Immunogenicity of intrathecal plasmid gene delivery: Cytokine release and effects on transgene expression

Journal of Gene Medicine

Volumn 11, Issue 9, 2009, Pages 782-790

  Hughes, Travis S ^a   Langer, Stephen J ^a   Virtanen, Salla I ^a   Chavez, Raymond A ^b   Watkins, Linda R ^a   Milligan, Erin D ^c   Leinwand, Leslie A ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Avigen Inc   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

CpG; Gene therapy; Inflammatory; Intrathecal; Lipopolysaccharide; Plasmid

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; NAKED DNA; PLASMID VECTOR; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID FLOW; CYTOKINE RELEASE; GENE EXPRESSION; GENE THERAPY; HUMAN; HUMAN CELL; IMMUNOGENICITY; LUMBOSACRAL SPINE; NEUROPATHIC PAIN; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN DNA BINDING; RAT;

ANIMALS; CELL LINE; CPG ISLANDS; CYTOKINES; GENE EXPRESSION; GENE THERAPY; HUMANS; INJECTIONS, SPINAL; MALE; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; TOLL-LIKE RECEPTOR 9; TRANSFECTION; TRANSGENES;

ANIMALIA; RATTUS;

EID: 70349495241     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1364     Document Type: Article

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