Selective GSK-3β inhibitors attenuate the cisplatin-induced cytotoxicity of auditory cells

Hearing Research

Volumn 257, Issue 1-2, 2009, Pages 53-62

  Park, Hee Je ^a   Kim, Hyung Jin ^b   Bae, Gi Sang ^a   Seo, Sang Wan ^a,c   Kim, Do Yun ^a   Jung, Won Seok ^a   Kim, Min Sun ^a   Song, Mi Young ^a   Kim, Eun Kyung ^a   Kwon, Kang Beom ^a   Hwang, Sung Yeon ^a   Song, Ho Joon ^a   Park, Cheung Seog ^c   Park, Rae Kil ^b   Chong, Myong Soo ^a   Park, Sung Joo ^a  

^a Wonkwang University   (South Korea)

^b Kyung Hee University   (South Korea)

^c Kyung Hee University Hospital   (South Korea)

Author keywords

Cochlea; GSK 3; Hair cell; Hearing loss; Ototoxicity

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; CASPASE 3; CASPASE 8; CASPASE 9; CISPLATIN; GLYCOGEN SYNTHASE KINASE 3BETA; GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR; INTERLEUKIN 16; INTERLEUKIN 1BETA; LITHIUM CHLORIDE; PHOSPHOTRANSFERASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CASPASE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; INDOLE DERIVATIVE; INTERLEUKIN 6; MALEIMIDE DERIVATIVE; PROTEIN KINASE INHIBITOR;

ACOUSTIC NERVE FIBER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUDITORY THRESHOLD; BRAIN STEM RESPONSE; CELL DESTRUCTION; CELL PROTECTION; CONTROLLED STUDY; CORTI ORGAN; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVATION; HAIR CELL; MOUSE; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; RAT; ANIMAL; AUDITORY STIMULATION; BAGG ALBINO MOUSE; BLOOD; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EVOKED BRAIN STEM AUDITORY RESPONSE; HEARING LOSS; INTRAPERITONEAL DRUG ADMINISTRATION; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PATHOPHYSIOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; TIME;

ACOUSTIC STIMULATION; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL LINE; CISPLATIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GLYCOGEN SYNTHASE KINASE 3; HAIR CELLS, AUDITORY; HEARING LOSS; INDOLES; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1BETA; INTERLEUKIN-6; LITHIUM CHLORIDE; MALEIMIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; ORGAN CULTURE TECHNIQUES; ORGAN OF CORTI; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70349417708     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.heares.2009.08.001     Document Type: Article

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