Expression of the CD7 ligand K-12 in human thymic epithelial cells: Regulation by IFN-γ

Journal of Clinical Immunology

Volumn 25, Issue 1, 2005, Pages 41-49

  Lam, Gordon K ^a   Liao, Hua Xin ^a   Xue, Yan ^a   Alam, S Munir ^a   Scearce, Richard M ^a   Kaufman, Russel E ^a   Sempowski, Gregory D ^a   Haynes, Barton F ^a,b  

^a DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY   (United States)

Author keywords

CD7; Human; K12; Thymic epithelial cells

Indexed keywords

CD7 ANTIGEN; CELL PROTEIN; GAMMA INTERFERON; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTEIN K12; UNCLASSIFIED DRUG;

ARTICLE; CYTOKINE RELEASE; EPITHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; MICROENVIRONMENT; MYASTHENIA GRAVIS; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; THYMOCYTE; THYMUS; UPREGULATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD7; CELLS, CULTURED; CLONING, MOLECULAR; EPITHELIAL CELLS; FIBROBLASTS; HUMANS; INTERFERON TYPE II; INTERFERON-GAMMA, RECOMBINANT; MEMBRANE PROTEINS; T-LYMPHOCYTES; THYMUS GLAND; UP-REGULATION;

EID: 15244358223     PISSN: 02719142     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10875-005-0356-5     Document Type: Article

References (22)

1. Sempowski GD, Lee DM, Kaufman RE, Haynes BF: Structure and function of the CD7 molecule. Crit Rev Immunol 19:331-348, 1999
2. Jung LK, Roy AK, Chakkalath HR: CD7 augments T cell proliferation via the interleukin-2 autocrine pathway. Cell Immunol 141:189-199, 1992
3. + T cells. Fur J Immunol 21:1195-1200, 1991
4. Rabinowich H, Pricop L, Herberman RB, Whiteside TL: Expression and function of CD7 molecule on human natural killer cells. J Immunol 152:517-526, 1994
5. Sempowski GD, Lee DM, Scearce RM, Patel DD, Haynes BF: Resistance of CD7-deficient mice to lipopolysaccharide-induced shock syndromes. J Exp Med 189:1011-1016, 1999
6. Sempowski GD, Cross SJ, Heinly CS, Scearce RM, Haynes BF: CD7 and CD28 are required for murine CD4(+)CD25(+) regulatory T cell homeostasis and prevention of thyroiditis. J Immunol 172:787-794, 2004
7. Heinly CS, Sempowski GD, Lee DM, Patel DD, McDermott PM, Scearce RM, et al.: Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. Int Immunol 13:157-166, 2001
8. Slentz-Kesler KA, Hale LP, Kaufman RE: Identification and characterization of K12 (SECTM1), a novel human gene that encodes a golgi-associated protein with transmembrane and secreted isoforms. Genomics 47:327-340, 1998
9. Lyman SD, Escobar S, Rousseau AM, Armstrong A, Fanslow WC: Identification of CD7 as a cognate of the human K12 (SECTM1) protein. J Biol Chem 275:3431-3437, 2000
10. +CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules. J Immunol 160:3290-3298, 1998
11. Aruffo A, Seed B: Molecular cloning of t wo CD7 (T-cell leukemia antigen) cDNAs by a COS cell expression system. EMBO J 6:3313-3316, 1987
12. Alam SM, Travers PJ, Wung JL, Nasholds W, Redpath S, Jameson SC, et al.: T-cell-receptor affinity and thymocyte positive selection.[see comment]. Nature 381:616-620, 1996
13. Scearce RM, Eisenbarth GS: Production of monoclonal antibodies reacting with the cytoplasm and surface of differentiated cells. In Methods in Enzymology, Vol 103, Conn PH (ed). Academic Press, 1983, p. 459
14. Jung LK, Fu SM, Hara T, Kapoor N, Good RA: Defective expression of T cell-associated glycoprotein in severe combined immunodeficiency. J Clin Invest 77:940-946, 1986
15. Sempowski GD, Hale LP, Sundy JS, Massey JM, Koup RA, Douek, DC, et al.: Leukemia inhibitory factor, oncostatin M, IL-6, and stem cell factor mRNA expression in human thymus increases with age and is associated with thymic atrophy. J Immunol 164:2180-2187, 2000
16. Haynes BF, Markert ML, Sempowski GD, Patel DD, Hale LP: The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Ann Rev Immunol 18:529-560, 2000
17. Sempowski GD, Haynes BF: Immune reconstitution in patients with HIV infection. Annu Rev Med 53:269-284, 2002
18. + alpha beta T cells with intermediate TCR induced in the liver of mice by IL-12. J Immunol 154:4333-4340, 1995
19. + T cells and their IFN-gamma production in the generalized Shwartzman reaction. J Immunol 160:3522-3527, 1998
20. Seki S, Abo T, Ohteki T, Sugiura K, Kumagai K: Unusual alpha beta-T cells expanded in autoimmune 1pr mice are probably a counterpart of normal T cells in the liver. J Immunol 147:1214-1221, 1991
21. + alpha beta T cells with potent cytotoxicity in the liver of mice via production of IL-12 from Kupffer cells. J Immunol 156:2436-2442, 1996
22. Lee DM, Staats HF, Sundy JS, Patel DD, Sempowski GD, Scearce RM, et al.: Immunologic characterization of CD7-deficient mice. J Immunol 160:5749-5756, 1998