Intrathecal injection of naked plasmid DNA provides long-term expression of secreted proteins

Molecular Therapy

Volumn 17, Issue 1, 2009, Pages 88-94

  Hughes, Travis S ^a   Langer, Stephen J ^a   Johnson, Kirk W ^b   Chavez, Raymond A ^b   Watkins, Linda R ^a   Milligan, Erin D ^c   Leinwand, Leslie A ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b Avigen Inc   (United States)

^c UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CPG OLIGODEOXYNUCLEOTIDE; INTERLEUKIN 10; NAKED DNA; PLASMID DNA;

ANIMAL EXPERIMENT; ARTICLE; CEREBROSPINAL FLUID EXAMINATION; CISTERNA MAGNA; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION REGULATION; GENE TARGETING; LONG TERM POTENTIATION; LUMBAR PUNCTURE; LUMBAR VERTEBRA; MALE; MATRIX ATTACHMENT REGION; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; RAT; TRANSGENE; VERTEBRA;

ALKALINE PHOSPHATASE; ANIMALS; HUMANS; INJECTIONS, SPINAL; INTERLEUKIN-10; MALE; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY;

RATTUS;

EID: 58149266656     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.230     Document Type: Article

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