HSP40 ameliorates impairment of insulin secretion by inhibiting huntingtin aggregation in a hd pancreatic β cell model

Bioscience, Biotechnology and Biochemistry

Volumn 73, Issue 8, 2009, Pages 1787-1792

  Ye, Cui Fang ^a,b   Li, He ^a,b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^c WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Heat shock protein 40; Huntington's disease; Insulin secretion; NIT 1 cell

Indexed keywords

AGGREGATE FORMATION; CELL LINES; CELL MODEL; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 40; HUNTINGTIN; HUNTINGTON'S DISEASE; INSULIN RELEASE; INSULIN SECRETION; MUTANT HUNTINGTIN; NIT-1 CELL; OVER-EXPRESSION; SURVIVAL FACTOR;

AGGREGATES; CELL CULTURE; INSULIN; PROTEINS;

CELL MEMBRANES;

HD PROTEIN, HUMAN; HEAT SHOCK PROTEIN 40; INSULIN; MESSENGER RNA; NERVE PROTEIN; NUCLEAR PROTEIN; PROTEIN KINASE B;

ANIMAL; ARTICLE; CELL LINE; CYTOPLASM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; HUNTINGTON CHOREA; METABOLISM; MOUSE; MUTATION; PANCREAS ISLET BETA CELL; PATHOLOGY; PHOSPHORYLATION; PROTEIN BINDING; SECRETION;

ANIMALS; CELL LINE; CYTOPLASM; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HSP40 HEAT-SHOCK PROTEINS; HUMANS; HUNTINGTON DISEASE; INSULIN; INSULIN-SECRETING CELLS; MICE; MUTATION; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; TRANSFECTION;

EID: 69949182428     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.90147     Document Type: Article

References (39)

1. Huntington's Disease Collaborative Research Group, Cell, 72, 971-983 (1993).
2. Schilling G, Sharp AH, Loev SJ, Wagster MV, Li SH, Stine OC, and Ross CA, Hum. Mol. Genet., 4, 1365-1371 (1995).
3. Farrer LA, Clin. Genet., 27, 62-67 (1985).
4. Hurlbert MS, Zhou W, Wasmeier C, Kaddis FG, Hutton JC, and Freed CR, Diabetes, 48, 649-651 (1999).
5. Luesse HG, Schiefer J, Spruenken A, Puls C, Block F, and Kosinski CM, Behav. Brain Res., 126, 185-195 (2001).
6. Ross CA, Neuron, 35, 819-822 (2002).
7. Lin X, Cummings CJ, and Zoghbi HY, Neuron, 24, 499-502 (1999).
8. Sugars KL and Rubinsztein DC, TIGS, 19, 233-238 (2003).
9. Li H, Li SH, Johnston H, Shelbourne PF, and Li XJ, Nat. Genet., 25, 385-389 (2000).
10. Gunawardena S, Her LS, Brusch RG, Laymon RA, Niesman IR, Gordesky-Gold B, Sintasath L, Bonini NM, and Goldstein LS, Neuron, 40, 25-40 (2003).
11. Lee WC, Yoshihara M, and Littleton JT, Proc. Natl. Acad. Sci. USA, 101, 3224-3229 (2004).
12. Goswami A, Dikshit P, Mishra A, Mulherkar S, Nukina N, and Jana NR, Biochem. Biophys. Res. Commun., 342, 184-190 (2006).
13. Carmichael J, Chatellier J, Woolfson A, Milstein C, Fersht AR, and Rubinsztein DC, Proc. Natl. Acad. Sci. USA, 97, 9701-9705 (2000).
14. Muchowski PJ, Schaffar G, Sittler A, Wanker EE, Hayer-Hartl MK, and Hartl FU, Proc. Natl. Acad. Sci. USA, 97, 7841-7846 (2000).
15. Hartl FU, Nature, 381, 571-579 (1996).
16. Sathasivam K, Hobbs C, Turmaine M, Mangiarini L, Mahal A, Bertaux F, Wanker EE, Doherty P, Davies SW, and Bates GP, Hum. Mol. Genet., 8, 813-822 (1999).
17. Björkqvist M, Fex M, Renström E, Wierup N, Petersén A, Gil J, Bacos K, Popovic N, Li JY, Sundler F, Brundin P, and Mulder H, Hum. Mol. Genet., 14, 565-574 (2005).
18. Chan TO, Rittenhouse SE, and Tsichlis PN, Annu. Rev. Biochem., 68, 965-1014 (1999).
19. Humbert S, Bryson EA, Cordelieres FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, and Saudou F, Dev. Cell, 2, 831-837 (2002).
20. Gines S, Ivanova E, Seong IS, Saura CA, and MacDonald ME, J. Biol. Chem., 27, 50514-50522 (2003).
21. Zala D, Colin E, Rangone H, Liot G, Humbert S, and Saudou F, Hum. Mol. Genet., 17, 3837-3846 (2008).
22. Rangone H, Poizat G, Troncoso J, Ross CA, MacDonald ME, Saudou F, and Humbert S, Eur. J. Neuroscl, 19, 273-279 (2004).
23. Kulkarni RN, Bruning JC, Winnay JN, Postic C, Magnuson MA, and Kahn CR, Cell, 96, 329-339 (1999).
24. Nakata M, Okada T, Ozawa K, and Yada T, Biochem. Biophys. Res. Commun., 353, 1046-1051 (2007).
25. Park S, Ahn IS, Kwon DY, Ko BS, and Jun WK, Biosci. Biotechnol. Biochem., 72, 2815-2823 (2008).
26. Lawlor MA and Alessi DR, J. Cell Sci., 114, 2903-2910 (2001).
27. Ye C, Zhang Y, Wang W, Wang J, and Li H, Neuroscl Lett., 442, 63-68 (2008).
28. Ristow M, J. Mol. Med., 82, 510-529 (2004).
29. Jenkins BG, Klivenyi P, Kustermann E, Andreassen OA, Ferrante RJ, Rosen BR, and Beal MF, J. Neurochem., 74, 2108-2119 (2000).
30. Gutekunst CA, Levey AI, Heilman CJ, Whaley WL, Yi H, Nash NR, Rees HD, Madden JJ, and Hersch SM, Proc. Natl. Acad. Sci. USA, 92, 8710-8714 (1995).
31. Li H, Li SH, Cheng AL, Mangiarini L, Bates GP, and Li XJ, Hum. Mol. Genet., 8, 1227-1236 (1999).
32. Gauthier LR, Charrin BC, Borrell-Pages M, Dompierre JP, Rangone H, Cordelieres FP, De Mey J, MacDonald ME, Lessmann V, Humbert S, and Saudou F, Cell, 118, 127-138 (2004).
33. Li H, Wyman T, Yu ZX, Li SH, and Li XJ, Hum. Mol. Genet., 12, 2021-2030 (2003).
34. Edwardson JM, Wang CT, Gong B, Wyttenbach A, Bai J, Jackson MB, Chapman ER, and Morton AJ, J. Biol. Chem., 278, 30849-30853 (2003).
35. Lu Z and Cyr DM, J. Biol. Chem., 273, 5970-5978 (1998).
36. Meacham GC, Lu Z, King S, Sorscher E, Tousson A, and Cyr DM, EMBO J., 18, 1492-1505 (1999).
37. Jana NR, Tanaka M, Wang G, and Nukina N, Hum. Mol. Genet., 9, 2009-2018 (2000).
38. Suhr ST, Senit MC, Whitelegge JP, Faull KF, Cuizon DB, and Gage FH, J. Cell Biol, 153, 283-294 (2001).
39. Morton AJ and Edwardson JM, J. Neurochem., 76, 166-172 (2001).