Twice the amount of α-carotene isolated from carrots is as effective as β-carotene in maintaining the vitamin A status of Mongolian gerbils

Journal of Nutrition

Volumn 135, Issue 11, 2005, Pages 2622-2626

  Tanumihardjo, Sherry A ^a   Howe, Julie A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Carotenoids; Conversion factors; Mongolian gerbils; Retinol; Vitamin A; retinol

Indexed keywords

ALPHA CAROTENE; BETA CAROTENE; LIVER EXTRACT; OIL; RETINOL; RETINOL ACETATE; RETINOL PALMITATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CARROT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEATH; DIETARY INTAKE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG ISOLATION; FEEDING; GERBIL; ISOLATED LIVER; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; SAPONIFICATION; STATISTICAL SIGNIFICANCE; SUPPLEMENTATION; TIME;

ANIMALIA; DAUCUS CAROTA; GERBILLINAE; MERIONES UNGUICULATUS;

EID: 31544441349     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/135.11.2622     Document Type: Article

References (36)

1. Tanumihardjo SA, Yang, Z. Carotenoids: epidemiology of health effects. In: Caballero B, Allen L, Prentice A, editors. Encyclopedia of human nutrition, 2nd ed. Oxford: Elsevier Ltd; 2005. p. 339-45.
2. D'Odorico A, Martines D, Kiechl S, Egger G, Oberhollenzer F, Bonvicini P, Sturniolo GC, Naccaroto R, Willeit J. High plasma levels of α- and β-carotene are associated with a lower risk of atherosclerosis: results from the Bruneck study. Atherosclerosis. 2000;153:231-9.
3. Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for vitamin C vitamin E, selenium, and carotenoids. Washington, DC: National Academy Press; 2000. p. 325-82.
4. Institute of Medicine, Food and Nutrition Board. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 2001. p. 65-126.
5. Surles RL, Weng N, Simon PW, Tanumihardjo SA. Carotenoid profiles and consumer sensory evaluation of specialty carrots (Daucus carota, L.) of various colors. J Agric Food Chem. 2004;52:3417-21.
6. Porter Dosti M, Mills JP, Simon PW, Tanumihardjo SA. Bioavailability of β-carotene (βC) from purple carrots is the same as typical orange carrots while high-βC carrots increase βC stores in Mongolian gerbils (Meriones unguiculatus). Br J Nutr. In press.
7. Tanumihardjo SA, Horvitz MA, Simon PW. The difference in bioavailability of beta-carotene from three types of carrots. Report of the XXI International Vitamin A Consultative Group meeting, Marakech, Morocco. Washington, DC: International Life Sciences Research Foundation; 2004. p. 72.
8. Zhou J-R, Gugger ET, Erdman JW, Jr. The crystalline form of carotenes and the food matrix in carrot root decrease the relative bioavailability of beta- and alpha-carotene in the ferret model. J Am Coll Nutr. 1996;15:84-91.
9. Singh H, Cama HR. Enzymatic cleavage of carotenoids. Biochim Biophys Acta. 1974;370:49-61.
10. McAnally JS, Szymanski CD. Metabolism of alpha-carotene. Nature. 1966;210:1366.
11. Ames SR, Swanson WJ, Harris PL. Biochemical studies on vitamin A. XV. Biopotencies of geometric isomers of vitamin A aldehyde in the rat. J Am Chem Soc. 1955;77:4136-8.
12. 14C]β-carotene and the presence of other carotenoids in rats and monkeys. J Nutr. 1990;120:81-7.
13. Barua AB, Olson JA. β-Carotene is converted primarily to retinoids in rats in vivo. J Nutr. 2000;130:1996-2001.
14. Ribaya-Mercado JD, Holmgren SC, Fox JG, Russell RM. Dietary β-carotene absorption and metabolism in ferrets and rats. J Nutr. 1989;119:665-8.
15. Furusho T, Kataoka E, Yasuhara T, Wada M, Masushige S. Retinol equivalence of carotenoids can be evaluated by hepatic vitamin A content. Int J Vitam Nutr Res. 2000;70:43-7.
16. de Pee S, West CE, Muhilal, Karyadi D, Hautvast JG. Lack of improvement in vitamin A status with increased consumption of dark-green leafy vegetables. Lancet. 1995;346:75-81.
17. Lee CM, Boileau AC, Boileau TWM, Williams AW, Swanson KS, Heintz KA, Erdman JW, Jr. Review of animal models in carotenoid research. J Nutr. 1999;129:2271-7.
18. Pollack J, Campbell JM, Potter SM, Erdman JW, Jr. Mongolian gerbils (Meriones unguiculatus) absorb β-carotene intact from a test meal. J Nutr. 1994;124:869-73.
19. Lee CM, Lederman JD, Hofmann NE, Erdman JW, Jr. The Mongolian gerbil (Meriones unguiculatus) is an appropriate animal for evaluation of the conversion of β-carotene to vitamin A. J Nutr. 1998;128:280-6.
20. Thatcher AJ, Lee CM, Erdman JW, Jr. Tissue stores of β-carotene are not conserved for later use as a source of vitamin A during compromised vitamin A status in Mongolian gerbils (Meriones unguiculatus). J Nutr. 1998;128:1179-85.
21. House WA, Apgar J, Smith JC. The gerbil: a model for studying the metabolism of beta-carotene and minerals. Nutr Res. 1997;17:1293-302.
22. DeRitter E, Purcell AE. Carotenoid analytical methods. In: Bauernfeind JC, editor. Carotenoids as colorants and vitamin A precursors: technical and nutritional applications. New York, NY: Academic Press; 1981. p. 889.
23. Valentine AR, Tanumihardjo SA. Adjustments to the modified relative dose response (MRDR) test for assessment of vitamin A status minimize the blood volume used in piglets. J Nutr. 2004;134:1186-92.
24. 2-retinyl acetate. J Label Compds Radiopharm. 2001;44:365-72.
25. Tanumihardjo SA, Li J, Porter Dosti M. Lutein absorption is facilitated with co-supplementation of ascorbic acid in young adults. J Am Diet Assoc. 2005;105:114-8.
26. Horvitz MA, Simon PW, Tanumihardjo SA. Lycopene and β-carotene are bioavailable from lycopene 'red' carrots in humans. Eur J Clin Nutr. 2004;58:803-11.
27. Van Lieshout M, West CE, Muhilal, Permaesih D, Wang Y, Xu X, van Breemen RB, Creemers AFL, Verhoeven MA, Lugtenburg J. Bioefficacy of β-carotene dissolved in oil studied in children in Indonesia. Am J Clin Nutr. 2001;73:949-58.
28. Tanumihardjo SA, Permaesih D, Muherdiyantiningsih, Rustan E, Rusmil K, Fatah AC, Wilbur S, Muhilal, Karyadi D, Olson JA. Vitamin A status of Indonesian children infected with Ascaris lumbricoides after dosing with vitamin A supplements and albendazole. J Nutr. 1996;126:451-7.
29. National Research Council. Nutrient requirements in laboratory animals, 4th ed. Washington, DC: National Academy Press; 1995.
30. Tanumihardjo SA, Barua AB, Olson JA. Use of 3,4-didehydroretinol to assess vitamin A status in rats. Int J Vitam Nutr Res. 1987;57:127-32.
31. Kelley SK, Green MH. Plasma retinol is a major determinant of vitamin A utilization in rats. J Nutr. 1998;128:1767-73.
32. Muhilal H, Glover J. The affinity of retinol and its analogues for retinolbinding protein. Biochem Soc Trans. 1975;3:744-6.
33. Robeson CD, Blum WP, Dieterle JM, Cawley JD, Baxter JG. Chemistry of vitamin A. XXV. Geometrical isomers of vitamin A aldehyde and an isomer of its α-ionone analog J Am Chem Soc. 1955;77:4120-5.
34. Escaron AL, Tanumihardjo SA. Absorption of lutein and β-carotene supplements in the Mongolian gerbil. Int J Vitam Nutr Res. In press.
35. Tanumihardjo SA, Penniston KL. Simplified methodology to determine breast milk retinol concentrations. J Lipid Res. 2002;43:350-5.
36. Reeves PG, Forrest HN, Fahey GC, Jr. AIN 93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN76A rodent diet. J Nutr. 1993;123:1939-51.