, A. A., Varterasian, M., Gadgeel, S., Reid, J., Mitchell, D. Y., Hanson, L., DeLuca, P., Bruzek, L., Piens, J., Asbury, P., Van Becelaere, K., Herrera, R., Sebolt-Leopold, J., and Meyer, M. B. (2005) Phase I and pharmacodynamic study of the oral MEK inhibitor CI-1040 in patients with advanced malignancies. J. Clin. Oncol. 23, 5281-5293
-
(2005)
J. Clin. Oncol
, vol.23
, pp. 5281-5293
-
-
Lorusso, P.M.1
Adjei, A.A.2
Varterasian, M.3
Gadgeel, S.4
Reid, J.5
Mitchell, D.Y.6
Hanson, L.7
DeLuca, P.8
Bruzek, L.9
Piens, J.10
Asbury, P.11
Van Becelaere, K.12
Herrera, R.13
Sebolt-Leopold, J.14
Meyer, M.B.15
-
18
-
-
23644437498
-
Formation of regulatory patterns during signal propagation in a Mammalian cellular network
-
Ma'ayan, A., Jenkins, S. L., Neves, S., Hasseldine, A., Grace, E., Dubin-Thaler, B., Eungdamrong, N. J., Weng, G., Ram, P. T., Rice, J. J., Kershenbaum, A., Stolovitzky, G. A., Blitzer, R. D., and Iyengar, R. (2005) Formation of regulatory patterns during signal propagation in a Mammalian cellular network. Science 309, 1078-1083
-
(2005)
Science
, vol.309
, pp. 1078-1083
-
-
Ma'ayan, A.1
Jenkins, S.L.2
Neves, S.3
Hasseldine, A.4
Grace, E.5
Dubin-Thaler, B.6
Eungdamrong, N.J.7
Weng, G.8
Ram, P.T.9
Rice, J.J.10
Kershenbaum, A.11
Stolovitzky, G.A.12
Blitzer, R.D.13
Iyengar, R.14
-
19
-
-
0033555859
-
Emergent properties of networks of biological signaling pathways
-
Bhalla, U. S., and Iyengar, R. (1999) Emergent properties of networks of biological signaling pathways. Science 283, 381-387
-
(1999)
Science
, vol.283
, pp. 381-387
-
-
Bhalla, U.S.1
Iyengar, R.2
-
20
-
-
0037047611
-
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
-
Bhalla, U. S., Ram, P. T., and Iyengar, R. (2002) MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network. Science 297, 1018-1023
-
(2002)
Science
, vol.297
, pp. 1018-1023
-
-
Bhalla, U.S.1
Ram, P.T.2
Iyengar, R.3
-
21
-
-
25444448797
-
Spontaneous evolution of modularity and network motifs
-
Kashtan, N., and Alon, U. (2005) Spontaneous evolution of modularity and network motifs. Proc. Natl. Acad. Sci. U. S. A. 102, 13773-13778
-
(2005)
Proc. Natl. Acad. Sci. U. S. A
, vol.102
, pp. 13773-13778
-
-
Kashtan, N.1
Alon, U.2
-
22
-
-
0032910168
-
Organization and regulation of mitogen-activated protein kinase signaling pathways
-
Garrington, T. P., and Johnson, G. L. (1999) Organization and regulation of mitogen-activated protein kinase signaling pathways. Curr. Opin. Cell Biol. 11, 211-218
-
(1999)
Curr. Opin. Cell Biol
, vol.11
, pp. 211-218
-
-
Garrington, T.P.1
Johnson, G.L.2
-
23
-
-
0030963439
-
cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway
-
Vossler, M. R., Yao, H., York, R. D., Pan, M. G., Rim, C. S., and Stork, P. J. (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf- and Rap1-dependent pathway. Cell 89, 73-82
-
(1997)
Cell
, vol.89
, pp. 73-82
-
-
Vossler, M.R.1
Yao, H.2
York, R.D.3
Pan, M.G.4
Rim, C.S.5
Stork, P.J.6
-
24
-
-
0034659736
-
Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes
-
Busca, R., Abbe, P., Mantoux, F., Aberdam, E., Peyssonnaux, C., Eychene, A., Ortonne, J. P., and Ballotti, R. (2000) Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes. EMBO J. 19, 2900-2910
-
(2000)
EMBO J
, vol.19
, pp. 2900-2910
-
-
Busca, R.1
Abbe, P.2
Mantoux, F.3
Aberdam, E.4
Peyssonnaux, C.5
Eychene, A.6
Ortonne, J.P.7
Ballotti, R.8
-
25
-
-
0027716596
-
Inhibition by cAMP of Ras-depenndent activation of Raf
-
Cook, S. J., and McCormick, F. (1993) Inhibition by cAMP of Ras-depenndent activation of Raf. Science 262, 1069-1072
-
(1993)
Science
, vol.262
, pp. 1069-1072
-
-
Cook, S.J.1
McCormick, F.2
-
26
-
-
0027772672
-
Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3-,5--monophosphae
-
Wu, J., Dent, P., Jelinek, T., Wolfman, A., Weberr, M. J., and Sturgill, T. W. (1883) Inhibition of the EGF-activated MAP kinase signaling pathway by adenosine 3-,5--monophosphae. Science 262, 1065-1069
-
(1883)
Science
, vol.262
, pp. 1065-1069
-
-
Wu, J.1
Dent, P.2
Jelinek, T.3
Wolfman, A.4
Weberr, M.J.5
Sturgill, T.W.6
-
27
-
-
22544463087
-
Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels
-
Dumaz, N., and Marais, R. (2005) Integrating signals between cAMP and the RAS/RAF/MEK/ERK signalling pathways. Based on the anniversary prize of the Gesellschaft fur Biochemie und Molekularbiologie Lecture delivered on 5 July 2003 at the Special FEBS Meeting in Brussels. FEBS J. 272, 3491-3504
-
(2005)
FEBS J
, vol.272
, pp. 3491-3504
-
-
Dumaz, N.1
Marais, R.2
-
28
-
-
0041529686
-
Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras
-
Dumaz, N., and Marais, R. (2003) Protein kinase A blocks Raf-1 activity by stimulating 14-3-3 binding and blocking Raf-1 interaction with Ras. J. Biol. Chem. 278, 29819-29823
-
(2003)
J. Biol. Chem
, vol.278
, pp. 29819-29823
-
-
Dumaz, N.1
Marais, R.2
-
29
-
-
0347363834
-
Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
-
Brummer, T., Naegele, H., Reth, M., and Misawa, Y. (2003) Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf. Oncogene 22, 8823-8834
-
(2003)
Oncogene
, vol.22
, pp. 8823-8834
-
-
Brummer, T.1
Naegele, H.2
Reth, M.3
Misawa, Y.4
-
30
-
-
19944430124
-
Regulation of Raf-1 by direct feedback phosphorylation
-
Dougherty, M. K., Muller, J., Ritt, D. A., Zhou, M., Zhou, X. Z., Copeland, T. D., Conrads, T. P., Veenstra, T. D., Lu, K. P., and Morrison, D. K. (2005) Regulation of Raf-1 by direct feedback phosphorylation. Mol. Cell 17, 215-224
-
(2005)
Mol. Cell
, vol.17
, pp. 215-224
-
-
Dougherty, M.K.1
Muller, J.2
Ritt, D.A.3
Zhou, M.4
Zhou, X.Z.5
Copeland, T.D.6
Conrads, T.P.7
Veenstra, T.D.8
Lu, K.P.9
Morrison, D.K.10
-
31
-
-
33644856401
-
Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase
-
Balan, V., Leicht, D. T., Zhu, J., Balan, K., Kaplun, A., Singh-Gupta, V., Qin, J., Ruan, H., Comb, M. J., and Tzivion, G. (2006) Identification of novel in vivo Raf-1 phosphorylation sites mediating positive feedback Raf-1 regulation by extracellular signal-regulated kinase. Mol. Biol. Cell 17, 1141-1153
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1141-1153
-
-
Balan, V.1
Leicht, D.T.2
Zhu, J.3
Balan, K.4
Kaplun, A.5
Singh-Gupta, V.6
Qin, J.7
Ruan, H.8
Comb, M.J.9
Tzivion, G.10
-
32
-
-
0027948988
-
Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2
-
Jacobowitz, O., and Iyengar, R. (1994) Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2. Proc. Natl. Acad. Sci. U. S. A. 91, 10630-10634
-
(1994)
Proc. Natl. Acad. Sci. U. S. A
, vol.91
, pp. 10630-10634
-
-
Jacobowitz, O.1
Iyengar, R.2
-
33
-
-
0036051342
-
Molecular interpretation of ERK signal duration by immediate early gene products
-
Murphy, L. O., Smith, S., Chen, R. H., Fingar, D. C., and Blenis, J. (2002) Molecular interpretation of ERK signal duration by immediate early gene products. Nat. Cell Biol. 4, 556-564
-
(2002)
Nat. Cell Biol
, vol.4
, pp. 556-564
-
-
Murphy, L.O.1
Smith, S.2
Chen, R.H.3
Fingar, D.C.4
Blenis, J.5
-
34
-
-
0029818289
-
Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells
-
Cook, S. J., and McCormick, F. (1996) Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells. Biochem. J. 320(Pt 1), 237-245
-
(1996)
Biochem. J
, vol.320
, Issue.PART 1
, pp. 237-245
-
-
Cook, S.J.1
McCormick, F.2
-
35
-
-
0037044575
-
The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
-
Hoffman, A., Levchenko, A., Scott, M. L., and Baltimore, D. (2002) The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298, 1241-1245
-
(2002)
Science
, vol.298
, pp. 1241-1245
-
-
Hoffman, A.1
Levchenko, A.2
Scott, M.L.3
Baltimore, D.4
-
36
-
-
0028872649
-
Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
-
Marshall, C. J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185
-
(1995)
Cell
, vol.80
, pp. 179-185
-
-
Marshall, C.J.1
-
37
-
-
33847392514
-
Untangling the signalling wires
-
Kholodenko, B. N. (2007) Untangling the signalling wires. Nat. Cell Biol. 9, 247-249
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 247-249
-
-
Kholodenko, B.N.1
-
38
-
-
0042887050
-
The genetics of malignant melanoma: Lessons from mouse and man
-
Chin, L. (2003) The genetics of malignant melanoma: lessons from mouse and man. Nat. Rev. Cancer 3, 559-570
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 559-570
-
-
Chin, L.1
-
40
-
-
0033547426
-
Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes
-
Nesbit, M., Nesbit, H. K., Bennett, J., Andl, T., Hsu, M. Y., Dejesus, E., McBrian, M., Gupta, A. R., Eck, S. L., and Herlyn, M. (1999) Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes. Oncogene 18, 6469-6476
-
(1999)
Oncogene
, vol.18
, pp. 6469-6476
-
-
Nesbit, M.1
Nesbit, H.K.2
Bennett, J.3
Andl, T.4
Hsu, M.Y.5
Dejesus, E.6
McBrian, M.7
Gupta, A.R.8
Eck, S.L.9
Herlyn, M.10
-
41
-
-
4644237315
-
Melanin pigmentation in mammalian skin and its hormonal regulation
-
Slominski, A., Tobin, D. J., Shibahara, S., and Wortsman, J. (2004) Melanin pigmentation in mammalian skin and its hormonal regulation. Physiol. Rev. 84, 1155-1228
-
(2004)
Physiol. Rev
, vol.84
, pp. 1155-1228
-
-
Slominski, A.1
Tobin, D.J.2
Shibahara, S.3
Wortsman, J.4
-
42
-
-
33746589029
-
MC1R germline variants confer risk for BRAF-mutant melanoma
-
Landi, M. T., Bauer, J., Pfeiffer, R. M., Elder, D. E., Hulley, B., Minghetti, P., Calista, D., Kanetsky, P. A., Pinkel, D., and Bastian, B. C. (2006) MC1R germline variants confer risk for BRAF-mutant melanoma. Science 313, 521-522
-
(2006)
Science
, vol.313
, pp. 521-522
-
-
Landi, M.T.1
Bauer, J.2
Pfeiffer, R.M.3
Elder, D.E.4
Hulley, B.5
Minghetti, P.6
Calista, D.7
Kanetsky, P.A.8
Pinkel, D.9
Bastian, B.C.10
-
43
-
-
0035997011
-
Mechanisms for temporal tuning and filtering by postsynaptic signaling pathways
-
Bhalla, U. S. (2002) Mechanisms for temporal tuning and filtering by postsynaptic signaling pathways. Biophys. J. 83, 740-752
-
(2002)
Biophys. J
, vol.83
, pp. 740-752
-
-
Bhalla, U.S.1
-
44
-
-
33748054771
-
-
Gao, L., Feng, Y., Bowers, R., Becker-Hapak, M., Gardner, J., Council, L., Linette, G., Zhao, H., and Cornelius, L. A. (2006) Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis. Cancer Res. 66, 7880-7888
-
Gao, L., Feng, Y., Bowers, R., Becker-Hapak, M., Gardner, J., Council, L., Linette, G., Zhao, H., and Cornelius, L. A. (2006) Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis. Cancer Res. 66, 7880-7888
-
-
-
-
45
-
-
0141484562
-
Biological networks: The tinkerer as an engineer
-
Alon, U. (2003) Biological networks: the tinkerer as an engineer. Science 301, 1866-1867
-
(2003)
Science
, vol.301
, pp. 1866-1867
-
-
Alon, U.1
-
46
-
-
4944258252
-
Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate
-
Hornberg, J. J., Tijssen, M. R., and Lankelma, J. (2004) Synergistic activation of signalling to extracellular signal-regulated kinases 1 and 2 by epidermal growth factor and 4 beta-phorbol 12-myristate 13-acetate. Eur. J. Biochem. 271, 3905-3913
-
(2004)
Eur. J. Biochem
, vol.271
, pp. 3905-3913
-
-
Hornberg, J.J.1
Tijssen, M.R.2
Lankelma, J.3
-
47
-
-
29144462587
-
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
-
Garnett, M. J., Rana, S., Paterson, H., Barford, D., and Marais, R. (2005) Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol. Cell 20, 963-969
-
(2005)
Mol. Cell
, vol.20
, pp. 963-969
-
-
Garnett, M.J.1
Rana, S.2
Paterson, H.3
Barford, D.4
Marais, R.5
-
48
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan, P. T., Garnett, M. J., Roe, S. M., Lee, S., Niculescu-Duvaz, D., Good, V. M., Jones, C. M., Marshall, C. J., Springer, C. J., Barford, D., and Marais, R. (2004) Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116, 855-867
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
Jones, C.M.7
Marshall, C.J.8
Springer, C.J.9
Barford, D.10
Marais, R.11
-
49
-
-
4644367485
-
Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype
-
Yamaguchi, T., Wallace, D. P., Magenheimer, B. S., Hempson, S. J., Grantham, J. J., and Calvet, J. P. (2004) Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. J. Biol. Chem. 279, 40419-40430
-
(2004)
J. Biol. Chem
, vol.279
, pp. 40419-40430
-
-
Yamaguchi, T.1
Wallace, D.P.2
Magenheimer, B.S.3
Hempson, S.J.4
Grantham, J.J.5
Calvet, J.P.6
-
50
-
-
0034666006
-
Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase
-
Sidovar, M. F., Kozlowski, P., Lee, J. W., Collins, M. A., He, Y., and Graves, L. M. (2000) Phosphorylation of serine 43 is not required for inhibition of c-Raf kinase by the cAMP-dependent protein kinase. J. Biol. Chem. 275, 28688-28694
-
(2000)
J. Biol. Chem
, vol.275
, pp. 28688-28694
-
-
Sidovar, M.F.1
Kozlowski, P.2
Lee, J.W.3
Collins, M.A.4
He, Y.5
Graves, L.M.6
-
51
-
-
33847355217
-
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
-
Santos, S. D., Verveer, P. J., and Bastiaens, P. I. (2007) Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate. Nat. Cell Biol. 9, 324-330
-
(2007)
Nat. Cell Biol
, vol.9
, pp. 324-330
-
-
Santos, S.D.1
Verveer, P.J.2
Bastiaens, P.I.3
-
52
-
-
17344362384
-
Prediction and validation of the distinct dynamics of transient and sustained ERK activation
-
Sasagawa, S., Ozaki, Y., Fujita, K., and Kuroda, S. (2005) Prediction and validation of the distinct dynamics of transient and sustained ERK activation. Nat. Cell Biol. 7, 365-373
-
(2005)
Nat. Cell Biol
, vol.7
, pp. 365-373
-
-
Sasagawa, S.1
Ozaki, Y.2
Fujita, K.3
Kuroda, S.4
-
53
-
-
28244433436
-
B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade
-
Robubi, A., Mueller, T., Fueller, J., Hekman, M., Rapp, U. R., and Dandekar, T. (2005) B-Raf and C-Raf signaling investigated in a simplified model of the mitogenic kinase cascade. Biol. Chem. 386, 1165-1171
-
(2005)
Biol. Chem
, vol.386
, pp. 1165-1171
-
-
Robubi, A.1
Mueller, T.2
Fueller, J.3
Hekman, M.4
Rapp, U.R.5
Dandekar, T.6
-
54
-
-
0037442752
-
Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation
-
Satyamoorthy, K., Li, G., Gerrero, M. R., Brose, M. S., Volpe, P., Weber, B. L., Van Belle, P., Elder, D. E., and Herlyn, M. (2003) Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res. 63, 756-759
-
(2003)
Cancer Res
, vol.63
, pp. 756-759
-
-
Satyamoorthy, K.1
Li, G.2
Gerrero, M.R.3
Brose, M.S.4
Volpe, P.5
Weber, B.L.6
Van Belle, P.7
Elder, D.E.8
Herlyn, M.9
-
55
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun, S. Y., Rosenberg, L. M., Wang, X., Zhou, Z., Yue, P., Fu, H., and Khuri, F. R. (2005) Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 65, 7052-7058
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
Zhou, Z.4
Yue, P.5
Fu, H.6
Khuri, F.R.7
|