Regulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats

Gene Therapy

Volumn 11, Issue 11, 2004, Pages 933-940

  Wu, C M ^a   Lin, M W ^b   Cheng, J T ^a   Wang, Y M ^b   Huang, Y W ^b   Sun, W Z ^c   Lin, C R ^b,c  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Beta endorphin; Chronic constriction injury; Doxycycline; Electroporation

Indexed keywords

BETA ENDORPHIN; DOXYCYCLINE; NALOXONE; OPIATE AGONIST; PROOPIOMELANOCORTIN; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ELECTROPORATION; GENE DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC TRANSFECTION; IN VIVO STUDY; LIMB INJURY; MALE; MICRODIALYSIS; MONONEUROPATHY; NERVE CELL CULTURE; NERVE COMPRESSION; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PLASMID; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; REPRESSOR GENE; SCIATIC NERVE; SILENCER GENE; SPINAL CORD NERVE CELL;

ANALGESIA; ANIMALS; ANTI-BACTERIAL AGENTS; BETA-ENDORPHIN; CELLS, CULTURED; DNA; DOXYCYCLINE; ELECTROPORATION; GENE EXPRESSION REGULATION; GENE THERAPY; INJECTIONS, INTRAPERITONEAL; NEURONS, AFFERENT; PRO-OPIOMELANOCORTIN; RATS; RATS, INBRED STRAINS; SPINAL CORD INJURIES; TRANSFECTION;

EID: 2942716688     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3302244     Document Type: Article

References (37)

1. Oyama T et al. Profound analgesic effects of beta-endorphin in man. Lancet 1980; 1: 122-124.
2. Wen HL et al. Intrathecal administration of beta-endorphin and dynorphin-(1-13) for the treatment of intractable pain. Life Sci 1985; 37: 1213-1220.
3. Yaksh TL, Henry JL. Antinociceptive effects of intrathecally administered human beta-endorphin in the rat and cat. Can J Physiol Pharmacol 1978; 56: 754-759.
4. Yaksh TL, Gross KE, Li CC. Studies on the intrathecal effect of beta-endorphin in primate. Brain Res 1982; 241: 261-269.
5. Mack KJ, Killian A, Weyhenmeyer JA. Comparison of mu, delta, and kappa opiate binding sites in rat brain and spinal cord. Life Sci 1984; 34: 281-285.
6. Atweh SF, Kuhar MJ. Autoradiographic localization of opiatereceptors in rat brain. I. Spinal and lower medulla. Brain Res 1977; 124: 53-67.
7. Morris BJ, Herz A. Distinct distribution of opioid receptor typesin rat lumbar spinal cord. Naunyn-Schmiedebergs Arch Pharmacol 1987; 336: 240-243.
8. Kitahata LM, Collins JG. Spinal action of narcotic analgesics. Anesthesiology 1981; 54: 153-163.
9. Aimone LD, Yaksh TL. Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo. Peptides 1989; 10: 1127-1131.
10. Go VL, Yaksh TL. Release of substance P from the cat spinal cord. J Physiol 1987; 391: 141-167.
11. Seybold VS, Elde RP. Receptor autoradiography in thoracic spinal cord: correlation of neurotransmitter binding sites with sympathoadrenal neurons. J Neurosci 1984; 4: 2533-2542.
12. Brazenor GA. Long term intrathecal administration of morphine: a comparison of bolus infection via reservoir with continuous infusion by implanted pump. Neurosurgery 1987; 21: 484-491.
13. Oyama T, Murakawa T, Baba S, Nagao H. Continuous vs bolus epidural morphine. Acta Anaesthesiol Scand (Suppl) 1987; 85: 77-79.
14. Penn RD, Paice JA. Chronic intrathecal morphine for intractable pain. J Neurosurg 1987; 67: 182-186.
15. Richelson E. Spinal opiate administration for chronic pain: a major advance in therapy. Mayo Clin Proc 1981; 56: 523.
16. Hassenbusch SJ et al. Constant infusion of morphine for intractable cancer pain using an implanted pump. J Neurosurg 1990; 73: 405-409.
17. Lin CR et al. Electroporation-mediated pain-killer gene therapy for mononeuropathic rats. Gene Therapy 2002; 18: 1247-1253.
18. Finegold AA, Mannes AJ, Iadarola MJ. A paracrine paradigm for in vivo gene therapy in the central nervous system: treatment of chronic pain. Hum Gene Ther 1999; 10: 1251-1257.
19. Lin CR et al. Electroporation for direct spinal gene transfer in rats. Neurosci Lett 2002; 317: 1-4.
20. Rubanyi GM. The future of human gene therapy. Mol Aspects Med 2001; 22: 113-142.
21. Weber W, Fussenegger M. Artificial mammalian gene regulation networks-novel approaches for gene therapy and bioengineering. J Biotechnol 2002; 98: 161-187.
22. Clackson T. Regulated gene expression systems. Gene Therapy 2000; 7: 120-125.
23. Baron U, Bujard H. Tet repressor-based system for regulated gene expression in eukaryotic cells: principles and advances. Methods Enzymol 2000; 327: 401-421.
24. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci USA 1992; 89: 5547-5551.
25. Gossen M et al. Transcriptional activation by tetracyclines in mammalian cells. Science 1995; 268: 1766-1769.
26. Bohl D, Salvetti A, Moullier P, Heard JM. Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector. Blood 1998; 92: 1512-1517.
27. Saitoh Y et al. Analgesia induced by transplantation of encapsulated tumor cells secreting beta-endorphin. J Neurosurg 1995; 82: 630-634.
28. Saitoh Y et al. Dose-dependent doxycycline-mediated adrenocorticotropic hormone secretion from encapsulated Teton proopiomelanocortin Neuro2A cells in the subarachnoid space. Hum Gene Ther 1998; 9: 997-1002.
29. Ishii K, Isono M, Inoue R, Hori S. Attempted gene therapy for intractable pain: dexamethasone-mediated exogenous control of beta-endorphin secretion in genetically modified cells and intrathecal transplantation. Exp Neurol 2000; 166: 90-98.
30. Gehl J, Mir LM. Determination of optimal parameters for in vivo gene transfer by electroporation, using a rapid in vivo test for cell permeabilization. Biochem Biophys Res Commun 1999; 261: 377-380.
31. Lan CY et al. Immunoneutralization of c-Fos using intrathecal antibody electroporation attenuates chronic constrictive injury-induced hyperalgesia and regulates preprodynorphin expression in rats. Anesthesiology 2003; 99: 938-946.
32. Teichler Zallen D. US gene therapy in crisis. Trends Genet 2000; 16: 272-275.
33. Osumi N, Inoue T. Gene transfer into cultured mammalian embryos by electroporation. Methods 2001; 24: 35-42.
34. Maruyama H et al. Skin-targeted gene transfer using in vivo electroporation. Gene Therapy 2001; 23: 1808-1812.
35. Lin CR et al. Intrathecal spinal progenitor cell transplantation for the treatment of neuropathic pain. Cell Transplant 2002; 11: 17-24.
36. Lin CR et al. Antinociceptive potentiation and attenuation of tolerance by intrathecal electric stimulation in rats. Anesth Analg 2003; 96: 1711-1716.
37. Hargreaves K et al. A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32: 77-88.