Two splice variants of the wilms' tumor 1 gene have distinct functions during sex determination and nephron formation

Cell

Volumn 106, Issue 3, 2001, Pages 319-329

  Hammes, Annette ^a   Guo, Jian Kan ^a   Lutsch, Gudrun ^a   Leheste, Joerg Robert ^a   Landrock, Danilo ^a   Ziegler, Ulrike ^a   Gubler, Marie Claire ^b   Schedl, Andreas ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; ZINC FINGER PROTEIN;

ALTERNATIVE RNA SPLICING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE INSERTION; GENE MUTATION; GENETIC ANALYSIS; GLOMERULOSCLEROSIS; IN VITRO STUDY; KIDNEY DEVELOPMENT; KIDNEY DISEASE; MOUSE; MOUSE STRAIN; NEPHROBLASTOMA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SEX DETERMINATION; SEX TRANSFORMATION; TUMOR SUPPRESSOR GENE;

ANIMALIA;

EID: 0035839099     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00453-6     Document Type: Article

References (45)

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3. Donor splice-site mutations in WT1 are responsible for Frasier syndrome
4. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
5. Production and analysis of chimeric mice
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9. Direct interaction of SRY-related protein SOX9 and steroidogenic factor 1 regulates transcription of the human anti-Mullerian hormone gene
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15. The human sex-determining gene sry is a direct target of wt1
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17. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis
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19. The evolution of WT1 sequence and expression pattern in the vertebrates
20. Positionally cloned gene for a novel glomerular protein-nephrin - Is mutated in congenital nephrotic syndrome
21. Do intronic mutations affecting splicing of WT1 exon 9 cause Frasier syndrome?
22. The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation
23. Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms
24. WT-1 is required for early kidney development
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26. Molecular basis for modulation of biological function by alternate splicing of the Wilms' tumor suppressor protein
27. Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
28. The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin
29. The Wilms' tumor 1 gene: Oncogene or tumor suppressor gene?
30. Complete sequencing of the Fugu WAGR region from WT1 to PAX6: Dramatic compaction and conservation of synteny with human chromosome 11p13
31. YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
32. Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
33. Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF- 1 in sex-specific gene expression
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35. A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys-Drash syndrome
36. Primary structure of mouse and rat nephrin cDNA and structure and expression of the mouse gene
37. Congenital nephrotic syndrome in mice lacking CD2-associated protein
38. The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Mullerian-inhibiting substance, and the androgen receptor
39. Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function
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42. Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9
43. Whole mount in situ hybridization of vertebrate embryos
44. Homologous recombination for gene replacement in mouse cell lines