The use of solvent isotope effects in the pursuit of enzyme mechanisms

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 50, Issue 11-12, 2007, Pages 1052-1062

  Schowen, Richard L ^a,b  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Catalysis; Deuterium oxide; Enzyme; Heavy water; Isotope effect; Reaction mechanism

Indexed keywords

DEUTERIUM; ENZYMES;

'CURRENT; BASIC PRINCIPLES; ENZYME MECHANISM; ISOTOPE EFFECT; RATE MEASUREMENTS; REACTION MECHANISM; SOLVENT ISOTOPE EFFECTS;

HEAVY WATER;

AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BLOOD CLOTTING FACTOR 10A; CLAVULANIC ACID; DEUTERIUM OXIDE; DNA POLYMERASE; ISOTOPE; OXIDE; PENICILLIN G; PROTHROMBIN; PROTIUM OXIDE; RIBONUCLEASE A; RNA POLYMERASE; UNCLASSIFIED DRUG;

BIOCHEMISTRY; BLOOD CLOTTING; CATALYSIS; CHEMICAL BINDING; CHEMICAL BOND; CHEMICAL REACTION; CONFORMATIONAL TRANSITION; DIELECTRIC CONSTANT; ENERGY; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYMOLOGY; EQUILIBRIUM CONSTANT; FRACTIONATION; GEOMETRY; HYDROLYSIS; ISOTOPE TRACING; KINETICS; NUCLEAR MAGNETIC RESONANCE; ORGANIC CHEMISTRY; PH MEASUREMENT; REVIEW; VISCOSITY;

PROTIUM;

EID: 38349065198     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.1436     Document Type: Review

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