메뉴 건너뛰기




Volumn 25, Issue 1, 2009, Pages 19-29

Sex determination and SRY: down to a wink and a nudge?

Author keywords

[No Author keywords available]

Indexed keywords

TESTIS DETERMINING FACTOR; TRANSCRIPTION FACTOR SOX9;

EID: 58149333236     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tig.2008.10.008     Document Type: Review
Times cited : (266)

References (91)
  • 1
    • 33846829951 scopus 로고    scopus 로고
    • Sex determination and gonadal development in mammals
    • Wilhelm D., et al. Sex determination and gonadal development in mammals. Physiol. Rev. 87 (2007) 1-28
    • (2007) Physiol. Rev. , vol.87 , pp. 1-28
    • Wilhelm, D.1
  • 2
    • 33846195840 scopus 로고    scopus 로고
    • Sry and the hesitant beginnings of male development
    • Polanco J.C., and Koopman P. Sry and the hesitant beginnings of male development. Dev. Biol. 302 (2007) 13-24
    • (2007) Dev. Biol. , vol.302 , pp. 13-24
    • Polanco, J.C.1    Koopman, P.2
  • 3
    • 4644299516 scopus 로고    scopus 로고
    • SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    • Sekido R., et al. SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors. Dev. Biol. 274 (2004) 271-279
    • (2004) Dev. Biol. , vol.274 , pp. 271-279
    • Sekido, R.1
  • 4
    • 27744559963 scopus 로고    scopus 로고
    • Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination
    • Wilhelm D., et al. Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev. Biol. 287 (2005) 111-124
    • (2005) Dev. Biol. , vol.287 , pp. 111-124
    • Wilhelm, D.1
  • 5
    • 19544384917 scopus 로고    scopus 로고
    • Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads
    • Taketo T., et al. Expression of SRY proteins in both normal and sex-reversed XY fetal mouse gonads. Dev. Dyn. 233 (2005) 612-622
    • (2005) Dev. Dyn. , vol.233 , pp. 612-622
    • Taketo, T.1
  • 7
    • 0036360220 scopus 로고    scopus 로고
    • Sex-determining genes in mice: building pathways
    • Chadwick D., and Goode J. (Eds), Wiley
    • Lovell-Badge R., et al. Sex-determining genes in mice: building pathways. In: Chadwick D., and Goode J. (Eds). The Genetics and Biology of Sex Determination (2002), Wiley 4-22
    • (2002) The Genetics and Biology of Sex Determination , pp. 4-22
    • Lovell-Badge, R.1
  • 8
    • 33746784794 scopus 로고    scopus 로고
    • Goat SRY induces testis development in XX transgenic mice
    • Pannetier M., et al. Goat SRY induces testis development in XX transgenic mice. FEBS Lett. 580 (2006) 3715-3720
    • (2006) FEBS Lett. , vol.580 , pp. 3715-3720
    • Pannetier, M.1
  • 9
    • 47249149614 scopus 로고    scopus 로고
    • Boys, girls and shuttling of SRY and SOX9
    • Sim H., et al. Boys, girls and shuttling of SRY and SOX9. Trends Endocrinol. Metab. 19 (2008) 213-222
    • (2008) Trends Endocrinol. Metab. , vol.19 , pp. 213-222
    • Sim, H.1
  • 10
    • 33644667202 scopus 로고    scopus 로고
    • NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY
    • Thevenet L., et al. NHERF2/SIP-1 interacts with mouse SRY via a different mechanism than human SRY. J. Biol. Chem. 280 (2005) 38625-38630
    • (2005) J. Biol. Chem. , vol.280 , pp. 38625-38630
    • Thevenet, L.1
  • 11
    • 12344251708 scopus 로고    scopus 로고
    • Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein
    • Oh H.J., et al. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein. Biol. Reprod. 72 (2005) 407-415
    • (2005) Biol. Reprod. , vol.72 , pp. 407-415
    • Oh, H.J.1
  • 12
    • 0344875027 scopus 로고    scopus 로고
    • Testis determination requires insulin receptor family function in mice
    • Nef S., et al. Testis determination requires insulin receptor family function in mice. Nature 426 (2003) 291-295
    • (2003) Nature , vol.426 , pp. 291-295
    • Nef, S.1
  • 13
    • 3042762359 scopus 로고    scopus 로고
    • One tissue, two fates: molecular genetic events that underlie testis versus ovary development
    • Brennan J., and Capel B. One tissue, two fates: molecular genetic events that underlie testis versus ovary development. Nat. Rev. Genet. 5 (2004) 509-521
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 509-521
    • Brennan, J.1    Capel, B.2
  • 14
    • 11144329603 scopus 로고    scopus 로고
    • Signaling at the crossroads of gonad development
    • Ross A.J., and Capel B. Signaling at the crossroads of gonad development. Trends Endocrinol. Metab. 16 (2005) 19-25
    • (2005) Trends Endocrinol. Metab. , vol.16 , pp. 19-25
    • Ross, A.J.1    Capel, B.2
  • 15
    • 1942505197 scopus 로고    scopus 로고
    • A microdeletion in the ligand binding domain of human steroidogenic factor 1 causes XY sex reversal without adrenal insufficiency
    • Correa R.V., et al. A microdeletion in the ligand binding domain of human steroidogenic factor 1 causes XY sex reversal without adrenal insufficiency. J. Clin. Endocrinol. Metab. 89 (2004) 1767-1772
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 1767-1772
    • Correa, R.V.1
  • 16
    • 6344258377 scopus 로고    scopus 로고
    • Gonadal dysgenesis without adrenal insufficiency in a 46, XY patient heterozygous for the nonsense C16X mutation: a case of SF1 haploinsufficincy
    • Mallet D., et al. Gonadal dysgenesis without adrenal insufficiency in a 46, XY patient heterozygous for the nonsense C16X mutation: a case of SF1 haploinsufficincy. J. Clin. Endocrinol. Metab. 89 (2004) 4829-4832
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 4829-4832
    • Mallet, D.1
  • 17
    • 33947505860 scopus 로고    scopus 로고
    • Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46,XY disorders of sex development with normal adrenal function
    • Lin L., et al. Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46,XY disorders of sex development with normal adrenal function. J. Clin. Endocrinol. Metab. 92 (2007) 991-999
    • (2007) J. Clin. Endocrinol. Metab. , vol.92 , pp. 991-999
    • Lin, L.1
  • 18
    • 0037378633 scopus 로고    scopus 로고
    • Porcine SRY promoter is a target for steroidogenic factor-1
    • Pilon N., et al. Porcine SRY promoter is a target for steroidogenic factor-1. Biol. Reprod. 68 (2003) 1098-1106
    • (2003) Biol. Reprod. , vol.68 , pp. 1098-1106
    • Pilon, N.1
  • 19
    • 33745145872 scopus 로고    scopus 로고
    • The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation form an unspliced RNA with a retained intron
    • Bor Y.C., et al. The Wilms' tumor 1 (WT1) gene (+KTS isoform) functions with a CTE to enhance translation form an unspliced RNA with a retained intron. Genes Dev. 20 (2006) 1597-1608
    • (2006) Genes Dev. , vol.20 , pp. 1597-1608
    • Bor, Y.C.1
  • 20
    • 44149089568 scopus 로고    scopus 로고
    • A GATA4/WT1 cooperation regulates transcription of genes reguired for mammalian sex determination and differentiaton
    • Miyamoto Y., et al. A GATA4/WT1 cooperation regulates transcription of genes reguired for mammalian sex determination and differentiaton. BMC Mol. Biol. 9 (2008) 44
    • (2008) BMC Mol. Biol. , vol.9 , pp. 44
    • Miyamoto, Y.1
  • 21
    • 45149093155 scopus 로고    scopus 로고
    • Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer
    • Sekido R., and Lovell-Badge R. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature 453 (2008) 930-934
    • (2008) Nature , vol.453 , pp. 930-934
    • Sekido, R.1    Lovell-Badge, R.2
  • 22
    • 2542514539 scopus 로고    scopus 로고
    • Functional analysis of Sox8 and Sox9 during sex determination in the mouse
    • Chaboissier M.-C., et al. Functional analysis of Sox8 and Sox9 during sex determination in the mouse. Development 131 (2004) 1891-1901
    • (2004) Development , vol.131 , pp. 1891-1901
    • Chaboissier, M.-C.1
  • 23
    • 30344475256 scopus 로고    scopus 로고
    • Homozygous inactivation of Sox9 causes complete XY sex reversal in mice
    • Barrionuevo F., et al. Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. Biol. Reprod. 74 (2006) 195-201
    • (2006) Biol. Reprod. , vol.74 , pp. 195-201
    • Barrionuevo, F.1
  • 24
    • 0037143766 scopus 로고    scopus 로고
    • A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination
    • Gasca S., et al. A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 11199-11204
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 11199-11204
    • Gasca, S.1
  • 25
    • 19944432874 scopus 로고    scopus 로고
    • Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice
    • Kidokoro T., et al. Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Dev. Biol. 278 (2005) 511-525
    • (2005) Dev. Biol. , vol.278 , pp. 511-525
    • Kidokoro, T.1
  • 26
    • 34248233673 scopus 로고    scopus 로고
    • Extended pedigree with multiple cases of XX sex reversal in the absence of SRY and of a mutation at the SOX9 locus
    • Temel S.G., et al. Extended pedigree with multiple cases of XX sex reversal in the absence of SRY and of a mutation at the SOX9 locus. Sex Dev. 1 (2007) 24-34
    • (2007) Sex Dev. , vol.1 , pp. 24-34
    • Temel, S.G.1
  • 27
    • 39049085821 scopus 로고    scopus 로고
    • XX maleness and XX true hermaphroditism in SRY-negative monozygous twins: additional evidence for a common origin
    • Maciel-Guerra A.T., et al. XX maleness and XX true hermaphroditism in SRY-negative monozygous twins: additional evidence for a common origin. J. Clin. Endocrinol. Metab. 93 (2008) 339-343
    • (2008) J. Clin. Endocrinol. Metab. , vol.93 , pp. 339-343
    • Maciel-Guerra, A.T.1
  • 28
    • 33644989691 scopus 로고    scopus 로고
    • Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern
    • Bagheri-Fam S., et al. Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern. Dev. Biol. 291 (2006) 382-397
    • (2006) Dev. Biol. , vol.291 , pp. 382-397
    • Bagheri-Fam, S.1
  • 29
    • 3042730829 scopus 로고    scopus 로고
    • Long-range activation of Sox9 in Odd Sex (Ods) mice
    • Qin Y., et al. Long-range activation of Sox9 in Odd Sex (Ods) mice. Hum. Mol. Genet. 13 (2004) 1213-1218
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 1213-1218
    • Qin, Y.1
  • 30
    • 0036185305 scopus 로고    scopus 로고
    • Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins
    • Shen J.H., and Ingraham H.A. Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins. Mol. Endocrinol. 16 (2002) 529-540
    • (2002) Mol. Endocrinol. , vol.16 , pp. 529-540
    • Shen, J.H.1    Ingraham, H.A.2
  • 31
    • 33745198924 scopus 로고    scopus 로고
    • Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    • Kim Y., et al. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol. 4 (2006) e187
    • (2006) PLoS Biol. , vol.4
    • Kim, Y.1
  • 32
    • 4444294105 scopus 로고    scopus 로고
    • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex dterminanation
    • Schmahl J., et al. Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex dterminanation. Development 131 (2004) 3627-3636
    • (2004) Development , vol.131 , pp. 3627-3636
    • Schmahl, J.1
  • 33
    • 36748999377 scopus 로고    scopus 로고
    • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination
    • Kim Y., et al. Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 16558-16563
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 16558-16563
    • Kim, Y.1
  • 34
    • 38349098647 scopus 로고    scopus 로고
    • Loss of Fgfr2 leads to partial XY sex reversal
    • Bagheri-Fam S., et al. Loss of Fgfr2 leads to partial XY sex reversal. Dev. Biol. 314 (2008) 71-83
    • (2008) Dev. Biol. , vol.314 , pp. 71-83
    • Bagheri-Fam, S.1
  • 35
    • 17844392598 scopus 로고    scopus 로고
    • A novel isoform of Vinexin, Vinexin g, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad
    • Matsuyama M., et al. A novel isoform of Vinexin, Vinexin g, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells 10 (2005) 421-434
    • (2005) Genes Cells , vol.10 , pp. 421-434
    • Matsuyama, M.1
  • 36
    • 34547464541 scopus 로고    scopus 로고
    • The hotei mutation of medaka in the anti-Müllerian hormone receptor causes the dysregulation of germ cell and sexual development
    • Morinaga C., et al. The hotei mutation of medaka in the anti-Müllerian hormone receptor causes the dysregulation of germ cell and sexual development. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 9691-9696
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 9691-9696
    • Morinaga, C.1
  • 37
    • 34249854973 scopus 로고    scopus 로고
    • SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development
    • Wilhelm D., et al. SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J. Biol. Chem. 282 (2007) 10553-10560
    • (2007) J. Biol. Chem. , vol.282 , pp. 10553-10560
    • Wilhelm, D.1
  • 38
    • 20044370153 scopus 로고    scopus 로고
    • Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via cAMP-PKA phosphorylation
    • Malki S., et al. Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via cAMP-PKA phosphorylation. EMBO J. 24 (2005) 1798-1809
    • (2005) EMBO J. , vol.24 , pp. 1798-1809
    • Malki, S.1
  • 39
    • 27744466334 scopus 로고    scopus 로고
    • Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development
    • Nef S., et al. Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development. Dev. Biol. 287 (2005) 361-377
    • (2005) Dev. Biol. , vol.287 , pp. 361-377
    • Nef, S.1
  • 40
    • 33646198340 scopus 로고    scopus 로고
    • Retinoid signaling determines germ cell fate in mice
    • Bowles J., et al. Retinoid signaling determines germ cell fate in mice. Science 312 (2006) 596-600
    • (2006) Science , vol.312 , pp. 596-600
    • Bowles, J.1
  • 41
    • 33644521570 scopus 로고    scopus 로고
    • Retinoic acid regulates sex-specific timing of meiotic initiation in mice
    • Koubova J., et al. Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 2474-2479
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 2474-2479
    • Koubova, J.1
  • 42
    • 34748870401 scopus 로고    scopus 로고
    • Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice
    • MacLean G., et al. Apoptotic extinction of germ cells in testes of Cyp26b1 knockout mice. Endocrinology 148 (2007) 4560-4567
    • (2007) Endocrinology , vol.148 , pp. 4560-4567
    • MacLean, G.1
  • 43
    • 14044260735 scopus 로고    scopus 로고
    • The transcription factors steroidogenic factor-1 and Sox9 regulate expression of Vanin-1 during mouse testis development
    • Wilson M.J., et al. The transcription factors steroidogenic factor-1 and Sox9 regulate expression of Vanin-1 during mouse testis development. J. Biol. Chem. 280 (2005) 5917-5923
    • (2005) J. Biol. Chem. , vol.280 , pp. 5917-5923
    • Wilson, M.J.1
  • 44
    • 0037099299 scopus 로고    scopus 로고
    • The Wilms tumor suppressor WT1 early gonad development by activation of Sf1
    • Wilhelm D., and Englert C. The Wilms tumor suppressor WT1 early gonad development by activation of Sf1. Genes Dev. 16 (2002) 1839-1851
    • (2002) Genes Dev. , vol.16 , pp. 1839-1851
    • Wilhelm, D.1    Englert, C.2
  • 45
    • 34250200749 scopus 로고    scopus 로고
    • Wilms' tumor protein Wt1 is an activator of the Anti-Müllerian hormone receptor gene Amhr2
    • Klattig J., et al. Wilms' tumor protein Wt1 is an activator of the Anti-Müllerian hormone receptor gene Amhr2. Mol. Cell. Biol. 27 (2007) 4355-4364
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 4355-4364
    • Klattig, J.1
  • 46
    • 0036796863 scopus 로고    scopus 로고
    • Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
    • Tevosian S.G., et al. Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development 129 (2002) 4627-4634
    • (2002) Development , vol.129 , pp. 4627-4634
    • Tevosian, S.G.1
  • 47
    • 34347333577 scopus 로고    scopus 로고
    • The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models
    • Manuylov N.L., et al. The regulation of Sox9 gene expression by the GATA4/FOG2 transcriptional complex in dominant XX sex reversal mouse models. Dev. Biol. 307 (2007) 356-367
    • (2007) Dev. Biol. , vol.307 , pp. 356-367
    • Manuylov, N.L.1
  • 48
    • 33747064675 scopus 로고    scopus 로고
    • The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis
    • Gao F., et al. The Wilms tumor gene, Wt1, is required for Sox9 expression and maintenance of tubular architecture in the developing testis. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 11987-11992
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 11987-11992
    • Gao, F.1
  • 49
    • 1842418671 scopus 로고    scopus 로고
    • Sex determination: a 'window' of DAX1 activity
    • Ludbrook L.M., and Harley V.R. Sex determination: a 'window' of DAX1 activity. Trends Endocrinol. Metab. 15 (2004) 116-121
    • (2004) Trends Endocrinol. Metab. , vol.15 , pp. 116-121
    • Ludbrook, L.M.1    Harley, V.R.2
  • 50
    • 33847053927 scopus 로고    scopus 로고
    • DAX1: increasing complexity in the roles of this novel nuclear receptor
    • McCabe E.R.B. DAX1: increasing complexity in the roles of this novel nuclear receptor. Mol. Cell. Endocrinol. 265-266 (2007) 179-182
    • (2007) Mol. Cell. Endocrinol. , vol.265-266 , pp. 179-182
    • McCabe, E.R.B.1
  • 51
    • 0037348617 scopus 로고    scopus 로고
    • Dax1 regulates testis cord organization during gonadal differentiation
    • Meeks J.J., et al. Dax1 regulates testis cord organization during gonadal differentiation. Development 130 (2003) 1029-1036
    • (2003) Development , vol.130 , pp. 1029-1036
    • Meeks, J.J.1
  • 52
    • 34447291845 scopus 로고    scopus 로고
    • Male-to-female sex reversal associated with an approximately 250 kb deletion upstream of NR0B1 (DAX1)
    • Smyk M., et al. Male-to-female sex reversal associated with an approximately 250 kb deletion upstream of NR0B1 (DAX1). Hum. Genet. 122 (2007) 63-70
    • (2007) Hum. Genet. , vol.122 , pp. 63-70
    • Smyk, M.1
  • 53
    • 0037383725 scopus 로고    scopus 로고
    • Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by Wnt4 in the female developing gonad
    • Mizusaki H., et al. Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by Wnt4 in the female developing gonad. Mol. Endocrinol. 17 (2003) 507-519
    • (2003) Mol. Endocrinol. , vol.17 , pp. 507-519
    • Mizusaki, H.1
  • 54
    • 0036218777 scopus 로고    scopus 로고
    • Dax1 expression is dependent on steroidogenic factor 1in the developing gonad
    • Hoyle C., et al. Dax1 expression is dependent on steroidogenic factor 1in the developing gonad. Mol. Endocrinol. 16 (2002) 747-756
    • (2002) Mol. Endocrinol. , vol.16 , pp. 747-756
    • Hoyle, C.1
  • 55
    • 4944263717 scopus 로고    scopus 로고
    • Molecular mechanisms of DAX1 action
    • Iyer A.K., and McCabe E.R.B. Molecular mechanisms of DAX1 action. Mol. Genet. Metab. 83 (2004) 60-73
    • (2004) Mol. Genet. Metab. , vol.83 , pp. 60-73
    • Iyer, A.K.1    McCabe, E.R.B.2
  • 56
    • 0036019873 scopus 로고    scopus 로고
    • The role of SF1 in adrenal and reproductive function: insight from naturally occurring mutations in humans
    • Ozisik G., et al. The role of SF1 in adrenal and reproductive function: insight from naturally occurring mutations in humans. Mol. Genet. Metab. 76 (2002) 85-91
    • (2002) Mol. Genet. Metab. , vol.76 , pp. 85-91
    • Ozisik, G.1
  • 57
    • 33646582022 scopus 로고    scopus 로고
    • Mechanisms of disease: transcription factors in sex determination - relevance to human disorders of sex development
    • Nikolova G., and Vilain E. Mechanisms of disease: transcription factors in sex determination - relevance to human disorders of sex development. Nat. Clin. Pract. Endocrinol. Metab. 2 (2006) 231-238
    • (2006) Nat. Clin. Pract. Endocrinol. Metab. , vol.2 , pp. 231-238
    • Nikolova, G.1    Vilain, E.2
  • 58
    • 35948946482 scopus 로고    scopus 로고
    • Complete sex reversal in a WAGR syndrome patient
    • Le Caignec C., et al. Complete sex reversal in a WAGR syndrome patient. Am. J. Med. Genet. A. 143A (2007) 2692-2695
    • (2007) Am. J. Med. Genet. A. , vol.143 A , pp. 2692-2695
    • Le Caignec, C.1
  • 59
    • 35448952936 scopus 로고    scopus 로고
    • Correct dosage of Fog2 and Gata4 transcription factors is crucial for fetal testis development in mice
    • Bouma G.J., et al. Correct dosage of Fog2 and Gata4 transcription factors is crucial for fetal testis development in mice. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 14994-14999
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 14994-14999
    • Bouma, G.J.1
  • 60
    • 0037994140 scopus 로고    scopus 로고
    • Dax1 is required for testis determination
    • Meeks J.J., et al. Dax1 is required for testis determination. Nat. Genet. 34 (2003) 32-33
    • (2003) Nat. Genet. , vol.34 , pp. 32-33
    • Meeks, J.J.1
  • 61
    • 23144455957 scopus 로고    scopus 로고
    • Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells
    • Bouma G.J., et al. Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells. Development 132 (2005) 3045-3054
    • (2005) Development , vol.132 , pp. 3045-3054
    • Bouma, G.J.1
  • 62
    • 0041508536 scopus 로고    scopus 로고
    • Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad
    • Jeays-Ward K., et al. Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. Development 130 (2003) 3663-3670
    • (2003) Development , vol.130 , pp. 3663-3670
    • Jeays-Ward, K.1
  • 63
    • 33750489078 scopus 로고    scopus 로고
    • R-spondin1 is essential in sex determination, skin differentiation and malignancy
    • Parma P., et al. R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat. Genet. 38 (2006) 1304-1309
    • (2006) Nat. Genet. , vol.38 , pp. 1304-1309
    • Parma, P.1
  • 64
    • 42449095964 scopus 로고    scopus 로고
    • Ativation of β-catenin signaling by Rspo1 controls differentiation of the mammalian ovary
    • Chassot A.-A., et al. Ativation of β-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum. Mol. Genet. 17 (2008) 1264-1277
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 1264-1277
    • Chassot, A.-A.1
  • 65
    • 42449158088 scopus 로고    scopus 로고
    • R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling
    • Tomizuka K., et al. R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling. Hum. Mol. Genet. 17 (2008) 1278-1291
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 1278-1291
    • Tomizuka, K.1
  • 66
    • 53049106906 scopus 로고    scopus 로고
    • Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal
    • Maatouk D.M., et al. Stabilization of β-catenin in XY gonads causes male-to-female sex-reversal. Hum. Mol. Genet. 17 (2008) 2949-2955
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 2949-2955
    • Maatouk, D.M.1
  • 67
    • 49349112654 scopus 로고    scopus 로고
    • Wt1 negatively regulates β-catenin signaling during testis development
    • Chang H., et al. Wt1 negatively regulates β-catenin signaling during testis development. Development 135 (2008) 1875-1885
    • (2008) Development , vol.135 , pp. 1875-1885
    • Chang, H.1
  • 68
    • 33745505572 scopus 로고    scopus 로고
    • Foxl2 function in ovarian development
    • Uhlenhaut N.H., and Treier M. Foxl2 function in ovarian development. Mol. Genet. Metab. 88 (2006) 225-234
    • (2006) Mol. Genet. Metab. , vol.88 , pp. 225-234
    • Uhlenhaut, N.H.1    Treier, M.2
  • 69
    • 1342327343 scopus 로고    scopus 로고
    • The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance
    • Schmidt D., et al. The murine winged-helix transcription factor Foxl2 is required for granulosa cell differentiation and ovary maintenance. Development 131 (2004) 933-942
    • (2004) Development , vol.131 , pp. 933-942
    • Schmidt, D.1
  • 70
    • 26444511733 scopus 로고    scopus 로고
    • Foxl2 is required for commitment to ovary differentiation
    • Ottolenghi C., et al. Foxl2 is required for commitment to ovary differentiation. Hum. Mol. Genet. 14 (2005) 2053-2062
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 2053-2062
    • Ottolenghi, C.1
  • 71
    • 22144484502 scopus 로고    scopus 로고
    • Follicular cells acquire Sertoli cell characteristics after oocyte loss
    • Guigon C.J., et al. Follicular cells acquire Sertoli cell characteristics after oocyte loss. Endocrinology 146 (2005) 2992-3004
    • (2005) Endocrinology , vol.146 , pp. 2992-3004
    • Guigon, C.J.1
  • 72
    • 3843131804 scopus 로고    scopus 로고
    • The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad
    • Britt K.L., et al. The effects of estrogen on the expression of genes underlying the differentiation of somatic cells in the murine gonad. Endocrinology 145 (2004) 3950-3960
    • (2004) Endocrinology , vol.145 , pp. 3950-3960
    • Britt, K.L.1
  • 73
    • 35748965278 scopus 로고    scopus 로고
    • Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells
    • Ottolenghi C., et al. Loss of Wnt4 and Foxl2 leads to female-to-male sex reversal extending to germ cells. Hum. Mol. Genet. 16 (2007) 2795-2804
    • (2007) Hum. Mol. Genet. , vol.16 , pp. 2795-2804
    • Ottolenghi, C.1
  • 74
    • 0242664116 scopus 로고    scopus 로고
    • Sox3 is required for gonadal function, but not sex determination, in males and females
    • Weiss J., et al. Sox3 is required for gonadal function, but not sex determination, in males and females. Mol. Cell. Biol. 23 (2003) 8084-8091
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8084-8091
    • Weiss, J.1
  • 75
    • 1442360429 scopus 로고    scopus 로고
    • SOX3 is required during the formation of the hypothalamo-pituitary axis
    • Rizzoti K., et al. SOX3 is required during the formation of the hypothalamo-pituitary axis. Nat. Genet. 36 (2004) 247-255
    • (2004) Nat. Genet. , vol.36 , pp. 247-255
    • Rizzoti, K.1
  • 76
    • 38049103011 scopus 로고    scopus 로고
    • Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes
    • Wallis M.C., et al. Sex determination in platypus and echidna: autosomal location of SOX3 confirms the absence of SRY from monotremes. Chromosome Res. 15 (2007) 949-959
    • (2007) Chromosome Res. , vol.15 , pp. 949-959
    • Wallis, M.C.1
  • 77
    • 0036872682 scopus 로고    scopus 로고
    • FET-1: a novel W-linked, female specific gene up-regulated in the embryonic chicken ovary
    • Reed K.J., and Sinclair A.H. FET-1: a novel W-linked, female specific gene up-regulated in the embryonic chicken ovary. Gene Expr. Patterns 2 (2002) 83-86
    • (2002) Gene Expr. Patterns , vol.2 , pp. 83-86
    • Reed, K.J.1    Sinclair, A.H.2
  • 78
    • 36248967032 scopus 로고    scopus 로고
    • Sex determination in birds: HINTs from the sex chromosome?
    • Smith C.A. Sex determination in birds: HINTs from the sex chromosome?. Sex Dev. 1 (2007) 279-285
    • (2007) Sex Dev. , vol.1 , pp. 279-285
    • Smith, C.A.1
  • 79
    • 34548812861 scopus 로고    scopus 로고
    • The function of Dmrt genes in vertebrate development: It is not just about sex
    • Hong C.-S., et al. The function of Dmrt genes in vertebrate development: It is not just about sex. Dev. Biol. 310 (2007) 1-9
    • (2007) Dev. Biol. , vol.310 , pp. 1-9
    • Hong, C.-S.1
  • 80
    • 40649100327 scopus 로고    scopus 로고
    • A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis
    • Yoshimoto S., et al. A W-linked DM-domain gene, DM-W, participates in primary ovary development in Xenopus laevis. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 2469-2474
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 2469-2474
    • Yoshimoto, S.1
  • 81
    • 0037198690 scopus 로고    scopus 로고
    • DMY is a Y-specific DM-domain gene required for male development in the medaka fish
    • Matsuda M., et al. DMY is a Y-specific DM-domain gene required for male development in the medaka fish. Nature 417 (2002) 559-563
    • (2002) Nature , vol.417 , pp. 559-563
    • Matsuda, M.1
  • 82
    • 37249038475 scopus 로고    scopus 로고
    • Evidence for different origins of sex chromosome in closely related Oryzias fishes: substitution of the master sex-determining gene
    • Tanaka K., et al. Evidence for different origins of sex chromosome in closely related Oryzias fishes: substitution of the master sex-determining gene. Genetics 177 (2007) 2075-2081
    • (2007) Genetics , vol.177 , pp. 2075-2081
    • Tanaka, K.1
  • 83
    • 23344448138 scopus 로고    scopus 로고
    • Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus
    • Yao H.H., and Capel B. Temperature, genes, and sex: a comparative view of sex determination in Trachemys scripta and Mus musculus. J. Biochem. 138 (2005) 5-12
    • (2005) J. Biochem. , vol.138 , pp. 5-12
    • Yao, H.H.1    Capel, B.2
  • 84
    • 0036116125 scopus 로고    scopus 로고
    • The hormonal control of sexual development
    • Chadwick D., and Goode J. (Eds), Wiley
    • Renfree M.B., et al. The hormonal control of sexual development. In: Chadwick D., and Goode J. (Eds). The Genetics and Biology of Sex Determination (2002), Wiley 136-156
    • (2002) The Genetics and Biology of Sex Determination , pp. 136-156
    • Renfree, M.B.1
  • 85
    • 38349000730 scopus 로고    scopus 로고
    • PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovary
    • Guioli S., and Lovell-Badge R. PITX2 controls asymmetric gonadal development in both sexes of the chick and can rescue the degeneration of the right ovary. Development 134 (2007) 4199-4208
    • (2007) Development , vol.134 , pp. 4199-4208
    • Guioli, S.1    Lovell-Badge, R.2
  • 86
    • 40949110035 scopus 로고    scopus 로고
    • Mechanism of asymmetric ovarian development in chick embryos
    • Ishimaru Y., et al. Mechanism of asymmetric ovarian development in chick embryos. Development 135 (2008) 677-685
    • (2008) Development , vol.135 , pp. 677-685
    • Ishimaru, Y.1
  • 87
    • 53149147384 scopus 로고    scopus 로고
    • Ectopic expression of mouse Sry interferes with Wnt/β-catenin signaling in mouse embryonal carcinoma cell lines
    • Tamashiro D.A., et al. Ectopic expression of mouse Sry interferes with Wnt/β-catenin signaling in mouse embryonal carcinoma cell lines. Biochim. Biophys. Acta 1780 (2008) 1395-1402
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 1395-1402
    • Tamashiro, D.A.1
  • 88
    • 51249093042 scopus 로고    scopus 로고
    • Human SRY inhibits β-catenin-mediated transcription
    • Bernard P., et al. Human SRY inhibits β-catenin-mediated transcription. Int. J. Biochem. Cell Biol. 40 (2008) 2889-2900
    • (2008) Int. J. Biochem. Cell Biol. , vol.40 , pp. 2889-2900
    • Bernard, P.1
  • 89
    • 32944479204 scopus 로고    scopus 로고
    • Direct regulation of adult brain function by the male-specific factor SRY
    • Dewing P., et al. Direct regulation of adult brain function by the male-specific factor SRY. Curr. Biol. 16 (2006) 415-420
    • (2006) Curr. Biol. , vol.16 , pp. 415-420
    • Dewing, P.1
  • 90
    • 33748313401 scopus 로고    scopus 로고
    • Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem
    • Kim Y., and Capel B. Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem. Dev. Dyn. 235 (2006) 2292-2300
    • (2006) Dev. Dyn. , vol.235 , pp. 2292-2300
    • Kim, Y.1    Capel, B.2
  • 91
    • 2442514340 scopus 로고    scopus 로고
    • Interactions between Sox9 and β-catenin control chondrocyte differentiation
    • Akiyama H., et al. Interactions between Sox9 and β-catenin control chondrocyte differentiation. Genes Dev. 18 (2004) 1072-1087
    • (2004) Genes Dev. , vol.18 , pp. 1072-1087
    • Akiyama, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.