L-N-acetyl-cysteine protection against cisplatin-induced auditory neuronal and hair cell toxicity

Laryngoscope

Volumn 111, Issue 7, 2001, Pages 1147-1155

  Feghali, Joseph G ^a,b,c   Liu, Wei ^a   Van De Water, Thomas R ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b New York Ear and Hearing Foundation   (United States)

^c NONE   (United States)

Author keywords

Cisplatin; Hearing preservation; L N Acetyl cysteine; Otoprotection; Ototoxicity

Indexed keywords

ACETYLCYSTEINE; BRAIN DERIVED NEUROTROPHIC FACTOR; CISPLATIN; NEUROTROPHIN 3; PROTECTIVE AGENT; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CELL PROTECTION; CELL SURVIVAL; COCHLEA FENESTRA; COCHLEAR NERVE; CONTROLLED STUDY; CORTI ORGAN; DOSE RESPONSE; DRUG EXPOSURE; EXPLANT; HAIR CELL; IN VITRO STUDY; INNER EAR; MOLECULAR WEIGHT; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PUERPERIUM; RAT; SENSORY NERVE CELL;

EID: 0034944185     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200107000-00005     Document Type: Article

References (35)

1. Ototoxicity of high-dose cisplatin by bolus administration in patients with advanced cancer and normal hearing
2. Evaluation of cisplatin dose intensity: Current status and future prospects
3. Ototoxicity of chemotherapeutic agents
4. Differential diagnosis of sensorineural hearing loss
5. High dose cis-platinum diammine dichloride: Amelioration of renal toxicity by mannitol diuresis
6. Heating loss in children receiving cisplatin chemotherapy
7. Hearing loss in children and young adults receiving cisplatin with and without prior cranial irradiation
8. Cisplatinum ototoxicity in children
9. Diamminedichloroplatinum (II) ototoxicity in the guinea pig
10. The Cortitoxic effects of cisplatinum in the guinea pig
11. Cisplatin: Evaluation of its ototoxic potential
12. Degeneration of the organ of Corti following intravenous administration of cisplatin
13. Cisplatin-induced ototoxicity: The effect of pigmentation and inhibitory agents
14. Temporal bone histopathology of cisplatin ototoxicity
15. Early morphological and chemical changes induced by cisplatin in the guinea pig organ of Corti
16. NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells
17. Mammalian auditory hair cell regeneration/repair and protection: A review and future directions
18. Use of organotypic cultures of Corti's organ to study the protective effects of antioxidant molecules on cisplatin-induced damage of auditory hair cells
19. Biology of disease: Free radicals and tissue injury
20. Modification of cisplatin toxicity by antioxidants
21. Stimulatory effects of cisplatin on production of lipid peroxidation in renal tissues
22. Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis in rat kidney cortex: Different of antioxidant and radical scavengers
23. Role of glutathione for cisplatin nephrotoxicity in young and adult rats
24. Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: Antioxidant system
25. Mechanism of cisplatin ototoxicity: Antioxidant system
26. The metabolism of N-acetyl-cysteine by human endothelial cells
27. Cysteamine in combination with N-acetyl-cysteine prevents acetaminophen-induced hepatotoxicity
28. Clinical pharmacokinetics of N-acetyl-cysteine
29. Acetylcysteine treatment of keratitis sicca
30. Retinoic acid stimulates regeneration of mammalian auditory hair cells
31. Glutathione deficiency produced by inhibition of its synthesis, and its reversal: Applications in research and therapy
32. Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione
33. Use of a new device, the Micro Wick, to deliver medication to the inner ear
34. Review of round window membrane permeability
35. L- and D-methionine provide equivalent long-term protection against CDDP-induced ototoxicity in vivo, with partial in vitro and in vivo retention of antineoplastic activity