Cassava with enhanced β-carotene maintains adequate vitamin A status in Mongolian gerbils (Meriones unguiculatus) despite substantial cis-isomer content

British Journal of Nutrition

Volumn 102, Issue 3, 2009, Pages 342-349

  Howe, Julie A ^a,b   Maziya Dixon, Bussie ^c   Tanumihardjo, Sherry A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b AUBURN UNIVERSITY   (United States)

^c INTERNATIONAL INSTITUTE OF TROPICAL AGRICULTURE   (Nigeria)

Author keywords

(E) carotene; (Z) Carotene; Cassava; Cis Carotene; Trans Carotene; Vitamin A

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; CAROTENOID; RETINOL; COTTON SEED OIL; VITAMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CASSAVA; CIS ISOMER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIET THERAPY; FOOD COMPOSITION; GERBIL; LIVER LEVEL; MALE; NONHUMAN; NUTRITIONAL STATUS; RETINOL DEFICIENCY; VITAMIN BLOOD LEVEL; ANIMAL; BIOAVAILABILITY; BLOOD; BODY WEIGHT; CHEMISTRY; COMPARATIVE STUDY; ISOMERISM; LIVER;

GERBILLINAE; MANIHOT ESCULENTA; MERIONES UNGUICULATUS;

ANIMALS; BETA CAROTENE; BIOLOGICAL AVAILABILITY; BODY WEIGHT; COTTONSEED OIL; DIETARY SUPPLEMENTS; FOOD, FORTIFIED; GERBILLINAE; ISOMERISM; LIVER; MALE; MANIHOT; NUTRITIONAL STATUS; VITAMIN A; VITAMIN A DEFICIENCY; VITAMINS;

EID: 70149108293     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114508184720     Document Type: Article

References (49)

1. Iglesias C, Mayer J, Chavez L, et al. (1997) Genetic potential and stability of carotene content in cassava roots. Euphytica 94, 367-373.
2. Chavez AL, Sanchez T, Jaramillo G, et al. (2005) Variation of quality traits in cassava roots evaluated in landraces and improved clones. Euphytica 143, 125-133.
3. Surles RL, Weng N, Simon PW, et al. (2004) Carotenoid profiles and consumer sensory evaluation of specialty carrots (Daucus carota L.) of various colors. J Agric Food Chem 52, 3417-3421.
4. Institute of Medicine Food and Nutrition Board (2000) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, pp. 325-382. Washington, DC: National Academy Press.
5. de Pee S, West CE, Permaesih D, et al. (1998) Orange fruit is more effective than are dark-green, leafy vegetables in increasing serum concentrations of retinol and b-carotene in schoolchildren in Indonesia. Am J Clin Nutr 68, 1058-1067.
6. Tanumihardjo SA (2002) Factors influencing the conversion of carotenoids to retinol: bioavailability to bioconversion to bioefficacy. Int J Vitam Nutr Res 72, 40-45.
7. Faulks RM & Southon S (2005) Challenges to understanding and measuring carotenoid bioavailability. Biochim Biophys Acta 1740, 95-100.
8. van Lieshout M, West CE, Muhilal, et al. (2001) Bioefficacy of b-carotene dissolved in oil studied in children in Indonesia. Am J Clin Nutr 73, 949-958.
9. Jayarajan P, Reddy V & Mohanram M (1980) Effect of dietaryfat on absorption of beta-carotene from green leafy vegetables in children. Indian J Med Res 71, 53-56.
10. Jalal F, Nesheim MC, Agus Z, et al. (1998) Serum retinol concentrations in children are affected by food sources of b-carotene, fat intake, and anthelmintic drug treatment. Am J Clin Nutr 68, 623-629.
11. van het Hof K, West CE, Weststrate JA, et al. (2000) Dietary factors that affect the bioavailability of carotenoids. J Nutr 130, 503-506.
12. Garrett DA, Failla ML & Sarama RJ (1999) Development of an in vitro digestion method to assess carotenoid bioavailability from meals. J Agric Food Chem 47, 4301-4309.
13. Garrett DA, Failla ML & Sarama RJ (2000) Estimation of carotenoid bioavailability from fresh stir-fried vegetables using an in vitro digestion/Caco-2 cell culture model. J Nutr Biochem 11, 574-580.
14. Liu CS, Glahn RP & Liu RH (2004) Assessment of carotenoid bioavailability of whole foods using a Caco-2 cell culture model coupled with an in vitro digestion. J Agric Food Chem 52, 4330-4337.
15. During A & Harrison EH (2004) Intestinal absorption and metabolism of carotenoids: insights from cell culture. Arch Biochem Biophys 430, 77-88.
16. Kurilich AC, Britz SJ, Clevidence BA, et al. (2003) Isotopic labeling and LC-APCI-MS quantification for investigating absorption of carotenoids and phylloquinone from kale (Brassica oleracea). J Agric Food Chem 51, 4877-4883.
17. Vitamin A Tracer Task Force (members Furr HC, Green MH, Haskell M, Mokhtar N, Nestel P, Ribaya-Mercado J, Tanumihardjo SA, Wasantwisut E; lead drafters Tanumihardjo SA & Nestel P) (2004) Appropriate Uses of Vitamin A Tracer (Stable Isotope) Methodology. Washington, DC: ILSI Human Nutrition Institute.
18. Ribaya-Mercado JD, Holmgren SC, Fox JG, et al. (1989) Dietary b-carotene absorption and metabolism in ferrets and rats. J Nutr 119, 665-668.
19. Krinsky NI, Mathewsroth MM, Welankiwar S, et al. (1990) The metabolism of [14C] b-carotene and the presence of other carotenoids in rats and monkeys. J Nutr 120, 81-87.
20. Barua AB & Olson JA (2000) b-Carotene is converted primarily to retinoids in rats in vivo. J Nutr 130, 1996-2001.
21. Lee CM, Lederman JD, Hofmann NE, et al. (1989) The Mongolian gerbil (Meriones unguiculatus) is an appropriate animal model for evaluation of the conversion of b-carotene to vitamin A. J Nutr 128, 280-286.
22. Goodman DS & Blaner WS (1984) Biosynthesis, absorption, and hepatic metabolism of retinol. In The Retinoids, vol.2, pp. 1-39 [MB Sporn, AB Roberts and DS Goodman, editors]. Orlando, FL: Academic Press.
23. Pollack J, Campbell JM, Potter SM, et al. (1994) Mongolian gerbils (Meriones unguiculatus) absorb b-carotene intact from a test meal. J Nutr 124, 869-873.
24. House WA, Apgar J & Smith JC (1997) The gerbil: a model for studying the metabolism of b-carotene and minerals. Nutr Res 17, 1293-1302.
25. Thatcher AJ, Lee CM & Erdman JW Jr (1998) Tissue stores of b-carotene are not conserved for later use as a source of vitamin A during compromised vitamin A status in Mongolian gerbils (Meriones unguiculatus). J Nutr 128, 1179-1185.
26. Lee CM, Boileau AC, Boileau TWM, et al. (1999) Review of animal models in carotenoid research. J Nutr 129, 2271-2277.
27. Reeves PG, Forrest HN & Fahey GC Jr (1993) AIN 93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN76A rodent diet. J Nutr 123, 1939-1951.
28. Howe JA & Tanumihardjo SA (2006) Evaluation of analytical methods for carotenoid extraction from biofortified maize (Zea mays sp.). J Agric Food Chem 54, 7992-7997.
29. Moros EE, Darnoko D, Cheryan M, et al. (2002) Analysis of xanthophylls in corn by HPLC. J Agric Food Chem 50, 5787-5790.
30. Sharpless KE, Thomas JB, Sander LC, et al. (1996) Liquid chromatographic determination of carotenoids in human serum using an engineered C-30 and a C-18 stationary phase. J Chromatogr B: Biomed Appl 678, 187-195.
31. Howe JA & Tanumihardjo SA (2006) Carotenoid-biofortified maize maintains adequate vitamin A status in Mongolian gerbils. J Nutr 136, 2562-2567.
32. Tanumihardjo SA & Howe JA (2005) Twice the amount of bcarotene isolated from carrots is as effective as b-carotene in maintaining the vitamin A status of Mongolian gerbils. J Nutr 135, 2622-2626.
33. Porter Dosti M, Mills JP, Simon PW, et al. (2006) Bioavailability of b-carotene (bC) from purple carrots is the same as typical orange carrots while high-bC carrots increase bC stores in Mongolian gerbils (Meriones unguiculatus). Br J Nutr 96, 258-267.
34. Thurnham DI (2007) Bioequivalence of b-carotene and retinol. J Sci Food Agric 87, 13-39.
35. Montagnac JA, Davis CR & Tanumihardjo SA (2009) Processing techniques to reduce toxicity and antinutrients of cassava for use as a staple food. Comp Rev Food Sci Food Safety (In the Press).
36. Aman R, Schieber A & Carle R (2005) Effects of heating and illumination on trans-cis isomerization and degradation of b-carotene and lutein in isolated spinach chloroplasts. J Agric Food Chem 53, 9512-9518.
37. Rock CL, Lovalva JL, Emenhiser C, et al. (1998) Bioavailability of b-carotene is lower in raw than processed carrots and spinach in women. J Nutr 128, 913-916.
38. Thakkar SK, Maziya-Dixon B, Dixon AGOB-C, et al. (2007) Carotene micellarization during in vitro digestion and uptake by Caco-2 cells is directly proportional to b-carotene content in different genotypes of cassava. J Nutr 137, 2229-2233.
39. Davis C, Jing H, Howe JA, et al. (2008) b-Cryptoxanthin from supplements or carotenoid-enhanced maize maintains liver vitamin A in Mongolian gerbils (Meriones unguiculatus) better than or equal to b-carotene supplements. Br J Nutr 100, 786-793.
40. van Lieshout M, West CE & van Breemen RB (2003) Isotopic tracer techniques for studying the bioavailability and bioefficacy of dietary carotenoids, particularly b-carotene, in humans: a review. Am J Clin Nutr 77, 12-28.
41. Hume EM & Krebs HA (1949) Vitamin A Requirement of Human Adults. An Experimental Study of Vitamin A Deprivation in Man. A Report of the Vitamin A Sub-Committee of the Accessory Food Factors Committee. Report no. 264. London: HMSO.
42. Sauberlich HE, Hodges RE, Wallace DL, et al. (1974) Vitamin A metabolism and requirements in the human studied with the use of labeled retinol. Vitam Horm 32, 251-275.
43. Mills JP, Simon PW & Tanumihardjo SA (2007) b-Carotene from red carrot maintains vitamin A status, but lycopene bioavailability is lower relative to tomato paste in Mongolian gerbils. J Nutr 137, 1395-1400.
44. Davis CR, Howe JA, Rocheford TR, et al. (2008) The xanthophyll composition of biofortified maize (Zea mays sp.) does not influence the bioefficacy of provitamin A carotenoids in Mongolian gerbils (Meriones unguiculatus). J Agric Food Chem 56, 6745-6750.
45. Deming DM, Baker DH & Erdman JW Jr (2002) The relative vitamin A value of 9-cis b-carotene is less and that of 13-cis b-carotene may be greater than the accepted 50% of all-trans b-carotene in gerbils. J Nutr 132, 2709-2712.
46. Tyssandier V, Reboul E, Dumas JF, et al. (2003) Processing of vegetable-borne carotenoids in the human stomach and duodenum. Am J Physiol Gastrointest Liver Physiol 284, G913-G923.
47. You CS, Parker RS, Goodman KJ, et al. (1996) Evidence of cistrans isomerization of 9-cis-beta-carotene during absorption in humans. Am J Clin Nutr 64, 177-183.
48. Tanumihardjo SA (2008) Food-based approaches for ensuring adequate vitamin A nutrition. Comp Rev Food Sci Food Safety 7, 373-381.
49. Tang GW, Qin J, Dolnikowski GG, et al. (2003) Short-term (intestinal) and long-term (postintestinal) conversion of b-carotene to retinol in adults as assessed by a stable-isotope reference method. Am J Clin Nutr 78, 259-266.