Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination

PLoS Biology

Volumn 7, Issue 9, 2009, Pages

  Bogani, Debora ^a   Siggers, Pam ^a   Brixey, Rachel ^a   Warr, Nick ^a   Beddow, Sarah ^a   Edwards, Jessica ^a   Williams, Debbie ^a   Wilhelm, Dagmar ^b   Koopman, Peter ^b   Flavell, Richard A ^c   Chi, Hongbo ^d   Ostrer, Harry ^e   Wells, Sara ^f   Cheeseman, Michael ^a,f   Greenfield, Andy ^a  

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f Medical Research Council Harwell Institute   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; SYNAPTOPHYSIN; TESTIS DETERMINING FACTOR;

ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FEMALE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PHYLOGENY; POINT MUTATION; PROTEIN EXPRESSION; REPRODUCTION; SEX DETERMINATION; TESTIS DEVELOPMENT; ANIMAL; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; OVARY; PRENATAL DEVELOPMENT; SEX DETERMINATION PROCESS; SEX DIFFERENTIATION DISORDER; SIGNAL TRANSDUCTION; TESTIS;

MAMMALIA; MUS;

ANIMALS; DISORDERS OF SEX DEVELOPMENT; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MALE; MAP KINASE KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; OVARY; POINT MUTATION; SEX DETERMINATION PROCESSES; SEX-DETERMINING REGION Y PROTEIN; TESTIS;

EID: 70349781856     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000196     Document Type: Article

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