Interrogating and predicting tolerated sequence diversity in protein folds: Application to E. elaterium trypsin inhibitor-II cystine-knot miniprotein

PLoS Computational Biology

Volumn 5, Issue 9, 2009, Pages

  Lahti, Jennifer L ^a   Silverman, Adam P ^a   Cochran, Jennifer R ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLONING; SCAFFOLDS (BIOLOGY);

AMINO ACID SEQUENCE; COVARIANCE ANALYSIS; ENGINEERING APPLICATIONS; MINI-PROTEINS; MOLECULAR SCAFFOLDS; MULTIPLE LOOPS; PROTEIN ENGINEERING; SEQUENCE ANALYSIS; SEQUENCE DIVERSITY; TRYPSIN INHIBITOR;

AMINO ACIDS;

CYSTINE KNOT MINIPROTEIN; ECBALLIUM ELATERIUM TRYPSIN INHIBITOR II; POLYPEPTIDE; UNCLASSIFIED DRUG; PEPTIDE LIBRARY; TRYPSIN; TRYPSIN INHIBITOR; VEGETABLE PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CLONE; CONTROLLED STUDY; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN FAMILY; PROTEIN FOLDING; SEQUENCE ANALYSIS; SURFACE PROPERTY; CHEMICAL STRUCTURE; CHEMISTRY; CUCUMBER; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; PROTEIN DOMAIN; YEAST;

ECBALLIUM ELATERIUM;

AMINO ACID SEQUENCE; CLONING, MOLECULAR; CUCURBITACEAE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PLANT PROTEINS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; SEQUENCE ANALYSIS, PROTEIN; TRYPSIN; TRYPSIN INHIBITORS; YEASTS;

EID: 70349664200     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1000499     Document Type: Article

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