Corticotropin-releasing hormone (CRH) expression and protein kinase A mediated CRH receptor signalling in an immortalized hypothalamic cell line

Journal of Neuroendocrinology

Volumn 15, Issue 5, 2003, Pages 521-529

  Kasckow, John ^a,b   Mulchahey, J J ^c   Aguilera, G ^d   Pisarska, M ^a   Nikodemova, M ^d   Chen, H C ^d   Herman, J P ^a,b   Murphy, E K ^b   Liu, Y ^d   Rizvi, T A ^a   Dautzenberg, F M ^e   Sheriff, S ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c Phase 2 Discovery Inc   (United States)

^d EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^e Axovan Ltd   (Switzerland)

Author keywords

Corticotropin releasing hormone; CREB; Hypothalamus; Receptor; Stress; SV40 large T antigen

Indexed keywords

CELL MARKER; CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; MICROTUBULE ASSOCIATED PROTEIN 2; NEUROPEPTIDE; RNA; VASOPRESSIN; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL IMMORTALIZATION; CELL LINE; CELL LYSATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; GENE EXPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOTHALAMUS NUCLEUS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; INCUBATION TIME; MOLECULAR CLONING; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT; RETROVIRUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIGNAL TRANSDUCTION; SIMIAN VIRUS 40; TISSUE CULTURE;

EID: 0038274084     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.2003.01026.x     Document Type: Article

References (44)

1. Vale WW, Vaughan J, Perrin M. Corticotropin-releasing factor (CRH) family of ligands and their receptors. The Endocrinologist 1997; 7: 3S-9S.
2. Herman JP, Prewitt CMF, Cullinan WE. Neuronal circuit regulation of the hypothalamo-pituitary-adrenocortical stress axis. Crit Rev Neurobiol 1996; 10: 371-394.
3. Swanson LW, Simmons DM. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: a hybridization histochemical study in the rat. J Comp Neurol 1989; 285: 413-435.
4. Chang CP, Pearse RV, O'Connell S, Rosenfeld MG. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain. Neuron 1993; 11: 1187-1195.
5. Lovenberg TW, Liaw CW, Grigoriadis DE, Clevenger W, Chalmers DT, DeSouza EB, Oltersdorf T. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci USA 1995; 92: 836-840.
6. Chen FM, Bilezijian LM, Perrin MH, Rivier J, Vale W. CRH receptor mediated stimulation of adenylate cyclase activity in rat brain. Brain Res 1996; 381: 49-57.
7. 2g receptor. Mol Endocrinol 1998; 12: 1077-1085.
8. DeSouza EB. Corticotropin-releasing factor receptors. physiology, pharmacology, biochemistry and role in central nervous system and immune disorders. Psychoneuroendocrinology 1995; 20: 789-819.
9. Chalmers DT, Lovenberg TW, DeSouza EB. Localization of a novel corticotropin-releasing factor receptor (CRH2) mRNA expression to specific subcortical nuclei in the rat brain: comparison with CRH1 receptor mRNA expression. J Neurosci 1995; 15: 6340-6350.
10. Dautzenberg FM, Kilpatrick GJ, Hanger RL, Moreau JL. Molecular biology of the CRH receptor - in the mood. Peptides 2001; 22: 753-760.
11. Aguilera G, Rabadan-Diehl M, Nikodemova. Regulation of corticotropin-releasing hormone receptors. Peptides 2001; 22: 769-775.
12. Lim MC, Shipston MJ, Antoni FA. Posttranslational modulation of glucocorticoid feedback inhibition at the pituitary level. Endocrinology 2002; 143: 3796-3801.
13. Kasckow JW, Regmi A, Gill PS, Parkes DG, Geracioti TD. Regulation of corticotropin-releasing factor (CRH) messenger RNA and CRH peptide in the amygdala: studies in primary amygdalar cultures. Endocrinology 1997; 138: 4774-4792.
14. Parkes DG, Yamamoto GY, Vaughan JM, Vale WW. Characterization and regulation of corticotropin-releasing factor in the human hepatoma NPLC-KC cell line. Neuroendocrinology 1993; 57: 663-666.
15. Frisa PS, Goodman MN, Smith GM, Silver J, Jacobberger JW. Immortalization of immature and mature mouse astrocytes with the SV 40 T antigen. J Neurosci Res 1994; 39: 47-56.
16. Vale W, Vaughan J, Yamamoto G, Bruhn T, Douglas C, Dalton D, Rivier C, Rivier J. Assay of corticotropin-releasing factor. Methods Enzymol 1983; 103: 565.
17. Sheriff S, Dautzenberg FM, Mulchahey JJ, Pisarska M, Hauger RL, Chance WT, Balasubramaniam A, Kasckow JW. Interaction of neuropeptide Y and corticotropin-releasing hormone signalling pathways in AR-5 amygdalar cells. Peptides 2002; 23: 87-96.
18. Rivier J, Speiss J, Vale WW. Characterization of rat hypothalamic corticotropin-releasing factor. Proc Natl Acad Sci USA 1983; 80: 4851-4855.
19. Gordon EA, Kohout TA, Fishman PH. Characterization of functional neuropeptide Y receptors in a human neuroblastoma cell line. J Neurochem 1990; 55: 505-513.
20. Fishman PH, Nussbaum SE, Duman RS. Characterization and regulation of beta 1 adrenergic receptors in a human neuroepithelioma cell line. J Neurochem 1991; 56: 596-602.
21. Gwosdow AR, Spencer JA, O'Connell NA, Abou-Samra AB. Interleukin-1 activates protein kinase A and stimulates adrenocorticotropic hormone release from AtT-20 cells. Endocrinology 1993; 132: 710-714.
22. Sheriff S, Balasubramaniam A. Inhibitory and stimulatory effects of neuropeptide Y (17-36) on rat cardiac adenylate cyclase activity. J Biol Chem 1992; 267: 4680-4685.
23. Kemp BE, Garves DJ, Benjamini E, Krebs EG. Role of multiple basic residues in determining the substrate specificity of cyclic AMPdependent protein kinase. J Biol Chem 1977; 252: 4888-4891.
24. Xing S, Furminger TL, Tong Q, Jhian SM. Signal transduction pathways activated by RET oncoproteins in PC12 pheochromocytoma cells. J Biol Chem 1998; 273: 4909-4914.
25. Ross PC, Kostas CM, Ramabhadran TV. A variant of the human corticotropin-releasing factor (CRF) receptor: cloning, expression and pharmacology. Biochem Biophys Res Commun 1994; 205: 1836-1842.
26. Kasckow JW, Parkes DG, Owens MJ, Stipetic MD, Han JH, Nemeroff CB, Vale WW. The BE(2)-M17 neuroblastoma cell line synthesizes and secretes corticotropin-releasing factor. Brain Res 1994; 654: 159-162.
27. Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons. Mol Endocrinol 1995; 9: 467-477.
28. Gao W, Hatten ME. Immortalizing oncogenes subvert the establishment of granule cell identity for the developing cerebellum. Development 1995; 120: 1059-1070.
29. Lendahl UK. The use of cell lines in neurobiology. TINS 1991; 13: 132-137.
30. Mugele K, Kugler H, Spiess J. Immortalization of a fetal rat brain cell line that expresses corticotropin-releasing factor mRNA. DNA Cell Biol 1993; 12: 119-126.
31. Gill PS, Regmi A, Porter-Gill PA, Kasckow JW. Interleukin-1 regulation of corticotropin-releasing factor (CRH), glucocorticoid receptor, c-Fos and c-Jun messenger RNA in the NPL-KC cell line. Mol Cell Endocrinol 1998; 137: 31-39.
32. Kasckow JW, Han J, Parkes DG, Mulchahey JJ, Owens MJ, Risby ED, Fisher J, Nemeroff CB. Regulation of corticotropin-releasing factor secretion and synthesis in the human neuroblastoma clones - BE(2)-M17 and BE(2)-C. J Neuroendocrinol 1995; 7: 461-466.
33. Stephanou A, Melino G, Knight R, Annicchariarico-Petruzzeli N, Sarlis N, Finazzi-Agro A, Lightman S. Interleukin-6 and corticotropin-releasing hormone mRNA are modulated during differentiation of human neuroblastoma cells. Neuropeptides 1992; 23: 45-48.
34. Chen R, Lewis KA, Perrin MH, Vale WW. Expression cloning of a human corticotropin-releasing factor receptor. Proc Natl Acad Sci USA 1993; 90: 8967-8971.
35. Battaglia G, Webster EL, DeSouza EB. Characterization of corticotropin-releasing factor receptor-mediated adenylate cyclase activity in the rat central nervous system. Synapse 1987; 1: 572-581.
36. Gonzalez GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 1989; 59: 675-680.
37. Montminy M. Transcriptional regulation by cAMP. Annu Rev Biochem 1997; 66: 807-822.
38. Rossant CJ, Pinnock RD, Hughes J, Hall MD, McNulty S. Corticotropin-releasing factor type 1 and Type 2a receptors regulate phosphorylation of calcium/cyclic adenosine 3′,5′-monophosphate response element-binding protein and activation of p42/p44 mitogen-activated protein kinase. Endocrinology 1999; 140: 1525-1536.
39. Rivest S, Laflamme N, Nappi RE. Immune challenge and immobilization stress induce transcription of the gene encoding the CRH receptor in selective nuclei of the rat hypothalamus. J Neurosci 1995; 15: 2680-2695.
40. Mansi JA, Rivest S, Drolet G. Regulation of Corticotropin-releasing factor type 1 (CRH1) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRH. Endocrinology, 1996; 137: 4619-4629.
41. Parkes D, Rivest S, Lee S, Rivier C, Vale W. Corticotropin-releasing factor activates c-fos, NGFI-B, and corticotropin-releasing factor gene expression within the paraventricular nucleus of the rat hypothalamus. Mol Endocrinol 1993; 7: 1357-1367.
42. Ono N. Bedran De Castro JC, McCann SM. Ultrashort-loop positive feedback of corticotropin (ACTH)-releasing factor to enhance ACTH release in stress. Proc Natl Acad Sci USA 1985; 82: 3528-3531.
43. Silverman AJ, Hou-Yu A, Chen W. Corticotropin-releasing synapses within the paraventricular nucleus of the hypothalamus. Neuroendocrinology 1989; 49: 291-299.
44. Schobitz B, de Kloet ER, Holsboer F. Gene expression and function of interleukin 1, interleukin 6, and tumor necrosis factor in the brain. Prog Neurobiol 1994; 44: 397-432.