Growth factor-induced signaling of the pancreatic epithelium

Journal of Endocrinology

Volumn 185, Issue 1, 2005, Pages 45-56

  Kayali, A G ^b   Stotland, A ^b   Gunst, K V ^b   Kritzik, M ^b   Liu, G ^b   Dabernat, S ^a   Zhang, Y Q ^b   Wu, W ^b   Sarvetnick, Nora ^b  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN; EPIDERMAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 10; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOPROTEIN; PLATELET DERIVED GROWTH FACTOR AA; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CELL REGENERATION; CONTROLLED STUDY; EMBRYO DEVELOPMENT; EPITHELIUM CELL; GENE SEQUENCE; IMMUNOBLOTTING; IN VIVO STUDY; MOUSE; NONHUMAN; ONTOGENY; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

ANIMALS; EMBRYO; EPIDERMAL GROWTH FACTOR; EPITHELIUM; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTORS; GROWTH HORMONE; IMMUNOBLOTTING; INTERFERON TYPE II; ISLETS OF LANGERHANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED NOD; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REGENERATION; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 17844362238     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.05949     Document Type: Article

References (64)

1. Apelqvist A, Li H, Sommer L, Beatus P, Anderson DJ, Honjo T, Hrabe de Angelis M, Lendahl U & Edlund H 1999 Notch signalling controls pancreatic cell differentiation. Nature 400 877-881.
2. Arnush M, Gu D, Baugh C, Sawyer SP, Mroczkowski B, Krahl T & Sarvetnick N 1996 Growth factors in the regenerating pancreas of gamma-interferon transgenic mice. Laboratory Investigation 74 985-990.
3. Betsholtz C, Karlsson L & Lindahl P 2001 Developmental roles of platelet-derived growth factors. Bioessays 23 494-507.
4. Bhushan A, Itoh N, Kato S, Thiery JP, Czenrichow P, Bellusci S & Scharfmann R 2001 Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 128 5109-5117.
5. Bonfini L, Migliaccio E, Pelicci G, Lanfrancone L & Pelicci PG 1996 Not all Shc's roads lead to Ras. Trends in Biochemical Sciences 21 257-261.
6. Bongarzone ER, Byravan S, Givogri MI, Schonmann V & Campagnoni AT 2000 Platelet-derived growth factor and basic fibroblast growth factor regulate cell proliferation and the expression of notch-1 receptor in a new oligodendrocyte cell line. Journal of Neuroscience Research 62 319-328.
7. Brazil DP & Hemmings BA 2001 Ten years of protein kinase B signalling: a hard Akt to follow. Trends in Biochemical Sciences 26 657-664.
8. Cai Y, Lechner MS, Nihalani D, Prindle MJ, Holzman LB & Dressler GR 2002 Phosphorylation of Pax2 by the c-jun N-terminal kinase and enhanced Pax2-dependent transcription activation. Journal of Biological Chemistry 277 1217-1222.
9. Coffer PJ, Jin J & Woodgett JR 1998 Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochemistry Journal 335 1-13.
10. Cras-Meneur C & Scharfmann R 2002 FGFR1-IIIb is a putative marker of pancreatic progenitor cells. Mechanisms of Development 116 205-208.
11. Cras-Meneur C, Elghazi L, Czernichow P & Scharfmann R 2001 Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: a balance between proliferation and differentiation. Diabetes 50 1571-1579.
12. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y & Greenberg ME 1997 Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91 231-241.
13. Datta SR, Brunet A & Greenberg ME 1999 Cellular survival: a play in three Akts. Genes and Development 13 2905-2927.
14. Davis RJ 2000 Signal transduction by the JNK group of MAP kinases. Cell 103 239-252.
15. Denhardt DT 1996 Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: the potential for multiplex signalling. Biochemical Journal 318 729-747.
16. Dent P, Yacoub A, Fisher PB, Hagan MP & Grant S 2003 MAPK pathways in radiation responses. Oncogene 22 5885-5896.
17. Edlund H 2001 Factors controlling pancreatic cell differentiation and function. Diabetologia 44 1071-1079.
18. Edlund H 2002 Pancreatic organogenesis-developmental mechanisms and implications for therapy. Nature Reviews. Genetics 3 524-532.
19. Elghazi L, Cras-Meneur C, Czernichow P & Scharfmann R 2002 Role for FGFR2 IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation. PNAS 99 3884-3889.
20. Floss T, Arnold HH & Braun T 1997 A role for FGF-6 in skeletal muscle regeneration. Genes and Development 11 2040-2051.
21. Gittes GK, Galante PE, Hanahan D, Rutter WJ & Debase HT 1996 Lineage-specific morphogenesis in the developing pancreas: role of mesenchymal factors. Development 122 439-447.
22. Goldsworthy SM, Goldsworthy TL, Sprankle CS & Butterworth BE 1993 Variation in expression of genes used for normalization of Northern blots after induction of cell proliferation. Cell Proliferation 26 511-518.
23. Gu D & Sarvetnick N 1993 Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development 118 33-46.
24. Gu D & Sarvetnick N 1994 A transgenic model for studying islet development. Recent Progress in Hormone Research 49 161-165.
25. Hart AW, Baeza N, Apelqvist A & Edlund H 2000 Attenuation of FGF signalling in mouse beta-cells leads to diabetes. Nature 408 864-868.
26. Heasley LE & Johnson GL 1992 The beta-PDGF receptor induces neuronal differentiation of PC12 cells. Molecular Biology of the Cell 3 545-553.
27. Hoch RV & Soriano P 2003 Roles of PDGF in animal development. Development 130 4769-4784.
28. Huotari MA, Miettinen PJ, Palgi J, Koivisto T, Ustinov J, Harari D, Yarden Y & Otonkoski T 2002 ErbB signaling regulates lineage determination of developing pancreatic islet cells in embryonic organ culture. Endocrinology 143 4437-4446.
29. Ip YT & Davis RJ 1998 Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Current Opinion in Cell Biology 10 205-219.
30. Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ & Leahy JL 2001 Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60%-partial pancreatectomy rats. Diabetologia 44 2056-2065.
31. Kayali AG, Van Gunst K, Campbell IL, Stotland A, Kritzik M, Liu G, Flodstrom-Tullberg M, Zhang YQ & Sarvetnick N 2003 The stromal cell-derived factor-1 alpha/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. Journal of Cell Biology 163 859-869.
32. Krakowski ML, Kritzik MR, Jones EM, Krahl T, Lee J, Arnush M, Gu D & Sarvetnick N 1999a Pancreatic expression of keratinocyte growth factor leads to differentiation of islet hepatocytes and proliferation of duct cells. American Journal of Pathology 154 683-691.
33. Krakowski ML, Kritzik MR, Jones EM, Krahl T, Lee J, Arnush M, Gu D, Mroczkowski B & Sarvetnick N 1999b Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes. Journal of Endocrinology 162 167-175.
34. Kritzik MR, Jones E, Chen Z, Krakowski M, Krahl T, Good A, Wright C, Fox H & Sarvetnick N 1999 PDX-1 and Msx-2 expression in the regenerating and developing pancreas. Journal of Endocrinology 163 523-530.
35. Kritzik MR, Krahl T, Good A, Gu D, Lai C, Fox H & Sarvetnick N 2000a Expression of ErbB receptors during pancreatic islet development and regrowth. Journal of Endocrinology 165 67-77.
36. Kritzik MR, Krahl T, Good A, Krakowski M, St-Onge L, Gruss P, Wright C & Sarvetnick N 2000b Transcription factor expression during pancreatic islet regeneration. Molecular and Cellular Endocrinology 164 99-107.
37. Kuan CY, Yang DD, Samanta Roy DR, Davis RJ, Rakic P & Flavell RA 1999 The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22 667-676.
38. Kyriakis JM & Avruch J 2001 Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation. Physiological Reviews 81 807-869.
39. Lardelli M, Williams R & Lendahl U 1995 Notch-related genes in animal development. International Journal of Developmental Biology 39 769-780.
40. LeBras S, Czernichow P & Scharfmann R 1998 A search for tyrosine kinase receptors expressed in the rat embryonic pancreas. Diabetologia 41 1474-1481.
41. Liu G, Pakala SV, Gu D, Krahl T, Mocnik L & Sarvetnick N 2001 Cholecystokinin expression in the developing and regenerating pancreas and intestine. Journal of Endocrinology 169 233-240.
42. Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF & Docherty K 1999 Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells. Journal of Biological Chemistry 274 1011-1016.
43. Marshall CJ 1995 Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80 179-185.
44. Miettinen PJ, Berger JE, Meneses J, Phung Y, Pedersen RA, Werb Z & Derynck R 1995 Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor. Nature 376 337-341.
45. Miettinen PJ, Huotari M, Koivisto T, Ustinov J, Palgi J, Rasilanen S, Lehtonen E, Keski-Oja J & Otonkoski T 2000 Impaired migration and delayed differentiation of pancreatic islet cells in mice lacking EGF-receptors. Development 127 2617-2627.
46. Mikkola I, Bruun JA, Bjorkoy G, Holm T & Johansen T 1999 Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. Journal of Biological Chemistry 274 15115-15126.
47. Murphy LO, Smith S, Chen RH, Fingar DC & Blenis J 2002 Molecular interpretation of ERK signal duration by immediate early gene products. Nature Cell Biology 4 556-564.
48. Nielsen JH, Galsgaard ED, Moldrup A, Friedrichsen BN, Billestrup N, Hansen JA, Lee YC & Carlsson C 2001 Regulation of beta-cell mass by hormones and growth factors. Diabetes 50 (Suppl 1) S25-29.
49. Norgaard GA, Jensen JN & Jensen J 2003 FGF10 signaling maintains the pancreatic progenitor cell state revealing a novel role of Notch in organ development. Developmental Biology 264 323-338.
50. Ohuchi H, Hori Y, Yamasaki M, Harada H, Sekine K, Kato S & Itoh N 2000 FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development. Biochemical and Biophysical Research Communications 277 643-649.
51. Ornitz DM & Itoh N 2001 Fibroblast growth factors. Genome Biology 2 REVIEWS3005.
52. Pictet RL, Clark WR, Williams RH & Rutter WJ 1972 An ultrastructural analysis of the developing embryonic pancreas. Developmental Biology 29 436-467.
53. Ramet M, Lanot R, Zachary D & Manfruelli P 2002 JNK signaling pathway is required for efficient wound healing in Drosophila. Developmental Biology 241 145-156.
54. Ravichandran KS 2001 Signaling via Shc family adapter proteins. Oncogene 20 6322-6330.
55. Sarvetnick N, Liggitt D, Pitts SL, Hansen SE & Stewart TA 1988 Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma. Cell 52 773-782.
56. Sarvetnick N, Shizuru J, Liggitt D, Martin L, McIntyre B, Gregory A, Parslow T & Stewart T 1990 Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma. Nature 346 844-847.
57. Schlessinger J 2000 Cell signaling by receptor tyrosine kinases. Cell 103 211-225.
58. Simpson P 1998 Introduction: notch signalling and choice of cell fates in development. Seminars in Cell and Developmental Biology 9 581-582.
59. Slack JM 1995 Developmental biology of the pancreas. Development 121 1569-1580.
60. Sluss HK & Davis RJ 1997 Embryonic morphogenesis signaling pathway mediated by JNK targets the transcription factor JUN and the TGF-beta homologue decapentaplegic. Journal of Cellular Biochemistry 67 1-12.
61. Stanton LA, Underhill TM & Beier F 2003 MAP kinases in chondrocyte differentiation. Developmental Biology 263 165-175.
62. Vanhaesebroeck B & Alessi DR 2000 The PI3K-PDK1 connection: more than just a road to PKB. Biochemical Journal 346 561-576.
63. Widmann C, Gibson S, Jarpe MB & Johnson GL 1999 Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiological Reviews 79 143-180.
64. Zhang YQ & Sarvetnick N 2003 Development of cell markers for the identification and expansion of islet progenitor cells. Diabetes/Metabolism Research and Reviews 19 363-374.